Gerald Tiu
@geraldctiu.bsky.social
Physician-scientist interested in gene regulation, RNA biology, synthetic and chemical biology, pediatric cancer, stem cell transplant
Peds heme onc fellow at LPCH/Stanford, current pediatrics resident at UCSF
Peds heme onc fellow at LPCH/Stanford, current pediatrics resident at UCSF
Reposted by Gerald Tiu
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Reposted by Gerald Tiu
Congrats to HHMI Investigator David R. Liu on receiving the 2025 Breakthrough Prize in Life Sciences! He is recognized for developing base editing & prime editing: 2 breakthrough gene-editing technologies that enable the correction or replacement of virtually any genetic mutation. hhmi.news/3RA6shj
April 5, 2025 at 11:27 PM
Congrats to HHMI Investigator David R. Liu on receiving the 2025 Breakthrough Prize in Life Sciences! He is recognized for developing base editing & prime editing: 2 breakthrough gene-editing technologies that enable the correction or replacement of virtually any genetic mutation. hhmi.news/3RA6shj
Reposted by Gerald Tiu
NEW: Researchers have sued the NIH and HHS, alleging that they have engaged in a "reckless and illegal purge to stamp out NIH-funded research that addresses topics and populations that they disfavor" by terminating hundreds of grants, violating the APA, Fifth Amendment and the Separation of Powers.
storage.courtlistener.com
April 2, 2025 at 6:59 PM
NEW: Researchers have sued the NIH and HHS, alleging that they have engaged in a "reckless and illegal purge to stamp out NIH-funded research that addresses topics and populations that they disfavor" by terminating hundreds of grants, violating the APA, Fifth Amendment and the Separation of Powers.
Reposted by Gerald Tiu
regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:
March 24, 2025 at 1:57 PM
regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:
Reposted by Gerald Tiu
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
March 20, 2025 at 1:31 PM
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
Reposted by Gerald Tiu
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 3:48 PM
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Reposted by Gerald Tiu
Jim Wilson cuts to the chase at #PMWC2025, “most patients in need will not get access to gene therapies because they are too rare or too poor”, focus should be on disrupting the commercial model
February 5, 2025 at 5:48 PM
Jim Wilson cuts to the chase at #PMWC2025, “most patients in need will not get access to gene therapies because they are too rare or too poor”, focus should be on disrupting the commercial model
Reposted by Gerald Tiu
🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 25, 2025 at 5:33 PM
🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
“Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
Reposted by Gerald Tiu
The first preprint of 2025! Together with Matvei, @halfacrocodile.bsky.social, & our amazing team, we are excited to share PARADE: an AI framework for designing mRNA UTRs with enhanced cell-type specificity & stability. www.biorxiv.org/content/10.1...
A generative framework for enhanced cell-type specificity in rationally designed mRNAs
mRNA delivery offers new opportunities for disease treatment by directing cells to produce therapeutic proteins. However, designing highly stable mRNAs with programmable cell type-specificity remains ...
www.biorxiv.org
January 2, 2025 at 1:10 PM
The first preprint of 2025! Together with Matvei, @halfacrocodile.bsky.social, & our amazing team, we are excited to share PARADE: an AI framework for designing mRNA UTRs with enhanced cell-type specificity & stability. www.biorxiv.org/content/10.1...
Reposted by Gerald Tiu
ICYMI: I wrote about the rollout of Casgevy, the first CRISPR treatment, a year after its approval.
Due to manufacturing complexities, insurance delays, and the extensive preparation involved for patients, just two people in the US have received it as of December.
www.wired.com/story/the-wo...
Due to manufacturing complexities, insurance delays, and the extensive preparation involved for patients, just two people in the US have received it as of December.
www.wired.com/story/the-wo...
The World’s First Crispr Drug Gets a Slow Start
The first medical treatment to use Crispr gene editing has been on the market for a year. Its complexity means few patients in the US have received it yet.
www.wired.com
January 2, 2025 at 4:21 PM
ICYMI: I wrote about the rollout of Casgevy, the first CRISPR treatment, a year after its approval.
Due to manufacturing complexities, insurance delays, and the extensive preparation involved for patients, just two people in the US have received it as of December.
www.wired.com/story/the-wo...
Due to manufacturing complexities, insurance delays, and the extensive preparation involved for patients, just two people in the US have received it as of December.
www.wired.com/story/the-wo...
Reposted by Gerald Tiu
Criticizing is fast and easy. Creating is slow and difficult.
The two hours you spent on a book or movie took someone two years to produce.
Anyone can tear down someone else's work. The true test of insight is whether you can help them improve it or build something of your own.
The two hours you spent on a book or movie took someone two years to produce.
Anyone can tear down someone else's work. The true test of insight is whether you can help them improve it or build something of your own.
December 22, 2024 at 3:41 PM
Criticizing is fast and easy. Creating is slow and difficult.
The two hours you spent on a book or movie took someone two years to produce.
Anyone can tear down someone else's work. The true test of insight is whether you can help them improve it or build something of your own.
The two hours you spent on a book or movie took someone two years to produce.
Anyone can tear down someone else's work. The true test of insight is whether you can help them improve it or build something of your own.
Reposted by Gerald Tiu
Today, several #NobelPrize Laureates arrive in Stockholm, warmly welcomed by Hans Ellegren. Here we see David Baker stepping off the plane at Arlanda.
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
December 5, 2024 at 12:48 PM
Today, several #NobelPrize Laureates arrive in Stockholm, warmly welcomed by Hans Ellegren. Here we see David Baker stepping off the plane at Arlanda.
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
Reposted by Gerald Tiu
For our inaugural @bsky.app post – 2 papers and the cover of Science @science.org!!
Dr. Nish Reddy et al. built T cells that suppress inflammation in specific tissues bit.ly/4fX8JxN
Dr. Milos Simic, Dr. Payal Watchmaker et al. built T cells that deliver therapies to the brain bit.ly/4g0I5Ej
Dr. Nish Reddy et al. built T cells that suppress inflammation in specific tissues bit.ly/4fX8JxN
Dr. Milos Simic, Dr. Payal Watchmaker et al. built T cells that deliver therapies to the brain bit.ly/4g0I5Ej
December 5, 2024 at 11:59 PM
For our inaugural @bsky.app post – 2 papers and the cover of Science @science.org!!
Dr. Nish Reddy et al. built T cells that suppress inflammation in specific tissues bit.ly/4fX8JxN
Dr. Milos Simic, Dr. Payal Watchmaker et al. built T cells that deliver therapies to the brain bit.ly/4g0I5Ej
Dr. Nish Reddy et al. built T cells that suppress inflammation in specific tissues bit.ly/4fX8JxN
Dr. Milos Simic, Dr. Payal Watchmaker et al. built T cells that deliver therapies to the brain bit.ly/4g0I5Ej