Febri Gunawan Sugiokto
@febrigunawan48.bsky.social
PhD student at Dr. Renfeng Li lab
Working with EBV (mostly): epigenetic, transcriptomics, proteomics
DM: ❌❌❌
Working with EBV (mostly): epigenetic, transcriptomics, proteomics
DM: ❌❌❌
Pinned
🧬 New preprint! We find PIAS1 regulates EBNA1, the key EBV protein for episome maintenance. PIAS1 binds oriP & SUMOylates EBNA1, stabilizing episomes + restricting lytic replication. 🚨 PIAS1 may also regulate KSHV & HPV → a potential pan-viral therapeutic target?
Reposted by Febri Gunawan Sugiokto
🧪For anyone interested in EBV in autoimmunity, I strongly urge you to read this incredible study by @shady-myounis.bsky.social, Bill Robinson, and @tobiaslanz.bsky.social. It is not only a scientific tour de force, it has a deeply provocative discussion that everyone in the field should consider 1/
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 19, 2025 at 5:24 PM
🧪For anyone interested in EBV in autoimmunity, I strongly urge you to read this incredible study by @shady-myounis.bsky.social, Bill Robinson, and @tobiaslanz.bsky.social. It is not only a scientific tour de force, it has a deeply provocative discussion that everyone in the field should consider 1/
Reposted by Febri Gunawan Sugiokto
Whoah
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 13, 2025 at 11:05 PM
Whoah
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
EBV not only causes multiple sclerosis, it also might be the root of SLE
www.science.org/doi/10.1126/...
An EBV vaccine to rid ourselves of these horrible autoimmune conditions (and many cancers)?
#lupus #medsky #RheumSky
@christosargyrop.bsky.social
Reposted by Febri Gunawan Sugiokto
New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" rdcu.be/eM95H
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
October 28, 2025 at 7:10 PM
New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" rdcu.be/eM95H
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
Reposted by Febri Gunawan Sugiokto
Pitt faculty taking a stand against the higher education "compact"
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
University of Pittsburgh professors push back against Trump 'compact' for higher education
University of Pittsburgh professors have asked their school to reject a Trump "compact" that promises more access to federal resources to schools that sign on to his agenda
www.wesa.fm
October 31, 2025 at 4:10 PM
Pitt faculty taking a stand against the higher education "compact"
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
www.wesa.fm/identity-com...
I know of a few other news stories about similar faculty action.
Please share them here.
Reposted by Febri Gunawan Sugiokto
Welp. Thanks to the Republican gov shutdown I have a bunch of hours back in my week due to a NIH study section not meeting.
These poor applicants. They will be waiting week by week for government to reopen and to find out what will happen to their grant application.
These poor applicants. They will be waiting week by week for government to reopen and to find out what will happen to their grant application.
October 20, 2025 at 3:14 PM
Welp. Thanks to the Republican gov shutdown I have a bunch of hours back in my week due to a NIH study section not meeting.
These poor applicants. They will be waiting week by week for government to reopen and to find out what will happen to their grant application.
These poor applicants. They will be waiting week by week for government to reopen and to find out what will happen to their grant application.
Reposted by Febri Gunawan Sugiokto
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
October 6, 2025 at 9:42 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
Reposted by Febri Gunawan Sugiokto
2025 Nobel Prize in Physiology or Medicine #nobelprize
E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
October 6, 2025 at 9:32 AM
2025 Nobel Prize in Physiology or Medicine #nobelprize
E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
Reposted by Febri Gunawan Sugiokto
Strengthening nucleic acid biosecurity screening against generative protein design tools www.science.org/doi/10.1126/... 🧬🖥️🧪
October 3, 2025 at 2:37 PM
Strengthening nucleic acid biosecurity screening against generative protein design tools www.science.org/doi/10.1126/... 🧬🖥️🧪
Reposted by Febri Gunawan Sugiokto
Imagine a scientific journal called Infection and Immunity not focusing on viruses and the immune response?!
October 2, 2025 at 6:20 PM
Imagine a scientific journal called Infection and Immunity not focusing on viruses and the immune response?!
