Vignuzzi Lab
@vignuzzilab.bsky.social
Antiviral therapeutics and virology. ASTAR ID Labs in Singapore. Diversity and compassion in STEM and academia, LGBTQQIP2SAA and anyone under the rainbow. Major in virology, minor in fitness.
Reposted by Vignuzzi Lab
Sharing this, quite relevant this week. www.thelancet.com/journals/lan...
Remembering my sister Rosalind Franklin
Rosalind Franklin died of ovarian cancer in 1958 aged 37 years. Sympathy and feminism
have combined to give us her familiar image as a downtrodden woman scientist, brilliant
but neglected, a heroine t...
www.thelancet.com
November 8, 2025 at 10:25 AM
Sharing this, quite relevant this week. www.thelancet.com/journals/lan...
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
November 7, 2025 at 10:15 AM
Szarina brought in virus snowflake cutout-yourself printouts to prepare for the Singapore winter and Christmas!
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.
November 6, 2025 at 9:58 AM
Today we had a computational virology workshop with Profs. Veronika Bernhauerova (Charles University Czechia) and Bartek Lisowski (Jagiellonian University Krakow, Dr. Spyros Lytras (Univ Tokyo) and Cedric Tan (UCL Crick Institute). 4 hours of chit chat and coming up with ways to collaborate.
Afternoon coffee break at Top Coffee Shop in Asia, number 6 in the world, dunno who’s list but must be an important one: Apartment Cafe. With Veronika Bernhauerova from Charles University Czechia and Bartek Lisowski of Jagiellonian University in Krakow Poland.
November 4, 2025 at 10:46 AM
Afternoon coffee break at Top Coffee Shop in Asia, number 6 in the world, dunno who’s list but must be an important one: Apartment Cafe. With Veronika Bernhauerova from Charles University Czechia and Bartek Lisowski of Jagiellonian University in Krakow Poland.
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference
The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...
www.biorxiv.org
November 4, 2025 at 3:17 AM
First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...
Welcome to our lab Mingcong (Albert) to our lab! Albert is from Chengdu China and will be an intern in our lab for the next seven months working with Fadi Alnaji.
October 21, 2025 at 10:46 PM
Welcome to our lab Mingcong (Albert) to our lab! Albert is from Chengdu China and will be an intern in our lab for the next seven months working with Fadi Alnaji.
Happy Diwali
Happy Deepavali
To all celebrating in Singapore and beyond!
Happy Deepavali
To all celebrating in Singapore and beyond!
October 20, 2025 at 2:36 AM
Happy Diwali
Happy Deepavali
To all celebrating in Singapore and beyond!
Happy Deepavali
To all celebrating in Singapore and beyond!
Be positive. Love thyself. Try to love others too.
October 13, 2025 at 2:24 AM
Be positive. Love thyself. Try to love others too.
Happening now. Prof. Kartik Chandran, in Singapore this week for the HCV & Flaviviruses conference, is speaking to ID Labs scientists on their coronavirus research.
October 10, 2025 at 4:15 AM
Happening now. Prof. Kartik Chandran, in Singapore this week for the HCV & Flaviviruses conference, is speaking to ID Labs scientists on their coronavirus research.
Reposted by Vignuzzi Lab
🦠 "Social Virology at the Tri-Kingdom Interface in Birds and Mammals" 🐥
We have a new 4y (open to intl students) PhD project advertised through the NorthWestBio Doctoral Training Partnership (lnkd.in/ee8hRpN6 ) between QUBelfast and Lancaster on virus-bacterial interactions across vertebrates!
We have a new 4y (open to intl students) PhD project advertised through the NorthWestBio Doctoral Training Partnership (lnkd.in/ee8hRpN6 ) between QUBelfast and Lancaster on virus-bacterial interactions across vertebrates!
October 5, 2025 at 8:52 PM
🦠 "Social Virology at the Tri-Kingdom Interface in Birds and Mammals" 🐥
We have a new 4y (open to intl students) PhD project advertised through the NorthWestBio Doctoral Training Partnership (lnkd.in/ee8hRpN6 ) between QUBelfast and Lancaster on virus-bacterial interactions across vertebrates!
