Adam MacLean
@adamlmaclean.bsky.social
Assistant professor @USC. Modeling cell fate with dynamical systems & statistical inference. What makes a stem cell? macleanlab.usc.edu he/him
Pinned
Adam MacLean
@adamlmaclean.bsky.social
· Nov 11
Hello! Re-introduction due to 🚀 of late
My lab studies cell fate. I 💙 haematopoietic stem cells, dynamical systems, Bayesian stats, single-cell genomics & ⚔️ metastatic cancer
I’m here for bsky as a place for kind discussion: deep dumb weird fun et al.
Also occasional kid content +/- science songs
My lab studies cell fate. I 💙 haematopoietic stem cells, dynamical systems, Bayesian stats, single-cell genomics & ⚔️ metastatic cancer
I’m here for bsky as a place for kind discussion: deep dumb weird fun et al.
Also occasional kid content +/- science songs
Reposted by Adam MacLean
Thank you Adam Maclean @adamlmaclean.bsky.social for sharing your experience of fee-free Open Access publishing in @dev-journal.bsky.social via our Read & Publish agreement with The University of Queensland.
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
October 29, 2025 at 4:44 PM
Thank you Adam Maclean @adamlmaclean.bsky.social for sharing your experience of fee-free Open Access publishing in @dev-journal.bsky.social via our Read & Publish agreement with The University of Queensland.
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
See all institutions: www.biologists.com/library-hub/...
#OA #OpenAccess #ReadAndPublish
The ability of kids to convince me they know more than they know is truly amazing.
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
October 21, 2025 at 3:51 PM
The ability of kids to convince me they know more than they know is truly amazing.
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
Exhibit: family charades. I am acting, 7yo is guessing.
One word; two syllables.
Meaning: something you eat with that is not a spoon.
First syllable: chop.
Second syllable: rhymes with lick.
7yo: Knife!
October 13, 2025 at 8:11 PM
Reposted by Adam MacLean
Really enjoyed talking about mathematical biology (and a little about being an associate dean) in @parmvir.com's Biology in Numbers podcast on the 2025 @smbmathbiology.bsky.social annual meeting!
Bolero superfans, don't @ me! 🧪
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
Bolero superfans, don't @ me! 🧪
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
S3 Ep1: SMB 2025
Podcast Episode · Biology in Numbers · 09/29/2025 · 53m
podcasts.apple.com
October 1, 2025 at 10:01 PM
Really enjoyed talking about mathematical biology (and a little about being an associate dean) in @parmvir.com's Biology in Numbers podcast on the 2025 @smbmathbiology.bsky.social annual meeting!
Bolero superfans, don't @ me! 🧪
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
Bolero superfans, don't @ me! 🧪
(I'm at 33:43)
podcasts.apple.com/us/podcast/b...
Reposted by Adam MacLean
Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!
September 30, 2025 at 7:20 PM
Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!
This was fun and great to learn about the research (and trivia) of colleagues from #SMB2025 this summer in Edmonton. Thanks to @parmvir.com for hosting a great podcast 🙌 🧬 🔢
podcasts.apple.com/us/podcast/s...
podcasts.apple.com/us/podcast/s...
September 30, 2025 at 11:12 PM
This was fun and great to learn about the research (and trivia) of colleagues from #SMB2025 this summer in Edmonton. Thanks to @parmvir.com for hosting a great podcast 🙌 🧬 🔢
podcasts.apple.com/us/podcast/s...
podcasts.apple.com/us/podcast/s...
Reposted by Adam MacLean
Also starring:
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
This year's @smbmathbiology.bsky.social meeting provided us with another delightful mashup of math biologists (and me) talking about science, and in Amy's case, ultra-running and conference coffee ☕
Thanks to all the excellent attendees who agreed to speak with me for Biology in Numbers.
#scicomm
Thanks to all the excellent attendees who agreed to speak with me for Biology in Numbers.
#scicomm
I do regret not asking @parmvir.com about her ultra-running in the podcast: open.spotify.com/episode/7rpv... but even better, she's interviewed here too!
