Gilles FISCHER
@gillesfischer.bsky.social
Evolution, Genomics, Yeast
Reposted by Gilles FISCHER
When colonizing a new habitat, organisms adapt to maximize their reproductive success via #LifeHistory #evolution. @ecoevodevolab.bsky.social @cbank.bsky.social show that life history evolution facilitates niche diversification across a range of theoretical models @plosbiology.org 🧪 plos.io/4p7YT0a
November 13, 2025 at 10:02 AM
When colonizing a new habitat, organisms adapt to maximize their reproductive success via #LifeHistory #evolution. @ecoevodevolab.bsky.social @cbank.bsky.social show that life history evolution facilitates niche diversification across a range of theoretical models @plosbiology.org 🧪 plos.io/4p7YT0a
Reposted by Gilles FISCHER
In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
18S and 25S Exonuclease Resistant Ribosomal RNA Molecules Are Produced by 5′‐End Modification During TOR Inhibition.
Saccharomyces cerevisiae produces exonuclease-resistant rRNA molecules upon TOR inhibition. This phenomenon occurs when cells enter the diauxic phase, upon addition of rapamycin to the culture, or wh...
onlinelibrary.wiley.com
November 10, 2025 at 2:10 PM
In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Gilles FISCHER
Nouvelle vidéo 🎉
Pourquoi le prix Nobel de physique 2024 concernait l'I.A. ? Comment sont nés les réseaux de neurones ? Quel est le lien avec les champs quantiques ?
Toutes ces réponses en 13 minutes ⤵️
youtu.be/2kbAId70b_I
Pourquoi le prix Nobel de physique 2024 concernait l'I.A. ? Comment sont nés les réseaux de neurones ? Quel est le lien avec les champs quantiques ?
Toutes ces réponses en 13 minutes ⤵️
youtu.be/2kbAId70b_I
La Physique de l'I.A.
YouTube video by ScienceClic
youtu.be
November 6, 2025 at 11:55 AM
Nouvelle vidéo 🎉
Pourquoi le prix Nobel de physique 2024 concernait l'I.A. ? Comment sont nés les réseaux de neurones ? Quel est le lien avec les champs quantiques ?
Toutes ces réponses en 13 minutes ⤵️
youtu.be/2kbAId70b_I
Pourquoi le prix Nobel de physique 2024 concernait l'I.A. ? Comment sont nés les réseaux de neurones ? Quel est le lien avec les champs quantiques ?
Toutes ces réponses en 13 minutes ⤵️
youtu.be/2kbAId70b_I
Reposted by Gilles FISCHER
Independently evolved supergenes control colony social organization and queen reproductive strategies in several ant lineages. Sigeman et al. uncover a novel 9 Mb supergene controlling queen size and social organization in Myrmica ruginodis.
🔗 doi.org/10.1093/molbev/msaf255
#evobio #molbio #ants
🔗 doi.org/10.1093/molbev/msaf255
#evobio #molbio #ants
November 5, 2025 at 11:24 AM
Independently evolved supergenes control colony social organization and queen reproductive strategies in several ant lineages. Sigeman et al. uncover a novel 9 Mb supergene controlling queen size and social organization in Myrmica ruginodis.
🔗 doi.org/10.1093/molbev/msaf255
#evobio #molbio #ants
🔗 doi.org/10.1093/molbev/msaf255
#evobio #molbio #ants
Reposted by Gilles FISCHER
The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
Happy 40th birthday Yeast: Yeast: Vol 42, No 11
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
onlinelibrary.wiley.com
November 5, 2025 at 3:59 PM
The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
You can browse it at this link:
onlinelibrary.wiley.com/toc/10970061...
Reposted by Gilles FISCHER
Evolutionary responses to increased opportunity for sexual selection in yeast https://www.biorxiv.org/content/10.1101/2025.11.03.686343v1
November 5, 2025 at 4:31 AM
Evolutionary responses to increased opportunity for sexual selection in yeast https://www.biorxiv.org/content/10.1101/2025.11.03.686343v1
Reposted by Gilles FISCHER
If you have a loved one who's been "doing their own research" on TikTok (or, really, anywhere) about whether the Earth is round, you could try showing them this article instead. ⚛️🧪🔭 physicsworld.com/a/fighting-f...
