Adam MacLean
@adamlmaclean.bsky.social
Assistant professor @USC. Modeling cell fate with dynamical systems & statistical inference. What makes a stem cell? macleanlab.usc.edu he/him
Pinned
Adam MacLean
@adamlmaclean.bsky.social
Β· Nov 11
Hello! Re-introduction due to π of late
My lab studies cell fate. I π haematopoietic stem cells, dynamical systems, Bayesian stats, single-cell genomics & βοΈ metastatic cancer
Iβm here for bsky as a place for kind discussion: deep dumb weird fun et al.
Also occasional kid content +/- science songs
My lab studies cell fate. I π haematopoietic stem cells, dynamical systems, Bayesian stats, single-cell genomics & βοΈ metastatic cancer
Iβm here for bsky as a place for kind discussion: deep dumb weird fun et al.
Also occasional kid content +/- science songs
As I hurtle headlong towards the coming semester, I am really feeling these epic closing words of advice from Gian-Carlo Rota.
[very grateful to the transcription from Leo Goldmakher, h/t @lianafaye.bsky.social]
web.williams.edu/Mathematics/...
[very grateful to the transcription from Leo Goldmakher, h/t @lianafaye.bsky.social]
web.williams.edu/Mathematics/...
January 8, 2026 at 4:41 PM
As I hurtle headlong towards the coming semester, I am really feeling these epic closing words of advice from Gian-Carlo Rota.
[very grateful to the transcription from Leo Goldmakher, h/t @lianafaye.bsky.social]
web.williams.edu/Mathematics/...
[very grateful to the transcription from Leo Goldmakher, h/t @lianafaye.bsky.social]
web.williams.edu/Mathematics/...
This is fascinating! I thought I saw some flowering driving down the 395 over the weekend (near the 14 junction) but I did not take any pictures.
December 10, 2025 at 9:59 PM
This is fascinating! I thought I saw some flowering driving down the 395 over the weekend (near the 14 junction) but I did not take any pictures.
Yes except in my head it has to be Ofc. ofc just looks odd π€·ββοΈ
December 10, 2025 at 9:45 PM
Yes except in my head it has to be Ofc. ofc just looks odd π€·ββοΈ
Reposted by Adam MacLean
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Adam MacLean
Thank you Adam Maclean @adamlmaclean.bsky.social for sharing your experience of fee-free Open Access publishing in @dev-journal.bsky.social via our Read & Publish agreement with The University of Queensland.
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
October 29, 2025 at 4:44 PM
Thank you Adam Maclean @adamlmaclean.bsky.social for sharing your experience of fee-free Open Access publishing in @dev-journal.bsky.social via our Read & Publish agreement with The University of Queensland.
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
The ability of kids to convince me they know more than they know is truly amazing.
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
October 21, 2025 at 3:51 PM
The ability of kids to convince me they know more than they know is truly amazing.
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
we aren't allowed to write cocaine?
October 14, 2025 at 3:49 PM
we aren't allowed to write cocaine?
October 13, 2025 at 8:11 PM
Reposted by Adam MacLean
Really enjoyed talking about mathematical biology (and a little about being an associate dean) in @parmvir.com's Biology in Numbers podcast on the 2025 @smbmathbiology.bsky.social annual meeting!
Bolero superfans, don't @ me! π§ͺ
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
Bolero superfans, don't @ me! π§ͺ
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
S3 Ep1: SMB 2025
Podcast Episode Β· Biology in Numbers Β· 09/29/2025 Β· 53m
podcasts.apple.com
October 1, 2025 at 10:01 PM
Really enjoyed talking about mathematical biology (and a little about being an associate dean) in @parmvir.com's Biology in Numbers podcast on the 2025 @smbmathbiology.bsky.social annual meeting!
Bolero superfans, don't @ me! π§ͺ
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
Bolero superfans, don't @ me! π§ͺ
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
Reposted by Adam MacLean
Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!
September 30, 2025 at 7:20 PM
Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!
Who knows if the cows were more or less interested in my poster than the poster session attendees would have been.
Also good idea @mathcancer.bsky.social to flip the script, it was great to hear from our host Parmvir too!
Also good idea @mathcancer.bsky.social to flip the script, it was great to hear from our host Parmvir too!
October 1, 2025 at 4:01 PM
Who knows if the cows were more or less interested in my poster than the poster session attendees would have been.