Reposted by Febri Gunawan Sugiokto
October 1, 2025 at 7:17 PM
Reposted by Febri Gunawan Sugiokto
Check out PMI talks tomorrow at the SOM Grad Student Symposium:
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
Tomorrow from 8am-6pm, The Assembly transforms into a celebration of graduate research, innovation, and sustainability at the 30th School of Medicine Graduate Student Research Symposium.
See you tomorrow—bring your energy, your ideas, and join a scientific experience that is setting new standards!
See you tomorrow—bring your energy, your ideas, and join a scientific experience that is setting new standards!
October 1, 2025 at 2:35 AM
Check out PMI talks tomorrow at the SOM Grad Student Symposium:
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !
ASM 🥳
A reminder to please support non-profit publishers.
It’s good for science and scientists.
It’s a responsible use of taxpayer dollars.
It requires resisting peer pressure to submit to Nature journals.
Thanks @bacteriality.bsky.social for this helpful slide for microbiology journals.
It’s good for science and scientists.
It’s a responsible use of taxpayer dollars.
It requires resisting peer pressure to submit to Nature journals.
Thanks @bacteriality.bsky.social for this helpful slide for microbiology journals.
September 28, 2025 at 12:11 AM
ASM 🥳
Reposted by Febri Gunawan Sugiokto
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Reposted by Febri Gunawan Sugiokto
Thanks to @asm.org and colleagues for stadning up for public health. Call Congress today and demand Kennedy's resignation
asm.org/press-releas...
asm.org/press-releas...
September 8, 2025 at 11:15 AM
Thanks to @asm.org and colleagues for stadning up for public health. Call Congress today and demand Kennedy's resignation
asm.org/press-releas...
asm.org/press-releas...
Reposted by Febri Gunawan Sugiokto
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Reposted by Febri Gunawan Sugiokto
As RFK testifies in front of the Senate today, ASV wants to emphasize the risks posed by his decisions related to virus outbreaks and the public health of Americans. Together with our partner organizations, we call for RFK's resignation: asm.org/press-releas...
Joint Statement Calling for Secretary Kennedy Resignation
The American Society for Microbiology released a joint statement calling for the resignation of HHS Secretary Robert F. Kennedy Jr.
asm.org
September 4, 2025 at 7:24 PM
As RFK testifies in front of the Senate today, ASV wants to emphasize the risks posed by his decisions related to virus outbreaks and the public health of Americans. Together with our partner organizations, we call for RFK's resignation: asm.org/press-releas...
🧬 New preprint! We find PIAS1 regulates EBNA1, the key EBV protein for episome maintenance. PIAS1 binds oriP & SUMOylates EBNA1, stabilizing episomes + restricting lytic replication. 🚨 PIAS1 may also regulate KSHV & HPV → a potential pan-viral therapeutic target?
September 2, 2025 at 10:35 PM
🧬 New preprint! We find PIAS1 regulates EBNA1, the key EBV protein for episome maintenance. PIAS1 binds oriP & SUMOylates EBNA1, stabilizing episomes + restricting lytic replication. 🚨 PIAS1 may also regulate KSHV & HPV → a potential pan-viral therapeutic target?
Reposted by Febri Gunawan Sugiokto
EBNA1 SUMOylation by PIAS1 Suppresses EBV Lytic Replication and Enhances Episome Maintenance https://www.biorxiv.org/content/10.1101/2025.09.01.673444v1
September 2, 2025 at 4:18 AM
EBNA1 SUMOylation by PIAS1 Suppresses EBV Lytic Replication and Enhances Episome Maintenance https://www.biorxiv.org/content/10.1101/2025.09.01.673444v1
Reposted by Febri Gunawan Sugiokto
Win for #openscience!
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science
https://go.nature.com/4kIRR01
https://go.nature.com/4kIRR01
Transparent peer review to be extended to all of Nature’s research papers
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
go.nature.com
June 16, 2025 at 6:40 PM
Win for #openscience!
