Hepworth Lab
@hepworth-lab.bsky.social
Mucosal Immunology Lab at the University of Manchester
New paper out from the lab, led by Maddy Hurry. We investigate how stroke leads to peripheral complications in the gut through dysregulation of IgA mediated host-commensal crosstalk.
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions
Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous sys…
www.sciencedirect.com
November 22, 2025 at 1:12 PM
New paper out from the lab, led by Maddy Hurry. We investigate how stroke leads to peripheral complications in the gut through dysregulation of IgA mediated host-commensal crosstalk.
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
@lydiabeckeriii.bsky.social
@diiirm.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Hepworth Lab
so excited to share our article in @nature.com Immunology on the many challenges of climate change has for our immune function, infection susceptibility and disease and the need for new ways to research this. Will do a thread later! 🧪 @lydiabeckeriii.bsky.social @exposomeimmunology.bsky.social
The role of ecoimmunology in tackling the emerging threats of climate change and the exposome
Nature Immunology - Climate change creates a multitude of challenges over the human life-course, influencing our exposomes and shaping immune function — requiring researchers to consider...
urldefense.com
November 14, 2025 at 11:17 AM
so excited to share our article in @nature.com Immunology on the many challenges of climate change has for our immune function, infection susceptibility and disease and the need for new ways to research this. Will do a thread later! 🧪 @lydiabeckeriii.bsky.social @exposomeimmunology.bsky.social
Reposted by Hepworth Lab
BIG NEWS!
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
November 3, 2025 at 5:58 PM
BIG NEWS!
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!
Keynotes include:
Andrew McKenzie, Kazuyo Moro.
ilc6vancouver.com
#ILC6 #ILC6Vancouver #2026ILC6
(1/3)
A few more weeks to apply for this postdoc in mucosal immunology and ILC biology, please share in your networks and with interested candidates.
Postdoc opportunity in the lab for a budding ILC biologist.
Informal enquiries welcome - please spread the word.
Ad closes in 4 weeks.
www.jobs.manchester.ac.uk/Job/JobDetai...
Informal enquiries welcome - please spread the word.
Ad closes in 4 weeks.
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate - mucosal immunology and innate lymphoid cell (ILC) biology:Oxford Road
The Hepworth laboratory within the Lydia Becker Institute of Immunology and Inflammation at the University of Manchester wish to appoint a laboratory-based Research Associate to an exciting project in mucosal immunology and innate lymphoid cell (ILC) biology.
www.jobs.manchester.ac.uk
November 5, 2025 at 3:00 PM
A few more weeks to apply for this postdoc in mucosal immunology and ILC biology, please share in your networks and with interested candidates.
Reposted by Hepworth Lab
Friday we celebrated our new MRC Centre of Research Excellence in Exposome Immunology: a joint venture with Oxford that we call MOXIE (Manchester-Oxford Immunology of the Exposome). This challenging adventure is off to a great start. @exposomeimmunology.bsky.social
October 20, 2025 at 1:09 PM
Friday we celebrated our new MRC Centre of Research Excellence in Exposome Immunology: a joint venture with Oxford that we call MOXIE (Manchester-Oxford Immunology of the Exposome). This challenging adventure is off to a great start. @exposomeimmunology.bsky.social
Postdoc opportunity in the lab for a budding ILC biologist.
Informal enquiries welcome - please spread the word.
Ad closes in 4 weeks.
www.jobs.manchester.ac.uk/Job/JobDetai...
Informal enquiries welcome - please spread the word.
Ad closes in 4 weeks.
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate - mucosal immunology and innate lymphoid cell (ILC) biology:Oxford Road
The Hepworth laboratory within the Lydia Becker Institute of Immunology and Inflammation at the University of Manchester wish to appoint a laboratory-based Research Associate to an exciting project in mucosal immunology and innate lymphoid cell (ILC) biology.
www.jobs.manchester.ac.uk
October 9, 2025 at 2:39 PM
Postdoc opportunity in the lab for a budding ILC biologist.
Informal enquiries welcome - please spread the word.
