Mònica Sánchez-Guixé
@guixe-m.bsky.social
Postdoctoral fellow at the @bbglab.bsky.social in @irbbarcelona.bsky.social. Interested in computational biology and Pediatric Cancer Genomics 🧬👩💻
Pinned
Mònica Sánchez-Guixé
@guixe-m.bsky.social
· Nov 25
Children who develop two independent tumors during childhood are extremely rare
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
🧪🧬Interested in pediatric cancer genomics? Check out my last work on the origins of second malignancies in children 👇
Reposted by Mònica Sánchez-Guixé
Today, Nuria López-Bigas @nlbigas.bsky.social and Mònica Sánchez-Guixé @guixe-m.bsky.social are at the #BarcelonaBiomed Conference, organised by #IRBBarcelona.
A great occasion to share our projects related to childhood cancers.
A great occasion to share our projects related to childhood cancers.
November 11, 2025 at 1:54 PM
Today, Nuria López-Bigas @nlbigas.bsky.social and Mònica Sánchez-Guixé @guixe-m.bsky.social are at the #BarcelonaBiomed Conference, organised by #IRBBarcelona.
A great occasion to share our projects related to childhood cancers.
A great occasion to share our projects related to childhood cancers.
Reposted by Mònica Sánchez-Guixé
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 27, 2025 at 2:39 PM
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
Reposted by Mònica Sánchez-Guixé
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 23, 2025 at 6:07 PM
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
Reposted by Mònica Sánchez-Guixé
As a researcher at the start of its career, I find this very frightening…
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Is academic research becoming too competitive? Nature examines the data
Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.
www.nature.com
October 20, 2025 at 7:16 PM
As a researcher at the start of its career, I find this very frightening…
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Mònica Sánchez-Guixé
📢 Thrilled to share our latest paper, KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma, from my PhD, is now published in Cancer Research!
Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...
#Epigenetics #Cancer #EwingSarcoma
Huge thanks to the team!
Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...
#Epigenetics #Cancer #EwingSarcoma
Huge thanks to the team!
KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
Abstract. Ewing Sarcoma (EwS) is a highly aggressive tumor arising in bones and soft tissues driven by the fusion oncoprotein EWSR1::FLI1. This aberrant transcription factor binds to GGAA microsatelli...
aacrjournals.org
October 14, 2025 at 7:38 PM
📢 Thrilled to share our latest paper, KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma, from my PhD, is now published in Cancer Research!
Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...
#Epigenetics #Cancer #EwingSarcoma
Huge thanks to the team!
Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...
#Epigenetics #Cancer #EwingSarcoma
Huge thanks to the team!
Reposted by Mònica Sánchez-Guixé
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Reposted by Mònica Sánchez-Guixé
🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
October 8, 2025 at 3:01 PM
🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
✍️ #IRBBarcelona & University of Washington
➡️ bit.ly/42wcIN5
📌 DOI: 10.1038/s41586-025-09521-x
#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social
🧵👇
Reposted by Mònica Sánchez-Guixé
📣 Youth4Kids 2025 🎗️
Let's start with @guixe-m.bsky.social from @irbbarcelona.org. Her work focuses on the origin of second malignancies in children or the factors underlying the response to immunotherapies.
Looking forward to listening to her talk!
@r4knetwork.bsky.social
Let's start with @guixe-m.bsky.social from @irbbarcelona.org. Her work focuses on the origin of second malignancies in children or the factors underlying the response to immunotherapies.
Looking forward to listening to her talk!
@r4knetwork.bsky.social
June 2, 2025 at 7:24 AM
📣 Youth4Kids 2025 🎗️
Let's start with @guixe-m.bsky.social from @irbbarcelona.org. Her work focuses on the origin of second malignancies in children or the factors underlying the response to immunotherapies.
Looking forward to listening to her talk!
@r4knetwork.bsky.social
Let's start with @guixe-m.bsky.social from @irbbarcelona.org. Her work focuses on the origin of second malignancies in children or the factors underlying the response to immunotherapies.