Reposted by Febri Gunawan Sugiokto
Mars: simplifying bioinformatics workflows through a containerized approach to tool integration and management academic.oup.com/bioinformati... 🧬🖥️🧪 github.com/GenomicAI/mars
May 26, 2025 at 6:30 PM
Mars: simplifying bioinformatics workflows through a containerized approach to tool integration and management academic.oup.com/bioinformati... 🧬🖥️🧪 github.com/GenomicAI/mars
Reposted by Febri Gunawan Sugiokto
NIH PostBac program is open again! And I will be hiring! #JobPostComing
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
www.training.nih.gov
April 8, 2025 at 10:09 PM
NIH PostBac program is open again! And I will be hiring! #JobPostComing
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
Reposted by Febri Gunawan Sugiokto
Challenging times.
Harvard at risk of losing $9 billion in federal funds as US launches review
www.reuters.com/world/us/us-...
Harvard at risk of losing $9 billion in federal funds as US launches review
www.reuters.com/world/us/us-...
US reviewing federal contracts, grants to Harvard over antisemitism allegations
The administration of Republican President Donald Trump announced a review on Monday of federal contracts and grants at Harvard University over allegations of antisemitism.
www.reuters.com
April 1, 2025 at 12:19 AM
Challenging times.
Harvard at risk of losing $9 billion in federal funds as US launches review
www.reuters.com/world/us/us-...
Harvard at risk of losing $9 billion in federal funds as US launches review
www.reuters.com/world/us/us-...
Reposted by Febri Gunawan Sugiokto
New this evening (3/28): Major update in NIH grant termination numbers.
❌ 695 NIH grants now terminated (up from 429)
❌ 232 on HIV/AIDS
❌ 44 on cancer
❌ 28 on Alzheimer's
❌ 123 on Covid*
*And this doesn't count cancelled non-NIH Covid grants.
HUGE THANKS to @noamross.net for pushing the updates!
❌ 695 NIH grants now terminated (up from 429)
❌ 232 on HIV/AIDS
❌ 44 on cancer
❌ 28 on Alzheimer's
❌ 123 on Covid*
*And this doesn't count cancelled non-NIH Covid grants.
HUGE THANKS to @noamross.net for pushing the updates!
Airtable | Everyone's app platform
Airtable is a low-code platform for building collaborative apps. Customize your workflow, collaborate, and achieve ambitious outcomes. Get started for free.
airtable.com
March 28, 2025 at 10:07 PM
New this evening (3/28): Major update in NIH grant termination numbers.
❌ 695 NIH grants now terminated (up from 429)
❌ 232 on HIV/AIDS
❌ 44 on cancer
❌ 28 on Alzheimer's
❌ 123 on Covid*
*And this doesn't count cancelled non-NIH Covid grants.
HUGE THANKS to @noamross.net for pushing the updates!
❌ 695 NIH grants now terminated (up from 429)
❌ 232 on HIV/AIDS
❌ 44 on cancer
❌ 28 on Alzheimer's
❌ 123 on Covid*
*And this doesn't count cancelled non-NIH Covid grants.
HUGE THANKS to @noamross.net for pushing the updates!
Reposted by Febri Gunawan Sugiokto
“If large numbers of academics working in the U.S. do decide to leave, Gold doubts other countries will be able to absorb them all. The end result, he warns, could be an exodus of talent from global science. “My biggest fear,” he says, is that “we’re going to lose a cohort of researchers.”” 🧪
Overseas universities see opportunity in U.S. ‘brain drain’
But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own
www.science.org
March 21, 2025 at 11:28 AM
“If large numbers of academics working in the U.S. do decide to leave, Gold doubts other countries will be able to absorb them all. The end result, he warns, could be an exodus of talent from global science. “My biggest fear,” he says, is that “we’re going to lose a cohort of researchers.”” 🧪
Reposted by Febri Gunawan Sugiokto
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration
Are you thinking about leaving?
https://go.nature.com/4bMGd0J
Are you thinking about leaving?
https://go.nature.com/4bMGd0J
These frustrated scientists want to leave the United States – do you? Take Nature’s poll
Nature - In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.
go.nature.com
March 15, 2025 at 2:13 PM
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration
Are you thinking about leaving?
https://go.nature.com/4bMGd0J
Are you thinking about leaving?
https://go.nature.com/4bMGd0J