Innovative Genomics Institute
@innovativegenomics.bsky.social
Using genome engineering to solve humanity’s greatest problems in health, climate & sustainable agriculture. UC Berkeley, UCSF, UC Davis. https://innovativegenomics.org/
New from IGI's @marsonlab.bsky.social and @juliacarnevale.bsky.social, with co-authors @jenniferdoudna.bsky.social, @j-eyquem.bsky.social, James Nuñez!
Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social
December 15, 2025 at 5:56 PM
New from IGI's @marsonlab.bsky.social and @juliacarnevale.bsky.social, with co-authors @jenniferdoudna.bsky.social, @j-eyquem.bsky.social, James Nuñez!
The first-ever personalized CRISPR medicine, genomics meets AI + automation, editing gut microbes for health + climate applications, field trials for climate-resistant crops — 2025 has been an exciting year for the IGI! Learn about these + more in our annual Impact Report: https://ow.ly/h2OA50XIAVV
December 15, 2025 at 4:10 PM
The first-ever personalized CRISPR medicine, genomics meets AI + automation, editing gut microbes for health + climate applications, field trials for climate-resistant crops — 2025 has been an exciting year for the IGI! Learn about these + more in our annual Impact Report: https://ow.ly/h2OA50XIAVV
Cow farming is a major source of greenhouse gases. New research from IGI Investigators at UC Berkeley and UC Davis uncovers a microbial blueprint for climate-friendly cows. Read here: https://ow.ly/4wbu50XAkzZ
December 11, 2025 at 7:05 PM
Cow farming is a major source of greenhouse gases. New research from IGI Investigators at UC Berkeley and UC Davis uncovers a microbial blueprint for climate-friendly cows. Read here: https://ow.ly/4wbu50XAkzZ
Reposted by Innovative Genomics Institute
A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the remarkable people chosen for Nature’s 10 2025
Check out the full list: go.nature.com/4rIQH8H
Check out the full list: go.nature.com/4rIQH8H
December 8, 2025 at 5:37 PM
A fired public-health official, a mosquito breeder and a baby with a smile seen around the world. These are just a few of the remarkable people chosen for Nature’s 10 2025
Check out the full list: go.nature.com/4rIQH8H
Check out the full list: go.nature.com/4rIQH8H
Reposted by Innovative Genomics Institute
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
Viral enzymes degrade to evade
Across all domains of life, immune systems rely on nucleotide-based signaling molecules
to activate defense responses. In a recent Cell Host & Microbe study, Doherty, Nomburg,
and colleagues identify ...
www.cell.com
December 10, 2025 at 5:24 PM
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
Congrats to IGI's Jill Banfield, Jennifer Doudna, Mary Firestone, Patrick Hsu, Alex Marson, Kris Niyogi, Eva Nogales, Dan Nomura, and Jennifer Puck — each is on Clarivate's Highly Cited Researchers 2025 list for ranking in the top 1% in their field by citations!
December 10, 2025 at 5:20 PM
Congrats to IGI's Jill Banfield, Jennifer Doudna, Mary Firestone, Patrick Hsu, Alex Marson, Kris Niyogi, Eva Nogales, Dan Nomura, and Jennifer Puck — each is on Clarivate's Highly Cited Researchers 2025 list for ranking in the top 1% in their field by citations!
Reposted by Innovative Genomics Institute
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 6:04 PM
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
🥂Congrats to IGI's Venkatesan Sundaresan and Imtiyaz Khanday on being awarded the VinFuture Prize in recognition of their work developing self-cloning crops! Read more: https://ow.ly/JbPO50XFWgm
December 9, 2025 at 3:55 PM
🥂Congrats to IGI's Venkatesan Sundaresan and Imtiyaz Khanday on being awarded the VinFuture Prize in recognition of their work developing self-cloning crops! Read more: https://ow.ly/JbPO50XFWgm
You've heard of elf on a shelf. Now get ready for gene editor on a green predator...