Also good idea @mathcancer.bsky.social to flip the script, it was great to hear from our host Parmvir too!
Also good idea @mathcancer.bsky.social to flip the script, it was great to hear from our host Parmvir too!
This was fun and great to learn about the research (and trivia) of colleagues from #SMB2025 this summer in Edmonton. Thanks to @parmvir.com for hosting a great podcast π 𧬠π’
podcasts.apple.com/us/podcast/s...
podcasts.apple.com/us/podcast/s...
September 30, 2025 at 11:12 PM
This was fun and great to learn about the research (and trivia) of colleagues from #SMB2025 this summer in Edmonton. Thanks to @parmvir.com for hosting a great podcast π 𧬠π’
podcasts.apple.com/us/podcast/s...
podcasts.apple.com/us/podcast/s...
Reposted by Adam MacLean
Also starring:
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
This year's @smbmathbiology.bsky.social meeting provided us with another delightful mashup of math biologists (and me) talking about science, and in Amy's case, ultra-running and conference coffee β
Thanks to all the excellent attendees who agreed to speak with me for Biology in Numbers.
#scicomm
Thanks to all the excellent attendees who agreed to speak with me for Biology in Numbers.
#scicomm
September 30, 2025 at 8:59 PM
Also starring:
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
Reposted by Adam MacLean
Phylogenetic tree inference from single-cell RNA sequencing data www.biorxiv.org/content/10.1... #singlecell
September 22, 2025 at 4:01 PM
Phylogenetic tree inference from single-cell RNA sequencing data www.biorxiv.org/content/10.1... #singlecell
Reposted by Adam MacLean
Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.
Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox refβhalf mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 22, 2025 at 8:12 PM
Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.
Sometimes I get the feeling I'm working in the wrong subfield of biology
www.cell.com/current-biol...
www.cell.com/current-biol...
Wound-dependent leg amputations to combat infections in an ant society
Frank etΒ al. provide the first example of the use of amputations to treat infected
leg wounds in a non-human animal. The findings demonstrate that ants can adapt their
treatment modality depending on ...
www.cell.com
September 3, 2025 at 5:26 PM
Sometimes I get the feeling I'm working in the wrong subfield of biology
www.cell.com/current-biol...
www.cell.com/current-biol...
Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
August 12, 2025 at 11:34 PM
Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
"When they see us coming
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
July 28, 2025 at 6:11 PM
"When they see us coming
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
Reposted by Adam MacLean
In this week's post Jesse Kreger (@adamlmaclean.bsky.socialβ¬) discusses his latest work in #cancer #systems #immunology together with Edgar Gonzalez to study the mechanisms of response of breast cancer to #checkPointInhibitors
Discovering mechanisms of response via CSI (Cancer Systems Immunology)
mathematical-oncology.org
mathematical-oncology.org
July 25, 2025 at 3:20 PM
In this week's post Jesse Kreger (@adamlmaclean.bsky.socialβ¬) discusses his latest work in #cancer #systems #immunology together with Edgar Gonzalez to study the mechanisms of response of breast cancer to #checkPointInhibitors
Thanks for the great science and great company. Next year will be time to swap the poutine for pilsner and I'll hope to see you in Graz! #SMB2025
July 19, 2025 at 6:28 PM
Thanks for the great science and great company. Next year will be time to swap the poutine for pilsner and I'll hope to see you in Graz! #SMB2025
For the most part everything ran on time! Also crucial to success of course, as well as being just good manners. I wholeheartedly endorse the session chair energy of Kelsey Gasior:
"If you run over time, I will body slam you off stage."
"If you run over time, I will body slam you off stage."
July 19, 2025 at 6:28 PM
For the most part everything ran on time! Also crucial to success of course, as well as being just good manners. I wholeheartedly endorse the session chair energy of Kelsey Gasior:
"If you run over time, I will body slam you off stage."
"If you run over time, I will body slam you off stage."
I was overall really impressed with the organization, bravo to the team. The venue worked well; this is IMO crucial to a great conference experience in that it permits ease of hopping between parallel sessions (bar a few squeaky doors) to cram in as many minisymposia talks as is humanly possible.
July 19, 2025 at 6:28 PM
I was overall really impressed with the organization, bravo to the team. The venue worked well; this is IMO crucial to a great conference experience in that it permits ease of hopping between parallel sessions (bar a few squeaky doors) to cram in as many minisymposia talks as is humanly possible.