Adam MacLean
@adamlmaclean.bsky.social
Assistant professor @USC. Modeling cell fate with dynamical systems & statistical inference. What makes a stem cell? macleanlab.usc.edu he/him
October 13, 2025 at 8:11 PM
Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
August 12, 2025 at 11:34 PM
Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
www.biorxiv.org/content/10.1...
Thanks for the great science and great company. Next year will be time to swap the poutine for pilsner and I'll hope to see you in Graz! #SMB2025
July 19, 2025 at 6:28 PM
Thanks for the great science and great company. Next year will be time to swap the poutine for pilsner and I'll hope to see you in Graz! #SMB2025
Couldn't leave Canada without breakfast poutine. Some scattered thoughts and Takeaways from #SMB2025...
I had a super fun week, so many conversations, short and long, with science friends old and new.
I had a super fun week, so many conversations, short and long, with science friends old and new.
July 19, 2025 at 6:28 PM
Couldn't leave Canada without breakfast poutine. Some scattered thoughts and Takeaways from #SMB2025...
I had a super fun week, so many conversations, short and long, with science friends old and new.
I had a super fun week, so many conversations, short and long, with science friends old and new.
Mohit Jolly kicking off the last day of #SMB2025 presenting a compelling case for understanding EMT via gene exp "teams"
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
July 18, 2025 at 4:02 PM
Mohit Jolly kicking off the last day of #SMB2025 presenting a compelling case for understanding EMT via gene exp "teams"
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
Ending with a heartfelt shoutout to the 'SMB team'
Q: Which is more important: the journey or the destination?
A: the company.
Fantastic plenary this morning from @yosoykit.bsky.social highlighting the power of stochastic processes to inform clinical decision-making in gastrointestinal cancers. #SMB2025
July 16, 2025 at 4:54 PM
Fantastic plenary this morning from @yosoykit.bsky.social highlighting the power of stochastic processes to inform clinical decision-making in gastrointestinal cancers. #SMB2025
Followed by a compelling description of the genome as a bureaucracy... even if we argue over the relative utility of the information processing capabilities of the cell, it's redundancies (compared to human-made systems) are impressively expansive. #SMB2025
July 15, 2025 at 4:54 PM
Followed by a compelling description of the genome as a bureaucracy... even if we argue over the relative utility of the information processing capabilities of the cell, it's redundancies (compared to human-made systems) are impressively expansive. #SMB2025
Kicking off day 2 is plenary from Fred Adler with some lovely badly-drawn diagrams, always great to see alternatives to the hegemony of the diagrammatically bland biorender et al.
#SMB2025
#SMB2025
July 15, 2025 at 4:47 PM
Kicking off day 2 is plenary from Fred Adler with some lovely badly-drawn diagrams, always great to see alternatives to the hegemony of the diagrammatically bland biorender et al.
#SMB2025
#SMB2025
"Patients should be their own control"
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
July 14, 2025 at 11:17 PM
"Patients should be their own control"
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
- great & pithy takeaway from @sandyanderson.bsky.social in his talk on the adoption of adaptive therapies in the clinic #SMB2025 #MathOnco
Celebrate every win. Ideally with beer.
Congratulations to Anupam. His first postdoc paper out of the lab was accepted today. Coming soon..…
Congratulations to Anupam. His first postdoc paper out of the lab was accepted today. Coming soon..…
May 13, 2025 at 8:15 PM
Celebrate every win. Ideally with beer.
Congratulations to Anupam. His first postdoc paper out of the lab was accepted today. Coming soon..…
Congratulations to Anupam. His first postdoc paper out of the lab was accepted today. Coming soon..…
Thanks to everyone who attended #SysBioSC2025. There's nothing quite like gathering people together in a room to dig deep into fascinating science and learn new things. Big 🙏 to the NSF-Simons Center at UCI who made it possible.
(emerging into the CA sun sure helps too)
#SingleCell #Genomics
(emerging into the CA sun sure helps too)
#SingleCell #Genomics
May 13, 2025 at 5:10 AM
Thanks to everyone who attended #SysBioSC2025. There's nothing quite like gathering people together in a room to dig deep into fascinating science and learn new things. Big 🙏 to the NSF-Simons Center at UCI who made it possible.
(emerging into the CA sun sure helps too)
#SingleCell #Genomics
(emerging into the CA sun sure helps too)
#SingleCell #Genomics
I'm excited to announce that we have been able to reduce the registration fee for last-minute applicants to $30 due to funding climate uncertainty. Deadline: 4/30
**Systems Biology of Single Cells** 2025, May 8-9, 2025 at UC Irvine, don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
**Systems Biology of Single Cells** 2025, May 8-9, 2025 at UC Irvine, don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
April 23, 2025 at 4:39 AM
I'm excited to announce that we have been able to reduce the registration fee for last-minute applicants to $30 due to funding climate uncertainty. Deadline: 4/30
**Systems Biology of Single Cells** 2025, May 8-9, 2025 at UC Irvine, don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
**Systems Biology of Single Cells** 2025, May 8-9, 2025 at UC Irvine, don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
TWO days left to register and submit your abstracts to **Systems Biology of Single Cells** 2025, taking place May 8-9, 2025 @UCIrvine
don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
March 26, 2025 at 11:27 PM
TWO days left to register and submit your abstracts to **Systems Biology of Single Cells** 2025, taking place May 8-9, 2025 @UCIrvine
don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
don't miss out 😎
cellfate.uci.edu/2025sysbiosc/
🌟 Systems Biology of Single Cells 🌟 at UC Irvine, May 8-9, 2025
Submit your abstracts for contributed talks or posters today!
- developing theories of cell state dynamics?
- integrating multiomic and spatial data at atlas scale?
- engineering cells for therapeutics?
