Enfu Hui
@enfuhui.bsky.social
Professor @UCSD. Biologist, husband, dad, nerd 🤓, and 🎾 fan. https://www.huilab-ucsd.org
Pinned
Enfu Hui
@enfuhui.bsky.social
· Jan 4
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
Reposted by Enfu Hui
We are hiring! Several projects available in mucosal immunology and stem cell transplantation using functional genomics and spatial transcriptomics. Could you please help us spread the word? @ljiresearch.bsky.social
Postdoctoral Position in Immunology
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
January 9, 2025 at 3:25 AM
We are hiring! Several projects available in mucosal immunology and stem cell transplantation using functional genomics and spatial transcriptomics. Could you please help us spread the word? @ljiresearch.bsky.social
Reposted by Enfu Hui
For all those providing reviews of scientific papers–firstly, thank you. We would not have a useful scientific literature without you. Secondly, please keep in mind that your reviews are read not only by the PIs but also students. There is no place for anger or impolite language in a review.... 1/
January 7, 2025 at 4:23 PM
For all those providing reviews of scientific papers–firstly, thank you. We would not have a useful scientific literature without you. Secondly, please keep in mind that your reviews are read not only by the PIs but also students. There is no place for anger or impolite language in a review.... 1/
Reposted by Enfu Hui
Good night Blue Sky
January 7, 2025 at 3:06 AM
Good night Blue Sky
Reposted by Enfu Hui
When did the taste of the scientific community changed from liking simple elegant experiments to preferring complicated and expensive experiments?
January 6, 2025 at 9:00 AM
When did the taste of the scientific community changed from liking simple elegant experiments to preferring complicated and expensive experiments?
Reposted by Enfu Hui
📣 DEADLINE COMING UP (Jan 15!) to apply for a short talk at the all-new Keystone Symposium on female reproductive biology!!
The meeting is April 10-12 2025, mark your calendars!
keysym.us/KSFemaleRege...
🧪
@keystonesymposia.bsky.social
#reprosky
The meeting is April 10-12 2025, mark your calendars!
keysym.us/KSFemaleRege...
🧪
@keystonesymposia.bsky.social
#reprosky
Regenerative Biology of the Female Reproductive System | Keystone Symposia
Join us at the Keystone Symposia on Regenerative Biology of the Female Reproductive System, April 2025, in Beverly, with field leaders!
keysym.us
January 6, 2025 at 4:59 PM
📣 DEADLINE COMING UP (Jan 15!) to apply for a short talk at the all-new Keystone Symposium on female reproductive biology!!
The meeting is April 10-12 2025, mark your calendars!
keysym.us/KSFemaleRege...
🧪
@keystonesymposia.bsky.social
#reprosky
The meeting is April 10-12 2025, mark your calendars!
keysym.us/KSFemaleRege...
🧪
@keystonesymposia.bsky.social
#reprosky
Reposted by Enfu Hui
I am thrilled to share that my PhD research project has just been published in @natureportfolio.bsky.social #NatureAging !
We discovered how senescent cells use the ganglioside GD3 as a Senescence Immune Checkpoint to escape immune clearance. #NKcells #Siglec7
www.nature.com/articles/s43...
We discovered how senescent cells use the ganglioside GD3 as a Senescence Immune Checkpoint to escape immune clearance. #NKcells #Siglec7
www.nature.com/articles/s43...
A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging - Nature Aging
This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-rel...
www.nature.com
December 31, 2024 at 3:18 PM
I am thrilled to share that my PhD research project has just been published in @natureportfolio.bsky.social #NatureAging !
We discovered how senescent cells use the ganglioside GD3 as a Senescence Immune Checkpoint to escape immune clearance. #NKcells #Siglec7
www.nature.com/articles/s43...
We discovered how senescent cells use the ganglioside GD3 as a Senescence Immune Checkpoint to escape immune clearance. #NKcells #Siglec7
www.nature.com/articles/s43...
Reposted by Enfu Hui
Thrilled to share I’ll officially start next Monday as a tenure-track Assistant Professor at the Department of Industrial and Molecular Pharmaceutics, Purdue University! My lab will focus on high-precision in vivo biomedical imaging for drug discovery.
January 5, 2025 at 8:14 PM
Thrilled to share I’ll officially start next Monday as a tenure-track Assistant Professor at the Department of Industrial and Molecular Pharmaceutics, Purdue University! My lab will focus on high-precision in vivo biomedical imaging for drug discovery.
Reposted by Enfu Hui
Macrophages need to adjust their appetite based on whats happening around them... but how to make a macrophage hungrier? Annalise Bond assembled a list of biophysical and biochemical parameters that can tune phagocytosis. @jcellsci.bsky.social @biologists.bsky.social
doi.org/10.1242/jcs....
doi.org/10.1242/jcs....
Biochemical and biophysical mechanisms macrophages use to tune phagocytic appetite
Summary: Macrophages regulate their phagocytic appetite to rapidly clear pathogens and debris while minimizing damage to the surrounding tissue. We discuss the molecular toolkit for tuning macrophage ...
journals.biologists.com
January 3, 2025 at 4:42 PM
Macrophages need to adjust their appetite based on whats happening around them... but how to make a macrophage hungrier? Annalise Bond assembled a list of biophysical and biochemical parameters that can tune phagocytosis. @jcellsci.bsky.social @biologists.bsky.social
doi.org/10.1242/jcs....
doi.org/10.1242/jcs....
Reposted by Enfu Hui
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
Functional differences between rodent and human PD-1 linked to evolutionary divergence
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.
www.science.org
January 3, 2025 at 7:34 PM
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
Reposted by Enfu Hui
Don't miss this fantastic study by @enfuhui.bsky.social & colleagues published this week in #Science #Immunology!
First issue of #Science #Immunology out for 2025! Check out this paper by Masabuchi et al. defining why rodent and human PD-1 function differently!🐀🚶♀️@enfuhui.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional differences between rodent and human PD-1 linked to evolutionary divergence
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.
www.science.org
January 3, 2025 at 8:09 PM
Don't miss this fantastic study by @enfuhui.bsky.social & colleagues published this week in #Science #Immunology!
Reposted by Enfu Hui
First issue of #Science #Immunology out for 2025! Check out this paper by Masabuchi et al. defining why rodent and human PD-1 function differently!🐀🚶♀️@enfuhui.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional differences between rodent and human PD-1 linked to evolutionary divergence
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.
www.science.org
January 3, 2025 at 7:46 PM
First issue of #Science #Immunology out for 2025! Check out this paper by Masabuchi et al. defining why rodent and human PD-1 function differently!🐀🚶♀️@enfuhui.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
January 4, 2025 at 12:34 AM
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...