Felix Randow
@felixrandow.bsky.social
Immunologist x cell biologist x microbiologist at MRC LMB in Cambridge. Occasionally birdwatching. Less nerdy than my bio sounds. Views my own.
Reposted by Felix Randow
Gisela Otten has joined the Board of Directors and will Chair the Board of the Women’s team at Cambridge United Football Club. Gisela joined @felixrandow.bsky.social's group at the LMB in 2017 and spent 6 years playing for Cambridge United Women. #LMBAlumni
www.cambridgeunited.com/news/mike-da...
www.cambridgeunited.com/news/mike-da...
Mike Davey and Gisela Otten join Board of Directors | Cambridge United F.C.
www.cambridgeunited.com
July 14, 2025 at 2:09 PM
Gisela Otten has joined the Board of Directors and will Chair the Board of the Women’s team at Cambridge United Football Club. Gisela joined @felixrandow.bsky.social's group at the LMB in 2017 and spent 6 years playing for Cambridge United Women. #LMBAlumni
www.cambridgeunited.com/news/mike-da...
www.cambridgeunited.com/news/mike-da...
Reposted by Felix Randow
Another insightful piece recently out @natsmb.nature.com delineating how Shigella utilises its effector IpaH1.4 to counteract host RNF213-induced LPS ubiquitylation. Very interesting work by the lab of @felixrandow.bsky.social. If you want to, have a go at it: www.nature.com/articles/s41...
Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213 - Nature Structural & Molecular Biology
Naydenova, Boyle and Pathe et al. report that Shigella uses the ubiquitin E3 ligase IpaH1.4 to evade lipopolysaccharide ubiquitylation in infected cells by degrading the host E3 ligase RNF213. Using c...
www.nature.com
April 15, 2025 at 9:04 AM
Another insightful piece recently out @natsmb.nature.com delineating how Shigella utilises its effector IpaH1.4 to counteract host RNF213-induced LPS ubiquitylation. Very interesting work by the lab of @felixrandow.bsky.social. If you want to, have a go at it: www.nature.com/articles/s41...
Reposted by Felix Randow
How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
April 9, 2025 at 9:09 AM
How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp
#LMBResearch🧪
RNF213, a host E3 ligase, ubiquitylates LPS to mark cytosol-invading bacteria for autophagy. But how do cytosol-adapted bacteria escape? We found that Shigella's E3 ligase IpaH1.4 blocks LPS ubiquitylation by degrading RNF213 via the proteasome.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213 - Nature Structural & Molecular Biology
Naydenova, Boyle and Pathe et al. report that Shigella uses the ubiquitin E3 ligase IpaH1.4 to evade lipopolysaccharide ubiquitylation in infected cells by degrading the host E3 ligase RNF213. Using c...
www.nature.com
April 9, 2025 at 9:44 PM
RNF213, a host E3 ligase, ubiquitylates LPS to mark cytosol-invading bacteria for autophagy. But how do cytosol-adapted bacteria escape? We found that Shigella's E3 ligase IpaH1.4 blocks LPS ubiquitylation by degrading RNF213 via the proteasome.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Felix Randow
Not long until the deadline for this faculty position @dunnschool.bsky.social...
Are you the one to lead a group doing great research in a special environment, while teaching outstanding students?
www.path.ox.ac.uk/vacancy/asso...
Are you the one to lead a group doing great research in a special environment, while teaching outstanding students?
www.path.ox.ac.uk/vacancy/asso...
February 17, 2025 at 5:05 PM
Not long until the deadline for this faculty position @dunnschool.bsky.social...
Are you the one to lead a group doing great research in a special environment, while teaching outstanding students?
www.path.ox.ac.uk/vacancy/asso...
Are you the one to lead a group doing great research in a special environment, while teaching outstanding students?
www.path.ox.ac.uk/vacancy/asso...
Reposted by Felix Randow
Exciting news: Registration for the 2025 UK Proteotasis & Autophagy meeting (3-5th June) is open: tinyurl.com/mr3p49f9
Joint 2025 Autophagy UK and Proteostasis UK conference | University of Dundee, UK
Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!
tinyurl.com
February 18, 2025 at 9:33 AM
Exciting news: Registration for the 2025 UK Proteotasis & Autophagy meeting (3-5th June) is open: tinyurl.com/mr3p49f9
Reposted by Felix Randow
There are few moments more rewarding in running a lab than having a student defend their PhD thesis. Congratulations Dr. @marianapdc.bsky.social for this amazing achievement. And thanks to @lloydlab.bsky.social and Bart Lambrecht for being the examiners.
