Gord Fishell
@gordfishell.bsky.social
labs at HMS Neurobiology and the Stanley center at the Broad, doing our best to understand cortical interneurons through developmental genetics and physiology.
And now the Neuromorphic piece has been picked up a one of the 10 most notable AI papers this week! Exciting! Well done Suraj!!
aiworld.eu/story/this-w...
aiworld.eu/story/this-w...
This Week's 10 Most Notable AI Research Papers - Week 41
This week’s AI research highlights how technological innovation and societal responsibility are increasingly intertwined. Studies range from AI-driven advances ...
aiworld.eu
November 4, 2025 at 2:33 PM
And now the Neuromorphic piece has been picked up a one of the 10 most notable AI papers this week! Exciting! Well done Suraj!!
aiworld.eu/story/this-w...
aiworld.eu/story/this-w...
Well to complement my son's efforts here is some background into my own first foray into neuromorphic computing. The original article can be seen in PNAS! A big shout out to Suraj Honnuraiah, who made it all happen! www.growkudos.com/publications...
November 4, 2025 at 2:31 PM
Well to complement my son's efforts here is some background into my own first foray into neuromorphic computing. The original article can be seen in PNAS! A big shout out to Suraj Honnuraiah, who made it all happen! www.growkudos.com/publications...
Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies
Spiking Neural Networks (SNNs) have gained increasing attention for their ability to operate on low-power neuromorphic hardware, offering a pathway toward energy-efficient large language models (LLMs)...
www.biorxiv.org
November 3, 2025 at 7:52 PM
Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
In a whimsical review of his arXiv.org paper, my son Will discusses the use of TempoBench in evaluating LLMs. I particularly enjoyed the faux ad for the TempoBench "product". You go Will! wfishell.github.io/landing.html
arXiv.org e-Print archive
arXiv.org
November 3, 2025 at 3:25 AM
In a whimsical review of his arXiv.org paper, my son Will discusses the use of TempoBench in evaluating LLMs. I particularly enjoyed the faux ad for the TempoBench "product". You go Will! wfishell.github.io/landing.html
Really excited to see my son Will @fishell_will publish his first work Tempobench that measures temporal causality and reasoning in LLMs. arxiv.org/abs/2510.27544
Mechanics of Learned Reasoning 1: TempoBench, A Benchmark for Interpretable Deconstruction of Reasoning System Performance
Large Language Models (LLMs) are increasingly excelling and outpacing human performance on many tasks. However, to improve LLM reasoning, researchers either rely on ad-hoc generated datasets or formal...
arxiv.org
November 3, 2025 at 3:09 AM
Really excited to see my son Will @fishell_will publish his first work Tempobench that measures temporal causality and reasoning in LLMs. arxiv.org/abs/2510.27544
New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
August 25, 2025 at 7:13 PM
New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
I am so excited about this combined analysis of the selective CRHR2 population within the lateral septum and how they control defensive behavior. Dionnet was truly a gifted graduate student. Keep your eyes on this one!
Our new preprint: 𝐅𝐞𝐚𝐭𝐮𝐫𝐞-𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐭𝐡𝐫𝐞𝐚𝐭 𝐜𝐨𝐝𝐢𝐧𝐠 𝐢𝐧 𝐥𝐚𝐭𝐞𝐫𝐚𝐥 𝐬𝐞𝐩𝐭𝐮𝐦 𝐠𝐮𝐢𝐝𝐞𝐬 𝐝𝐞𝐟𝐞𝐧𝐬𝐢𝐯𝐞 𝐚𝐜𝐭𝐢𝐨𝐧.
We describe how the LS guides defensive responses by forming critical computations built from functionally and molecularly distinct cells and their afferent inputs.
www.researchsquare.com/article/rs-6...
We describe how the LS guides defensive responses by forming critical computations built from functionally and molecularly distinct cells and their afferent inputs.
www.researchsquare.com/article/rs-6...
