existwell
@existwell.bsky.social
Science of psychedelics & other altered states of consciousness
Center for Psychedelic and Consciousness Research
@jhpsychedelics.bsky.social
Johns Hopkins University School of Medicine
Oxford Uehiro Institute
Yaden Lab
www.YadenLab.com
Center for Psychedelic and Consciousness Research
@jhpsychedelics.bsky.social
Johns Hopkins University School of Medicine
Oxford Uehiro Institute
Yaden Lab
www.YadenLab.com
New paper led by CPCR postdoc Praachi Tiwari!
The psychedelic DOI alters locomotion depending on dose & species (thru 5-HT₂A receptors) aiding understanding anxiety-like behavior in animal models of psychedelics.
(w/ @viditavaidya.bsky.social and her great lab)
www.sciencedirect.com/science/arti...
The psychedelic DOI alters locomotion depending on dose & species (thru 5-HT₂A receptors) aiding understanding anxiety-like behavior in animal models of psychedelics.
(w/ @viditavaidya.bsky.social and her great lab)
www.sciencedirect.com/science/arti...
Acute DOI treatment evokes dose and species-dependent locomotor effects on the elevated plus maze
Recent evidence suggests that psychedelics hold promise in treating a range of neuropsychiatric disorders, highlighting the need to better understand …
www.sciencedirect.com
November 11, 2025 at 3:07 PM
New paper led by CPCR postdoc Praachi Tiwari!
The psychedelic DOI alters locomotion depending on dose & species (thru 5-HT₂A receptors) aiding understanding anxiety-like behavior in animal models of psychedelics.
(w/ @viditavaidya.bsky.social and her great lab)
www.sciencedirect.com/science/arti...
The psychedelic DOI alters locomotion depending on dose & species (thru 5-HT₂A receptors) aiding understanding anxiety-like behavior in animal models of psychedelics.
(w/ @viditavaidya.bsky.social and her great lab)
www.sciencedirect.com/science/arti...
New article published in
@jamahealthforum.com that examines and critiques 4 aspects of the current pathwork of regulations covering access to psychedelics––and then provides constructive, sensible, and actionable ways forward for each.
Work led by drug policy expert @caleighpropes.bsky.social
@jamahealthforum.com that examines and critiques 4 aspects of the current pathwork of regulations covering access to psychedelics––and then provides constructive, sensible, and actionable ways forward for each.
Work led by drug policy expert @caleighpropes.bsky.social
New today in JAMA Health Forum: Our team discusses how to fill policy gaps surrounding the use of psychedelics to treat mental health and substance use conditions, should they be approved by the US Food and Drug Administration.
Gaps in US Psychedelic Policy and How to Close Them | Health Policy - By @caleighpropes.bsky.social, @katherinecheung.bsky.social, Matthew Eisenberg, David Yaden | @jama.com Health Forum jamanetwork.com/journals/jam...
November 10, 2025 at 3:37 PM
New article published in
@jamahealthforum.com that examines and critiques 4 aspects of the current pathwork of regulations covering access to psychedelics––and then provides constructive, sensible, and actionable ways forward for each.
Work led by drug policy expert @caleighpropes.bsky.social
@jamahealthforum.com that examines and critiques 4 aspects of the current pathwork of regulations covering access to psychedelics––and then provides constructive, sensible, and actionable ways forward for each.
Work led by drug policy expert @caleighpropes.bsky.social
Reposted by existwell
New today in JAMA Health Forum: Our team discusses how to fill policy gaps surrounding the use of psychedelics to treat mental health and substance use conditions, should they be approved by the US Food and Drug Administration.
Gaps in US Psychedelic Policy and How to Close Them | Health Policy - By @caleighpropes.bsky.social, @katherinecheung.bsky.social, Matthew Eisenberg, David Yaden | @jama.com Health Forum jamanetwork.com/journals/jam...
Gaps in US Psychedelic Policy and How to Close Them
This Viewpoint discusses how to fill policy gaps surrounding the use of psychedelics to treat mental health and substance use conditions, should they be approved by the US Food and Drug Administration...
jamanetwork.com
November 7, 2025 at 9:36 PM
New today in JAMA Health Forum: Our team discusses how to fill policy gaps surrounding the use of psychedelics to treat mental health and substance use conditions, should they be approved by the US Food and Drug Administration.