February 7, 2025 at 8:45 PM
There are few moments more rewarding in running a lab than having a student defend their PhD thesis. Congratulations Dr. @marianapdc.bsky.social for this amazing achievement. And thanks to @lloydlab.bsky.social and Bart Lambrecht for being the examiners.
Reposted by Felix Randow
Congratulations to @lara-kruger.bsky.social, postdoc in @deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social, who is leaving the LMB to establish her own research group at @institutcurie.bsky.social in Paris!
Best of luck to you Lara!
#LMBAlumni
Best of luck to you Lara!
#LMBAlumni
February 6, 2025 at 10:23 AM
Congratulations to @lara-kruger.bsky.social, postdoc in @deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social, who is leaving the LMB to establish her own research group at @institutcurie.bsky.social in Paris!
Best of luck to you Lara!
#LMBAlumni
Best of luck to you Lara!
#LMBAlumni
Reposted by Felix Randow
How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR
& NV
shorturl.at/fImjA
& NV
shorturl.at/fImjA
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
shorturl.at
January 29, 2025 at 5:33 PM
How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR
& NV
shorturl.at/fImjA
& NV
shorturl.at/fImjA
Reposted by Felix Randow
Guess what? You got it, another @plosbiology.org focus issue of thought-provoking Perspectives and Essays on an issue relevant to this Keystone Symposium
What can I say? We clearly care a lot about many of the topics at these joint meetings
Take a look and let us know what you think! 👀⬇️
🧪
What can I say? We clearly care a lot about many of the topics at these joint meetings
Take a look and let us know what you think! 👀⬇️
🧪
At #KSSustainFuture25 session on waste upcycling, bioremediation, biomanufacturing, biodegradation
@plosbiology.org recently published a relevant focus issue exploring biological solutions to reduce CO2 emissions, get rid of plastics, produce food sustainably & generate energy plos.io/3MiXJyW
🧪⬇️
@plosbiology.org recently published a relevant focus issue exploring biological solutions to reduce CO2 emissions, get rid of plastics, produce food sustainably & generate energy plos.io/3MiXJyW
🧪⬇️
Going for green: Biology for planetary sustainability - PLOS Collections
Our green planet is beginning to show a lot of signs of decay triggered by the demands of our modern lifestyle and constantly growing population numbers. It is our responsibility to try to balance the...
plos.io
January 23, 2025 at 12:49 AM
Guess what? You got it, another @plosbiology.org focus issue of thought-provoking Perspectives and Essays on an issue relevant to this Keystone Symposium
What can I say? We clearly care a lot about many of the topics at these joint meetings
Take a look and let us know what you think! 👀⬇️
🧪
What can I say? We clearly care a lot about many of the topics at these joint meetings
Take a look and let us know what you think! 👀⬇️
🧪
Reposted by Felix Randow
We made it to 100! 📢💯 The #ubiquitin and #ubl Starter Pack now includes 100 profiles to follow if you’re interested in any aspect of the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.
January 21, 2025 at 11:10 AM
We made it to 100! 📢💯 The #ubiquitin and #ubl Starter Pack now includes 100 profiles to follow if you’re interested in any aspect of the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.
Reposted by Felix Randow
By my reckoning, yesterday marked the 50th anniversary of ubiquitin's discovery! 🎈🎉🎁🥂
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. | PNAS
A polypeptide of 8500 molecular weight is described that induces the differentiation
of T (thymus-derived) cell and B (bone-marrow-derived) cell im...
www.pnas.org
January 16, 2025 at 1:25 PM
By my reckoning, yesterday marked the 50th anniversary of ubiquitin's discovery! 🎈🎉🎁🥂
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Felix Randow
We just can't stop recruiting!
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
January 14, 2025 at 4:52 PM
We just can't stop recruiting!
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
After lots of teasing by @npariente.bsky.social I updated my profile picture. No more impersonation of my younger self!
