Hennig-Lab
@hennig-lab.bsky.social
Research around the world of RNAs
Reposted by Hennig-Lab
Congrats to the Grünewald, Topf groups & et. al @cssbhamburg.bsky.social on their Nature paper! 📃 🍾
Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙
Glad that our SPC facility have contributed to this work!@embl.org
Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙
Glad that our SPC facility have contributed to this work!@embl.org
September 8, 2025 at 1:57 PM
Congrats to the Grünewald, Topf groups & et. al @cssbhamburg.bsky.social on their Nature paper! 📃 🍾
Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙
Glad that our SPC facility have contributed to this work!@embl.org
Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙
Glad that our SPC facility have contributed to this work!@embl.org
Reposted by Hennig-Lab
Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 11, 2025 at 3:07 PM
Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hennig-Lab
"Hey Bob, just dock the AF3 prediction into density and deposit"
August 7, 2025 at 5:04 PM
"Hey Bob, just dock the AF3 prediction into density and deposit"
Instagram-ready group picture from our lab hike
July 29, 2025 at 3:49 PM
Instagram-ready group picture from our lab hike
The most expensive bike stand in the world! 😢
July 11, 2025 at 2:21 PM
The most expensive bike stand in the world! 😢
If you are interested in cellular RNA transport, check out Simone Heber's first corresponding author paper: www.cell.com/cell-reports...
Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.
Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.
A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C in the oskar mRNA transport complex
Gaber et al. identify a direct protein-protein interaction between the oskar mRNA
transport particle components Staufen and Tropomyosin1-I/C. They map the interaction
surface at amino acid resolution ...
www.cell.com
June 28, 2025 at 11:04 AM
If you are interested in cellular RNA transport, check out Simone Heber's first corresponding author paper: www.cell.com/cell-reports...
Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.
Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.
Reposted by Hennig-Lab
Happy to see @embl.org highlight our work on protein design at Korbel group with @typaslab.bsky.social and @hennig-lab.bsky.social !
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
EMBL researchers have developed a new AI framework – AlphaDesign – which can design new proteins that might have therapeutic benefits.
Using AlphaDesign, the researchers succeeded in creating synthetic inhibitors for a bacterial phage defence system.
www.embopress.org/doi/full/10....
Using AlphaDesign, the researchers succeeded in creating synthetic inhibitors for a bacterial phage defence system.
www.embopress.org/doi/full/10....
June 26, 2025 at 2:24 AM
Happy to see @embl.org highlight our work on protein design at Korbel group with @typaslab.bsky.social and @hennig-lab.bsky.social !
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.
Reposted by Hennig-Lab
Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
June 19, 2025 at 8:10 AM
Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
New publication by the Korbel group @embl.org. Very cool new protein design pipeline. We just validated some of the designs for them by NMR . See below for more.
AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology www.embopress.org/doi/full/10....
AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology www.embopress.org/doi/full/10....
AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology
imageimageAlphaDesign combines hallucination and sequence generation to design various classes
of proteins, from monomers to oligomers and site-specific binders. AlphaDesign was
applied to design in v...
www.embopress.org
June 17, 2025 at 2:02 PM
New publication by the Korbel group @embl.org. Very cool new protein design pipeline. We just validated some of the designs for them by NMR . See below for more.
AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology www.embopress.org/doi/full/10....
AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology www.embopress.org/doi/full/10....
Last Saturday I rode the Vätternrundan with the charity organization "I move for cancer" to raise money for breast cancer research. The goal was to finish the ride of 315 km around beautiful lake Vättern faster than 9 h.
June 16, 2025 at 12:05 PM
Last Saturday I rode the Vätternrundan with the charity organization "I move for cancer" to raise money for breast cancer research. The goal was to finish the ride of 315 km around beautiful lake Vättern faster than 9 h.
Billionaires are attacking our rights, our media, and our freedom. It’s time to resist. I just signed this petition—add your name and be part of the movement: act.gp/3Rqfnlz #TimeToResist
Think corporate elites should not control our rights and freedom? Sign - Greenpeace International
Billionaires and corporations are tightening their grip on our democracies — and silencing dissent. They weaken protections for people and the planet, bankroll politicians who serve their interests, c...
act.gp
June 6, 2025 at 10:40 AM
Billionaires are attacking our rights, our media, and our freedom. It’s time to resist. I just signed this petition—add your name and be part of the movement: act.gp/3Rqfnlz #TimeToResist
If you are inclined to support cancer research, check this out and donate. You also keep me motivated 😁: egeninsamling.brostcancerforbundet.se/fundraisers/...
