Gilles Gouspillou
@gillesgouspillou.bsky.social
Scientist interested in skeletal muscle physiology, mitochondrial biology and aging.
Pinned
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected
during healthy muscle aging but identify altered mitochondrial calcium handling as
a potential key driving mechanis...
www.cell.com
Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
Reposted by Gilles Gouspillou
Mitochondrial dynamics proteins have other functions than just regulating mito dynamics, but they are often forgotten.
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPa...
physoc.onlinelibrary.wiley.com
November 22, 2025 at 5:08 PM
Mitochondrial dynamics proteins have other functions than just regulating mito dynamics, but they are often forgotten.
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Gilles Gouspillou
Strength training improves mitochondrial bioenergetics and skeletal muscle integrity in women with Myotonic Dystrophy Type 1.
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
A 12‐Week Strength Training Improves Mitochondrial Respiration, H2O2 Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1
Background
Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats in the DMPK gene, causing the accumulation of toxic RNA that sequesters RNA-binding proteins. Clinically, DM1 is characte.....
onlinelibrary.wiley.com
November 18, 2025 at 9:14 PM
Strength training improves mitochondrial bioenergetics and skeletal muscle integrity in women with Myotonic Dystrophy Type 1.
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Gilles Gouspillou
Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28...
@jphysiol.bsky.social
@jphysiol.bsky.social
NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training-induced changes in muscle morphology, function and gene networks relative to placebo ingestion...
doi.org
October 27, 2025 at 2:10 PM
Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28...
@jphysiol.bsky.social
@jphysiol.bsky.social
Reposted by Gilles Gouspillou
Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected
during healthy muscle aging but identify altered mitochondrial calcium handling as
a potential key driving mechanis...
www.cell.com
February 10, 2025 at 9:39 PM
Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
Reposted by Gilles Gouspillou
Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans
Circulating taurine concentration is not associated with age, muscle mass, strength, physical performance, or mitochondrial function in humans. Taurine deficiency is therefore unlikely to be a primar....
onlinelibrary.wiley.com
August 12, 2025 at 3:21 PM
Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Gilles Gouspillou
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
link.springer.com
April 29, 2025 at 3:56 AM
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Reposted by Gilles Gouspillou
📣 CALL FOR PAPERS 📣
Organised by @pgreenhaff.bsky.social & focusing on:
🚑 Injury and rehabilitation
⛰️ Altitude physiology
🦵 Muscle adaptation
🚴 Exercise training
💉 Pharmacological interventions
⚙️ Body composition
🔗 buff.ly/2sVbnLk
Organised by @pgreenhaff.bsky.social & focusing on:
🚑 Injury and rehabilitation
⛰️ Altitude physiology
🦵 Muscle adaptation
🚴 Exercise training
💉 Pharmacological interventions
⚙️ Body composition
🔗 buff.ly/2sVbnLk
April 8, 2025 at 3:02 PM
📣 CALL FOR PAPERS 📣
Organised by @pgreenhaff.bsky.social & focusing on:
🚑 Injury and rehabilitation
⛰️ Altitude physiology
🦵 Muscle adaptation
🚴 Exercise training
💉 Pharmacological interventions
⚙️ Body composition
🔗 buff.ly/2sVbnLk
Organised by @pgreenhaff.bsky.social & focusing on:
🚑 Injury and rehabilitation
⛰️ Altitude physiology
🦵 Muscle adaptation
🚴 Exercise training
💉 Pharmacological interventions
⚙️ Body composition
🔗 buff.ly/2sVbnLk
Reposted by Gilles Gouspillou
The PowerLab ( uofgpowerlab.weebly.com ) is having some big turnover this summer and this opens the door to take on new PhD students to work on projects related to muscular adaptations to use/disuse across various structural levels.
Happy to chat!!
Happy to chat!!
My Site
About Me I am currently an Associate Professor in the Department of Human Health and Nutritional Sciences (HHNS) in the College of Biological Sciences (CBS) at the University of Guelph and Director...
uofgpowerlab.weebly.com
April 4, 2025 at 5:03 PM
The PowerLab ( uofgpowerlab.weebly.com ) is having some big turnover this summer and this opens the door to take on new PhD students to work on projects related to muscular adaptations to use/disuse across various structural levels.
