Jens Hjerling Leffler
@hjerling-leffler.bsky.social
Molecular Psychiatry, Neuroscience, Genetics, Professor at Karolinska Insitutet
Reposted by Jens Hjerling Leffler
Pet peeve: when someone invites you to a meeting but instead of sending a calendar invitation, they just send a zoom link in an email.
If you want profs to actually show up for meetings-- send a calendar invitation!
#AcademicSky #ScienceSky #MedSky #EpiSky
If you want profs to actually show up for meetings-- send a calendar invitation!
#AcademicSky #ScienceSky #MedSky #EpiSky
a netflix ad shows a woman in a blue dress
ALT: a netflix ad shows a woman in a blue dress
media.tenor.com
November 16, 2025 at 12:53 AM
Pet peeve: when someone invites you to a meeting but instead of sending a calendar invitation, they just send a zoom link in an email.
If you want profs to actually show up for meetings-- send a calendar invitation!
#AcademicSky #ScienceSky #MedSky #EpiSky
If you want profs to actually show up for meetings-- send a calendar invitation!
#AcademicSky #ScienceSky #MedSky #EpiSky
Reposted by Jens Hjerling Leffler
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD
rdcu.be/ePmwD
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Nature Neuroscience - Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations....
rdcu.be
November 12, 2025 at 12:12 PM
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD
rdcu.be/ePmwD
Reposted by Jens Hjerling Leffler
Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies
Spiking Neural Networks (SNNs) have gained increasing attention for their ability to operate on low-power neuromorphic hardware, offering a pathway toward energy-efficient large language models (LLMs)...
www.biorxiv.org
November 3, 2025 at 7:52 PM
Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
Reposted by Jens Hjerling Leffler
✨Hello folks!✨
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
November 1, 2025 at 5:20 PM
✨Hello folks!✨
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦
"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"
🔗http://bit.ly/49syndi
Read our overview below!
🧵1/6
Reposted by Jens Hjerling Leffler
Hey bsky-ers! New preprint from the lab on #psilocybin & social behaviour in #female mice in contexts relevant to eating disorders (food restriction, exercise & combo of) by PhD student Sheida 💙🦋
Psilocybin exerts differential effects on social behaviour and inflammation in mice in contexts of activity-based anorexia (ABA) https://www.biorxiv.org/content/10.1101/2025.10.14.682467v1
October 16, 2025 at 8:21 AM
Hey bsky-ers! New preprint from the lab on #psilocybin & social behaviour in #female mice in contexts relevant to eating disorders (food restriction, exercise & combo of) by PhD student Sheida 💙🦋
Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia
October 8, 2025 at 9:35 AM
Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia
Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)
October 8, 2025 at 9:05 AM
Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)
Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).
October 8, 2025 at 9:03 AM
Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).
Reposted by Jens Hjerling Leffler
A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex
Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…
www.sciencedirect.com
September 18, 2025 at 4:16 PM
A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.
September 11, 2025 at 11:56 AM
Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.
Reposted by Jens Hjerling Leffler
Incredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...
Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons
Objective Converging evidence from neuroimaging studies and genome-wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology o...
onlinelibrary.wiley.com
September 7, 2025 at 2:44 AM
Incredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Jens Hjerling Leffler
How do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social
‼️ New manuscript alert ‼️ I’m thrilled to share this work examining chronic stress-related “depression” and immune cells at the blood brain barrier: www.nature.com/articles/s41...
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
Nature Communications - Chronic stress is a risk factor for depression, yet the mechanisms are unclear. Here, the authors show in mice that stress drives interferon-mediated neutrophil recruitment...
www.nature.com
September 1, 2025 at 11:28 AM
How do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social
Reposted by Jens Hjerling Leffler
Understanding why antidepressants don't always work 🧠🛡️
New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression.
📖https://bit.ly/469cXyI
New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression.
📖https://bit.ly/469cXyI
September 4, 2025 at 8:35 AM
Understanding why antidepressants don't always work 🧠🛡️
New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression.
📖https://bit.ly/469cXyI
New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression.
📖https://bit.ly/469cXyI
Reposted by Jens Hjerling Leffler
New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
August 25, 2025 at 7:13 PM
New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
Reposted by Jens Hjerling Leffler
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:08 AM
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Reposted by Jens Hjerling Leffler
Wow
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
July 25, 2025 at 10:29 PM
Wow
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Reposted by Jens Hjerling Leffler
Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...
Professor of Pharmacology - Uppsala University
Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University
www.uu.se
June 24, 2025 at 3:18 PM
Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...
I definitely never regretted the decision to leave New York for Stockholm and Karolinska - now you can join us: big call for assistant professors across medical disciplines coming up. news.ki.se/ki-to-recrui...
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
news.ki.se
June 19, 2025 at 6:08 AM
I definitely never regretted the decision to leave New York for Stockholm and Karolinska - now you can join us: big call for assistant professors across medical disciplines coming up. news.ki.se/ki-to-recrui...
Reposted by Jens Hjerling Leffler
#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience!
Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.
Sharing appreciated, and happy #FluorescenceFriday !
Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.
Sharing appreciated, and happy #FluorescenceFriday !
June 13, 2025 at 1:33 PM
#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience!
Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.
Sharing appreciated, and happy #FluorescenceFriday !
Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.
Sharing appreciated, and happy #FluorescenceFriday !
Reposted by Jens Hjerling Leffler
Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms.
We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
June 6, 2025 at 9:34 AM
Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms.
We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
Reposted by Jens Hjerling Leffler
While commercialization and decreasing costs has democratized access to genomics and transcriptomics techniques for many, including in the neurosciences (good thing), there's been, IMO, some issues in adoption without corresponding best case analysis practices from the genomics field (bad thing)
June 5, 2025 at 12:53 PM
While commercialization and decreasing costs has democratized access to genomics and transcriptomics techniques for many, including in the neurosciences (good thing), there's been, IMO, some issues in adoption without corresponding best case analysis practices from the genomics field (bad thing)
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet
Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi
ki.varbi.com
June 2, 2025 at 5:20 PM
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
Reposted by Jens Hjerling Leffler
Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs!
Let the journey begin! 🧬🧫🔬
Let the journey begin! 🧬🧫🔬
May 28, 2025 at 11:37 AM
Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs!
Let the journey begin! 🧬🧫🔬
Let the journey begin! 🧬🧫🔬
Reposted by Jens Hjerling Leffler
Lastly to round up the 🧵: Science works doesn't mean every scientific study produces a fact ready for public consumption. Scientific work is incremental, iterative, nonlinear, slow, imperfect, relentless. Continuous improvement upon what was. Science works not despite but because of many failures.
May 28, 2025 at 3:50 AM
Lastly to round up the 🧵: Science works doesn't mean every scientific study produces a fact ready for public consumption. Scientific work is incremental, iterative, nonlinear, slow, imperfect, relentless. Continuous improvement upon what was. Science works not despite but because of many failures.
Reposted by Jens Hjerling Leffler
At times like these it's important to remember the 3 branches of science
May 26, 2025 at 10:04 PM
At times like these it's important to remember the 3 branches of science