Tom Guest
@guestlost.bsky.social
Postdoc scientist, University of Würzburg
Bacterial genetics, RNA, the microbiome and host. The rest of the time outdoors 🚵⛷️🏔️
Bacterial genetics, RNA, the microbiome and host. The rest of the time outdoors 🚵⛷️🏔️
Reposted by Tom Guest
🔊 Interested in doing a PhD on RNA-binding proteins in an abundant microbiota species and becoming a member of the German Priority Programme “Illuminating Gene Functions in the Human Gut Microbiome”? Apply here: www.uni-wuerzburg.de/karriere/sin...
Job offer for a PhD student position at the Chair of Microbiology
www.uni-wuerzburg.de
December 1, 2025 at 9:20 AM
🔊 Interested in doing a PhD on RNA-binding proteins in an abundant microbiota species and becoming a member of the German Priority Programme “Illuminating Gene Functions in the Human Gut Microbiome”? Apply here: www.uni-wuerzburg.de/karriere/sin...
Reposted by Tom Guest
Our lab is offering 3 PhD projects this year across 3 different topics: antibiotic resistance mechanisms, evolution of pathogenic bacteria, and fundamental mechanisms of gene regulation.
www.findaphd.com/phds/?Keywor...
www.findaphd.com/phds/?Keywor...
grainger birmingham PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
October 7, 2025 at 3:53 PM
Our lab is offering 3 PhD projects this year across 3 different topics: antibiotic resistance mechanisms, evolution of pathogenic bacteria, and fundamental mechanisms of gene regulation.
www.findaphd.com/phds/?Keywor...
www.findaphd.com/phds/?Keywor...
Reposted by Tom Guest
Congrats to Ann-Sophie Rüttiger who successfully defended her PhD this week! 🎓
She focused on global RNA-binding proteins in Bacteroides—bacteria lacking Hfq, ProQ, CsrA, Khp—culminating in the discovery of a post-transcriptional network governed by RbpB (www.nature.com/articles/s41467-024-55383-8).
She focused on global RNA-binding proteins in Bacteroides—bacteria lacking Hfq, ProQ, CsrA, Khp—culminating in the discovery of a post-transcriptional network governed by RbpB (www.nature.com/articles/s41467-024-55383-8).
September 25, 2025 at 10:06 AM
Congrats to Ann-Sophie Rüttiger who successfully defended her PhD this week! 🎓
She focused on global RNA-binding proteins in Bacteroides—bacteria lacking Hfq, ProQ, CsrA, Khp—culminating in the discovery of a post-transcriptional network governed by RbpB (www.nature.com/articles/s41467-024-55383-8).
She focused on global RNA-binding proteins in Bacteroides—bacteria lacking Hfq, ProQ, CsrA, Khp—culminating in the discovery of a post-transcriptional network governed by RbpB (www.nature.com/articles/s41467-024-55383-8).
Reposted by Tom Guest
New preprint from the lab, in collaboration with Wenhan Zhu (U Vanderbilt): using dual RNA-seq during B. theta colonization of the host mucous layer, we identify IroR--an iron-response sRNA that tunes capsule expression and facilitates adaptation to iron limitation.
doi.org/10.1101/2025.09.08.672848
doi.org/10.1101/2025.09.08.672848
An RNA regulates iron homeostasis and host mucus colonization in Bacteroides thetaiotaomicron
Symbiotic bacteria in the human intestinal microbiota provide many pivotal functions to human health and occupy distinct biogeographic niches within the gut. Yet the molecular basis underlying niche-s...
doi.org
September 9, 2025 at 7:49 AM
New preprint from the lab, in collaboration with Wenhan Zhu (U Vanderbilt): using dual RNA-seq during B. theta colonization of the host mucous layer, we identify IroR--an iron-response sRNA that tunes capsule expression and facilitates adaptation to iron limitation.
doi.org/10.1101/2025.09.08.672848
doi.org/10.1101/2025.09.08.672848
Reposted by Tom Guest
Ablation of polysaccharide breakdown in Bacteroides thetaiotaomicron prevents cross-feeding and growth of Salmonella Typhimurium in the mouse gut https://www.biorxiv.org/content/10.1101/2025.08.08.669261v1
August 9, 2025 at 4:18 AM
Ablation of polysaccharide breakdown in Bacteroides thetaiotaomicron prevents cross-feeding and growth of Salmonella Typhimurium in the mouse gut https://www.biorxiv.org/content/10.1101/2025.08.08.669261v1
Reposted by Tom Guest
New preprint! We characterise the small, regulatory RNA Arp which controls DNA uptake and twitching motilty in A. baumannii. Led by our Dr Fergal Hamrock @hamrockfergal.bsky.social and in collaboration with @westermannlab.bsky.social and Mike Gebhardt's lab!
DNA uptake and twitching motility are controlled by the small RNA Arp through repression of pilin translation in Acinetobacter baumannii https://www.biorxiv.org/content/10.1101/2025.07.19.665661v1
July 21, 2025 at 2:56 PM
New preprint! We characterise the small, regulatory RNA Arp which controls DNA uptake and twitching motilty in A. baumannii. Led by our Dr Fergal Hamrock @hamrockfergal.bsky.social and in collaboration with @westermannlab.bsky.social and Mike Gebhardt's lab!
Reposted by Tom Guest
DNA uptake and twitching motility are controlled by the small RNA Arp through repression of pilin translation in Acinetobacter baumannii https://www.biorxiv.org/content/10.1101/2025.07.19.665661v1
July 20, 2025 at 4:16 AM
DNA uptake and twitching motility are controlled by the small RNA Arp through repression of pilin translation in Acinetobacter baumannii https://www.biorxiv.org/content/10.1101/2025.07.19.665661v1
Reposted by Tom Guest
Very honored that our recent study on Bacteroides morphotypes was spotlighted 🔦 in Trends in Microbiology by Eric Martens & Qinnan Yang: www.cell.com/trends/micro....
