Harrison Stratton
@hstratton.bsky.social
Neuroscientist | First Gen | Tech enthusiast. Postdoc at University of Pittsburgh studying mechanisms underlying chronic pain in the periphery and spinal cord.
Reposted by Harrison Stratton
Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...
Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications
Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...
www.nature.com
September 10, 2025 at 6:37 PM
Fascinating new work reveals how anti-CV2/CRMP5 autoantibodies may be a potential driver of neuropathic pain in paraneoplastic syndromes. This mechanistic insight suggests a new therapeutic approach for patients. www.nature.com/articles/s41...
Reposted by Harrison Stratton
So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization.
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy
Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies ag...
www.biorxiv.org
October 9, 2025 at 5:05 PM
So excited to share our preprint uncovering FGFR3 autoantibodies as pathogenic drivers of pain sensitization.
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
Using patient serum, human DRG and rat models, we found that autoantibodies can find FGFR3 on sensory neurons to induce hyperexcitability and hypersensitivity.
#PainResearch #Autoimmunity
Reposted by Harrison Stratton
I realized reading Dear Reader, the Unauthorized Autobiography of Kim Jong Il that some extraordinary men can see mitochondria with their naked eyes just walking around so I’m not surprised.
RFK Jr: “I’m looking at kids as I walk through the airports today and see these kids that are just overburdened with mitochondrial challenges, inflammation. You can tell from their faces, movements, and lack of social connection”
August 28, 2025 at 2:11 AM
I realized reading Dear Reader, the Unauthorized Autobiography of Kim Jong Il that some extraordinary men can see mitochondria with their naked eyes just walking around so I’m not surprised.
Reposted by Harrison Stratton
The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social
August 31, 2025 at 12:08 PM
The latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social
Reposted by Harrison Stratton
Webinar – 8 September
Artificial Intelligence (AI) in Exploratory Human Research
Register: bit.ly/478tBk2
ML/AI approaches are currently redrawing statistics, as they demonstrate an ability to separate complex data finding unpredicted patterns.
#PainEducation
Artificial Intelligence (AI) in Exploratory Human Research
Register: bit.ly/478tBk2
ML/AI approaches are currently redrawing statistics, as they demonstrate an ability to separate complex data finding unpredicted patterns.
#PainEducation
August 25, 2025 at 1:00 PM
Webinar – 8 September
Artificial Intelligence (AI) in Exploratory Human Research
Register: bit.ly/478tBk2
ML/AI approaches are currently redrawing statistics, as they demonstrate an ability to separate complex data finding unpredicted patterns.
#PainEducation
Artificial Intelligence (AI) in Exploratory Human Research
Register: bit.ly/478tBk2
ML/AI approaches are currently redrawing statistics, as they demonstrate an ability to separate complex data finding unpredicted patterns.
#PainEducation
Reposted by Harrison Stratton
Please consider donating. This is an incredible resource that is the foundation for so much of what we know in biology.
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 27, 2025 at 2:15 AM
Please consider donating. This is an incredible resource that is the foundation for so much of what we know in biology.
Reposted by Harrison Stratton
very well done video on what is happening to basic health research right now all over the US: www.nytimes.com/2025/08/24/o...
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
August 24, 2025 at 6:41 PM
very well done video on what is happening to basic health research right now all over the US: www.nytimes.com/2025/08/24/o...
Reposted by Harrison Stratton
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 22, 2025 at 10:21 PM
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Harrison Stratton
The list of the latest published pain papers is out now on PRF! Dr. Qiufu Ma's curated list for August 15-21, 2025 and his choice for Editor's pick can be found here: painresearchforum.org/paper @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social
August 22, 2025 at 6:06 PM
The list of the latest published pain papers is out now on PRF! Dr. Qiufu Ma's curated list for August 15-21, 2025 and his choice for Editor's pick can be found here: painresearchforum.org/paper @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social
Reposted by Harrison Stratton
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI -
Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy
www.jci.org
August 19, 2025 at 4:55 PM
This work is finally online as in-press preview!
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...
Reposted by Harrison Stratton
A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.
Jiang et al. find that collapsin response mediator protein 2 phosphorylation in CD4+ T cells affects spinal infiltration and pain modulation, hinting at novel therapies for rheumatoid arthritis–related chronic pain. Learn more in #PAIN bit.ly/3HnqDO4
August 18, 2025 at 1:48 PM
A big game changer in the CRMP2 game bringing together old and new litterature and further validating CRMP2 phosphorylation at S522 as a excellent therapeutic target for alleviating pain.
Really enjoyed going to see the Steeler's preseason game yesterday! The Steeler's played well but in the end lost to Tampa Bay. It was my first time to a Steeler's game and I have to say I enjoyed it. Although it was very hot!
August 17, 2025 at 11:57 PM
Really enjoyed going to see the Steeler's preseason game yesterday! The Steeler's played well but in the end lost to Tampa Bay. It was my first time to a Steeler's game and I have to say I enjoyed it. Although it was very hot!
Reposted by Harrison Stratton
This preprint: www.biorxiv.org/content/10.1... is now accepted for publication in JCI! Heavily revised manuscript with tons of exciting new data should be online soon. Huge congrats to @dianatavf.bsky.social who led this project with incredible creativity and skill, just like she always does!
Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy
Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus that is caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight into the disea...
www.biorxiv.org
August 16, 2025 at 4:09 PM
This preprint: www.biorxiv.org/content/10.1... is now accepted for publication in JCI! Heavily revised manuscript with tons of exciting new data should be online soon. Huge congrats to @dianatavf.bsky.social who led this project with incredible creativity and skill, just like she always does!