We have a new 4y (open to intl students) PhD project advertised through the NorthWestBio Doctoral Training Partnership (lnkd.in/ee8hRpN6 ) between QUBelfast and Lancaster on virus-bacterial interactions across vertebrates!
Had a reminder by my colleague Amit Singhal that two years ago to this day our faculty had a retreat in my medieval village of Noyers-sur-Serein. Missing this clunky old house! 🏰 ❤️
October 6, 2025 at 2:03 AM
Had a reminder by my colleague Amit Singhal that two years ago to this day our faculty had a retreat in my medieval village of Noyers-sur-Serein. Missing this clunky old house! 🏰 ❤️
Reposted by Vignuzzi Lab
New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution
Genotype-by-Inhibitor Interactions to Dissect Enterovirus Replication
Replication organelles of positive-sense RNA viruses are essential to virus biology, yet their molecular mechanisms remain poorly defined. While deep mutational scanning (DMS) measures the impact of m...
researchsquare.com
September 29, 2025 at 8:13 PM
New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution
Very cool paper that I presented to journal club today by Singer et al, by Tal Danino and Charlie Rice labs.
I LOVE this paper!
rdcu.be/eH4le
As a postdoc in Andino lab 20 years ago, we took a similar strategy to deliver recombinant RNA viruses or saRNA by intracellular S. typhimurium.
I LOVE this paper!
rdcu.be/eH4le
As a postdoc in Andino lab 20 years ago, we took a similar strategy to deliver recombinant RNA viruses or saRNA by intracellular S. typhimurium.
Engineered bacteria launch and control an oncolytic virus
Nature Biomedical Engineering - CAPPSID relies on an engineered S. typhimurium to act as a synthetic ‘capsid’ to transcribe and deliver viral RNA inside cancer cells, launching a virus...
rdcu.be
September 25, 2025 at 6:16 AM
Very cool paper that I presented to journal club today by Singer et al, by Tal Danino and Charlie Rice labs.
I LOVE this paper!
rdcu.be/eH4le
As a postdoc in Andino lab 20 years ago, we took a similar strategy to deliver recombinant RNA viruses or saRNA by intracellular S. typhimurium.
I LOVE this paper!
rdcu.be/eH4le
As a postdoc in Andino lab 20 years ago, we took a similar strategy to deliver recombinant RNA viruses or saRNA by intracellular S. typhimurium.
Lab 🌈 at @astar-idlabs.bsky.social annual retreat at Universal Studios Singapore! What’s your colour? Where’s your pot of gold?
September 20, 2025 at 2:37 AM
Lab 🌈 at @astar-idlabs.bsky.social annual retreat at Universal Studios Singapore! What’s your colour? Where’s your pot of gold?
My lab found me in my hiding spot when I try to avoid responsibilities.
Back to work.
Back to work.
September 12, 2025 at 4:44 AM
My lab found me in my hiding spot when I try to avoid responsibilities.
Back to work.
Back to work.
Interested in attending the EMBO Lecture Course, entitled "RNA virus infection and host immune responses," hosted in Faridabad, India, on 11 – 14 February 2026?
sign up here:
meetings.embo.org/event/26-rna...
sign up here:
meetings.embo.org/event/26-rna...
RNA virus infection and host immune responses
The India I EMBO Lecture Course on “RNA virus infection and host immune responses” addresses cutting-edge research in emerging and reemerging RNA viruses, with particular emphasis on fundamental infe…
meetings.embo.org
September 11, 2025 at 5:06 AM
Interested in attending the EMBO Lecture Course, entitled "RNA virus infection and host immune responses," hosted in Faridabad, India, on 11 – 14 February 2026?
sign up here:
meetings.embo.org/event/26-rna...
sign up here:
meetings.embo.org/event/26-rna...
Congratulations to Jolene Fu from the University of Malaya in Kuala Lumpur. Today she defended her PhD thesis on COVID immune escape and evolution. Excellent dissertation and oral defence.