Reposted by existwell
Citation impact and actual impact are not the same thing. What is the prototypical paper from the social-behavioral sciences that had both a huge citation impact and a huge actual (by your definition) impact?
Vote by naming a paper or liking someone else's nomination. One box filled per day.
Vote by naming a paper or liking someone else's nomination. One box filled per day.
November 5, 2025 at 2:33 PM
Citation impact and actual impact are not the same thing. What is the prototypical paper from the social-behavioral sciences that had both a huge citation impact and a huge actual (by your definition) impact?
Vote by naming a paper or liking someone else's nomination. One box filled per day.
Vote by naming a paper or liking someone else's nomination. One box filled per day.
Reposted by existwell
Join us at Johns Hopkins University in Baltimore, Maryland for an exceptional opportunity to work and train in psychedelic science and medicine.
Please share widely and apply if you qualify!
Please share widely and apply if you qualify!
Postdoctoral Fellowship Opportunity
We are looking for excellent MD Psychiatrist applicants to work & train at the CPCR at Johns Hopkins
@jhpsychedelics.bsky.social, the largest and most comprehensive psychedelic research program in the world.
Email Dr. Sandeep Nayak smn@jhmi.edu
We are looking for excellent MD Psychiatrist applicants to work & train at the CPCR at Johns Hopkins
@jhpsychedelics.bsky.social, the largest and most comprehensive psychedelic research program in the world.
Email Dr. Sandeep Nayak smn@jhmi.edu
November 4, 2025 at 4:54 PM
Join us at Johns Hopkins University in Baltimore, Maryland for an exceptional opportunity to work and train in psychedelic science and medicine.
Please share widely and apply if you qualify!
Please share widely and apply if you qualify!
Reposted by existwell
Next talk from the #NaturalPhilosophy Symposium is Simon DeDeo @simondedeo.bsky.social on Hard Proofs and Good Reasons, followed by commentary by Jeremy Goodman.
Next talk from the #NaturalPhilosophy Symposium is Jennifer Nagel on The Natural Structure of Common Knowledge, with commentary by Steven Gross.
www.youtube.com/watch?v=uEiQ...
www.youtube.com/watch?v=uEiQ...
November 4, 2025 at 4:31 PM
Next talk from the #NaturalPhilosophy Symposium is Simon DeDeo @simondedeo.bsky.social on Hard Proofs and Good Reasons, followed by commentary by Jeremy Goodman.
Reposted by existwell
For this week’s New Yorker (and in celebration of Halloween!), I wrote about how fictional monsters have gone from mean and horrendous to humanized and misunderstood.
In the past few decades, monsters have gone from menaces to misfits. Why do we feel the need to humanize them? https://newyorkermag.visitlink.me/ixYof5
October 31, 2025 at 8:48 PM
For this week’s New Yorker (and in celebration of Halloween!), I wrote about how fictional monsters have gone from mean and horrendous to humanized and misunderstood.
Postdoctoral Fellowship Opportunity
We are looking for excellent MD Psychiatrist applicants to work & train at the CPCR at Johns Hopkins
@jhpsychedelics.bsky.social, the largest and most comprehensive psychedelic research program in the world.
Email Dr. Sandeep Nayak smn@jhmi.edu
We are looking for excellent MD Psychiatrist applicants to work & train at the CPCR at Johns Hopkins
@jhpsychedelics.bsky.social, the largest and most comprehensive psychedelic research program in the world.
Email Dr. Sandeep Nayak smn@jhmi.edu
October 30, 2025 at 7:53 PM
Postdoctoral Fellowship Opportunity
We are looking for excellent MD Psychiatrist applicants to work & train at the CPCR at Johns Hopkins
@jhpsychedelics.bsky.social, the largest and most comprehensive psychedelic research program in the world.
Email Dr. Sandeep Nayak smn@jhmi.edu
We are looking for excellent MD Psychiatrist applicants to work & train at the CPCR at Johns Hopkins
@jhpsychedelics.bsky.social, the largest and most comprehensive psychedelic research program in the world.