Vätternrundan 315 km under 9:00 h with IMFC: 14th of June 2025
The goal is to finish one of the biggest bike events of the world in under 9:00 h (315 km, average riding speed 37 km/h, on the 14th of June 2025), while supporting cancer research (specifically breas...
egeninsamling.brostcancerforbundet.se
May 28, 2025 at 10:16 AM
If you are inclined to support cancer research, check this out and donate. You also keep me motivated 😁: egeninsamling.brostcancerforbundet.se/fundraisers/...
Reposted by Hennig-Lab
The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-molecule multimodal timing of in vivo mRNA synthesis
mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...
www.biorxiv.org
April 29, 2025 at 8:31 PM
The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Hennig-Lab
“We've arranged a society based on science and technology, in which nobody understands anything about science and technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces.”
~ Carl Sagan
~ Carl Sagan
April 26, 2025 at 1:51 PM
“We've arranged a society based on science and technology, in which nobody understands anything about science and technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces.”
~ Carl Sagan
~ Carl Sagan
Reposted by Hennig-Lab
What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...
Genome-wide mapping of mesoscale neuronal RNA organization and condensation
Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...
www.biorxiv.org
April 21, 2025 at 1:48 PM
What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...
Reposted by Hennig-Lab
120 light years from Earth, there's a planet that may be covered in a living ocean. Here's my story on a tantalizing hint of life beyond the Solar System. Gift link: nyti.ms/3GbrEaZ 🧪
Astronomers Detect a Signature of Life on a Distant Planet (Gift Article)
Further studies are needed to determine whether K2-18b, which orbits a star 120 light-years away, is inhabited, or even habitable.
nyti.ms
April 16, 2025 at 11:05 PM
120 light years from Earth, there's a planet that may be covered in a living ocean. Here's my story on a tantalizing hint of life beyond the Solar System. Gift link: nyti.ms/3GbrEaZ 🧪
Reposted by Hennig-Lab
Looks like the evidence for this weird chemical abundance in an exoplanet atmosphere has gotten stronger with new JWST data: www.nytimes.com/2025/04/16/s...
Is it really a sign of life? That’s still not clear; lots of analysis left to do. But it’ll be interesting to see how it all pans out! 🧪 🔭
Is it really a sign of life? That’s still not clear; lots of analysis left to do. But it’ll be interesting to see how it all pans out! 🧪 🔭
April 17, 2025 at 3:00 AM
Looks like the evidence for this weird chemical abundance in an exoplanet atmosphere has gotten stronger with new JWST data: www.nytimes.com/2025/04/16/s...
Is it really a sign of life? That’s still not clear; lots of analysis left to do. But it’ll be interesting to see how it all pans out! 🧪 🔭
Is it really a sign of life? That’s still not clear; lots of analysis left to do. But it’ll be interesting to see how it all pans out! 🧪 🔭
Reposted by Hennig-Lab
Ever wondered how several individual RBPs cooperate to repress translation?
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
April 12, 2025 at 11:29 AM
Ever wondered how several individual RBPs cooperate to repress translation?
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!
www.biorxiv.org/content/10.1...
Reposted by Hennig-Lab
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
April 11, 2025 at 8:35 AM
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (www.biorxiv.org/content/10.1...). Great collaboration with Olivier Duss (@olivierduss.bsky.social). Great Work Marco Payr (@marcopayr.bsky.social) and thanks for the video, explaining our paper.
April 11, 2025 at 4:35 AM
Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (www.biorxiv.org/content/10.1...). Great collaboration with Olivier Duss (@olivierduss.bsky.social). Great Work Marco Payr (@marcopayr.bsky.social) and thanks for the video, explaining our paper.
Reposted by Hennig-Lab
Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published:
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
March 25, 2025 at 5:54 PM
Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published:
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
www.pnas.org/doi/10.1073/...
The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n
Reposted by Hennig-Lab
On Fox News claiming this is no biggie. 🤷♂️🫣
Where're the "but her emails" folks now???
March 25, 2025 at 6:09 AM
On Fox News claiming this is no biggie. 🤷♂️🫣
Reposted by Hennig-Lab
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social
March 24, 2025 at 9:55 PM
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social
An impressive talk by Dorothee Kern at the GBM Mosbacher Kolloquium last Friday and I was honoured to make the laudatory introduction to her Eduard Buchner Prize.
March 24, 2025 at 3:14 PM
An impressive talk by Dorothee Kern at the GBM Mosbacher Kolloquium last Friday and I was honoured to make the laudatory introduction to her Eduard Buchner Prize.
Reposted by Hennig-Lab
What an amazing experience to be at the 76th Mosbacher kolloquim! Awesome talks on protein design and structural biology and a lot of conceptual discussions on where the field is going. Glad to also have been able to present our poster on binder design using BindCraft!
March 23, 2025 at 12:14 PM
What an amazing experience to be at the 76th Mosbacher kolloquim! Awesome talks on protein design and structural biology and a lot of conceptual discussions on where the field is going. Glad to also have been able to present our poster on binder design using BindCraft!