Dr. Jolene Fu, PhD!
Dr. Jolene Fu, PhD!
September 9, 2025 at 2:41 AM
Congratulations to Jolene Fu from the University of Malaya in Kuala Lumpur. Today she defended her PhD thesis on COVID immune escape and evolution. Excellent dissertation and oral defence.
Dr. Jolene Fu, PhD!
Dr. Jolene Fu, PhD!
Immigrant to new Citizens, 1977-1980, Canada. Our Citizenship photos.
Why was my photo different? Always the odd one out!
Why was my photo different? Always the odd one out!
September 8, 2025 at 6:31 AM
Immigrant to new Citizens, 1977-1980, Canada. Our Citizenship photos.
Why was my photo different? Always the odd one out!
Why was my photo different? Always the odd one out!
Welcome to Paul Foucambert! Paul is an MD from France, seeking experience in biomedical sciences, and will be part of our Vignuzzi lab family for the next three years developing new vaccine strategies, learning about molecular virology and sharing his medical and clinical insights.
Welcome Paul!
Welcome Paul!
September 2, 2025 at 7:47 AM
Welcome to Paul Foucambert! Paul is an MD from France, seeking experience in biomedical sciences, and will be part of our Vignuzzi lab family for the next three years developing new vaccine strategies, learning about molecular virology and sharing his medical and clinical insights.
Welcome Paul!
Welcome Paul!
Welcome Dariel Tanoto to our lab!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!
September 1, 2025 at 5:06 AM
Welcome Dariel Tanoto to our lab!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!
Dariel is a Research Officer that will be working with our postdoctoral scientist Fish Poh on new RNA therapeutics.
And with that we can add 🇮🇩 to our lab flags!
ift.onlinelibrary.wiley.com/doi/10.1111/...
Paolo, the computational biologist in my group, leads me into research fields I thought I never thought I'd see. It was nice to be part of this work from different ASTAR teams in food sciences!
Paolo, the computational biologist in my group, leads me into research fields I thought I never thought I'd see. It was nice to be part of this work from different ASTAR teams in food sciences!
pH‐Dependent Effect of Lecithin on Lupin‐Protein‐Based Egg Custard Mimics
ABSTRACT
This study presents lupin-protein-stabilized emulsions across pH 6.0–8.0, containing 9.92% protein and 7.97% lipid, which formed egg custard mimics upon steaming. To support emulsion stabil.....
ift.onlinelibrary.wiley.com
August 28, 2025 at 5:42 AM
ift.onlinelibrary.wiley.com/doi/10.1111/...
Paolo, the computational biologist in my group, leads me into research fields I thought I never thought I'd see. It was nice to be part of this work from different ASTAR teams in food sciences!
Paolo, the computational biologist in my group, leads me into research fields I thought I never thought I'd see. It was nice to be part of this work from different ASTAR teams in food sciences!
South East Asian Tick-borne Diseases symposium is happening now at NUS in Singapore.
August 28, 2025 at 2:23 AM
South East Asian Tick-borne Diseases symposium is happening now at NUS in Singapore.
Dr. Gamou Fall visited A*IDL today to present research by her Yellow Fever reference center and the WHO center for arboviruses and hemorrhagic fevers at Institut Pasteur de Dakar in Senegal.
Setting up new collaborations between Singapore and Senegal.
Setting up new collaborations between Singapore and Senegal.
August 27, 2025 at 6:49 AM
Dr. Gamou Fall visited A*IDL today to present research by her Yellow Fever reference center and the WHO center for arboviruses and hemorrhagic fevers at Institut Pasteur de Dakar in Senegal.
Setting up new collaborations between Singapore and Senegal.
Setting up new collaborations between Singapore and Senegal.
Reposted by Vignuzzi Lab
Last day at @vignuzzilab.bsky.social ! Leaving in The Office style. Been a fruitful journey and definitely grew me scientifically🧬🔬!
August 22, 2025 at 4:55 AM
Last day at @vignuzzilab.bsky.social ! Leaving in The Office style. Been a fruitful journey and definitely grew me scientifically🧬🔬!