Low biomass bacterial transcriptomics takes shape
Bornet et al. apply a low-input bacterial RNA-seq pipeline to transcriptionally profile
small, medium, and large cell populations of the human gut symbiont Bacteroides thetaiotaomicron
separated by fl...
www.cell.com
July 8, 2025 at 10:59 AM
Very honored that our recent study on Bacteroides morphotypes was spotlighted 🔦 in Trends in Microbiology by Eric Martens & Qinnan Yang: www.cell.com/trends/micro....
Reposted by Tom Guest
Our latest: www.cell.com/cell-reports/fulltext/S2211-1247(25)00615-1. Links Bacteroides cell size w/ gene expression. Protocol works even for single cells. 🦠
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Bornet et al. investigate the morphological heterogeneity of Bacteroides thetaiotaomicron
cells observed both in laboratory culture and inside the mammalian GI tract. The authors
show that cell size i...
www.cell.com
June 17, 2025 at 7:11 PM
Our latest: www.cell.com/cell-reports/fulltext/S2211-1247(25)00615-1. Links Bacteroides cell size w/ gene expression. Protocol works even for single cells. 🦠
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Reposted by Tom Guest
The study was published in the journal @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti...
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. …
www.sciencedirect.com
June 17, 2025 at 3:22 PM
The study was published in the journal @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti...
Reposted by Tom Guest
We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!
jobs.sciencecareers.org/job/673667/j...
jobs.sciencecareers.org/job/673667/j...
junior professorship position (f/m/d) in Single-Cell Systems Biology - Würzburg (Stadt), Bayern (DE) job with Julius-Maximilians-University Würzburg - Faculty of Medicine | 673667
The Julius-Maximilians-University Würzburg, Faculty of Medicine is offering one junior professorship position (f/m/d) in Single-Cell Systems Biology.
jobs.sciencecareers.org
June 2, 2025 at 9:29 AM
We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!
jobs.sciencecareers.org/job/673667/j...
jobs.sciencecareers.org/job/673667/j...
Reposted by Tom Guest
Genome-wide binding of the cyclic AMP receptor protein in enteroaggregative Escherichia coli suggests a role in modulating virulence https://www.biorxiv.org/content/10.1101/2025.05.09.652842v1
May 10, 2025 at 4:17 AM
Genome-wide binding of the cyclic AMP receptor protein in enteroaggregative Escherichia coli suggests a role in modulating virulence https://www.biorxiv.org/content/10.1101/2025.05.09.652842v1
Reposted by Tom Guest
An Archaeal Transcription Factor Bridges Prokaryotic and Eukaryotic Regulatory Paradigms www.biorxiv.org/content/10.1... #jcampubs
May 7, 2025 at 1:15 PM
An Archaeal Transcription Factor Bridges Prokaryotic and Eukaryotic Regulatory Paradigms www.biorxiv.org/content/10.1... #jcampubs
Reposted by Tom Guest
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - @tclavel.bsky.social @rwth.bsky.social go.nature.com/3GA6gg4
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - Nature Biotechnology
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
go.nature.com
April 30, 2025 at 2:32 PM
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - @tclavel.bsky.social @rwth.bsky.social go.nature.com/3GA6gg4
Reposted by Tom Guest
Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT https://www.biorxiv.org/content/10.1101/2025.04.07.647523v1
April 8, 2025 at 4:20 AM
Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT https://www.biorxiv.org/content/10.1101/2025.04.07.647523v1
Reposted by Tom Guest
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
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my.corehr.com
February 22, 2025 at 8:07 PM
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
Reposted by Tom Guest
📣Fully funded PhD position available in our lab at @uniwuerzburg.bsky.social, in collaboration with Dr. Connolly at Newcastle University (@ruamicro.bsky.social). "Dissecting the RNA-centric landscape of microbiota-pathogen interactions in the gut”. 🦠
Apply here: www.uni-wuerzburg.de/karriere/sin...
Apply here: www.uni-wuerzburg.de/karriere/sin...
PhD student position at the Chair for Microbiology
www.uni-wuerzburg.de
February 14, 2025 at 8:25 AM
📣Fully funded PhD position available in our lab at @uniwuerzburg.bsky.social, in collaboration with Dr. Connolly at Newcastle University (@ruamicro.bsky.social). "Dissecting the RNA-centric landscape of microbiota-pathogen interactions in the gut”. 🦠
Apply here: www.uni-wuerzburg.de/karriere/sin...
Apply here: www.uni-wuerzburg.de/karriere/sin...
Reposted by Tom Guest
🧪We are hiring!!!🧪
2 postdocs in #RNAbiology #bioengineering for our @volkswagenstiftung.bsky.social funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/Jobs/2024/1_Postdoc_momentum_Sharma_2025-01_V0.pdf
2 postdocs in #RNAbiology #bioengineering for our @volkswagenstiftung.bsky.social funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/Jobs/2024/1_Postdoc_momentum_Sharma_2025-01_V0.pdf
December 19, 2024 at 2:04 PM
🧪We are hiring!!!🧪
2 postdocs in #RNAbiology #bioengineering for our @volkswagenstiftung.bsky.social funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/Jobs/2024/1_Postdoc_momentum_Sharma_2025-01_V0.pdf
2 postdocs in #RNAbiology #bioengineering for our @volkswagenstiftung.bsky.social funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/Jobs/2024/1_Postdoc_momentum_Sharma_2025-01_V0.pdf