Looking forward to listening to her talk!
@r4knetwork.bsky.social
Last day in the Clinical Cancer Genomics here in Amsterdam! Very nice talks and insightful views of the overall uses of genomic data in Europe. And very useful feedback in my poster on the origins of pediatric rhabodid tumors @bbglab.bsky.social #CCG2025 #CCG25
March 21, 2025 at 2:43 PM
Last day in the Clinical Cancer Genomics here in Amsterdam! Very nice talks and insightful views of the overall uses of genomic data in Europe. And very useful feedback in my poster on the origins of pediatric rhabodid tumors @bbglab.bsky.social #CCG2025 #CCG25
Reposted by Mònica Sánchez-Guixé
Today Mònica Sánchez-Guixé presented her talk entitled "Timing the origins of pediatric rhabdoid tumors" at the Node Seminar Series of @irbbarcelona.org
Interesting talk and interesting discussion after. It's always a pleasure to share our work.
Well done @guixe-m.bsky.social 👏👏
Interesting talk and interesting discussion after. It's always a pleasure to share our work.
Well done @guixe-m.bsky.social 👏👏
February 19, 2025 at 1:44 PM
Today Mònica Sánchez-Guixé presented her talk entitled "Timing the origins of pediatric rhabdoid tumors" at the Node Seminar Series of @irbbarcelona.org
Interesting talk and interesting discussion after. It's always a pleasure to share our work.
Well done @guixe-m.bsky.social 👏👏
Interesting talk and interesting discussion after. It's always a pleasure to share our work.
Well done @guixe-m.bsky.social 👏👏
Reposted by Mònica Sánchez-Guixé
We’re enjoying a fantastic first day of our second Annual Meeting for the CGI-Clinics project, thanks to the organisation of @irbbarcelona.org 👏 so far we’ve heard updates on communication, tumour boards, patient empowerment and data harnessing here in beautiful Barcelona ☀️
January 23, 2025 at 2:44 PM
We’re enjoying a fantastic first day of our second Annual Meeting for the CGI-Clinics project, thanks to the organisation of @irbbarcelona.org 👏 so far we’ve heard updates on communication, tumour boards, patient empowerment and data harnessing here in beautiful Barcelona ☀️
Reposted by Mònica Sánchez-Guixé
As we are quite new in that network, we take the chance to share our research achievements of the last year.
Here you can follow a short 🧵of our latest publications:
1️⃣
www.nature.com/articles/s41...
Here you can follow a short 🧵of our latest publications:
1️⃣
www.nature.com/articles/s41...
Five latent factors underlie response to immunotherapy - Nature Genetics
Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden, T cell effective infiltration, TGF-β activity in the microenvironment, prior treatment and tumor proliferative potential.
www.nature.com
January 21, 2025 at 3:51 PM
As we are quite new in that network, we take the chance to share our research achievements of the last year.
Here you can follow a short 🧵of our latest publications:
1️⃣
www.nature.com/articles/s41...
Here you can follow a short 🧵of our latest publications:
1️⃣
www.nature.com/articles/s41...
Reposted by Mònica Sánchez-Guixé
Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing
#ccg2025
#ccg2025
January 10, 2025 at 1:30 PM
Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing
#ccg2025
#ccg2025
Reposted by Mònica Sánchez-Guixé
📢 We're hiring!
🟠Postdoc Fellows Stefanie Wculek, Patrick Aloy, @batllelab.bsky.social
🟠Research Assistant/Bioinformatician @bbglab.bsky.social
🟠Public Procurement Officer
🟠Academic Officer
🟠Program Secretary
➡️ bit.ly/3MR4wO8
🧪
🟠Postdoc Fellows Stefanie Wculek, Patrick Aloy, @batllelab.bsky.social
🟠Research Assistant/Bioinformatician @bbglab.bsky.social
🟠Public Procurement Officer
🟠Academic Officer
🟠Program Secretary
➡️ bit.ly/3MR4wO8
🧪
December 23, 2024 at 10:02 AM
📢 We're hiring!