September 30, 2025 at 8:59 PM
Also starring:
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
@adamlmaclean.bsky.social
@gosiaweh.bsky.social
@mathcancer.bsky.social
@thomasewoolley.bsky.social
Luis Sordo Vieira
Mobolaji Williams
Kira Pugh
and Francisca Olajide
@smbmathbiology.bsky.social #scicomm #BiologyInNumbers
Reposted by Adam MacLean
Phylogenetic tree inference from single-cell RNA sequencing data www.biorxiv.org/content/10.1... #singlecell
September 22, 2025 at 4:01 PM
Phylogenetic tree inference from single-cell RNA sequencing data www.biorxiv.org/content/10.1... #singlecell
Reposted by Adam MacLean
Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.
Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 22, 2025 at 8:12 PM
Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.
Sometimes I get the feeling I'm working in the wrong subfield of biology
www.cell.com/current-biol...
www.cell.com/current-biol...
Wound-dependent leg amputations to combat infections in an ant society
Frank et al. provide the first example of the use of amputations to treat infected
leg wounds in a non-human animal. The findings demonstrate that ants can adapt their
treatment modality depending on ...
www.cell.com
September 3, 2025 at 5:26 PM
Sometimes I get the feeling I'm working in the wrong subfield of biology
www.cell.com/current-biol...
www.cell.com/current-biol...
Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
August 12, 2025 at 11:34 PM
Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
"When they see us coming
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
July 28, 2025 at 6:11 PM
"When they see us coming
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
The birdies all try an' hide
But they still go for peanuts
When coated with cyanide."
Reposted by Adam MacLean
In this week's post Jesse Kreger (@adamlmaclean.bsky.social) discusses his latest work in #cancer #systems #immunology together with Edgar Gonzalez to study the mechanisms of response of breast cancer to #checkPointInhibitors
Discovering mechanisms of response via CSI (Cancer Systems Immunology)
mathematical-oncology.org
mathematical-oncology.org
July 25, 2025 at 3:20 PM
In this week's post Jesse Kreger (@adamlmaclean.bsky.social) discusses his latest work in #cancer #systems #immunology together with Edgar Gonzalez to study the mechanisms of response of breast cancer to #checkPointInhibitors
Couldn't leave Canada without breakfast poutine. Some scattered thoughts and Takeaways from #SMB2025...
I had a super fun week, so many conversations, short and long, with science friends old and new.
I had a super fun week, so many conversations, short and long, with science friends old and new.
July 19, 2025 at 6:28 PM
Couldn't leave Canada without breakfast poutine. Some scattered thoughts and Takeaways from #SMB2025...
I had a super fun week, so many conversations, short and long, with science friends old and new.
I had a super fun week, so many conversations, short and long, with science friends old and new.
This is such a cool paper and dataset from lab of @arjunraj.bsky.social. There are [ahem] a lot of spatial transcriptomics papers out there. Here's a [rare?] example of one from which we can truly learn some interesting things...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids
Gastruloids are three-dimensional stem-cell-based models that recapitulate key aspects of mammalian gastrulation, including formation of an anterior-posterior (AP) axis. However, we do not have detail...
www.biorxiv.org
July 18, 2025 at 8:50 PM
This is such a cool paper and dataset from lab of @arjunraj.bsky.social. There are [ahem] a lot of spatial transcriptomics papers out there. Here's a [rare?] example of one from which we can truly learn some interesting things...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mohit Jolly kicking off the last day of #SMB2025 presenting a compelling case for understanding EMT via gene exp "teams"
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
July 18, 2025 at 4:02 PM
Mohit Jolly kicking off the last day of #SMB2025 presenting a compelling case for understanding EMT via gene exp "teams"
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
Fantastic plenary this morning from @yosoykit.bsky.social highlighting the power of stochastic processes to inform clinical decision-making in gastrointestinal cancers. #SMB2025
July 16, 2025 at 4:54 PM
Fantastic plenary this morning from @yosoykit.bsky.social highlighting the power of stochastic processes to inform clinical decision-making in gastrointestinal cancers. #SMB2025
Kicking off day 2 is plenary from Fred Adler with some lovely badly-drawn diagrams, always great to see alternatives to the hegemony of the diagrammatically bland biorender et al.