Reposted by Harrison Stratton
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 5:49 PM
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Reposted by Harrison Stratton
What do you think Lee et al.’s findings in @natcomms.nature.com of a feedforward amplification circuit for cool sensation, as well as a modality-specific spinal pathway for thermal processing, do for our understanding of thermosensation? bit.ly/3JlS8rS #PRF
August 13, 2025 at 2:00 PM
What do you think Lee et al.’s findings in @natcomms.nature.com of a feedforward amplification circuit for cool sensation, as well as a modality-specific spinal pathway for thermal processing, do for our understanding of thermosensation? bit.ly/3JlS8rS #PRF
Reposted by Harrison Stratton
Hats off to lead author Tony Lim who drove this project from writing the fellowship application, to establishing new techniques in the lab.
We developed a reversible self-amplifying RNA (saRNA) system that encodes innate immune suppression directly within saRNA.
Next step, in vivo!
We developed a reversible self-amplifying RNA (saRNA) system that encodes innate immune suppression directly within saRNA.
Next step, in vivo!
A promising new approach for self-amplifying RNA that avoids triggering strong inflammatory responses in cells, paving the way for safer, longer-lasting gene therapies without immune suppression.
buff.ly/xQWCPhJ
buff.ly/xQWCPhJ
August 10, 2025 at 10:22 AM
Hats off to lead author Tony Lim who drove this project from writing the fellowship application, to establishing new techniques in the lab.
We developed a reversible self-amplifying RNA (saRNA) system that encodes innate immune suppression directly within saRNA.
Next step, in vivo!
We developed a reversible self-amplifying RNA (saRNA) system that encodes innate immune suppression directly within saRNA.
Next step, in vivo!
Reposted by Harrison Stratton
Just posted on Pain Research Forum! Dr. Greg Scherrer's curated list of pain-related papers published August 1-7, 2025 and his choice for Editor's pick. Check it out at painresearchforum.org @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social
August 8, 2025 at 10:27 PM
Just posted on Pain Research Forum! Dr. Greg Scherrer's curated list of pain-related papers published August 1-7, 2025 and his choice for Editor's pick. Check it out at painresearchforum.org @iasp.bsky.social @nyupainresearch.bsky.social @utdpaincenter.bsky.social @sutherlandphd.bsky.social
Check out our new paper in Nature Communications! CRMP5 is a central regulator of pain and DRG hyper-excitability!
I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41...
This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes.
#PainResearch
This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes.
#PainResearch
Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications
Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...
www.nature.com
August 8, 2025 at 11:45 AM
Check out our new paper in Nature Communications! CRMP5 is a central regulator of pain and DRG hyper-excitability!
Reposted by Harrison Stratton
What do you think Li et al.’s findings in @natcomms.nature.com of a non-canonical dynorphin receptor does to change our understanding of the endogenous opioid system? bit.ly/3J9hxoA #EditorsPick #PRF
August 6, 2025 at 2:00 PM
What do you think Li et al.’s findings in @natcomms.nature.com of a non-canonical dynorphin receptor does to change our understanding of the endogenous opioid system? bit.ly/3J9hxoA #EditorsPick #PRF
Reposted by Harrison Stratton
‘Congress has your back’: US senators tell scientists they want to protect NIH budget
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘Congress has your back’: US senators tell scientists they want to protect NIH budget
Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.
www.nature.com
August 1, 2025 at 2:51 PM
‘Congress has your back’: US senators tell scientists they want to protect NIH budget
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Harrison Stratton
Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #podcast #newepisode #PRF
July 30, 2025 at 7:00 PM
Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #podcast #newepisode #PRF
Reposted by Harrison Stratton
cool explainer thread ⬇️
The Grant Submission Process Part 1B
We went through the basics of the grant submission process last time, but there were some aspects that are helped by understanding how to read a Notice of Funding Opportunity (NOFO). We’ll go over the parent R01 announcement:
grants.nih.gov/grants/guide...
We went through the basics of the grant submission process last time, but there were some aspects that are helped by understanding how to read a Notice of Funding Opportunity (NOFO). We’ll go over the parent R01 announcement:
grants.nih.gov/grants/guide...
PA-25-301: NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) PA-25-301. NIH
grants.nih.gov
July 28, 2025 at 10:44 PM
cool explainer thread ⬇️
Reposted by Harrison Stratton
We're hiring! Nature Neuroscience is hiring an Associate or Senior Editor with experience in cellular and molecular neuroscience, glia, and genomics to work in our New York or Shanghai office. Applications are due August 19.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Associate or Senior Editor, Nature Neuroscience
Title: Associate or Senior Editor, Nature Neuroscience Location(s): New York or Shanghai – Hybrid working model Application Deadline: August 18th About Springer Nature Springer Nature is one of the le...
springernature.wd3.myworkdayjobs.com
July 22, 2025 at 7:10 PM
We're hiring! Nature Neuroscience is hiring an Associate or Senior Editor with experience in cellular and molecular neuroscience, glia, and genomics to work in our New York or Shanghai office. Applications are due August 19.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Check out this most recent webinar on improving trust in clinical trials. An incredibly important topic!
Did you have a chance to catch @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social discuss “trustworthiness” in clinical trial data? Watch the recording here bit.ly/4luQVMS
July 28, 2025 at 8:48 PM
Check out this most recent webinar on improving trust in clinical trials. An incredibly important topic!