Email Dr. Sandeep Nayak smn@jhmi.edu
Reposted by existwell
Psychedelics alter neurovascular coupling, which means we need to critically re-evaluate fMRI findings of acute psychedelic effects
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function - Nature Neuroscience
Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.
www.nature.com
October 27, 2025 at 7:07 PM
Psychedelics alter neurovascular coupling, which means we need to critically re-evaluate fMRI findings of acute psychedelic effects
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
On the second anniversary of Roland Griffiths' death, I'm taking the opportunity to reflect on the value of scientific curiosity and the virtue of constant curiosity about life in general that he seemed to me to so consistently embody.
October 21, 2025 at 9:09 PM
On the second anniversary of Roland Griffiths' death, I'm taking the opportunity to reflect on the value of scientific curiosity and the virtue of constant curiosity about life in general that he seemed to me to so consistently embody.
Reposted by existwell
It has been an absolute joy to learn from and engage with the brilliant @lilweb.bsky.social @rikepetzschner.bsky.social @danasmall.bsky.social. I am so proud of our collaboration on the future of #interoception and #RL. May you find as much inspiration in reading this paper as we did in writing it.
For the past couple of years I met weekly with 3 amazing younger scientists @lilweb.bsky.social @debyee.bsky.social @rikepetzschner.bsky.social to share ideas and teach each other. No agenda. It was often the favorite part of my week. Then we started writing. www.sciencedirect.com/science/arti...
The interoceptive origin of reinforcement learning
Rewards play a crucial role in sculpting all motivated behavior. Traditionally, research on reinforcement learning has centered on how rewards guide l…
www.sciencedirect.com
June 11, 2025 at 9:26 AM
It has been an absolute joy to learn from and engage with the brilliant @lilweb.bsky.social @rikepetzschner.bsky.social @danasmall.bsky.social. I am so proud of our collaboration on the future of #interoception and #RL. May you find as much inspiration in reading this paper as we did in writing it.
Reposted by existwell
Mindscape Ask Me Anything | October 2025. Hopefully this one answers once and for all why the universe isn't a black hole if it was so densely packed at early times. #MindscapePodcast
www.preposterousuniverse.com/podcast/2025...
www.preposterousuniverse.com/podcast/2025...
October 13, 2025 at 11:49 AM
Mindscape Ask Me Anything | October 2025. Hopefully this one answers once and for all why the universe isn't a black hole if it was so densely packed at early times. #MindscapePodcast
www.preposterousuniverse.com/podcast/2025...
www.preposterousuniverse.com/podcast/2025...
Reposted by existwell
🧠 New Psychedelic Article in Schizophrenia Bulletin!
We argue that visual hallucinations in psychedelics and Lewy body disease may share common mechanisms ⇒ visual degradation & cortical excitation.
academic.oup.com/schizophreni...
Excited to see this spark discussion!
#Neuroscience #Psychedelics
We argue that visual hallucinations in psychedelics and Lewy body disease may share common mechanisms ⇒ visual degradation & cortical excitation.
academic.oup.com/schizophreni...
Excited to see this spark discussion!
#Neuroscience #Psychedelics
Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases
AbstractBackground and Hypothesis. Visual hallucinations (VH) are a core symptom of both Lewy body diseases (LBDs; eg, Parkinson’s disease and dementia wit
academic.oup.com
October 6, 2025 at 5:32 PM
🧠 New Psychedelic Article in Schizophrenia Bulletin!
We argue that visual hallucinations in psychedelics and Lewy body disease may share common mechanisms ⇒ visual degradation & cortical excitation.
academic.oup.com/schizophreni...
Excited to see this spark discussion!
#Neuroscience #Psychedelics
We argue that visual hallucinations in psychedelics and Lewy body disease may share common mechanisms ⇒ visual degradation & cortical excitation.
academic.oup.com/schizophreni...
Excited to see this spark discussion!
#Neuroscience #Psychedelics
Reposted by existwell
Terrific framing of my work on "weirdness" by Ellie and David, before after and during their interview of me on Overthink. Probably the best engagement with that dimension of my work that I've seen so far.
podcasts.apple.com/us/podcast/w...
podcasts.apple.com/us/podcast/w...
Weirdness with Eric Schwitzgebel
Podcast Episode · Overthink · 07/15/2025 · 57m
podcasts.apple.com
August 4, 2025 at 4:18 PM
Terrific framing of my work on "weirdness" by Ellie and David, before after and during their interview of me on Overthink. Probably the best engagement with that dimension of my work that I've seen so far.
podcasts.apple.com/us/podcast/w...
podcasts.apple.com/us/podcast/w...