#SMB2025
#SMB2025
July 15, 2025 at 4:47 PM
Kicking off day 2 is plenary from Fred Adler with some lovely badly-drawn diagrams, always great to see alternatives to the hegemony of the diagrammatically bland biorender et al.
#SMB2025
#SMB2025
"Patients should be their own control"
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
July 14, 2025 at 11:17 PM
"Patients should be their own control"
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
Reposted by Adam MacLean
Next up is former student & friend @stroblmar.bsky.social presenting new work with @cancerconnector.bsky.social on “Bridging the gap: What preclinical experiments can teach us about cancer drug scheduling” #MathOnco #SMB2025
July 14, 2025 at 5:18 PM
Next up is former student & friend @stroblmar.bsky.social presenting new work with @cancerconnector.bsky.social on “Bridging the gap: What preclinical experiments can teach us about cancer drug scheduling” #MathOnco #SMB2025
#SMB2025 check out this app to manage your minisymposia scheduling (always an intricate dance to get to all the interesting talks)
...also offers talk recommendations and "poster buddies"
...also offers talk recommendations and "poster buddies"
Try posting on the app:
beta.axy-app.com/smb2025
beta.axy-app.com/smb2025
Axy
Axy attendees website
beta.axy-app.com
July 14, 2025 at 2:20 PM
#SMB2025 check out this app to manage your minisymposia scheduling (always an intricate dance to get to all the interesting talks)
...also offers talk recommendations and "poster buddies"
...also offers talk recommendations and "poster buddies"
... 🎤 👈 hello? Is #SMB2025 a thing? Are people* here?
*society for mathematical biologists that is; nothing against single-molecule biophysicists per se.
*society for mathematical biologists that is; nothing against single-molecule biophysicists per se.
July 12, 2025 at 10:18 PM
... 🎤 👈 hello? Is #SMB2025 a thing? Are people* here?
*society for mathematical biologists that is; nothing against single-molecule biophysicists per se.
*society for mathematical biologists that is; nothing against single-molecule biophysicists per se.
Out now @dev-journal.bsky.social
Transition paths across the epithelial-mesenchymal transition landscape are dictated by network logic
Through investigation into the role of logic in GRN models, we discovered that choice of logic (AND vs OR) profoundly impacts cell fate.
doi.org/10.1242/dev....
Transition paths across the epithelial-mesenchymal transition landscape are dictated by network logic
Through investigation into the role of logic in GRN models, we discovered that choice of logic (AND vs OR) profoundly impacts cell fate.
doi.org/10.1242/dev....
June 24, 2025 at 9:48 AM
Out now @dev-journal.bsky.social
Transition paths across the epithelial-mesenchymal transition landscape are dictated by network logic
Through investigation into the role of logic in GRN models, we discovered that choice of logic (AND vs OR) profoundly impacts cell fate.
doi.org/10.1242/dev....
Transition paths across the epithelial-mesenchymal transition landscape are dictated by network logic
Through investigation into the role of logic in GRN models, we discovered that choice of logic (AND vs OR) profoundly impacts cell fate.
doi.org/10.1242/dev....
next time I reply to a conceptually tricky reviewer 2 question, for which I have a less-than-perfect answer, I am sorely tempted to steal this line.
"Having been weaned intellectually on these distinctions and others like them, I could scarcely be more aware of their import and force" - T.S. Kuhn
"Having been weaned intellectually on these distinctions and others like them, I could scarcely be more aware of their import and force" - T.S. Kuhn
May 17, 2025 at 6:19 PM
next time I reply to a conceptually tricky reviewer 2 question, for which I have a less-than-perfect answer, I am sorely tempted to steal this line.
"Having been weaned intellectually on these distinctions and others like them, I could scarcely be more aware of their import and force" - T.S. Kuhn
"Having been weaned intellectually on these distinctions and others like them, I could scarcely be more aware of their import and force" - T.S. Kuhn