Hakim Boudrioua
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hakimb.bsky.social
Hakim Boudrioua
@hakimb.bsky.social
110 followers 550 following 8 posts
Microbiologist. Infectious diseases. Drug discovery.
University of Tübingen, Germany
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hakimb.bsky.social
Nice but exhausting on a daily basis
Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging
In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated ...
www.nature.com
November 13, 2025 at 8:14 AM
Reposted by Hakim Boudrioua
simonheilbronner.bsky.social
I am happy to share our latest preprint, spearheaded by Laura Camus. We show that tyrosin-dependent interactions can foster integration of S. aureus into the nasal microbiome. @cmfi.bsky.social @lmumuenchen.bsky.social
www.biorxiv.org/content/10.1...
May 7, 2025 at 11:16 AM
Reposted by Hakim Boudrioua
titzlab.bsky.social
Happy to share our latest #glycotime work with Sarah, Annabelle and @mariofares.bsky.social Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections @pubs.acs.org |Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa–Burkholderia cenocepacia Infections: A Biophysical Study
Chronic lung infections caused by Pseudomonas aeruginosa and Burkholderia cenocepacia pose a severe threat to immunocompromised patients, particularly those with cystic fibrosis. These pathogens often...
pubs.acs.org
April 26, 2025 at 5:50 AM
hakimb.bsky.social
Beautiful structures
plosbiology.org PLOS Biology @plosbiology.org · Apr 22
The unique #CellEnvelope of #corynebacteria: @tbharat-lab.bsky.social &co map the C. glutamicum cell surface, revealing a patchy S-layer & specific assembly of the PS2 protein, thereby informing our understanding of cell envelopes that contain #MycolicAcids @plosbiology.org 🧪 plos.io/3Y6JNgw
Left: The atomic model of the PS2 lattice is shown in top and side views. PS2 hexamers are repeated in the 2D sheet with a lattice constant of 176 Å. Each PS2 monomer is colored and labeled separately within the hexamer, which repeats throughout the lattice (with pore dimensions highlighted). The side view of the lattice shows the smooth surface facing the extracellular space and rough surface with coiled-coil segments protruding towards the MM. Top right: Interactions at the hexameric and trimeric interfaces are stabilized by both hydrophilic and hydrophobic residues. Bottom right: A cell envelope tomogram was used to overlay the cryo-EM structure of the S-layer onto the in situ S-layer tomographic density. A single slice of the tomogram is shown, with the overlayed PS2 S-layer lattice in green and the tomogram in grayscale. The S-layer (surface layer), MM (mycomembrane), IM (inner membrane), and Cytosol are labeled.
April 23, 2025 at 9:07 PM
Reposted by Hakim Boudrioua
sciencex.bsky.social
A new synthetic substance, C26, has been identified to inhibit Salmonella's infection process by targeting the central regulator HilD, offering a potential alternative to antibiotics. doi.org/g9fjsr
New pathoblocker can stop Salmonella infections early on
Pathogenic Salmonella injects effector proteins into the cells of the gastrointestinal tract to penetrate and multiply within them.
phys.org
April 15, 2025 at 1:47 AM
Reposted by Hakim Boudrioua
cmfi.bsky.social
🔬 New pathoblocker is to stop Salmonella infections early on

Possible alternative treatment method for infections with antibiotic-resistant germs.

📖 Study: tinyurl.com/2s3u4hwj

#Pathoblocker #Salmonella #Pathogenicity #AMR @dzif.bsky.social @unituebingen.bsky.social @mpi-bio-fml.bsky.social
Cut through a protein: Look inside the HilD Regulator and the binding site for the pathoblocker. The discovered substance C26 (blue) bound to the HilD regulator and acting as pathoblocker. In addition, the HilD AlphaFold predicted structure is depicted (black). Model by Thales Kronenberger. 3D visualization created by Leon Kokkoliadis/CMFI, University of Tübingen. © Leon Kokkoliadis, CC-BY-ND A detailed view of the interior of a protein. The identified pathoblocker C26 (blue) has been shown to bind to the HilD-Regulator. The figure also illustrates the protein structure as predicted by AlphaFold (black). Model by Thales Kronenberger. 3D visualization created by Leon Kokkoliadis/CMFI, University of Tübingen. © Leon Kokkoliadis, CC-BY-ND
April 14, 2025 at 11:29 AM
Reposted by Hakim Boudrioua
unituebingen.bsky.social
🔬 Neuer Pathoblocker stoppt Salmonelleninfektion, bevor sie beginnt

Mögliche alternative Behandlungsmethode für Infektionen mit antibiotikaresistenten Keimen.

Studie: doi.org/10.1126/scia...

#Pathoblocker #Salmonellen #Pathogenität #AMR @dzif.bsky.social @cmfi.bsky.social @mpi-bio-fml.bsky.social
Schnitt durch ein Protein: Blick ins Innere des HilD-Regulators und auf die Bindungsstelle für den Pathoblocker. Die entdeckte Substanz C26 (blau) bindet an den HilD-Regulator und wirkt als Pathoblocker. Zusätzlich ist die von Alpha Fold vorhergesagte Struktur von HilD abgebildet (schwarz). Modell von Thales Kronenberger. 3D-Visualisierung erstellt von Leon Kokkoliadis/CMFI, Universität Tübingen.
April 14, 2025 at 11:23 AM
Reposted by Hakim Boudrioua
mpi-bio-fml.bsky.social
A synthetic substance, C26, has been discovered to halt Salmonella infections early by targeting the HilD regulator. This novel approach could reshape antibiotic resistance treatment. Read the UofTübingen's press release: www.cmfi.uni-tuebingen.de/en/news-even...
April 14, 2025 at 8:40 AM
Reposted by Hakim Boudrioua
cic3r0.bsky.social
New hope against #Salmonella: Researchers from @unituebingen.bsky.social have developed C26, a compound that blocks infections early – targeted, gentle, and without disturbing the microbiome. A promising approach beyond #antibiotics.
doi.org/10.1126/scia...
Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity
Synthetic molecules targeting HilD provide an antivirulence strategy to disrupt Salmonella enterica pathogenicity.
doi.org
April 11, 2025 at 11:19 PM
hakimb.bsky.social
New research findings!
In a collaborative effort, we report sythetic small molecules that target HilD, the central regulator of Salmonella pathogenicity.
www.science.org/doi/10.1126/...
Discovery of synthetic small molecules targeting the central regulator of Salmonella pathogenicity
Synthetic molecules targeting HilD provide an antivirulence strategy to disrupt Salmonella enterica pathogenicity.
www.science.org
April 14, 2025 at 10:12 AM
Reposted by Hakim Boudrioua
erictopol.bsky.social
Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...
www.nature.com
March 26, 2025 at 5:48 PM
Reposted by Hakim Boudrioua
mfgrp.bsky.social
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
hakimb.bsky.social
Open Postdoc position in Tübingen.
Focus on Legionella genetics, membrane protein biogenesis and secretion.
November 20, 2024 at 10:34 PM