Haaris Ahsan Safdari
@haarissafdari.bsky.social
Cryo-EM @Prof Daniel Wilson Lab, Uni of Hamburg, Germany
Single particle cryo-EM, cryo-electron tomography
Single particle cryo-EM, cryo-electron tomography
If you are looking for a PhD with great science, great people, and great views of Hamburg, here is your chance! (In the lab of my wonderful former supervisor).
We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM…
www.uni-hamburg.de/en/stellenan...
www.uni-hamburg.de/en/stellenan...
Job advertisement
www.uni-hamburg.de
October 16, 2025 at 5:25 PM
If you are looking for a PhD with great science, great people, and great views of Hamburg, here is your chance! (In the lab of my wonderful former supervisor).
Reposted by Haaris Ahsan Safdari
VitriFlex: An Open-Source, Modular, and Customizable Robotic Platform for Cryo-EM Grid Preparation www.biorxiv.org/content/10.1101/2025.07.24.666634v1 #cryoem
July 30, 2025 at 9:05 AM
VitriFlex: An Open-Source, Modular, and Customizable Robotic Platform for Cryo-EM Grid Preparation www.biorxiv.org/content/10.1101/2025.07.24.666634v1 #cryoem
Reposted by Haaris Ahsan Safdari
Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… www.researchsquare.com/article/rs-6...
A Natural Depsipeptide Antibiotic that Targets the E site of the Bacterial Ribosome
A significant challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds. Although natural products produced by fungi and bacteria, particularly actinomycetes,...
www.researchsquare.com
July 14, 2025 at 11:29 AM
Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… www.researchsquare.com/article/rs-6...
Excited to share that I received the Best Poster Prize at Translation UK 2025 in Edinburgh!
Grateful to the @biochemsoc.bsky.social and Bioscience Reports for supporting young researchers.
#TranslationUK2025 #StructuralBiology #CryoEM
Grateful to the @biochemsoc.bsky.social and Bioscience Reports for supporting young researchers.
#TranslationUK2025 #StructuralBiology #CryoEM
July 4, 2025 at 8:28 PM
Excited to share that I received the Best Poster Prize at Translation UK 2025 in Edinburgh!
Grateful to the @biochemsoc.bsky.social and Bioscience Reports for supporting young researchers.
#TranslationUK2025 #StructuralBiology #CryoEM
Grateful to the @biochemsoc.bsky.social and Bioscience Reports for supporting young researchers.
#TranslationUK2025 #StructuralBiology #CryoEM
New preprint alert!
Read about Manikomycin, a hidden antibiotic from Streptomyces rimosus that targets the ribosomal E site, revealing a novel MOA against MDR pathogens.
Even old strains have surprises.
🧬💥 doi.org/10.21203/rs....
#Antibiotics #CryoEM #Microbiology
Read about Manikomycin, a hidden antibiotic from Streptomyces rimosus that targets the ribosomal E site, revealing a novel MOA against MDR pathogens.
Even old strains have surprises.
🧬💥 doi.org/10.21203/rs....
#Antibiotics #CryoEM #Microbiology
A Natural Depsipeptide Antibiotic that Targets the E site of the Bacterial Ribosome
A significant challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds. Although natural products produced by fungi and bacteria, particularly actinomycetes,...
doi.org
July 3, 2025 at 1:49 PM
New preprint alert!
Read about Manikomycin, a hidden antibiotic from Streptomyces rimosus that targets the ribosomal E site, revealing a novel MOA against MDR pathogens.
Even old strains have surprises.
🧬💥 doi.org/10.21203/rs....
#Antibiotics #CryoEM #Microbiology
Read about Manikomycin, a hidden antibiotic from Streptomyces rimosus that targets the ribosomal E site, revealing a novel MOA against MDR pathogens.
Even old strains have surprises.
🧬💥 doi.org/10.21203/rs....
#Antibiotics #CryoEM #Microbiology
Heading to #TranslationUK2025?
Come find me at Poster P002 – I’ll be showing how kasugamycin, edeine & GE81112 target different steps of 30S initiation complex formation 🧬
Let’s chat ribosomes, antibiotics & translation! @biochemsoc.bsky.social
#BiochemEvent #SciComm
Come find me at Poster P002 – I’ll be showing how kasugamycin, edeine & GE81112 target different steps of 30S initiation complex formation 🧬
Let’s chat ribosomes, antibiotics & translation! @biochemsoc.bsky.social
#BiochemEvent #SciComm
June 28, 2025 at 11:15 PM
Heading to #TranslationUK2025?