Feature-specific threat coding in lateral septum guides defensive action
The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral septum...
www.researchsquare.com
June 16, 2025 at 1:20 PM
I am so excited about this combined analysis of the selective CRHR2 population within the lateral septum and how they control defensive behavior. Dionnet was truly a gifted graduate student. Keep your eyes on this one!
At my last year of attending the McKnight conference. Such an amazing group of scientists. A big shout out to Lauren Orefice who gave an amazing talk this morning!
June 14, 2025 at 4:58 PM
At my last year of attending the McKnight conference. Such an amazing group of scientists. A big shout out to Lauren Orefice who gave an amazing talk this morning!
Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches! braininitiative.nih.gov/news-events/...
From the BRAIN Director: Q&A With Dr. Gordon Fishell and Dr. Bosiljka Tasic on Precise Brain Cell Delivery Systems | BRAIN Initiative
Newly published work funded by the NIH BRAIN Initiative offers a precision toolkit for accessing cells in the brain and spinal cord with unprecedented accuracy. The new delivery tools, about 1,000 in ...
braininitiative.nih.gov
June 14, 2025 at 4:54 PM
Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches! braininitiative.nih.gov/news-events/...
So I open up the NYtimes and there is my pal @ardemp.bskyverified.social saying that despite funding cuts he is staying in this country that he loves. Keep the faith you all!.... www.nytimes.com/2025/06/03/u...
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming
www.nytimes.com
June 3, 2025 at 12:40 PM
So I open up the NYtimes and there is my pal @ardemp.bskyverified.social saying that despite funding cuts he is staying in this country that he loves. Keep the faith you all!.... www.nytimes.com/2025/06/03/u...
Reposted by Gord Fishell
Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!
New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium. 🧠🔧
Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt...
Explore the full issue here: www.cell.com/neuron/current
Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt...
Explore the full issue here: www.cell.com/neuron/current
May 22, 2025 at 4:33 PM
Reposted by Gord Fishell
"Exploring brain circuits, one cell type—or more— at a time" www.cell.com/neuron/fullt...
Bosiljka Tasic & @gordfishell.bsky.social
@cp-neuron.bsky.social
Bosiljka Tasic & @gordfishell.bsky.social
@cp-neuron.bsky.social
Exploring brain circuits, one cell type—or more— at a time
This issue of Neuron, with accompanying papers in Cell, Cell Genomics, Cell Reports,
and Cell Reports Methods, contains studies describing methods for access to neuronal
and non-neuronal cell types wi...
www.cell.com
May 22, 2025 at 4:41 PM
"Exploring brain circuits, one cell type—or more— at a time" www.cell.com/neuron/fullt...
Bosiljka Tasic & @gordfishell.bsky.social
@cp-neuron.bsky.social
Bosiljka Tasic & @gordfishell.bsky.social
@cp-neuron.bsky.social
Yep, glad people in europe are taking notice. Hey guys, we are having a giant fire sale! Top scientists looking for relocation to the other side of the pond. Sad!
Our recent paper in Science was co-led by @sandehaan.bsky.social, former PhD student in a @ki.se -NIH project. NIH support for international projects is transformative, seeding dynamic collaborations, and looks like it may stop. It is with great sorrow that I watch the dismantling of US science.
NIH to suspend funds for research abroad as it overhauls policy - An exclusive story from the Nature News team
This NIH move threatens thousands of collaborative projects on infectious diseases, cancer and more
🧪 #AcademicSky #MedSky
@nature.com
www.nature.com/articles/d41...
This NIH move threatens thousands of collaborative projects on infectious diseases, cancer and more
🧪 #AcademicSky #MedSky
@nature.com
www.nature.com/articles/d41...
May 21, 2025 at 11:14 PM
Yep, glad people in europe are taking notice. Hey guys, we are having a giant fire sale! Top scientists looking for relocation to the other side of the pond. Sad!
Reposted by Gord Fishell
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
May 21, 2025 at 4:50 PM
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...
Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it!
urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com
May 21, 2025 at 4:57 PM
Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it!
urldefense.proofpoint.com/v2/url?u=htt...
urldefense.proofpoint.com/v2/url?u=htt...
Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!
New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium. 🧠🔧
Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt...
Explore the full issue here: www.cell.com/neuron/current
Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt...
Explore the full issue here: www.cell.com/neuron/current
May 21, 2025 at 4:55 PM
Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!
Even though it is spring....it seems to have gotten dark lately...."Within the last several days, Harvard University has received letters from most federal agencies indicating that nearly all of HMS’s active, direct federal grants have been terminated."
May 15, 2025 at 3:17 AM
Even though it is spring....it seems to have gotten dark lately...."Within the last several days, Harvard University has received letters from most federal agencies indicating that nearly all of HMS’s active, direct federal grants have been terminated."
I will fly to anywhere in the United States on my own dime to talk to people about basic science! I encourage all of you, particularly senior scientists to make this commitment. If you are looking for material ask @karalmarshall.bsky.social She has put together an amazing basic talk!
OK inspired by @karalmarshall.bsky.social I am reaching out to the public where ever I can. Traditionally Republicans have been incredibly supportive of science. We as scientists need to reach out to people across the spectrum to rally their support for basic science!
May 4, 2025 at 6:37 PM
I will fly to anywhere in the United States on my own dime to talk to people about basic science! I encourage all of you, particularly senior scientists to make this commitment. If you are looking for material ask @karalmarshall.bsky.social She has put together an amazing basic talk!
OK inspired by @karalmarshall.bsky.social I am reaching out to the public where ever I can. Traditionally Republicans have been incredibly supportive of science. We as scientists need to reach out to people across the spectrum to rally their support for basic science!
May 4, 2025 at 6:34 PM
OK inspired by @karalmarshall.bsky.social I am reaching out to the public where ever I can. Traditionally Republicans have been incredibly supportive of science. We as scientists need to reach out to people across the spectrum to rally their support for basic science!
Ask Kara for this talk! It is an amazing walk through for the general public.mmI am going to give a general talk to the public every time I am traveling through the USA. I have had a wonderful career. It is my students and postdocs I am worried about 🥺. Come help out!
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
youtu.be
May 4, 2025 at 6:17 PM
Ask Kara for this talk! It is an amazing walk through for the general public.mmI am going to give a general talk to the public every time I am traveling through the USA. I have had a wonderful career. It is my students and postdocs I am worried about 🥺. Come help out!
Reposted by Gord Fishell
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
youtu.be
May 3, 2025 at 7:20 PM
Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
Given all that is going on consider this quote from Bertram Russell's 1930 book The conquest of Happiness:
“The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”
“The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”
May 3, 2025 at 9:42 AM
Given all that is going on consider this quote from Bertram Russell's 1930 book The conquest of Happiness:
“The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”
“The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”
Heads up: A ton of papers from my group at the Broad, Pittsburgh, Irvine, Caltech, Duke, Berkeley and especially the Allen are on deck for a big consortium publication on new methods to target range of specific neuronal and non-neuronal cells coming out in Neuron and associated journals May 20th!
May 2, 2025 at 7:53 AM
Heads up: A ton of papers from my group at the Broad, Pittsburgh, Irvine, Caltech, Duke, Berkeley and especially the Allen are on deck for a big consortium publication on new methods to target range of specific neuronal and non-neuronal cells coming out in Neuron and associated journals May 20th!
Nuff said...https://www.harvard.edu/president/news/2025/the-promise-of-american-higher-education/
April 22, 2025 at 11:50 AM
Nuff said...https://www.harvard.edu/president/news/2025/the-promise-of-american-higher-education/
Color in the lines of your favorite proteins....can't wait to see David Ginty's full chest tattoo of a Pacinian corpsule!!!
Yes for Science tattoos!
Inked scientists choose scientific images to mark career accomplishments and illustrate their research passion
https://go.nature.com/42CnT65
https://go.nature.com/42CnT65
April 17, 2025 at 7:01 AM
Color in the lines of your favorite proteins....can't wait to see David Ginty's full chest tattoo of a Pacinian corpsule!!!