Isaiah Kletenik
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isaiahneuro.bsky.social
Isaiah Kletenik
@isaiahneuro.bsky.social
Assistant Professor, Harvard Medical School / Cognitive Neurologist, BWH / Network neuroimaging of cognition 🧠⚡️ @braincircuits.bsky.social
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Can a brain injury lead someone to commit a crime?

Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...
White matter disconnection in acquired criminality - Molecular Psychiatry
Molecular Psychiatry - White matter disconnection in acquired criminality
www.nature.com
Was fun presenting our work on network localization of aphantasia at #ASSC @assc28.bsky.social - I get pretty excited about #consciousness and visual mental imagery
July 7, 2025 at 8:33 PM
Nice coverage of our recent paper: “White matter disconnection in acquired criminality” in @springernature.com by @cuanschutz.bsky.social

news.cuanschutz.edu/news-stories...
Study Finds Link Between Brain Injury And Criminal Behavior
Study shows criminality is associated with damage to a key brain pathway involved in emotional control and judgment
news.cuanschutz.edu
June 26, 2025 at 10:36 PM
What is common knowledge in your field, but shocks outsiders?

There are almost no routine clinical applications of functional MRI for diagnosis and treatment in Neurology
What is common knowledge in your field, but shocks outsiders?

Scientists and governments aren’t colluding to hide the cure for cancer.
What is common knowledge in your field, but shocks outsiders?

Almost all of the bugs and problems and breakage in the software you use is known to the engineers, we just aren't allowed to fix it. Gotta ship new features.
June 17, 2025 at 3:50 PM
Can a brain injury lead someone to commit a crime?

Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...
White matter disconnection in acquired criminality - Molecular Psychiatry
Molecular Psychiatry - White matter disconnection in acquired criminality
www.nature.com
June 11, 2025 at 4:37 PM
Reposted by Isaiah Kletenik
How far we’ve come in the “imagery debate”!
May 27, 2025 at 11:48 AM
Reposted by Isaiah Kletenik
Interesting new lesion meta-analysis of aphantasia, in line with the importance of a specific region in the fusiform gyrus, previously identified by @alfredospagna.bsky.social et al, for visual mental imagery 🧠

www.medrxiv.org/content/10.1...
Visual Mental Imagery and Aphantasia Lesions Map onto a Convergent Brain Network
Background Visual mental imagery, the ability to volitionally form perceptual representations without corresponding external stimuli, allows reliving of past events, solving problems and imagining the...
www.medrxiv.org
May 27, 2025 at 9:35 AM
Can brain injury cause the loss of visual imagination?

We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social

www.medrxiv.org/content/10.1...
May 23, 2025 at 10:02 PM
Reposted by Isaiah Kletenik
When the moment came, Harvard didn’t hedge or flinch—it stood up. A reminder that integrity isn’t complicated, it’s just rare.
April 24, 2025 at 8:51 PM
Reposted by Isaiah Kletenik
This is high art
April 6, 2025 at 9:37 PM
How does early life adversity impact white matter brain connections and subsequent cognitive abilities?

Adversity was associated with lower white matter integrity and later difficulty with arithmetic & receptive language yet interpersonal resilience was protective.

www.pnas.org/doi/epub/10....
www.pnas.org
April 7, 2025 at 8:52 PM
Reposted by Isaiah Kletenik
Standing room only for 2 hour symposium on functional neurological disorder (#FND) at the #AAN2025 meeting - with a focus on functional seizures, post concussive syndrome / functional cognitive disorder & pathophysiology. #BarbaraDworetzky @mattburkemd.bsky.social
April 6, 2025 at 12:30 AM
What is midrash? Interesting analysis by Ishay Rosen-Zvi @harvarddivinity.bsky.social on unique midrashic terminology (and apparently the Qumran folks thought there was a Sefer haBrit given to Abraham 📜)
March 28, 2025 at 6:17 PM
Cool talk by Aaron Boes on clinical applications and cognitive prognosis from network neuroimaging @bostonchildrens.bsky.social @harvardmed.bsky.social
March 26, 2025 at 6:21 PM
Reposted by Isaiah Kletenik
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications
Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.
www.nature.com
March 26, 2025 at 1:54 AM
Reposted by Isaiah Kletenik
99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...
Comparison of Research Spending on New Drug Approvals by the NIH vs the Pharmaceutical Industry
This cross-sectional study examines National Institutes of Health and pharmaceutical industry investments in recent drug approvals.
jamanetwork.com
March 10, 2025 at 2:15 PM
Reposted by Isaiah Kletenik
Measles top Page One.

@usatoday.com
February 27, 2025 at 11:20 AM
Reposted by Isaiah Kletenik
Does human creativity map to a specific brain circuit? Can damage to this brain circuit increase creativity? New paper by Julian Kutsche @isaiahneuro.bsky.social @braincircuits.bsky.social out today in JAMA Network says answer to both is YES. Paper is open access and great thread below:
How can a brain disease increase creativity? We derive a brain circuit from creative tasks demonstrating they share reduced activity in the right frontal pole. Then we show that brain lesions & neurodegeneration that increase creativity are connected to this location
jamanetwork.com/journals/jam...
Mapping Neuroimaging Findings of Creativity and Brain Disease
This study using network mapping of meta-analytic data investigates whether creativity maps to a specific brain circuit and whether damage to that circuit aligns with creativity changes observed in pe...
jamanetwork.com
February 13, 2025 at 7:54 PM
How can a brain disease increase creativity? We derive a brain circuit from creative tasks demonstrating they share reduced activity in the right frontal pole. Then we show that brain lesions & neurodegeneration that increase creativity are connected to this location
jamanetwork.com/journals/jam...
Mapping Neuroimaging Findings of Creativity and Brain Disease
This study using network mapping of meta-analytic data investigates whether creativity maps to a specific brain circuit and whether damage to that circuit aligns with creativity changes observed in pe...
jamanetwork.com
February 13, 2025 at 4:11 PM
Reposted by Isaiah Kletenik
Do lesions that cause psychosis fall into a common brain network?

Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here:
jamanetwork.com/journals/jam...
February 12, 2025 at 9:01 PM
Reposted by Isaiah Kletenik
I hope you enjoy some of the ideas I put forward in “Metacognition in the listening brain”: Trends in Neurosciences www.cell.com/trends/neuro... — out now.
Metacognition in the listening brain
How do you know you have heard right? Metacognition, the ability to assess and monitor one’s own cognitive state, is key to understanding human communication in complex environments. However, the foun...
www.cell.com
February 11, 2025 at 4:03 PM
Reposted by Isaiah Kletenik
Contra Michel et al.s' recent (2024) Letter in TICS (@matthiasmichel.bsky.social @jorge-morales.bsky.social), I argue that the episodic memory findings in aphantasia are genuine and defend the episodic memory account of aphantasia.

www.sciencedirect.com/science/arti...
Defending the episodic memory account of aphantasia
www.sciencedirect.com
February 12, 2025 at 11:28 AM