Gregg Thomas
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Gregg Thomas
@gwct.bio
Bioinformatics Scientist at Harvard FAS Informatics. Evolution, Genomics, Phylogenetics. Dog walker. He/him. gwct.bio // informatics.fas.harvard.edu
Reposted by Gregg Thomas
📣 The Mendes Lab is recruiting PhD students in statistical phylogenetics! Interested, or know someone who might be? Details here 👉 tinyurl.com/542wyfb9 — please share!
July 12, 2025 at 6:47 PM
Recently I developed several Snakemake workflows for tasks related to Cactus and HAL files, including whole genome alignment and pangenome inference. The goal was to perform these tasks efficiently on SLURM-based (or possibly other) clusters. I hope they are useful!

github.com/harvardinfor...
GitHub - harvardinformatics/cactus-snakemake: Snakemake workflows for performing whole genome alignment with Cactus efficiently on SLURM clusters
Snakemake workflows for performing whole genome alignment with Cactus efficiently on SLURM clusters - harvardinformatics/cactus-snakemake
github.com
June 4, 2025 at 11:15 PM
Reposted by Gregg Thomas
New paper led by @glom.bsky.social!

"Unprecedented female female bias in the aye-aye, a highly unusual lemur from Madagascar"

1/
journals.plos.org/plosbiology/...
February 10, 2025 at 2:50 PM
Reposted by Gregg Thomas
The Pease Lab in the Dept of Evolution, Ecology, and Organismal Biology at The Ohio State University is looking for a Postdoc interested in genotype-phenotype-environment evolution in plant and animal genomes. Details at osu.wd1.myworkdayjobs.com/en-US/OSUCar... and more info at www.peaselab.org
January 10, 2025 at 2:58 PM
Reposted by Gregg Thomas
If you know anyone who might be interested in working as a technician before a PhD, I'm looking for someone to work with me to generate some amazing data to understand the genetics of behavior, sex differences, and reproduction in an evolutionary context. Bonus? Amazing and supportive department!
January 9, 2025 at 11:23 PM
Reposted by Gregg Thomas
Our paper on the evolution of male reproduction in murine rodents was selected as the editor's choice article in the January issue of Evolution!
This month's #EditorsChoice article: "Sperm competition intensity shapes divergence in both sperm morphology and reproductive genes across murine rodents" by Kopania et al. @ekopania.bsky.social https://buff.ly/3PoYFSE
January 7, 2025 at 3:47 PM
A thorough look at what I think is an often overlooked problem in popgen and comparative genomics in general!
First major paper from the lab! The work was led by super talented postdoc Maria Akopyan. She explored how reference bias skews estimates of diversity, demography, divergence & recombination rate with help from @elliecat.bsky.social
& awesome ungrad Matthew. Full thread coming soon 🤓
Divergent reference genomes compromise the reconstruction of demographic histories, selection scans, and population genetic summary statistics https://www.biorxiv.org/content/10.1101/2024.11.26.625554v1
December 4, 2024 at 12:45 AM
Great to work with @ekopania.bsky.social, @jeffreygood.bsky.social, and everyone else on this project! I was happy to be able to present Emily's cool figure showing dN/dS of genes in different tissues and different time-points at Evolution a couple years ago:
November 14, 2024 at 7:44 PM
I'd like to see the alignments...

xkcd.com/3010
Geometriphylogenetics
xkcd.com
November 12, 2024 at 5:25 PM
Reposted by Gregg Thomas
oh hey I wrote a FAQ for this question www.molecularecologist.com/2024/08/13/f...
October 28, 2024 at 6:52 PM
Reposted by Gregg Thomas
For phun I made a "starter pack" for people involved in developing phylogenetic methods. If you feel you should not be involved, or feel I missed you (it is difficult!), please let me know. go.bsky.app/D7LsGUM 🧪
October 22, 2024 at 1:05 PM
Reposted by Gregg Thomas
🚨🚨🚨Jobs at IU!🚨🚨🚨
Multiple positions in computational biology, broadly interpreted. Positions can be in multiple depts, including Biology, Informatics, and CS.

Please apply--we want new colleagues!

jobs.sciencecareers.org/job/664327/m...
Multiple, Tenured/Tenure-Track Faculty Positions in Computing in Biology, Health, and Wellness - Bloomington, Indiana job with Indiana University Bloomington | 664327
Invite applications for multiple tenure /tenure-track positions at the Assistant, Associate, or Full Professor ranks
jobs.sciencecareers.org
October 18, 2024 at 6:39 PM
Reposted by Gregg Thomas
I'm recruiting students / postdocs to join my new lab at the University of Rochester for Fall 2025 onwards! If you're interested in phylogenetic comparative methods, genome evolution, and/or computational biology, please get in touch! More info:

mhibbins.github.io
Hibbins Lab
mhibbins.github.io
October 2, 2024 at 8:01 PM
Reposted by Gregg Thomas
For phylo nerds interested in concordance and discordance...

Here's a tutorial that helps you calculate gene, site, and quartet concordance vectors for any branch on your tree.

iqtree.org/doc/recipes/...

(work with @3rdreviewer.bsky.social)

#phylogenetics 🧪 #evolution
September 5, 2024 at 11:25 PM
Reposted by Gregg Thomas
Adam Freedman gives a great overview of the pros and cons of current genome annotation pipelines. If you have RNAseq data, use BRAKER or Stringtie, if you have a high quality closely related annotation, TOGA performs very well. #Evol2024
July 27, 2024 at 6:43 PM
Reposted by Gregg Thomas
New preprint with Rob Lanfear!

"The meaning and measure of concordance factors in phylogenomics"

ecoevorxiv.org/repository/v...
January 3, 2024 at 8:07 PM