Ad closes in 4 weeks.
www.jobs.manchester.ac.uk/Job/JobDetai...
Informal enquiries welcome - please spread the word.
Ad closes in 4 weeks.
www.jobs.manchester.ac.uk/Job/JobDetai...
Nice article about the community of Lister fellows in Manchester!
Behind every #ListerPrize winner at @officialuom.bsky.social is a nurturing community of Fellows giving back, sharing advice, and seeding new ideas 🌱
🫶 A connected, caring community builds confidence and makes a difference.
Read the story now ⤵️
lister-institute.org.uk/a-thriving-f...
🫶 A connected, caring community builds confidence and makes a difference.
Read the story now ⤵️
lister-institute.org.uk/a-thriving-f...
October 1, 2025 at 4:52 PM
Nice article about the community of Lister fellows in Manchester!
Reposted by Hepworth Lab
We now have a very exciting technician post advertised as part of our long term Wellcome Trust funded team investigating the role of the glycocalyx during CNS inflammation. Supporint the lab, developing glycan analysis and research experience www.jobs.manchester.ac.uk/Job/JobDetai...
Research Technician in the Glyco-immunology (Dyer) Lab:Oxford Road
Include: background, duties, essential skills and experience, length of contract, full or part-time. Keep to 150 words.
www.jobs.manchester.ac.uk
September 22, 2025 at 10:39 AM
We now have a very exciting technician post advertised as part of our long term Wellcome Trust funded team investigating the role of the glycocalyx during CNS inflammation. Supporint the lab, developing glycan analysis and research experience www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Hepworth Lab
So pleased to see our research out in #ScienceImmunology demonstrating that CLPs regulate airway remodelling during allergy 🫁 Really proud of the hard work and collaboration that went into this project 🫱🏼🫲🏽. Definitely one to check out for lovers of the immuno-matrix & pretty pictures👇🏼🔬
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 20, 2025 at 6:04 PM
So pleased to see our research out in #ScienceImmunology demonstrating that CLPs regulate airway remodelling during allergy 🫁 Really proud of the hard work and collaboration that went into this project 🫱🏼🫲🏽. Definitely one to check out for lovers of the immuno-matrix & pretty pictures👇🏼🔬
Reposted by Hepworth Lab
Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
Lecturer in Neuroimmunology, Medicine, Medical Sciences & Nutrition (MED243A) | The University of Aberdeen
Browse and apply for current job openings at the University of Aberdeen across various schools, departments and roles, including admin and academic.
www.abdn.ac.uk
September 19, 2025 at 7:55 AM
Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
Reposted by Hepworth Lab
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
www.jobs.manchester.ac.uk
September 12, 2025 at 3:47 PM
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Hepworth Lab
New paper alert! 🎉 Check it out here: biorxiv.org/content/10.1... Here we show that intestinal bacterial, helminth and fungal challenges polarise CD4 T cell populations in the dural meninges.
Intestinal challenges shape the polarisation of protective dural memory CD4 T cells
The meninges house several innate and adaptive immune cell populations[1][1]–[3][2]. These predominantly localise within the dura mater and include gut-derived IgA-secreting plasma cells[4][3]. Whethe...
biorxiv.org
September 16, 2025 at 2:43 PM
New paper alert! 🎉 Check it out here: biorxiv.org/content/10.1... Here we show that intestinal bacterial, helminth and fungal challenges polarise CD4 T cell populations in the dural meninges.
Following on from the PDRA adverts, we are also happy to announce the MRC Core in Exposome Immunology PhD scheme, details below. Reach out with any questions
www.findaphd.com/phds/program...
www.bmh.manchester.ac.uk/study/resear...
www.findaphd.com/phds/program...
www.bmh.manchester.ac.uk/study/resear...
