Hannah Isles
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hannah-isles.bsky.social
Hannah Isles
@hannah-isles.bsky.social
1.5K followers 270 following 10 posts
Associate editor at Science Immunology
Swiftie ✌🏻
Sheffield, UK 🌳
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hannah-isles.bsky.social
On the April cover of #ScienceImmunology: The brain’s perception of hunger (rather than nutrient availability) regulates circulating immune cell dynamics. Read more here:
www.science.org/doi/10.1126/...
April 5, 2025 at 6:39 PM
hannah-isles.bsky.social
Science Swifties this is a must-read 🤩
March 12, 2025 at 2:57 PM
hannah-isles.bsky.social
In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.
Human naïve B cells recognize prepandemic influenza virus hemagglutinins
Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.
www.science.org
January 27, 2025 at 4:49 PM
Reposted by Hannah Isles
claireolingy.bsky.social
I’ll be here (joint with T cell Differentiation in Tissue Microenvironments) next week! Send me a message or email if you’d like to set up a time to chat. Looking forward to an exciting meeting!
keystonesymposia.bsky.social Keystone Symposia @keystonesymposia.bsky.social · Jan 1
Catch @drshrutinaik.bsky.social, @labfairfax.bsky.social, @ostunilab.bsky.social and Yasmine Belkaid for Innate Immune Memory. Submit your abstract for a poster presentation spot by Jan. 9th (11:59pm MST)! keysym.us/KSInnateImmu... #KSInnateImmune25 #keystoneconferences #innateimmunity
January 27, 2025 at 4:17 PM
Reposted by Hannah Isles
cnfogg.bsky.social
New review out in #science #immunology on tuberculosis immunopathology by @tomscriba.bsky.social et al.🫁🦠

www.science.org/doi/10.1126/...
Immunopathology in human tuberculosis
The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.
www.science.org
December 14, 2024 at 1:52 AM
hannah-isles.bsky.social
This week in #ScienceImmunology: Germinal Center B cells require asparagine (Asn) #metabolism for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase. @ajclarke.bsky.social @yfy1.bsky.social
Asparagine availability controls germinal center B cell homeostasis
Asparagine metabolism is a critical regulator of germinal center B cell function.
www.science.org
December 14, 2024 at 1:28 PM
Reposted by Hannah Isles
yfy1.bsky.social
Thrilled to share our latest work on how the non-essential amino acid #asparagine metabolically regulates germinal centers. Huge thanks to my PhD supervisor @ajclarke.bsky.social, colleagues, and collaborators at the @ndorms.bsky.social @ox.ac.uk and @crick.ac.uk

www.science.org/doi/10.1126/...
Asparagine availability controls germinal center B cell homeostasis
Asparagine metabolism is a critical regulator of germinal center B cell function.
www.science.org
December 13, 2024 at 9:12 PM
Reposted by Hannah Isles
mayerbarber.bsky.social
Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9
Graphical summary of our paper. In mice, prior lower airway exposure to diverse inflammatory stimuli, including chronic bacterial infections such as M. tuberculosis, acute bacterial infections such as pulmonary S. aureus, viral infections such as Influenza A, type-II allergic responses such as the OVA-Alum model, activation of pulmonary TLR9 by CpG or pulmonary TLR1/2 by Pam3CSK4 leads to reduced viral burden upon subsequent infection with SARS-CoV-2 (SCV2). (2) This SCV2 restriction occurs prior to induction of SCV2-specific adaptive immune responses and is mediated through innate immune responses, including the induction of IFN-I, TNFα and IL-1 and sustained changes to the TRM (Tissue resident macrophage) cellular compartment and the pulmonary epithelium. (3) Innate cytokine and TLR signaling to both recruited immune cells and the pulmonary epithelium creates a microenvironment in the lung that limits early replication of SCV2. IFN-I signaling to pulmonary ECs (epithelial cells) increases expression of interferon-stimulated genes, that likely cell-intrinsically limit viral replication. TNF- or IL-1 suppress SCV2 independently of IFN-I signaling. TNF acts exclusively through radio-resistant cell types such as the lung epithelium, whereas IL-1 affords control both direct and indirectly, through either stromal and hematopoietic cell types, to restrict overall early SCV2 burden.
December 6, 2024 at 10:38 PM
Reposted by Hannah Isles
mayerbarber.bsky.social
🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.
www.science.org
December 6, 2024 at 10:38 PM
Reposted by Hannah Isles
science.org
Two new studies in Science describe synthetic biology-based strategies that expand the possibilities of harnessing immune cells to treat disease.

Learn more in this week's issue: scim.ag/49nfztS
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions.
December 5, 2024 at 7:07 PM
Reposted by Hannah Isles
immunoeditor.bsky.social
Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.
www.science.org
November 29, 2024 at 7:30 PM
hannah-isles.bsky.social
New in #ScienceImmunology:

Research from @boztugk.bsky.social and team identifies an inborn error of #immunity caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses.

Read more: www.science.org/doi/10.1126/...
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation
Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.
www.science.org
November 23, 2024 at 8:53 AM
hannah-isles.bsky.social
Last week in #ScienceImmunology: An alternative approach to target TIM-3 for cancer #immunotherapy?

Zhang et al. found that palmitoylation of human TIM-3 promoted its stability. Blocking palmitoylation accelerated TIM-3 degradation, prevented immune #exhaustion and promoted anti-tumor #immunity
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity
Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.
www.science.org
November 21, 2024 at 6:24 PM
hannah-isles.bsky.social
Fantastic visit to @cambridgeuni.bsky.social pathology department today. Lots of exciting science and beautiful place to visit 🧪 thanks to @labliston.bsky.social for hosting!
November 19, 2024 at 7:02 PM
Reposted by Hannah Isles
immunoeditor.bsky.social
At #ScienceImmunology, I lead a fantastic team of #research #editors comprising Chris Fogg (@cnfogg.bsky.social), Claire Olingy (@claireolingy.bsky.social), and Hannah Isles (@hannah-isles.bsky.social)! Be sure to give them a follow!

www.science.org/journal/scii...
The Science Immunology editors in front of AAAS Headquarters in Washington DC. (L to R): Chris Fogg, Claire Olingy, Seth Thomas Scanlon, & Hannah Isles
November 14, 2024 at 8:55 AM
hannah-isles.bsky.social
New here 🙋🏻‍♀️
November 13, 2024 at 7:08 PM
Reposted by Hannah Isles
immunologyking.bsky.social
let's do this!! I am excited to reconnect with scientists here. thx @oneyrolles.bsky.social for the push 😀

#Immunology announcement:
SAVE THE DATE: 26-29 August in Basel 🇨🇭

Mauro Gaya (CIML) and I are organizing an #EMBO workshop on Adaptive #immunity in barrier tissues; details coming soon!
November 13, 2024 at 6:58 AM