December 8, 2025 at 7:52 PM
You've heard of elf on a shelf. Now get ready for gene editor on a green predator...
Out now in the The Atlantic — IGI's Jennifer Doudna and Fyodor Urnov on this year's remarkable progress in using #CRISPR to treat rare diseases. Read here: https://ow.ly/5vJ750XFQon
December 8, 2025 at 5:42 PM
Out now in the The Atlantic — IGI's Jennifer Doudna and Fyodor Urnov on this year's remarkable progress in using #CRISPR to treat rare diseases. Read here: https://ow.ly/5vJ750XFQon
Out today in Science Magazine — First author Veronika Kivenson and PIs Jill Banfield (The Banfield Lab) and Alanna Schepartz team up to reveal a new genetic code in #archaea, with implications for #methane and #climate, and #bioengineering! Learn more: https://ow.ly/Kuem50Xurh0
December 8, 2025 at 3:50 PM
Out today in Science Magazine — First author Veronika Kivenson and PIs Jill Banfield (The Banfield Lab) and Alanna Schepartz team up to reveal a new genetic code in #archaea, with implications for #methane and #climate, and #bioengineering! Learn more: https://ow.ly/Kuem50Xurh0
New from IGI's Carlotta Ronda and collaborators at Columbia University — a new method for editing gut bacteria in vivo using transposases. Read now in Science Magazine: https://ow.ly/U5uV50XAkfQ
December 4, 2025 at 9:45 PM
New from IGI's Carlotta Ronda and collaborators at Columbia University — a new method for editing gut bacteria in vivo using transposases. Read now in Science Magazine: https://ow.ly/U5uV50XAkfQ
Reposted by Innovative Genomics Institute
Out now in Nature Communications: Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses
www.nature.com/articles/s41...
@luisvalentin.bsky.social @lingdong-shi.bsky.social @martianmicrobe.bsky.social @mschoelmerich.bsky.social
www.nature.com/articles/s41...
@luisvalentin.bsky.social @lingdong-shi.bsky.social @martianmicrobe.bsky.social @mschoelmerich.bsky.social
Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses - Nature Communications
Borgs are large extrachromosomal elements of anaerobic methane-oxidizing archaea. Here, via in silico protein structure prediction of ~10,000 Borg proteins, the authors reveal that Borgs share numerou...
www.nature.com
November 28, 2025 at 9:01 PM
Out now in Nature Communications: Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses
www.nature.com/articles/s41...
@luisvalentin.bsky.social @lingdong-shi.bsky.social @martianmicrobe.bsky.social @mschoelmerich.bsky.social
www.nature.com/articles/s41...
@luisvalentin.bsky.social @lingdong-shi.bsky.social @martianmicrobe.bsky.social @mschoelmerich.bsky.social
Reposted by Innovative Genomics Institute
This paper was a wonderful collaborative effort between the wetlab and computational sides of our lab, and we look forward to our future projects building upon this model!
December 2, 2025 at 10:35 PM
This paper was a wonderful collaborative effort between the wetlab and computational sides of our lab, and we look forward to our future projects building upon this model!
Reposted by Innovative Genomics Institute
We're excited to share our lab's first lead paper!
We developed OriGen, a language model trained to generate plasmid origins of replication. 🔄🦠
The model generates sequences that are significantly different from wild type origins and, remarkably, they allow for replication in vivo.
Read it here ⬇️
We developed OriGen, a language model trained to generate plasmid origins of replication. 🔄🦠
The model generates sequences that are significantly different from wild type origins and, remarkably, they allow for replication in vivo.
Read it here ⬇️
Validate User
academic.oup.com
December 2, 2025 at 10:35 PM
We're excited to share our lab's first lead paper!
We developed OriGen, a language model trained to generate plasmid origins of replication. 🔄🦠
The model generates sequences that are significantly different from wild type origins and, remarkably, they allow for replication in vivo.