...and much much more
Submit your abstracts for contributed talks or posters today!
- developing theories of cell state dynamics?
- integrating multiomic and spatial data at atlas scale?
- engineering cells for therapeutics?
...and much much more
February 27, 2025 at 7:10 PM
🌟 Systems Biology of Single Cells 🌟 at UC Irvine, May 8-9, 2025
Submit your abstracts for contributed talks or posters today!
- developing theories of cell state dynamics?
- integrating multiomic and spatial data at atlas scale?
- engineering cells for therapeutics?
...and much much more
Submit your abstracts for contributed talks or posters today!
- developing theories of cell state dynamics?
- integrating multiomic and spatial data at atlas scale?
- engineering cells for therapeutics?
...and much much more
Thanks to everyone for a fantastic meeting #SACB2025 @cancersysbio.bsky.social
(I sure needed an injection of great science in *these times*)
@mathcancer.bsky.social closing out the show...
(I sure needed an injection of great science in *these times*)
@mathcancer.bsky.social closing out the show...
February 12, 2025 at 7:11 PM
Thanks to everyone for a fantastic meeting #SACB2025 @cancersysbio.bsky.social
(I sure needed an injection of great science in *these times*)
@mathcancer.bsky.social closing out the show...
(I sure needed an injection of great science in *these times*)
@mathcancer.bsky.social closing out the show...
Why aren't we this honest in (most) modern scientific writing?
January 17, 2025 at 5:47 PM
Why aren't we this honest in (most) modern scientific writing?
COMING SOON... 👀
January 14, 2025 at 5:56 PM
COMING SOON... 👀
Transapocalyptic ride to school...
January 8, 2025 at 4:53 PM
Transapocalyptic ride to school...
Happy new year!
may you live this year as boldly as PNAS did its font color choices in 2014.
may you live this year as boldly as PNAS did its font color choices in 2014.
January 2, 2025 at 5:43 PM
Happy new year!
may you live this year as boldly as PNAS did its font color choices in 2014.
may you live this year as boldly as PNAS did its font color choices in 2014.
Reading a Scientific American article from 1976 and tbh the ads are as interesting as the science
December 16, 2024 at 10:52 PM
Reading a Scientific American article from 1976 and tbh the ads are as interesting as the science
We also show how our results can infer network logic in cells undergoing EMT. Via the characterization of convertible vs non-convertible HMLER clones, we derive inequalities that distinguish network logic in via simple perturbations of the network.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 13, 2024 at 9:57 PM
We also show how our results can infer network logic in cells undergoing EMT. Via the characterization of convertible vs non-convertible HMLER clones, we derive inequalities that distinguish network logic in via simple perturbations of the network.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
For OR logic, the converse is true. Choice of logic flips the importance of network regulations and thus completely changes inferences one draws!
We undertake analysis of a large parameter space of tristable EMT models to show that these results hold true generally, also for alt model formulations.
We undertake analysis of a large parameter space of tristable EMT models to show that these results hold true generally, also for alt model formulations.
December 13, 2024 at 9:57 PM
For OR logic, the converse is true. Choice of logic flips the importance of network regulations and thus completely changes inferences one draws!
We undertake analysis of a large parameter space of tristable EMT models to show that these results hold true generally, also for alt model formulations.
We undertake analysis of a large parameter space of tristable EMT models to show that these results hold true generally, also for alt model formulations.
We discovered that the choice of logic (AND vs OR) leads to divergent and opposing phenotypes
For AND logic
👉 increasing direct activation of B destabilizes the intermediate state
👉 whereas increasing the inhibition of miR-200 destabilizes the epithelial state, leading to earlier initiation of EMT
For AND logic
👉 increasing direct activation of B destabilizes the intermediate state
👉 whereas increasing the inhibition of miR-200 destabilizes the epithelial state, leading to earlier initiation of EMT
December 13, 2024 at 9:57 PM
We discovered that the choice of logic (AND vs OR) leads to divergent and opposing phenotypes
For AND logic
👉 increasing direct activation of B destabilizes the intermediate state
👉 whereas increasing the inhibition of miR-200 destabilizes the epithelial state, leading to earlier initiation of EMT
For AND logic
👉 increasing direct activation of B destabilizes the intermediate state
👉 whereas increasing the inhibition of miR-200 destabilizes the epithelial state, leading to earlier initiation of EMT
So we built AND & OR versions of the three-node EMT network to study the effects of perturbing various interactions: direct activation of B, vs indirect activation of B (aka inhibition of A).
December 13, 2024 at 9:57 PM
So we built AND & OR versions of the three-node EMT network to study the effects of perturbing various interactions: direct activation of B, vs indirect activation of B (aka inhibition of A).
Transition paths across the EMT landscape are dictated by network logic.
A 🧵 on the perils of ignoring logic in ODE models of gene regulatory networks (GRNs)
🌟 also read on if you like: EMT, bifurcations, multistability, or Waddington-esque landscapes
www.biorxiv.org/content/10.1...
A 🧵 on the perils of ignoring logic in ODE models of gene regulatory networks (GRNs)
🌟 also read on if you like: EMT, bifurcations, multistability, or Waddington-esque landscapes
www.biorxiv.org/content/10.1...
December 13, 2024 at 9:57 PM
Transition paths across the EMT landscape are dictated by network logic.
A 🧵 on the perils of ignoring logic in ODE models of gene regulatory networks (GRNs)
🌟 also read on if you like: EMT, bifurcations, multistability, or Waddington-esque landscapes
www.biorxiv.org/content/10.1...
A 🧵 on the perils of ignoring logic in ODE models of gene regulatory networks (GRNs)
🌟 also read on if you like: EMT, bifurcations, multistability, or Waddington-esque landscapes
www.biorxiv.org/content/10.1...