Francesca Telese
@francescatelese.bsky.social
Studying the complexity of the brain to cure diseases. Genomics aficionado. Academic mom of 2. First generation college student. Lover of the outdoor life and espresso. https://www.teleselab.com
Reposted by Francesca Telese
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)
HuD controls widespread RNA stability to drive neuronal activity-dependent responses
Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...
www.biorxiv.org
September 9, 2025 at 2:41 PM
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)
How does cannabis use during adolescence impact brain development?
Using single-nuclei transcriptomics in mice, we found that cannabis and a genetic risk factor (Reln) interact to disrupt gene expression programs underlying neuronal migration of neuroblasts in the nucleus accumbens.
Using single-nuclei transcriptomics in mice, we found that cannabis and a genetic risk factor (Reln) interact to disrupt gene expression programs underlying neuronal migration of neuroblasts in the nucleus accumbens.
Single-Nucleus Transcriptomics Identifies Neuroblast Migration Programs Sensitive to Reelin and Cannabis in the Adolescent Nucleus Accumbens https://www.biorxiv.org/content/10.1101/2025.04.03.646846v1
April 4, 2025 at 5:49 PM
How does cannabis use during adolescence impact brain development?
Using single-nuclei transcriptomics in mice, we found that cannabis and a genetic risk factor (Reln) interact to disrupt gene expression programs underlying neuronal migration of neuroblasts in the nucleus accumbens.
Using single-nuclei transcriptomics in mice, we found that cannabis and a genetic risk factor (Reln) interact to disrupt gene expression programs underlying neuronal migration of neuroblasts in the nucleus accumbens.
Reposted by Francesca Telese
Our paper providing transcriptomic profiles of lateral septum (LS) cell types in human 🧠 is now online: www.cell.com/iscience/ful...
All data and code are publicly available online (links in the paper) and we provide an interactive web-based app to explore the data: libd.shinyapps.io/LS_snRNAseq/
All data and code are publicly available online (links in the paper) and we provide an interactive web-based app to explore the data: libd.shinyapps.io/LS_snRNAseq/
Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species
Neuroscience; Cellular neuroscience; Transcriptomics
www.cell.com
January 31, 2025 at 10:19 PM
Our paper providing transcriptomic profiles of lateral septum (LS) cell types in human 🧠 is now online: www.cell.com/iscience/ful...
All data and code are publicly available online (links in the paper) and we provide an interactive web-based app to explore the data: libd.shinyapps.io/LS_snRNAseq/
All data and code are publicly available online (links in the paper) and we provide an interactive web-based app to explore the data: libd.shinyapps.io/LS_snRNAseq/
Reposted by Francesca Telese
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
scim.ag
January 22, 2025 at 11:28 PM
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Reposted by Francesca Telese
A challenge for basic scientists is to guarantee that the future generation of health-care professionals and policymakers understands the importance of addiction and mental health research.
By Omar Abubaker, @karlakaun.bsky.social, @ericjnestler.bsky.social
bit.ly/42oULRu
#neuroskyence
By Omar Abubaker, @karlakaun.bsky.social, @ericjnestler.bsky.social
bit.ly/42oULRu
#neuroskyence
Neuroscientists need to do better at explaining basic mental health research
The knowledge gap between scientists, health-care professionals, policymakers and people with mental health conditions is growing, slowing the translation of basic science to new treatments.
bit.ly
January 21, 2025 at 4:44 PM
A challenge for basic scientists is to guarantee that the future generation of health-care professionals and policymakers understands the importance of addiction and mental health research.
By Omar Abubaker, @karlakaun.bsky.social, @ericjnestler.bsky.social
bit.ly/42oULRu
#neuroskyence
By Omar Abubaker, @karlakaun.bsky.social, @ericjnestler.bsky.social
bit.ly/42oULRu
#neuroskyence
Reposted by Francesca Telese
It is Faculty interview season, so I created a doc with compiled Chalk Talk advice! Please share widely- this shouldn't be hidden curriculum... there is a recipe for success! I will also share videos of my practice and actual UCSD chalk talk with anyone who wants it! DM me!
January 19, 2025 at 8:51 PM
It is Faculty interview season, so I created a doc with compiled Chalk Talk advice! Please share widely- this shouldn't be hidden curriculum... there is a recipe for success! I will also share videos of my practice and actual UCSD chalk talk with anyone who wants it! DM me!
Reposted by Francesca Telese
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Conferences & Schools – 2025 – Gene Regulation – Teif Lab
generegulation.org
January 14, 2025 at 7:14 PM
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Reposted by Francesca Telese
How does the brain avoid overwriting old memories when new ones are created? New data (in mice) provides a hint: old & new memories are processed during different stages of sleep www.nature.com/articles/d41...
Why don’t new memories overwrite old ones? Sleep science holds clues
Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.
www.nature.com
January 9, 2025 at 9:51 PM
How does the brain avoid overwriting old memories when new ones are created? New data (in mice) provides a hint: old & new memories are processed during different stages of sleep www.nature.com/articles/d41...
Reposted by Francesca Telese
If people want to help and are able to donate to help those affected by these LA fires, here are places they can donate:
friendsindeedpas.org/donate-to-fr...
cpf.salsalabs.org/disasterreli...
www.directrelief.org/emergency/ca...
www.pledge.to/ccfwildfirer...
www.globalgiving.org/projects/cal...
friendsindeedpas.org/donate-to-fr...
cpf.salsalabs.org/disasterreli...
www.directrelief.org/emergency/ca...
www.pledge.to/ccfwildfirer...
www.globalgiving.org/projects/cal...
California Fire Relief
In response to fire across California, Direct Relief provides N-95 masks, medicine, and other resources to public agencies and first responders in wildfire-affected communities.
www.directrelief.org
January 9, 2025 at 4:39 PM
If people want to help and are able to donate to help those affected by these LA fires, here are places they can donate:
friendsindeedpas.org/donate-to-fr...
cpf.salsalabs.org/disasterreli...
www.directrelief.org/emergency/ca...
www.pledge.to/ccfwildfirer...
www.globalgiving.org/projects/cal...
friendsindeedpas.org/donate-to-fr...
cpf.salsalabs.org/disasterreli...
www.directrelief.org/emergency/ca...
www.pledge.to/ccfwildfirer...
www.globalgiving.org/projects/cal...
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
Mammalian genomes host a diverse array of RNA that includes protein-coding and noncoding transcripts. However, the functional roles of most long nonco…
www.sciencedirect.com
December 22, 2024 at 4:16 PM
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Francesca Telese
This is fascinating! Congrats @brunetlab.bsky.social & colleagues! Cool findings on vascular/pericyte & meningeal/perivascular fibroblast cell types - important to exercise to keep those 🧠 blood vessels young and functional 🏃♀️🏋️♂️...but also what are the fibroblasts up to?!? 👀 🧪 #BBB #fibroblast
December 19, 2024 at 1:11 PM
This is fascinating! Congrats @brunetlab.bsky.social & colleagues! Cool findings on vascular/pericyte & meningeal/perivascular fibroblast cell types - important to exercise to keep those 🧠 blood vessels young and functional 🏃♀️🏋️♂️...but also what are the fibroblasts up to?!? 👀 🧪 #BBB #fibroblast
TF motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nucleosome fibre topology guides transcription factor binding to enhancers - Nature
Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.
www.nature.com
December 19, 2024 at 7:44 AM
TF motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Francesca Telese
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
December 12, 2024 at 2:48 PM
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
Reposted by Francesca Telese
Travel Award Stipends - Students, Postdocs, Junior faculty. GBB25 19-22 May, 2025, Yanuca Island, Fiji
Deadline: 17th January 2025.
More here: www.ibangs.org/travel-award... @twbredy.bsky.social
Deadline: 17th January 2025.
More here: www.ibangs.org/travel-award... @twbredy.bsky.social
December 11, 2024 at 5:19 PM
Travel Award Stipends - Students, Postdocs, Junior faculty. GBB25 19-22 May, 2025, Yanuca Island, Fiji
Deadline: 17th January 2025.
More here: www.ibangs.org/travel-award... @twbredy.bsky.social
Deadline: 17th January 2025.
More here: www.ibangs.org/travel-award... @twbredy.bsky.social
Reposted by Francesca Telese
Although studying sex differences in the brain is complex, it is essential. Armin Raznahan @bogglerapture.bsky.social explains why ignoring different patterns of risk for brain-based conditions among males and females does us all a disservice.
www.thetransmitter.org/sex-differen...
www.thetransmitter.org/sex-differen...
Males and females show different patterns of risk for brain-based conditions. Ignoring these differences does us all a disservice.
Although studying sex differences in the brain is complex, technically awkward and socioculturally loaded, it is absolutely essential.
www.thetransmitter.org
December 9, 2024 at 3:12 PM
Although studying sex differences in the brain is complex, it is essential. Armin Raznahan @bogglerapture.bsky.social explains why ignoring different patterns of risk for brain-based conditions among males and females does us all a disservice.
www.thetransmitter.org/sex-differen...
www.thetransmitter.org/sex-differen...
Reposted by Francesca Telese
Don't miss the Women and Gender-Minority Luncheon Symposium, "Respond Rapidly and Professionally to Macro- and Micro- Aggressions", sponsored by the Gender Equity and Inclusion Committee. #ACNP2024
📅 Today, December 10th
🕒 11:00am - 1:00pm MST
📍 Grand Saguaro
📅 Today, December 10th
🕒 11:00am - 1:00pm MST
📍 Grand Saguaro
December 10, 2024 at 4:00 PM
Don't miss the Women and Gender-Minority Luncheon Symposium, "Respond Rapidly and Professionally to Macro- and Micro- Aggressions", sponsored by the Gender Equity and Inclusion Committee. #ACNP2024
📅 Today, December 10th
🕒 11:00am - 1:00pm MST
📍 Grand Saguaro
📅 Today, December 10th
🕒 11:00am - 1:00pm MST
📍 Grand Saguaro
Reposted by Francesca Telese
Have you been interested combining Perturb-Seq screening with Cas12a’s unique capabilities for multiplexed guide RNA expression? Us too! So, we figured out some useful tricks to make that possible, which you can find in our new pre-print. Short thread below: www.biorxiv.org/content/10.1...
Degron-modified Cas12a enhances single-cell CRISPR screening
Single-cell CRISPR (Perturb-seq) screens have primarily relied on Cas9 whereas Cas12a, despite its unique effectiveness for multiplex guide expression, remains underexplored. This may be due to Cas12a...
www.biorxiv.org
December 9, 2024 at 1:05 PM
Have you been interested combining Perturb-Seq screening with Cas12a’s unique capabilities for multiplexed guide RNA expression? Us too! So, we figured out some useful tricks to make that possible, which you can find in our new pre-print. Short thread below: www.biorxiv.org/content/10.1...
Baking a prune cake for my kids before heading off to a conference! #ACNP #AcademicMom
December 7, 2024 at 10:28 PM
Baking a prune cake for my kids before heading off to a conference! #ACNP #AcademicMom
Excited for my 3rd #ACNP. My lab at #UCSD works on gene regulation in substance use disorders. Stop by my poster on Monday afternoon to check out our latest single cell genomics findings in outbred rats #genetics #genomics #singlecell #opioids
We are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣
Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
a poster of a witch and a girl with the words say something
ALT: a poster of a witch and a girl with the words say something
media.tenor.com
December 7, 2024 at 10:22 PM
Reposted by Francesca Telese
Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1
Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1
Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discov
www.biorxiv.org
November 28, 2024 at 2:33 AM
Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1
Pecan pie is ready. Happy Thanksgiving new 🦋 friends #thankgiving2024
November 28, 2024 at 4:03 AM
Pecan pie is ready. Happy Thanksgiving new 🦋 friends #thankgiving2024
Reposted by Francesca Telese
A ‘Wikipedia for cells’: researchers get an updated look at the Human Cell Atlas, and it’s remarkable
#HCA
@natureportfolio.bsky.social
www.nature.com/articles/d41...
#HCA
@natureportfolio.bsky.social
www.nature.com/articles/d41...
A ‘Wikipedia for cells’: researchers get an updated look at the Human Cell Atlas, and it’s remarkable
Coming less than a decade after its launch, the studies emerging from the global project are a major achievement. Funders should sign up for the long haul.
www.nature.com
November 21, 2024 at 7:17 AM
A ‘Wikipedia for cells’: researchers get an updated look at the Human Cell Atlas, and it’s remarkable
#HCA
@natureportfolio.bsky.social
www.nature.com/articles/d41...
#HCA
@natureportfolio.bsky.social
www.nature.com/articles/d41...