Read it here ⬇️
We developed OriGen, a language model trained to generate plasmid origins of replication. 🔄🦠
The model generates sequences that are significantly different from wild type origins and, remarkably, they allow for replication in vivo.
Read it here ⬇️
The ability to edit neurons could open new doors to treating brain disorders, but so far has proved challenging. A new study from IGI's Bruce Conklin sheds lights on why it's so tricky, which could impact how new brain-based editors are designed. Read here: https://ow.ly/qczT50XAjLq
December 3, 2025 at 4:30 PM
The ability to edit neurons could open new doors to treating brain disorders, but so far has proved challenging. A new study from IGI's Bruce Conklin sheds lights on why it's so tricky, which could impact how new brain-based editors are designed. Read here: https://ow.ly/qczT50XAjLq
Reposted by Innovative Genomics Institute
We're excited to help launch the inaugural Gordon research conference on #microbiome editing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/a6Am50X9XkE
October 27, 2025 at 3:05 PM
We're excited to help launch the inaugural Gordon research conference on #microbiome editing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/a6Am50X9XkE
Big news! Our team developed Neuro-PERC, a non-viral CRISPR delivery platform for genome editing of the brain. In our new preprint - bit.ly/NeuroPERC_pre - we report efficient editing in multiple models & species, including field-first results in large animals (pigs) 🧵👇
bit.ly
December 2, 2025 at 5:14 PM
IGI's Moi Expósito-Alonso (MOILAB) on his path from growing up in Spain and dreaming of becoming an ecologist to running a research group at Berkeley, studying plant adaptation to #ClimateChange. New from IGI's Emma MacKenzie! Read here: https://ow.ly/g4ph50XAjp4
December 2, 2025 at 4:15 PM
IGI's Moi Expósito-Alonso (MOILAB) on his path from growing up in Spain and dreaming of becoming an ecologist to running a research group at Berkeley, studying plant adaptation to #ClimateChange. New from IGI's Emma MacKenzie! Read here: https://ow.ly/g4ph50XAjp4
I named my fists pH and buffer because ya basic
December 1, 2025 at 6:12 PM
I named my fists pH and buffer because ya basic
Reposted by Innovative Genomics Institute
Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️
New in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin-like protease repeatedly acquired by multiple, ...
ow.ly
November 26, 2025 at 2:46 AM
Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️
Plant synthetic biology explained in 101 seconds, featuring IGI Investigator Patrick Shih! Watch here: https://youtu.be/yf8Zt4LHnhI?si=6MGoC71CdZTfom7N
December 1, 2025 at 4:40 PM
Plant synthetic biology explained in 101 seconds, featuring IGI Investigator Patrick Shih! Watch here: https://youtu.be/yf8Zt4LHnhI?si=6MGoC71CdZTfom7N
For the second year in a row, IGI had a booth at #NDiSTEM, the annual conference from SACNAS! More than a hundred students stopped by to learn about IGI and opportunities at the University of California.
November 26, 2025 at 4:02 PM
For the second year in a row, IGI had a booth at #NDiSTEM, the annual conference from SACNAS! More than a hundred students stopped by to learn about IGI and opportunities at the University of California.
Reposted by Innovative Genomics Institute
Such a privilege to see my summer mentee present her work at #ABRCMS2025!
November 23, 2025 at 2:21 AM
Such a privilege to see my summer mentee present her work at #ABRCMS2025!
Reposted by Innovative Genomics Institute
So happy to see this work out! Was such a pleasure to co-lead this effort with Erin. Do you like viral immune evasion, and using protein structure to study immune antagonists? Give it a read!
Work I co-led with @jnoms.bsky.social is now online at
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to …
www.sciencedirect.com
November 25, 2025 at 9:34 PM
So happy to see this work out! Was such a pleasure to co-lead this effort with Erin. Do you like viral immune evasion, and using protein structure to study immune antagonists? Give it a read!