BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria

go.nature.com/44GsxT2

This week was the 1st publication using our immune cell sequencing to accurately make medical diagnoses. It has enormous implications, as I've reviewed here erictopol.substack.com/p/the-first-... @scottboydlab.bsky.social @science.org @anshulkundaje.bsky.social @maximzaslavsky.bsky.social

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
www.science.org/doi/10.1126/...
@science.org @nikjoshilabyale.bsky.social

A new #ScienceImmunology Review discusses the mechanisms through which dendritic cells influence cytotoxic CD8+ T cell responses against cancer. scim.ag/3PU7hRo

Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells @bloodjournal.bsky.social
doi.org/10.1182/bloo...

Breaking: The FDA approved datopotamab deruxtecan for unresectable or metastatic HR+/HER2-negative #breastcancer. Congrats to @mskcancercenter.bsky.social's Komal Jhaveri, one of the lead accruers of the TROPION Breast 01 trial. www.fda.gov/drugs/resour...

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

β-adrenergic signaling is a key driver of metastasis & the β-blocker propranolol reduces metastasis through monocyte-dependent activation of cytotoxic CD4+ T cells
www.researchsquare.com/article/rs-5...

Immunotherapy shows sex bias—men respond better; women face more severe AEs. Understanding sex hormones, chromosomes, and epigenetics in immunity could lead to tailored immuno-oncology strategies. #Cancer #Immunotherapy #Oncology @oncoalert.bsky.social
rdcu.be/d49Mq

That was a really fun and fruitful collaboration, we learned so much from each other! Thanks again ☺️

Hello Bluesky! 👋 Here to share my work, learn from others, and talk science ☺️