January 12, 2025 at 12:37 PM
After lots of teasing by @npariente.bsky.social I updated my profile picture. No more impersonation of my younger self!
Reposted by Felix Randow
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu.
Repost appreciated.
Repost appreciated.
January 9, 2025 at 2:58 AM
PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu.
Repost appreciated.
Repost appreciated.
Reposted by Felix Randow
Real-time map from Surfers Against Sewage app. For those in blissful ignorance, this is what happens after normal heavy rains in Britain: huge swathes of UK coastline rendered unswimmable by water companies’ discharges. I know it’s old news but I refuse to become desensitized to the sheer awfulness
January 7, 2025 at 9:50 AM
Real-time map from Surfers Against Sewage app. For those in blissful ignorance, this is what happens after normal heavy rains in Britain: huge swathes of UK coastline rendered unswimmable by water companies’ discharges. I know it’s old news but I refuse to become desensitized to the sheer awfulness
Reposted by Felix Randow
We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation.
Details here 👇
www.nature.com/articles/s41...
Details here 👇
www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
www.nature.com
January 6, 2025 at 10:13 AM
We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation.
Details here 👇
www.nature.com/articles/s41...
Details here 👇
www.nature.com/articles/s41...
Reposted by Felix Randow
As we go through various steps of the peer-review process, @gmivienna.bsky.social comms team put together a nice summary of our recent #preprints : www.oeaw.ac.at/gmi/detail/n... Thx @philippdexheimer.bsky.social for the illustration
Autophagy Unveiled: The Dagdas Group is shining a light on cellular recycling
Autophagy keeps cells clean from harmful components. The group of Yasin Dagdas at the GMI studies how selective autophagy detects and removes damaged or unwanted cellular structures. In 2024, the Dagd...
www.oeaw.ac.at
January 7, 2025 at 7:19 AM
As we go through various steps of the peer-review process, @gmivienna.bsky.social comms team put together a nice summary of our recent #preprints : www.oeaw.ac.at/gmi/detail/n... Thx @philippdexheimer.bsky.social for the illustration
Reposted by Felix Randow
On Jan 6 1912, Alfred Wegener presented his theory of continental drift and supercontinent Pangaea's breakup into today's continents. Despite initial rejection, modern seismology and ocean drilling in the 1950s/60s validated his ideas, leading to the current understanding of plate tectonics. ⚒🧪
January 6, 2025 at 9:19 AM
On Jan 6 1912, Alfred Wegener presented his theory of continental drift and supercontinent Pangaea's breakup into today's continents. Despite initial rejection, modern seismology and ocean drilling in the 1950s/60s validated his ideas, leading to the current understanding of plate tectonics. ⚒🧪
Reposted by Felix Randow
Happy New Year! Let’s start with an updated starter pack. Now with 94 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.
January 6, 2025 at 1:02 PM
Happy New Year! Let’s start with an updated starter pack. Now with 94 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.
Reposted by Felix Randow
Peptidoglycan as danger signal promotes biofilm formation - great article by the Drescher lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
www.nature.com
January 4, 2025 at 2:21 PM
Peptidoglycan as danger signal promotes biofilm formation - great article by the Drescher lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Felix Randow
New paper out from Deretic’s lab!!! rupress.org/jcb/article/...
ATG9A facilitates the closure of mammalian autophagosomes
ATG9A contributes to the final stage in autophagosome biogenesis by directing autophagosome closure. It does so by recruiting ESCRT protein CHMP2A via IQGA
rupress.org
January 2, 2025 at 8:06 PM
New paper out from Deretic’s lab!!! rupress.org/jcb/article/...
Today in A Coruña. It has become a nice tradition for us to visit their annual photo exhibition.
December 26, 2024 at 6:20 PM
Today in A Coruña. It has become a nice tradition for us to visit their annual photo exhibition.
Reposted by Felix Randow
Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏
If you're interested in learning about the latest of fundamental mycobacteriology, sign up for #GRCMyco2025! Acceptances will start in September, check out the full program and please RT!
We're live with the program!
www.grc.org/biology-of-m...
www.grc.org/biology-of-m...
November 19, 2024 at 10:46 PM
Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏
Reposted by Felix Randow
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
December 12, 2024 at 3:19 PM
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering