Paul Macklin
@mathcancer.bsky.social
Associate Dean for Undergraduate Education at Indiana University School of Informatics, Computing and Engineering • mathematical biologist • multicellular systems & cancer with PhysiCell • OpenSource • astrophotography
Web: http://MathCancer.org
Web: http://MathCancer.org
Reposted by Paul Macklin
Our Solar System is orbiting the center of our Galaxy at about 220 km/s so in 2025 we collectively traveled something like 7 billion kilometers across the Milky Way. Once in a while, when you have a moment, it’s worthwhile to take a look around, see where you are, and appreciate how far you’ve come.
January 1, 2026 at 5:27 AM
Our Solar System is orbiting the center of our Galaxy at about 220 km/s so in 2025 we collectively traveled something like 7 billion kilometers across the Milky Way. Once in a while, when you have a moment, it’s worthwhile to take a look around, see where you are, and appreciate how far you’ve come.
Looking good, Iowa!
December 31, 2025 at 6:47 PM
Looking good, Iowa!
New office decorating :-) #mathbio #mathonco 🧪
Thanks for a great 2025, @fertiglab.bsky.social @coussenslab.bsky.social @jeanettejohnson.bsky.social @heberlr.bsky.social @liz-aguilar.bsky.social @rosvall-lab.bsky.social @juncowren.bsky.social & amazing collabs!
Here's to new adventures in 2026!
Thanks for a great 2025, @fertiglab.bsky.social @coussenslab.bsky.social @jeanettejohnson.bsky.social @heberlr.bsky.social @liz-aguilar.bsky.social @rosvall-lab.bsky.social @juncowren.bsky.social & amazing collabs!
Here's to new adventures in 2026!
December 27, 2025 at 9:38 PM
New office decorating :-) #mathbio #mathonco 🧪
Thanks for a great 2025, @fertiglab.bsky.social @coussenslab.bsky.social @jeanettejohnson.bsky.social @heberlr.bsky.social @liz-aguilar.bsky.social @rosvall-lab.bsky.social @juncowren.bsky.social & amazing collabs!
Here's to new adventures in 2026!
Thanks for a great 2025, @fertiglab.bsky.social @coussenslab.bsky.social @jeanettejohnson.bsky.social @heberlr.bsky.social @liz-aguilar.bsky.social @rosvall-lab.bsky.social @juncowren.bsky.social & amazing collabs!
Here's to new adventures in 2026!
#OpenSource for the win! #mathbio #mathonco 🧪
Our amazing collaborators at @bsc-cns.bsky.social are showing 50x speedups in @physicell.bsky.social after their deep analysis and optimization work. Code reviews and releases coming soon! :-) 1/2
Our amazing collaborators at @bsc-cns.bsky.social are showing 50x speedups in @physicell.bsky.social after their deep analysis and optimization work. Code reviews and releases coming soon! :-) 1/2
December 3, 2025 at 3:20 PM
#OpenSource for the win! #mathbio #mathonco 🧪
Our amazing collaborators at @bsc-cns.bsky.social are showing 50x speedups in @physicell.bsky.social after their deep analysis and optimization work. Code reviews and releases coming soon! :-) 1/2
Our amazing collaborators at @bsc-cns.bsky.social are showing 50x speedups in @physicell.bsky.social after their deep analysis and optimization work. Code reviews and releases coming soon! :-) 1/2
Reposted by Paul Macklin
Is the point of mathematical research to know *what* is true or to know *why* it's true? Emily Riehl lays out a strong argument - and what it has to do with AI - along great advice for the field in @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mathematics is hard for mathematicians to understand too
At a recent conference on mathematics in the age of automated proofs, mathematician and Fields Medalist Akshay Venkatesh presented “How do we talk to our students about AI?'' He quoted an email he'd r...
www.science.org
December 1, 2025 at 8:44 PM
Is the point of mathematical research to know *what* is true or to know *why* it's true? Emily Riehl lays out a strong argument - and what it has to do with AI - along great advice for the field in @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I've started some light reading of a classic. 🧪 #mathbio #mathonco
I'm inspired by great collaborators with @coussenslab.bsky.social, @fertiglab.bsky.social, Laura Heiser, and others to delve deeper and improve my immunology fundamentals.
I'm inspired by great collaborators with @coussenslab.bsky.social, @fertiglab.bsky.social, Laura Heiser, and others to delve deeper and improve my immunology fundamentals.
November 30, 2025 at 9:17 PM
I've started some light reading of a classic. 🧪 #mathbio #mathonco
I'm inspired by great collaborators with @coussenslab.bsky.social, @fertiglab.bsky.social, Laura Heiser, and others to delve deeper and improve my immunology fundamentals.
I'm inspired by great collaborators with @coussenslab.bsky.social, @fertiglab.bsky.social, Laura Heiser, and others to delve deeper and improve my immunology fundamentals.
Reposted by Paul Macklin
The bias is really baked in here
November 30, 2025 at 3:55 PM
The bias is really baked in here
In an unusual turn of events, AI search seems to lack self confidence.
November 27, 2025 at 9:17 PM
In an unusual turn of events, AI search seems to lack self confidence.
Reposted by Paul Macklin
VdB 14 and VdB 15 captured from my dark site in southern France end of September 🇫🇷 😊🔭
This was shot on the EdgeHD 8 with Hyperstar for a total integration time of about 5.5 hours using an OSC cam with just the UV/IR-Cut filter.
#Astrophotography
@kat-astro-bot.bsky.social what do you see?
This was shot on the EdgeHD 8 with Hyperstar for a total integration time of about 5.5 hours using an OSC cam with just the UV/IR-Cut filter.
#Astrophotography
@kat-astro-bot.bsky.social what do you see?
November 27, 2025 at 6:15 PM
VdB 14 and VdB 15 captured from my dark site in southern France end of September 🇫🇷 😊🔭
This was shot on the EdgeHD 8 with Hyperstar for a total integration time of about 5.5 hours using an OSC cam with just the UV/IR-Cut filter.
#Astrophotography
@kat-astro-bot.bsky.social what do you see?
This was shot on the EdgeHD 8 with Hyperstar for a total integration time of about 5.5 hours using an OSC cam with just the UV/IR-Cut filter.
#Astrophotography
@kat-astro-bot.bsky.social what do you see?
*somebody* has had a good Thanksgiving!
November 27, 2025 at 9:08 PM
*somebody* has had a good Thanksgiving!
Pleiades (Messier 45), 2025 edition.
This gorgeous reflection nebula is high
This combines 36 hours of imaging on a 115mm triplet across 2024 and 2025, taken from my Indiana backyard. 🔭🧪
High-quality prints are available from mathcancer.darkroom.com/products/neb...
This gorgeous reflection nebula is high
This combines 36 hours of imaging on a 115mm triplet across 2024 and 2025, taken from my Indiana backyard. 🔭🧪
High-quality prints are available from mathcancer.darkroom.com/products/neb...
November 23, 2025 at 8:15 AM
Pleiades (Messier 45), 2025 edition.
This gorgeous reflection nebula is high
This combines 36 hours of imaging on a 115mm triplet across 2024 and 2025, taken from my Indiana backyard. 🔭🧪
High-quality prints are available from mathcancer.darkroom.com/products/neb...
This gorgeous reflection nebula is high
This combines 36 hours of imaging on a 115mm triplet across 2024 and 2025, taken from my Indiana backyard. 🔭🧪
High-quality prints are available from mathcancer.darkroom.com/products/neb...
Reposted by Paul Macklin
Very excited to share the NASA/ESA/STScI press release of our team's work on Apep! It's a terrific writeup, complete with a brand new beautiful visualisation of the nebula geometry.
1/? ⚛️🔭🧪
science.nasa.gov/missions/web...
1/? ⚛️🔭🧪
science.nasa.gov/missions/web...
Webb First to Show 4 Dust Shells 'Spiraling' Apep, Limits Long Orbit - NASA Science
NASA’s James Webb Space Telescope has delivered a first of its kind: a crisp mid-infrared image of a system of four serpentine spirals of dust, one expanding
science.nasa.gov
November 19, 2025 at 10:08 PM
Very excited to share the NASA/ESA/STScI press release of our team's work on Apep! It's a terrific writeup, complete with a brand new beautiful visualisation of the nebula geometry.
1/? ⚛️🔭🧪
science.nasa.gov/missions/web...
1/? ⚛️🔭🧪
science.nasa.gov/missions/web...
It was tremendous fun to record this podcast with Ted Giovanis and the @jktgfoundation.bsky.social on our cancer simulation research and collaboration with @coussenslab.bsky.social and @fertiglab.bsky.social and other amazing people. 🧪
youtu.be/5xcFqA3JGxs?...
youtu.be/5xcFqA3JGxs?...
Driving Research | Episode 3 featuring Dr. Paul Macklin
YouTube video by JKTG | Foundation
youtu.be
November 15, 2025 at 2:47 PM
It was tremendous fun to record this podcast with Ted Giovanis and the @jktgfoundation.bsky.social on our cancer simulation research and collaboration with @coussenslab.bsky.social and @fertiglab.bsky.social and other amazing people. 🧪
youtu.be/5xcFqA3JGxs?...
youtu.be/5xcFqA3JGxs?...
@jsauce7.bsky.social would there be any interest in our pitching in for your Jan workshop?
November 15, 2025 at 2:16 PM
@jsauce7.bsky.social would there be any interest in our pitching in for your Jan workshop?
Reposted by Paul Macklin
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
November 15, 2025 at 2:10 PM
Announcing the 4th Netflux and Network Biology Virtual Conference, Jan 7! Free registration and abstract submission (Dec 12). Live demo of the new user-friendly Netflux webapp, student talks, keynote by Suzanne Gaudet (Novartis): bit.ly/4i1eQD6
It's a little disappointing that nobody in the @science.org article (and most discussions) mentions that ex post facto laws are unconstitutional. 🧪
Article I, Section 9:
www.senate.gov/about/origin...
A retroactive law is an ex post facto law.
www.senate.gov/about/origin...
Article I, Section 9:
www.senate.gov/about/origin...
A retroactive law is an ex post facto law.
www.senate.gov/about/origin...
November 14, 2025 at 3:13 PM
It's a little disappointing that nobody in the @science.org article (and most discussions) mentions that ex post facto laws are unconstitutional. 🧪
Article I, Section 9:
www.senate.gov/about/origin...
A retroactive law is an ex post facto law.
www.senate.gov/about/origin...
Article I, Section 9:
www.senate.gov/about/origin...
A retroactive law is an ex post facto law.
www.senate.gov/about/origin...
It was cloudy in Bloomington last night, but we did manage to catch traces of last night's Kp7 aurora. Original photo straight off the camera (left), and minor photoshop work to bring out the pillar (right). 🔭
November 13, 2025 at 2:05 PM
It was cloudy in Bloomington last night, but we did manage to catch traces of last night's Kp7 aurora. Original photo straight off the camera (left), and minor photoshop work to bring out the pillar (right). 🔭
Reposted by Paul Macklin
Spatial fibroblast niches define #Crohn’s fistulae
@nature.com @ox.ac.uk
www.nature.com/articles/s41...
@nature.com @ox.ac.uk
www.nature.com/articles/s41...
November 12, 2025 at 6:03 PM
Spatial fibroblast niches define #Crohn’s fistulae
@nature.com @ox.ac.uk
www.nature.com/articles/s41...
@nature.com @ox.ac.uk
www.nature.com/articles/s41...
Reposted by Paul Macklin
This comic is becoming increasingly realistic.
m.xkcd.com/3056/
m.xkcd.com/3056/
September 29, 2025 at 10:50 AM
This comic is becoming increasingly realistic.
m.xkcd.com/3056/
m.xkcd.com/3056/
Reposted by Paul Macklin
November 12, 2025 at 4:00 AM
Reposted by Paul Macklin
Have you heard about this?
"As the govt shutdown drags on, buildings at NASA's Goddard Space Flight Center (HQ for the Webb telescope among other missions) are being emptied without notice. Highly specialized equipment is at risk of being thrown away like trash."
h/t @climatebrad.hillheat.com
"As the govt shutdown drags on, buildings at NASA's Goddard Space Flight Center (HQ for the Webb telescope among other missions) are being emptied without notice. Highly specialized equipment is at risk of being thrown away like trash."
h/t @climatebrad.hillheat.com
NASA may be quietly gutting an iconic campus with what it calls strategic closures, workers fear | CNN
Buildings at Goddard’s Maryland campus are being emptied and padlocked, sources say. NASA leadership has pushed back against the concerns.
www.cnn.com
November 9, 2025 at 9:45 PM
Have you heard about this?
"As the govt shutdown drags on, buildings at NASA's Goddard Space Flight Center (HQ for the Webb telescope among other missions) are being emptied without notice. Highly specialized equipment is at risk of being thrown away like trash."
h/t @climatebrad.hillheat.com
"As the govt shutdown drags on, buildings at NASA's Goddard Space Flight Center (HQ for the Webb telescope among other missions) are being emptied without notice. Highly specialized equipment is at risk of being thrown away like trash."
h/t @climatebrad.hillheat.com
It's snowing on our Smurf habitat. Smokes Smurf jerky production may be impacted.
November 9, 2025 at 9:28 PM
It's snowing on our Smurf habitat. Smokes Smurf jerky production may be impacted.
Reposted by Paul Macklin
Penn State fans:
November 8, 2025 at 8:30 PM
Penn State fans:
Reposted by Paul Macklin
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
November 8, 2025 at 1:58 PM
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
So my daughter is reading Moby Dick for AP US literature. And the whale first appears (actively in the scene -- not just in stories or anecdotes) on page 595: 95% of the way into this short and easy read.
November 5, 2025 at 2:17 AM
So my daughter is reading Moby Dick for AP US literature. And the whale first appears (actively in the scene -- not just in stories or anecdotes) on page 595: 95% of the way into this short and easy read.