Fighting flat-Earth theory – Physics World
Rachel Brazil explores ways in which the physics community can best combat unscientific thinking, such as the belief the Earth is flat
physicsworld.com
October 31, 2025 at 2:22 PM
If you have a loved one who's been "doing their own research" on TikTok (or, really, anywhere) about whether the Earth is round, you could try showing them this article instead. ⚛️🧪🔭 physicsworld.com/a/fighting-f...
Reposted by Gilles FISCHER
Big congratulations to Dilanaz Arisan (@rquatrini.bsky.social 's lab) and Pablo Quintrel (@fcocubillosr.bsky.social 's lab) for winning the best posters awards sponsored by the #Yeast journal at the @smbe-chile2025.bsky.social conference in Puerto Varas 🎉🎉🎉
October 13, 2025 at 9:06 AM
Big congratulations to Dilanaz Arisan (@rquatrini.bsky.social 's lab) and Pablo Quintrel (@fcocubillosr.bsky.social 's lab) for winning the best posters awards sponsored by the #Yeast journal at the @smbe-chile2025.bsky.social conference in Puerto Varas 🎉🎉🎉
Reposted by Gilles FISCHER
The special issue will be guest-edited by @pjboynton.bsky.social (Wheaton College
Massachusetts, USA) and Pei-Yun Jenny Wu (CNRS
Bordeaux, France).
You can find more information on the accepted topics and submission instructions by using the QR code below:
Massachusetts, USA) and Pei-Yun Jenny Wu (CNRS
Bordeaux, France).
You can find more information on the accepted topics and submission instructions by using the QR code below:
September 8, 2025 at 5:26 PM
The special issue will be guest-edited by @pjboynton.bsky.social (Wheaton College
Massachusetts, USA) and Pei-Yun Jenny Wu (CNRS
Bordeaux, France).
You can find more information on the accepted topics and submission instructions by using the QR code below:
Massachusetts, USA) and Pei-Yun Jenny Wu (CNRS
Bordeaux, France).
You can find more information on the accepted topics and submission instructions by using the QR code below:
Reposted by Gilles FISCHER
New #Yeast paper out from the series #FantasticYeasts!!! @hittingerlab.bsky.social , Dana Opulente & team describe a novel species, Lachancea rosae, isolated from the wild rose Rosa californica 🌹
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Taxogenomic Analysis of a Novel Yeast Species, Lachancea rosae Sp. Nov. F.A., Isolated From the Wild Rose Rosa californica
The discovery, description, and taxogenomic analysis of a novel species of Lachancea revealed correlations between gene content and carbon and nitrogen physiological assays.
onlinelibrary.wiley.com
September 2, 2025 at 2:34 PM
New #Yeast paper out from the series #FantasticYeasts!!! @hittingerlab.bsky.social , Dana Opulente & team describe a novel species, Lachancea rosae, isolated from the wild rose Rosa californica 🌹
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Gilles FISCHER
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution https://www.biorxiv.org/content/10.1101/2025.09.12.675800v1
September 16, 2025 at 5:33 PM
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution https://www.biorxiv.org/content/10.1101/2025.09.12.675800v1
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution
Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...
www.biorxiv.org
September 16, 2025 at 6:42 PM
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gilles FISCHER
Reposted by Gilles FISCHER
Cool application of microbiome in food science
Using metagenomics on Colombian cacao, they mapped how microbes influence chocolate flavors. Then they built a defined microbial consortium that replicates premium chocolate flavors -- validated by trained tasters!
www.nature.com/articles/s41...
Using metagenomics on Colombian cacao, they mapped how microbes influence chocolate flavors. Then they built a defined microbial consortium that replicates premium chocolate flavors -- validated by trained tasters!
www.nature.com/articles/s41...
A defined microbial community reproduces attributes of fine flavour chocolate fermentation - Nature Microbiology
An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocol...
www.nature.com
August 19, 2025 at 8:07 PM
Cool application of microbiome in food science
Using metagenomics on Colombian cacao, they mapped how microbes influence chocolate flavors. Then they built a defined microbial consortium that replicates premium chocolate flavors -- validated by trained tasters!
www.nature.com/articles/s41...
Using metagenomics on Colombian cacao, they mapped how microbes influence chocolate flavors. Then they built a defined microbial consortium that replicates premium chocolate flavors -- validated by trained tasters!
www.nature.com/articles/s41...
Reposted by Gilles FISCHER
"Fungi can see and react to a wide range of colors." journals.asm.org/doi/abs/10.1...
How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology | Microbiology and Molecular Biology Reviews
SUMMARYFungi use light as a signal for the regulation of development, to guide the growth
of reproductive structures, and to protect the fungal cell from DNA damage produced
by light and UV radiation....
journals.asm.org
August 11, 2025 at 3:45 PM
"Fungi can see and react to a wide range of colors." journals.asm.org/doi/abs/10.1...
Reposted by Gilles FISCHER
The Yeast2025 meeting in Paris is over, and was so much fun. It was exciting to see a room full of yeast biologists, with more than 500 people. It was also great to be part of the dream team of organizers, led by @gillesfischer.bsky.social
July 27, 2025 at 1:52 PM
The Yeast2025 meeting in Paris is over, and was so much fun. It was exciting to see a room full of yeast biologists, with more than 500 people. It was also great to be part of the dream team of organizers, led by @gillesfischer.bsky.social
Reposted by Gilles FISCHER
At #yeast2025 and love the 90s hip hop style of the logo!
July 21, 2025 at 8:27 AM
At #yeast2025 and love the 90s hip hop style of the logo!
Reposted by Gilles FISCHER
Stunning! An 8-hour time-lapse to show the Earth is rotating while capturing the Milky Way.
July 16, 2025 at 2:30 PM
Stunning! An 8-hour time-lapse to show the Earth is rotating while capturing the Milky Way.
Reposted by Gilles FISCHER
The Meselson and Stahl experiment demonstrated in 1958 that DNA replicated semi-conservatively.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
July 8, 2025 at 1:49 AM
The Meselson and Stahl experiment demonstrated in 1958 that DNA replicated semi-conservatively.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.
Foundational finding, elegant experimental design.
Reposted by Gilles FISCHER
It’s out! The evolutionary origins of yeast point centromeres uncovered!
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
www.biorxiv.org
April 25, 2025 at 1:59 PM
It’s out! The evolutionary origins of yeast point centromeres uncovered!
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
🎉 The final Yeast 2025 conference program is now live!
Check out the full list of oral presentations and posters.
We can't wait to share the science (and more 🍷) with you!
🔗 premc.org/yeast2025/
🔗 yeast2025.exordo.com/programme/at...
#Yeast2025
Check out the full list of oral presentations and posters.
We can't wait to share the science (and more 🍷) with you!
🔗 premc.org/yeast2025/
🔗 yeast2025.exordo.com/programme/at...
#Yeast2025
Yeast 2025 - PremC
premc.org
June 16, 2025 at 10:32 AM
🎉 The final Yeast 2025 conference program is now live!
Check out the full list of oral presentations and posters.
We can't wait to share the science (and more 🍷) with you!
🔗 premc.org/yeast2025/
🔗 yeast2025.exordo.com/programme/at...
#Yeast2025
Check out the full list of oral presentations and posters.
We can't wait to share the science (and more 🍷) with you!
🔗 premc.org/yeast2025/
🔗 yeast2025.exordo.com/programme/at...
#Yeast2025
📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
June 9, 2025 at 1:02 PM
📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
Reposted by Gilles FISCHER
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
May 22, 2025 at 12:42 PM
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
🚨 We're hiring! 🚨
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
Postdoc_Evol_Genomics_Sorbonne.docx
Postdoctoral position in Yeast Evolutionary Genomics Hosting unit Laboratory of Computational, Quantitative, and Synthetic Biology (CQSB). The CQSB is an interdisciplinary research unit within the ...
docs.google.com
May 19, 2025 at 3:41 PM
🚨 We're hiring! 🚨
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential.
🔗 More info here:
docs.google.com/document/d/1...
Please repost!
#Postdoc #Genomics #Yeast #Polyploidy #Evolution
Reposted by Gilles FISCHER
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on codon optimality and conserved across species, establishes direct feedback coupling the translation of new proteins with the stability of the mRNA that encodes for them.
dlvr.it
May 17, 2025 at 3:19 PM
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay