Felipe Vaca
@felipevaca.bsky.social
Oncogenomics, bioinformatics, molecular biology, art.
Reposted by Felipe Vaca
Also from my 2024 Editors’ Choice selections (and free in #ScienceImmunology through February): Dunsmore, Ng, Blériot, Ginhoux, & al. provide a time- and space-resolved picture of tumor-associated #macrophage development in pancreatic tumors:
Timing and location dictate monocyte fate and their transition to tumor-associated macrophages
Intermediate tumor-associated macrophages (TAMs) emerge first and give rise to two more differentiated TAM populations in pancreatic cancer.
www.science.org
December 19, 2024 at 6:50 PM
Also from my 2024 Editors’ Choice selections (and free in #ScienceImmunology through February): Dunsmore, Ng, Blériot, Ginhoux, & al. provide a time- and space-resolved picture of tumor-associated #macrophage development in pancreatic tumors:
Reposted by Felipe Vaca
Why do some people, despite SARS-CoV-2 exposure, not develop an infection?
An ultra-early interferon response blocks Covid
www.thelancet.com/journals/ebi...
adds to protection from pre-existing, cross-reactive T cells in some people
An ultra-early interferon response blocks Covid
www.thelancet.com/journals/ebi...
adds to protection from pre-existing, cross-reactive T cells in some people
An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure
Our interferon-associated signature of early SARS-CoV-2 infection characterises a subgroup of exposed, uninfected contacts in three independent cohorts who may have successfully aborted infection prior to induction of adaptive immunity. The earlier transient upregulation of signature genes in PCR-negative compared to PCR-positive CHIM volunteers suggests that ultra-early interferon-associated innate immune responses correlate with, and may contribute to, protection against SARS-CoV-2 infection.
www.thelancet.com
December 11, 2024 at 11:39 PM
Why do some people, despite SARS-CoV-2 exposure, not develop an infection?
An ultra-early interferon response blocks Covid
www.thelancet.com/journals/ebi...
adds to protection from pre-existing, cross-reactive T cells in some people
An ultra-early interferon response blocks Covid
www.thelancet.com/journals/ebi...
adds to protection from pre-existing, cross-reactive T cells in some people
Reposted by Felipe Vaca
Predicting clotting events in 49 of 53 people with Covid!
An immunosensor that rapidly detects 4 different protein biomarkers
science.org/doi/10.1126/...
An immunosensor that rapidly detects 4 different protein biomarkers
science.org/doi/10.1126/...
Rapid prediction of acute thrombosis via nanoengineered immunosensors with unsupervised clustering for multiple circulating biomarkers
A nanoengineered immunosensor uses machine learning to detect multiple biomarkers for rapid prediction of acute thrombosis.
science.org
December 11, 2024 at 7:45 PM
Predicting clotting events in 49 of 53 people with Covid!
An immunosensor that rapidly detects 4 different protein biomarkers
science.org/doi/10.1126/...
An immunosensor that rapidly detects 4 different protein biomarkers
science.org/doi/10.1126/...
Reposted by Felipe Vaca
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 6:57 PM
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Reposted by Felipe Vaca
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naive and longitudinal samples throughout neoadjuvant chemotherapy https://www.biorxiv.org/content/10.1101/2024.11.25.625287v1
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naive and longitudinal samples throughout neoadjuvant chemotherapy https://www.biorxiv.org/content/10.1101/2024.11.25.625287v1
Triple negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be
www.biorxiv.org
November 29, 2024 at 5:49 AM
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naive and longitudinal samples throughout neoadjuvant chemotherapy https://www.biorxiv.org/content/10.1101/2024.11.25.625287v1
Reposted by Felipe Vaca
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
November 27, 2024 at 2:13 PM
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Reposted by Felipe Vaca
Just in time for thanksgiving our paper is out ☄️
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life - Nature Communications
Clonal hematopoiesis becomes increasingly common with age. Here the authors track stem cell dynamics in monozygotic twins and provide evidence that clonal hematopoiesis in later life reflects weak sel...
www.nature.com
November 28, 2024 at 5:15 AM
Just in time for thanksgiving our paper is out ☄️
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
using fluctuating methylation clocks as barcodes we show that the variation in the hematopoietic stem cell pool that (in most of us) leads to clonal hematopoiesis in later life is likely present *before birth*
👉🏼 www.nature.com/articles/s41...
Reposted by Felipe Vaca
Immune cells change in proportions with age - naive go down, effector go up. www.science.org/doi/10.1126/...
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
www.science.org
November 29, 2024 at 8:37 AM
Immune cells change in proportions with age - naive go down, effector go up. www.science.org/doi/10.1126/...
Reposted by Felipe Vaca
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
November 27, 2024 at 10:17 PM
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
Reposted by Felipe Vaca
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 20, 2024 at 8:33 PM
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Felipe Vaca
Reposted by Felipe Vaca
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
Somatic mutation and selection at epidemiological scale
As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...
www.medrxiv.org
November 20, 2024 at 2:28 PM
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...