Ghanendra Singh
@ghanendra.bsky.social
Computational Glioscientist. PhD student at Institute of Neural Engineering @TU Graz.
Decoding Astrocytic Leaky-Blood Brain Barrier
Decoding Astrocytic Leaky-Blood Brain Barrier
Reposted by Ghanendra Singh
Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials
novonordisk.com/content/nnco...
novonordisk.com/content/nnco...
News Details
novonordisk.com
November 24, 2025 at 2:55 PM
Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials
novonordisk.com/content/nnco...
novonordisk.com/content/nnco...
Reposted by Ghanendra Singh
🧪🧠 The first isogenic, five-cell #OrganOnChip model of the human neurovascular unit is now here!
Brain-Chip R1 brings together neurons, astrocytes, microglia, pericytes, and BMECs in a dynamic, perfused system that captures key features of the BBB and NVU—built for more predictive CNS research.
Brain-Chip R1 brings together neurons, astrocytes, microglia, pericytes, and BMECs in a dynamic, perfused system that captures key features of the BBB and NVU—built for more predictive CNS research.
November 18, 2025 at 6:36 PM
🧪🧠 The first isogenic, five-cell #OrganOnChip model of the human neurovascular unit is now here!
Brain-Chip R1 brings together neurons, astrocytes, microglia, pericytes, and BMECs in a dynamic, perfused system that captures key features of the BBB and NVU—built for more predictive CNS research.
Brain-Chip R1 brings together neurons, astrocytes, microglia, pericytes, and BMECs in a dynamic, perfused system that captures key features of the BBB and NVU—built for more predictive CNS research.
Reposted by Ghanendra Singh
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
November 20, 2025 at 9:04 PM
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
Reposted by Ghanendra Singh
Finally it’s here! 🌟⬇️
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
Fig. 1: Establishment of methods to identify astrocyte endfoot proteins. | Nature Communications
www.nature.com
November 6, 2025 at 11:26 AM
Finally it’s here! 🌟⬇️
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
Reposted by Ghanendra Singh
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
October 29, 2025 at 2:57 PM
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Interesting study on the beauty of Spiral Traveling Waves in the brain.
Rotating brain waves keep your thoughts on track
picower.mit.edu/news/after-d...
@picowerinstitute.bsky.social #neuroscience
picower.mit.edu/news/after-d...
@picowerinstitute.bsky.social #neuroscience
After distractions, rotating brain waves may help thought circle back to the task
To get back on track after a distraction, the cortex appears to employ a rotating traveling wave, a new study by MIT neuroscientists finds.
picower.mit.edu
October 31, 2025 at 1:09 PM
Interesting study on the beauty of Spiral Traveling Waves in the brain.
Reposted by Ghanendra Singh
Decoding Leaky-BBB 🧠 together with @astrocytenet.bsky.social and @dibenedetto-lab.bsky.social 🤩.
Women suffer from severe depression twice as often - but why this is so is not yet known. A possible cause could lie in the blood-brain barrier - a barrier in the brain. If it becomes "leaky", diseases can occur.
www.tugraz.at/en/news/arti...
www.tugraz.at/en/news/arti...
Link between Leaky Blood-Brain Barrier and Depression
TU Graz and the University of Regensburg are investigating the interaction of different cell types at the border between blood vessels and the brain. A particular focus is on sex-specific differences.
www.tugraz.at
October 22, 2025 at 4:14 PM
Decoding Leaky-BBB 🧠 together with @astrocytenet.bsky.social and @dibenedetto-lab.bsky.social 🤩.
Reposted by Ghanendra Singh
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
October 7, 2025 at 5:49 PM
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Reposted by Ghanendra Singh
Big week for astrocyte research: 3 new Science papers link astrocytes to behavior. We're excited to add to the momentum with our new PNAS paper: a theory, grounded in biology, proposing astrocytes as key players in memory storage and recall. w/ JJ Slotine and @krotov.bsky.social
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May 28, 2025 at 7:44 PM
Big week for astrocyte research: 3 new Science papers link astrocytes to behavior. We're excited to add to the momentum with our new PNAS paper: a theory, grounded in biology, proposing astrocytes as key players in memory storage and recall. w/ JJ Slotine and @krotov.bsky.social
(1/6)
(1/6)