FindAPhD : MRC CoRE in Exposome Immunology at The University of Manchester
Apply for a PhD: MRC CoRE in Exposome Immunology at The University of Manchester
www.findaphd.com
September 9, 2025 at 12:04 PM
Following on from the PDRA adverts, we are also happy to announce the MRC Core in Exposome Immunology PhD scheme, details below. Reach out with any questions
www.findaphd.com/phds/program...
www.bmh.manchester.ac.uk/study/resear...
www.findaphd.com/phds/program...
www.bmh.manchester.ac.uk/study/resear...
New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below:
www.jobs.manchester.ac.uk/Job/JobDetai...
www.bmh.manchester.ac.uk/research/ins...
www.jobs.manchester.ac.uk/Job/JobDetai...
www.bmh.manchester.ac.uk/research/ins...
Research Associate in MRC CoRE in Exposome Immunology (Defining Acute and Chronic Mucosal Responses to Pollution Exposure):Oxford Road
Project Title: Defining Acute and Chronic Mucosal Responses to Pollution Exposure
www.jobs.manchester.ac.uk
September 8, 2025 at 9:51 AM
New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below:
www.jobs.manchester.ac.uk/Job/JobDetai...
www.bmh.manchester.ac.uk/research/ins...
www.jobs.manchester.ac.uk/Job/JobDetai...
www.bmh.manchester.ac.uk/research/ins...
Reposted by Hepworth Lab
closing at the end of this week!
Another PDRA position! Join our team exploring how the mammalian immune system shapes microbiome ecology & evolution, and vice versa. In collaboration with @hepworth-lab.bsky.social funded by the @wellcometrust.bsky.social
www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in Microbial Ecology:Oxford Road
www.jobs.manchester.ac.uk
September 8, 2025 at 9:07 AM
closing at the end of this week!
Reposted by Hepworth Lab
Another PDRA position! Join our team exploring how the mammalian immune system shapes microbiome ecology & evolution, and vice versa. In collaboration with @hepworth-lab.bsky.social funded by the @wellcometrust.bsky.social
www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in Microbial Ecology:Oxford Road
www.jobs.manchester.ac.uk
August 27, 2025 at 8:52 AM
Another PDRA position! Join our team exploring how the mammalian immune system shapes microbiome ecology & evolution, and vice versa. In collaboration with @hepworth-lab.bsky.social funded by the @wellcometrust.bsky.social
www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Hepworth Lab
Cell Symposia: Host-microbiome dynamics
May 10–12, 2026 | Bruges, Belgium
by @cp-immunity.bsky.social @cp-cellhostmicrobe.bsky.social and @cp-trendsmicrobiol.bsky.social
www.cell-symposia.com/microbiome-2...
May 10–12, 2026 | Bruges, Belgium
by @cp-immunity.bsky.social @cp-cellhostmicrobe.bsky.social and @cp-trendsmicrobiol.bsky.social
www.cell-symposia.com/microbiome-2...
August 14, 2025 at 2:08 PM
Cell Symposia: Host-microbiome dynamics
May 10–12, 2026 | Bruges, Belgium
by @cp-immunity.bsky.social @cp-cellhostmicrobe.bsky.social and @cp-trendsmicrobiol.bsky.social
www.cell-symposia.com/microbiome-2...
May 10–12, 2026 | Bruges, Belgium
by @cp-immunity.bsky.social @cp-cellhostmicrobe.bsky.social and @cp-trendsmicrobiol.bsky.social
www.cell-symposia.com/microbiome-2...
Reposted by Hepworth Lab
🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases.
#Exposome #ImmunoSky
sites.manchester.ac.uk/lydia-becker...
#Exposome #ImmunoSky
sites.manchester.ac.uk/lydia-becker...
New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases
A groundbreaking £50M research centre at Manchester and Oxford will explore how environmental exposures, like pollution and microbes, rewire our immune system and drive chronic inflammatory diseases.
sites.manchester.ac.uk
July 16, 2025 at 9:41 AM
🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases.
#Exposome #ImmunoSky
sites.manchester.ac.uk/lydia-becker...
#Exposome #ImmunoSky
sites.manchester.ac.uk/lydia-becker...
Reposted by Hepworth Lab
Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...
Centre to study how exposome causes chronic inflammatory disease
A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases.
www.ukri.org
July 16, 2025 at 10:56 AM
Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...
Big news! Manchester, together with colleagues in Oxford, have been awarded an MRC CoRE in Exposome Immunology!! Exciting times ahead to uncover how pollution and other environmental factors worsen inflammatory diseases!!
A new £50m Medical Research Council Centre is set to study how environmental exposures cause chronic inflammatory diseases.
www.manchester.ac.uk/about/news/n...
www.manchester.ac.uk/about/news/n...
New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases
The environment is increasingly acknowledged to play a critical role in our risk of developing diseases, with 30,000 deaths attributed to air pollution alone in the UK each year. A new research centre...
www.manchester.ac.uk
July 16, 2025 at 9:01 AM
Big news! Manchester, together with colleagues in Oxford, have been awarded an MRC CoRE in Exposome Immunology!! Exciting times ahead to uncover how pollution and other environmental factors worsen inflammatory diseases!!
Reposted by Hepworth Lab
ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells
www.cell.com/immunity/ful... @cp-immunity.bsky.social
www.cell.com/immunity/ful... @cp-immunity.bsky.social
June 16, 2025 at 3:24 PM
ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells
www.cell.com/immunity/ful... @cp-immunity.bsky.social
www.cell.com/immunity/ful... @cp-immunity.bsky.social
So cool to see our recent review highlighted on the cover of @mucosalimmunol.bsky.social !!
Our latest issue is online now: www.mucosalimmunology.org/issue/S1933-..., including the cover inspiration “There’s no place like home: How local tissue microenvironments shape the function of innate lymphoid cells” www.mucosalimmunology.org/article/S193... from @hepworth-lab.bsky.social
April 14, 2025 at 3:17 PM
So cool to see our recent review highlighted on the cover of @mucosalimmunol.bsky.social !!
Reposted by Hepworth Lab
Come and work with me!
The Nature Micro team is expanding and we're looking for someone to champion microbial ecology, plant micro & related areas for the journal
Knowledge of microbial ecology/plant micro is desirable but we're open to applications from all microbiologists
Link below 👇
The Nature Micro team is expanding and we're looking for someone to champion microbial ecology, plant micro & related areas for the journal
Knowledge of microbial ecology/plant micro is desirable but we're open to applications from all microbiologists
Link below 👇
📢We are #hiring a full time editor to handle areas including microbial ecology & plant microbiology🦠🌱
This position will work closely with @naturecomms.bsky.social
#microsky #microbiomesky #ecologysky 🧪
Available in NYC, Madrid, or other US offices
Read more & apply here: shorturl.at/yvdYJ
This position will work closely with @naturecomms.bsky.social
#microsky #microbiomesky #ecologysky 🧪
Available in NYC, Madrid, or other US offices
Read more & apply here: shorturl.at/yvdYJ
Associate or Senior Editor (Nature Microbiology), Nature Communications
Title: Associate or Senior Editor (Nature Microbiology), Nature Communications Organisation: Nature Portfolio Locations: New York, Philadelphia, Washington DC, Jersey City or Madrid – hybrid working m...
springernature.wd3.myworkdayjobs.com
April 11, 2025 at 4:14 PM
Come and work with me!
The Nature Micro team is expanding and we're looking for someone to champion microbial ecology, plant micro & related areas for the journal
Knowledge of microbial ecology/plant micro is desirable but we're open to applications from all microbiologists
Link below 👇
The Nature Micro team is expanding and we're looking for someone to champion microbial ecology, plant micro & related areas for the journal
Knowledge of microbial ecology/plant micro is desirable but we're open to applications from all microbiologists
Link below 👇
Reposted by Hepworth Lab
Our latest study
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
Brain sensing of metabolic state regulates circulating monocytes
Brain-initiated hunger signals control circulating monocyte dynamics.
www.science.org
April 7, 2025 at 2:33 PM
Our latest study
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...
@science.org #Immunology on perception of #hunger and #immunity.
#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.
@ukri.org @fbmh-uom.bsky.social
www.science.org/doi/10.1126/...