Come find me at Poster P002 – I’ll be showing how kasugamycin, edeine & GE81112 target different steps of 30S initiation complex formation 🧬
Let’s chat ribosomes, antibiotics & translation! @biochemsoc.bsky.social
#BiochemEvent #SciComm
Come find me at Poster P002 – I’ll be showing how kasugamycin, edeine & GE81112 target different steps of 30S initiation complex formation 🧬
Let’s chat ribosomes, antibiotics & translation! @biochemsoc.bsky.social
#BiochemEvent #SciComm
Reposted by Haaris Ahsan Safdari
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
May 26, 2025 at 4:56 PM
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
Reposted by Haaris Ahsan Safdari
Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Welcome to TomoGuide
A step-by-step Cryo-ET guide
tomoguide.github.io
May 6, 2025 at 4:27 PM
Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Reposted by Haaris Ahsan Safdari
A colder frontier in cryo-EM 🧪🔬
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
April 23, 2025 at 8:49 AM
A colder frontier in cryo-EM 🧪🔬
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
Reposted by Haaris Ahsan Safdari
Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with inada and Zaher labs. Data collected by Bertrand Beckert at the DCI EPFL
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | PNAS
The integrated stress response (ISR) is a central signaling network that enables eukaryotic
cells to respond to a variety of different environmenta...
www.pnas.org
April 8, 2025 at 10:24 PM
Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with inada and Zaher labs. Data collected by Bertrand Beckert at the DCI EPFL
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Haaris Ahsan Safdari
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
March 21, 2025 at 3:16 PM
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Reposted by Haaris Ahsan Safdari
We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.
Image processing for cryo-electron microscopy
Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, …
meetings.embo.org
March 18, 2025 at 7:06 PM
We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.
Reposted by Haaris Ahsan Safdari
Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY!
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
March 20, 2025 at 7:56 AM
Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY!
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
Reposted by Haaris Ahsan Safdari
Reposted by Haaris Ahsan Safdari
Blocking IF3N delays bacterial translation initiation www.biorxiv.org/content/10.1101/2025.03.14.643242v1 #cryoem
March 17, 2025 at 7:10 AM
Blocking IF3N delays bacterial translation initiation www.biorxiv.org/content/10.1101/2025.03.14.643242v1 #cryoem
Reposted by Haaris Ahsan Safdari
The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation pubmed.ncbi.nlm.nih.gov/40075065/ #cryoem
March 14, 2025 at 6:40 PM
The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation pubmed.ncbi.nlm.nih.gov/40075065/ #cryoem
Reposted by Haaris Ahsan Safdari
Congrats to Haaris @haarissafdari.bsky.social for successfully defending his PhD thesis today - 2 days after his second first author paper came out! Good timing!
March 14, 2025 at 5:31 PM
Congrats to Haaris @haarissafdari.bsky.social for successfully defending his PhD thesis today - 2 days after his second first author paper came out! Good timing!
Reposted by Haaris Ahsan Safdari
Fascinating things happening at the IIMCB nowadays! This is one of the first patterns milled with our new TFS Hydra Bio Plasma-FIB, and - most likely - the smallest IIMCB logo ever!
March 13, 2025 at 11:21 AM
Fascinating things happening at the IIMCB nowadays! This is one of the first patterns milled with our new TFS Hydra Bio Plasma-FIB, and - most likely - the smallest IIMCB logo ever!
Reposted by Haaris Ahsan Safdari
Reposted by Haaris Ahsan Safdari
Reposted by Haaris Ahsan Safdari
Full link: www.nature.com/articles/s41...
March 12, 2025 at 6:43 PM
Full link: www.nature.com/articles/s41...
Reposted by Haaris Ahsan Safdari
Excited to share my first-author paper in Nature Communications! Using cryo-EM, we reveal how kasugamycin, edeine, and GE81112 inhibit bacterial translation initiation by binding the 30S ribosomal subunit in distinct ways.
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation - Nature Communications
The antibiotics kasugamycin, edeine and GE81112, inhibit translation initiation. Here, the authors present cryo-electron microscopy structures of 30S initiation intermediate complexes with these drugs...
www.nature.com
March 12, 2025 at 6:50 PM
Excited to share my first-author paper in Nature Communications! Using cryo-EM, we reveal how kasugamycin, edeine, and GE81112 inhibit bacterial translation initiation by binding the 30S ribosomal subunit in distinct ways.
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
Reposted by Haaris Ahsan Safdari
Our study on translation initiation inhibitors now published after peer review at nature.com/articles/s4146…. Great collaboration with Pohl Milon and team. Data collected at @cssbhamburg.bsky.social
March 12, 2025 at 6:32 PM
Our study on translation initiation inhibitors now published after peer review at nature.com/articles/s4146…. Great collaboration with Pohl Milon and team. Data collected at @cssbhamburg.bsky.social
Excited to share my first-author paper in Nature Communications! Using cryo-EM, we reveal how kasugamycin, edeine, and GE81112 inhibit bacterial translation initiation by binding the 30S ribosomal subunit in distinct ways.
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation - Nature Communications
The antibiotics kasugamycin, edeine and GE81112, inhibit translation initiation. Here, the authors present cryo-electron microscopy structures of 30S initiation intermediate complexes with these drugs...
www.nature.com
March 12, 2025 at 6:50 PM
Excited to share my first-author paper in Nature Communications! Using cryo-EM, we reveal how kasugamycin, edeine, and GE81112 inhibit bacterial translation initiation by binding the 30S ribosomal subunit in distinct ways.
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...