Goran Bajic
@gogo-science.bsky.social
Structural biologist interested in all things antibody and viruses. 🏳️🌈
bajiclab.org
bajiclab.org
Reposted by Goran Bajic
SBGrid's eLife paper received a citation in October from@gogo-science.bsky.social from Icahn School of Medicine at Mount Sinai in @science.org Immunology.
Read more here: buff.ly/s8uVL86
#SBGrid #ScienceMatters #StayConnected
Read more here: buff.ly/s8uVL86
#SBGrid #ScienceMatters #StayConnected
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.
buff.ly
November 18, 2025 at 5:05 PM
SBGrid's eLife paper received a citation in October from@gogo-science.bsky.social from Icahn School of Medicine at Mount Sinai in @science.org Immunology.
Read more here: buff.ly/s8uVL86
#SBGrid #ScienceMatters #StayConnected
Read more here: buff.ly/s8uVL86
#SBGrid #ScienceMatters #StayConnected
Reposted by Goran Bajic
How to develop good research questions
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
October 24, 2025 at 2:11 AM
How to develop good research questions
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
Reposted by Goran Bajic
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
October 22, 2025 at 2:55 PM
**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org
Reposted by Goran Bajic
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 9:55 PM
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Reposted by Goran Bajic
Feeling mitochondrially challenged lately?
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
The Origin and Diversification of Mitochondria
Moving beyond the simplistic view of mitochondria as the power house of the cell,
Roger et al. present the immense diversity of mitochondria and mitochondrial functions
across eukaryotes, and bring th...
www.cell.com
August 28, 2025 at 10:28 PM
Feeling mitochondrially challenged lately?
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
Here are two classic reviews on #mitochondria that should help.
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Goran Bajic
Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!
recruiting.ultipro.com
August 29, 2025 at 7:44 AM
Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!
New paper from the Coelho lab with a modest contribution from us:
🚨 New article! Our study "Human monoclonal antibodies protect against death caused by mpox" is now published:
👉 www.cell.com/cell/fulltex...
[1/9]
👉 www.cell.com/cell/fulltex...
[1/9]
Human monoclonal antibodies targeting A35 protect from death caused by mpox
Three potent mAbs against the conserved MPXV A35 protein block viral spread, protect
against lethal infection in mice, and align with protective antibody responses in
convalescent humans, establishing...
www.cell.com
August 26, 2025 at 9:36 PM
New paper from the Coelho lab with a modest contribution from us:
Reposted by Goran Bajic
🚨 New Publication!!!
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope
Rao et al. demonstrate that convergent somatic hypermutations in the light chain,
enriched within a sarbecovirus-specific public antibody clonotype, drive affinity
maturation. This antibody targets a ...
www.cell.com
August 12, 2025 at 6:52 PM
🚨 New Publication!!!
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
The latest from us:
www.cell.com/cell-reports...
With Camila Coelho’s lab, we describe how public clonotype #antibody affinity matures against an occluded epitope on #spike we call the central interface epitope! #cryoEM
www.cell.com/cell-reports...
With Camila Coelho’s lab, we describe how public clonotype #antibody affinity matures against an occluded epitope on #spike we call the central interface epitope! #cryoEM
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope
Rao et al. demonstrate that convergent somatic hypermutations in the light chain,
enriched within a sarbecovirus-specific public antibody clonotype, drive affinity
maturation. This antibody targets a ...
www.cell.com
August 12, 2025 at 6:16 PM
The latest from us:
www.cell.com/cell-reports...
With Camila Coelho’s lab, we describe how public clonotype #antibody affinity matures against an occluded epitope on #spike we call the central interface epitope! #cryoEM
www.cell.com/cell-reports...
With Camila Coelho’s lab, we describe how public clonotype #antibody affinity matures against an occluded epitope on #spike we call the central interface epitope! #cryoEM
Reposted by Goran Bajic
Mix-it-up: Accessible time-resolved cryo-EM on the millisecond timescale www.biorxiv.org/content/10.1101/2025.07.22.666177v1 #cryoem
July 27, 2025 at 6:40 PM
Mix-it-up: Accessible time-resolved cryo-EM on the millisecond timescale www.biorxiv.org/content/10.1101/2025.07.22.666177v1 #cryoem
Reposted by Goran Bajic
To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025
bit.ly/SciImm_free
bit.ly/SciImm_free
June 25, 2025 at 1:56 PM
To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025
bit.ly/SciImm_free
bit.ly/SciImm_free
May 31, 2025 at 12:28 AM
Latest from us: another productive collaboration with the Schmidt lab on #flu #antibody
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies
Broadly reactive human antibodies recognizing the head and stem of influenza hemagglutinin.
www.science.org
April 23, 2025 at 9:33 PM
Latest from us: another productive collaboration with the Schmidt lab on #flu #antibody
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Can’t wait to try this new feature out!
#CryoSPARC v4.7 is out! 🚀
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates
#cryoEM
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates
#cryoEM
April 9, 2025 at 2:27 PM
Can’t wait to try this new feature out!
All props to our students, Vishal and Iden, who spearheaded this study!
Glad to share our work from @camilahcoelho.bsky.social’s lab on identifying affinity-enhancing somatic hypermutations in public antibodies based on convergence and clonotype-enrichment!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody
Public antibodies that recognize conserved epitopes are critical for vaccine development, and identifying somatic hypermutations (SHMs) that enhance antigen affinity in these public responses is key t...
www.biorxiv.org
March 11, 2025 at 1:35 PM
All props to our students, Vishal and Iden, who spearheaded this study!
Our long-awaited study in collaboration with the Schmidt lab on H5Nx influenza recognition by naive B cells is out! #antibody #bcell #flu #avianflu #cryoEM
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Human naïve B cells recognize prepandemic influenza virus hemagglutinins
Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.
www.science.org
January 24, 2025 at 10:06 PM
Tonight is a fun night of proofreading manuscript journal proofs with Dionne Warwick in the background. #staytuned
January 9, 2025 at 4:02 AM
Tonight is a fun night of proofreading manuscript journal proofs with Dionne Warwick in the background. #staytuned
Reposted by Goran Bajic
We are hosting a cryo-EM grid nanofabrication workshop on 28 April 2025, as part of the Canadian Cryo-EM Nexus (ccemn.ca).
Learn how to make holey gold or holey carbon grids in your own laboratory!
Space is limited, so please apply at web.cvent.com/event/ee88ac...
Learn how to make holey gold or holey carbon grids in your own laboratory!
Space is limited, so please apply at web.cvent.com/event/ee88ac...
January 6, 2025 at 7:28 PM
We are hosting a cryo-EM grid nanofabrication workshop on 28 April 2025, as part of the Canadian Cryo-EM Nexus (ccemn.ca).
Learn how to make holey gold or holey carbon grids in your own laboratory!
Space is limited, so please apply at web.cvent.com/event/ee88ac...
Learn how to make holey gold or holey carbon grids in your own laboratory!
Space is limited, so please apply at web.cvent.com/event/ee88ac...
Reposted by Goran Bajic
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU
November 10, 2024 at 2:43 PM
Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list!
go.bsky.app/SinqoJU
go.bsky.app/SinqoJU