🟠Postdoc Fellows Stefanie Wculek, Patrick Aloy, @batllelab.bsky.social
🟠Research Assistant/Bioinformatician @bbglab.bsky.social
🟠Public Procurement Officer
🟠Academic Officer
🟠Program Secretary
➡️ bit.ly/3MR4wO8
🧪
🟠Postdoc Fellows Stefanie Wculek, Patrick Aloy, @batllelab.bsky.social
🟠Research Assistant/Bioinformatician @bbglab.bsky.social
🟠Public Procurement Officer
🟠Academic Officer
🟠Program Secretary
➡️ bit.ly/3MR4wO8
🧪
Reposted by Mònica Sánchez-Guixé
🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
OpenVariant: a toolkit to parse and operate multiple input file formats
AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc
academic.oup.com
December 12, 2024 at 10:11 AM
🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
🧪🧬Interested in pediatric cancer genomics? Check out my last work on the origins of second malignancies in children 👇
Children who develop two independent tumors during childhood are extremely rare
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
November 25, 2024 at 11:09 PM
🧪🧬Interested in pediatric cancer genomics? Check out my last work on the origins of second malignancies in children 👇
Reposted by Mònica Sánchez-Guixé
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
Reposted by Mònica Sánchez-Guixé
CGI-Clinics project just joined Bluesky.
Follow it to stay tuned on exciting updates coming soon about the project
👉 @cgiclinics.bsky.social
cgiclinics.eu
Follow it to stay tuned on exciting updates coming soon about the project
👉 @cgiclinics.bsky.social
cgiclinics.eu
November 19, 2024 at 3:19 PM
CGI-Clinics project just joined Bluesky.
Follow it to stay tuned on exciting updates coming soon about the project
👉 @cgiclinics.bsky.social
cgiclinics.eu
Follow it to stay tuned on exciting updates coming soon about the project
👉 @cgiclinics.bsky.social
cgiclinics.eu
Reposted by Mònica Sánchez-Guixé
We recently announced a dual new release of intOGen and boostDM
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
November 25, 2024 at 3:37 AM
We recently announced a dual new release of intOGen and boostDM
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations
➡️ Compendium of Cancer Driver Genes - www.intogen.org
➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm
Reposted by Mònica Sánchez-Guixé
Children who develop two independent tumors during childhood are extremely rare
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
November 25, 2024 at 3:07 PM
Children who develop two independent tumors during childhood are extremely rare
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
We wanted to see if our genomic technologies could shed light into those exceptional cases.
Read about it in this recent paper:
tinyurl.com/yt9m584d
Reposted by Mònica Sánchez-Guixé
I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo
November 12, 2024 at 11:49 AM
I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo
Hi everyone! Glad to see that science bluesky is growing so rapidly :)
My research focuses on pediatric cancer, genomics, and tumor evolution. Follow me if interested! 🧪🧬
My research focuses on pediatric cancer, genomics, and tumor evolution. Follow me if interested! 🧪🧬
November 20, 2024 at 8:06 PM
Hi everyone! Glad to see that science bluesky is growing so rapidly :)
My research focuses on pediatric cancer, genomics, and tumor evolution. Follow me if interested! 🧪🧬
My research focuses on pediatric cancer, genomics, and tumor evolution. Follow me if interested! 🧪🧬
Reposted by Mònica Sánchez-Guixé
Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
November 20, 2024 at 10:46 AM
Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
Reposted by Mònica Sánchez-Guixé
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology?
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
November 19, 2024 at 3:08 PM
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology?
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...
Pls share!
Reposted by Mònica Sánchez-Guixé
I’ve started making a starter pack for computational #cancer! Let me know if you’d like to be added or know someone who should be go.bsky.app/N6moBmG
November 12, 2024 at 8:58 PM
I’ve started making a starter pack for computational #cancer! Let me know if you’d like to be added or know someone who should be go.bsky.app/N6moBmG