Adam MacLean
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adamlmaclean.bsky.social
Adam MacLean
@adamlmaclean.bsky.social
Assistant professor @USC. Modeling cell fate with dynamical systems & statistical inference. What makes a stem cell? macleanlab.usc.edu he/him
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Hello! Re-introduction due to πŸš€ of late

My lab studies cell fate. I πŸ’™ haematopoietic stem cells, dynamical systems, Bayesian stats, single-cell genomics & βš”οΈ metastatic cancer

I’m here for bsky as a place for kind discussion: deep dumb weird fun et al.

Also occasional kid content +/- science songs
As I hurtle headlong towards the coming semester, I am really feeling these epic closing words of advice from Gian-Carlo Rota.

[very grateful to the transcription from Leo Goldmakher, h/t @lianafaye.bsky.social]

web.williams.edu/Mathematics/...
January 8, 2026 at 4:41 PM
This is fascinating! I thought I saw some flowering driving down the 395 over the weekend (near the 14 junction) but I did not take any pictures.
December 10, 2025 at 9:59 PM
Yes except in my head it has to be Ofc. ofc just looks odd πŸ€·β€β™‚οΈ
December 10, 2025 at 9:45 PM
Reposted by Adam MacLean
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Reposted by Adam MacLean
Thank you Adam Maclean @adamlmaclean.bsky.social for sharing your experience of fee-free Open Access publishing in @dev-journal.bsky.social via our Read & Publish agreement with The University of Queensland.

See all institutions: www.biologists.com/library-hub/...

#OA #OpenAccess #ReadAndPublish
October 29, 2025 at 4:44 PM
The ability of kids to convince me they know more than they know is truly amazing.

Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
October 21, 2025 at 3:51 PM
Ah I see okay!
October 14, 2025 at 4:18 PM
we aren't allowed to write cocaine?
October 14, 2025 at 3:49 PM
πŸ€ŒπŸ€
October 13, 2025 at 8:50 PM
Cool paper. Was the ad hominem really necessary though?

www.science.org/doi/10.1126/...
October 13, 2025 at 8:11 PM
Reposted by Adam MacLean
Really enjoyed talking about mathematical biology (and a little about being an associate dean) in @parmvir.com's Biology in Numbers podcast on the 2025 @smbmathbiology.bsky.social annual meeting!

Bolero superfans, don't @ me! πŸ§ͺ

(I'm at 33:43)

podcasts.apple.com/us/podcast/b...
S3 Ep1: SMB 2025
Podcast Episode Β· Biology in Numbers Β· 09/29/2025 Β· 53m
podcasts.apple.com
October 1, 2025 at 10:01 PM
Reposted by Adam MacLean
Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!
September 30, 2025 at 7:20 PM
Who knows if the cows were more or less interested in my poster than the poster session attendees would have been.

Also good idea @mathcancer.bsky.social to flip the script, it was great to hear from our host Parmvir too!
October 1, 2025 at 4:01 PM
This was fun and great to learn about the research (and trivia) of colleagues from #SMB2025 this summer in Edmonton. Thanks to @parmvir.com for hosting a great podcast πŸ™Œ 🧬 πŸ”’

podcasts.apple.com/us/podcast/s...
September 30, 2025 at 11:12 PM
Reposted by Adam MacLean
This year's @smbmathbiology.bsky.social meeting provided us with another delightful mashup of math biologists (and me) talking about science, and in Amy's case, ultra-running and conference coffee β˜•
Thanks to all the excellent attendees who agreed to speak with me for Biology in Numbers.

#scicomm
September 30, 2025 at 8:59 PM
Reposted by Adam MacLean
Phylogenetic tree inference from single-cell RNA sequencing data www.biorxiv.org/content/10.1... #singlecell
September 22, 2025 at 4:01 PM
Reposted by Adam MacLean
Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.
Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox refβ€”half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social

www.sciencedirect.com/science/arti...
September 22, 2025 at 8:12 PM
πŸ˜‚ perfect
September 4, 2025 at 4:54 AM
Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response

Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer

www.biorxiv.org/content/10.1...
August 12, 2025 at 11:34 PM
"When they see us coming
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
July 28, 2025 at 6:11 PM
Reposted by Adam MacLean
In this week's post Jesse Kreger (@adamlmaclean.bsky.social‬) discusses his latest work in #cancer #systems #immunology together with Edgar Gonzalez to study the mechanisms of response of breast cancer to #checkPointInhibitors
Discovering mechanisms of response via CSI (Cancer Systems Immunology)
mathematical-oncology.org
mathematical-oncology.org
July 25, 2025 at 3:20 PM
Thanks for the great science and great company. Next year will be time to swap the poutine for pilsner and I'll hope to see you in Graz! #SMB2025
July 19, 2025 at 6:28 PM
For the most part everything ran on time! Also crucial to success of course, as well as being just good manners. I wholeheartedly endorse the session chair energy of Kelsey Gasior:

"If you run over time, I will body slam you off stage."
July 19, 2025 at 6:28 PM
I was overall really impressed with the organization, bravo to the team. The venue worked well; this is IMO crucial to a great conference experience in that it permits ease of hopping between parallel sessions (bar a few squeaky doors) to cram in as many minisymposia talks as is humanly possible.
July 19, 2025 at 6:28 PM