Happy to chat!!
Happy to chat!!
Reposted by Gilles Gouspillou
www.nature.com/articles/s41...
A human brain map of mitochondrial respiratory capacity and diversity
A human brain map of mitochondrial respiratory capacity and diversity
A human brain map of mitochondrial respiratory capacity and diversity - Nature
The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...
www.nature.com
March 26, 2025 at 5:41 PM
www.nature.com/articles/s41...
A human brain map of mitochondrial respiratory capacity and diversity
A human brain map of mitochondrial respiratory capacity and diversity
Reposted by Gilles Gouspillou
Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
March 21, 2025 at 11:44 AM
Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...
Reposted by Gilles Gouspillou
« Use of sedentary subjects as the control group has led to potentially misleading interpretations. If physically active individuals were designated as the control group, a different interpretation would have been drawn ».
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
Sedentary death syndrome - PubMed
Sedentary death syndrome (SeDS) is a major public health burden due to its causing multiple chronic diseases and millions of premature deaths each year. Despite the impact of physical inactivity, very...
pubmed.ncbi.nlm.nih.gov
March 12, 2025 at 12:35 PM
« Use of sedentary subjects as the control group has led to potentially misleading interpretations. If physically active individuals were designated as the control group, a different interpretation would have been drawn ».
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
Reposted by Gilles Gouspillou
Macrophages excite muscle spindles with glutamate to bolster locomotion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
www.nature.com
March 12, 2025 at 4:58 PM
Macrophages excite muscle spindles with glutamate to bolster locomotion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gilles Gouspillou
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed
Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...
pubmed.ncbi.nlm.nih.gov
March 10, 2025 at 4:23 PM
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/
Reposted by Gilles Gouspillou
Immunomodulatory role of the stem cell circadian clock in muscle repair
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Immunomodulatory role of the stem cell circadian clock in muscle repair
The stem cell circadian clock orchestrates metabolic and immune signaling to time muscle regeneration following injury.
www.science.org
March 6, 2025 at 4:40 PM
Immunomodulatory role of the stem cell circadian clock in muscle repair
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications
Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...
www.nature.com
March 6, 2025 at 5:15 AM
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure of mitochondrial pyruvate carrier and its inhibition mechanism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure of mitochondrial pyruvate carrier and its inhibition mechanism - Nature
Structural findings define the architecture of the mitochondrial pyruvate carrier, delineate its substrate-binding site and translocation pathway, and reveal its major conformational states, providing...
www.nature.com
March 6, 2025 at 4:58 AM
Structure of mitochondrial pyruvate carrier and its inhibition mechanism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites - Nature Communications
Protein-mediated transport is implicated in trafficking fatty acids at contact sites of lipid droplets and mitochondria. Here, the authors use proteomics to catalogue the proteins at this contact site...
www.nature.com
March 4, 2025 at 10:20 PM
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gilles Gouspillou
@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...
A primer on global molecular responses to exercise in skeletal muscle: Omics in focus
Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over the past 2 decades, tran…
www.sciencedirect.com
February 16, 2025 at 2:03 PM
@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...
Reposted by Gilles Gouspillou
🚨APPLICATIONS CLOSE FRIDAY 21st FEBRUARY🚨
For our 2025 Editorial Board Fellowship scheme!
Read about Josiane Broussard's experience as an Editorial Fellow🎓👇
🔗 https://buff.ly/2s5K83y
For our 2025 Editorial Board Fellowship scheme!
Read about Josiane Broussard's experience as an Editorial Fellow🎓👇
🔗 https://buff.ly/2s5K83y
February 13, 2025 at 2:01 PM
🚨APPLICATIONS CLOSE FRIDAY 21st FEBRUARY🚨
For our 2025 Editorial Board Fellowship scheme!
Read about Josiane Broussard's experience as an Editorial Fellow🎓👇
🔗 https://buff.ly/2s5K83y
For our 2025 Editorial Board Fellowship scheme!
Read about Josiane Broussard's experience as an Editorial Fellow🎓👇
🔗 https://buff.ly/2s5K83y