Reposted by existwell
New in Philosophical Psychology: Derek Anderson & I review Feltz & Cokely’s Diversity and Disagreement (OUP, 2024). We applaud their empirical rigor linking personality & philosophical views, but question their (to our minds) overly hasty and sweeping philosophical conclusions.🧵
September 29, 2025 at 4:38 PM
New in Philosophical Psychology: Derek Anderson & I review Feltz & Cokely’s Diversity and Disagreement (OUP, 2024). We applaud their empirical rigor linking personality & philosophical views, but question their (to our minds) overly hasty and sweeping philosophical conclusions.🧵
Reposted by existwell
We need heroes. People to respect and emulate. People who inspire us to do our best and be our best. Jane Goodall was a hero, and she will remain one.
October 2, 2025 at 1:18 PM
We need heroes. People to respect and emulate. People who inspire us to do our best and be our best. Jane Goodall was a hero, and she will remain one.
Reposted by existwell
I think we can show that people with delusions vs people with lots of esoteric beliefs both have aberrant prediction errors, but for very different neurobiological reasons: one bottom up (patients) and one top-down (psychics)
September 30, 2025 at 3:25 PM
I think we can show that people with delusions vs people with lots of esoteric beliefs both have aberrant prediction errors, but for very different neurobiological reasons: one bottom up (patients) and one top-down (psychics)
Reposted by existwell
I don’t understand why one would think we are getting evidence against the reliability of intuitions when we find correlations between intuitions and personality traits
Suppose we run a study and find that 60% or people give one response, 40% give the opposite response…
1/
Suppose we run a study and find that 60% or people give one response, 40% give the opposite response…
1/
New in Philosophical Psychology: Derek Anderson & I review Feltz & Cokely’s Diversity and Disagreement (OUP, 2024). We applaud their empirical rigor linking personality & philosophical views, but question their (to our minds) overly hasty and sweeping philosophical conclusions.🧵
September 29, 2025 at 7:46 PM
I don’t understand why one would think we are getting evidence against the reliability of intuitions when we find correlations between intuitions and personality traits
Suppose we run a study and find that 60% or people give one response, 40% give the opposite response…
1/
Suppose we run a study and find that 60% or people give one response, 40% give the opposite response…
1/
New in Philosophical Psychology: Derek Anderson & I review Feltz & Cokely’s Diversity and Disagreement (OUP, 2024). We applaud their empirical rigor linking personality & philosophical views, but question their (to our minds) overly hasty and sweeping philosophical conclusions.🧵
September 29, 2025 at 4:38 PM
New in Philosophical Psychology: Derek Anderson & I review Feltz & Cokely’s Diversity and Disagreement (OUP, 2024). We applaud their empirical rigor linking personality & philosophical views, but question their (to our minds) overly hasty and sweeping philosophical conclusions.🧵
Reposted by existwell
Mikayla Kelley has an important new paper on why human beings even have a concept of intentional action
The key question: What does this concept do in our lives?
Her answer: Since we can't possibly evaluate all actions, it helps us choose which ones to evaluate
philpapers.org/rec/KELTNF-3
The key question: What does this concept do in our lives?
Her answer: Since we can't possibly evaluate all actions, it helps us choose which ones to evaluate
philpapers.org/rec/KELTNF-3
Mikayla Kelley, The Normative Function of Intentional Action - PhilPapers
This essay identifies a normative function of the concept of intentional action. Specifically, I argue that the concept of intentional action functions to focus our evaluative concern on some doings r...
philpapers.org
September 27, 2025 at 2:50 PM
Mikayla Kelley has an important new paper on why human beings even have a concept of intentional action
The key question: What does this concept do in our lives?
Her answer: Since we can't possibly evaluate all actions, it helps us choose which ones to evaluate
philpapers.org/rec/KELTNF-3
The key question: What does this concept do in our lives?
Her answer: Since we can't possibly evaluate all actions, it helps us choose which ones to evaluate
philpapers.org/rec/KELTNF-3
Reposted by existwell
10/ Led by former @hopkinsmedicine.bsky.social Megan Hosein and Zach Cordner, cochairs @fredbarrettphd.bsky.social and Trisha Suppes, CPCR’s Dr. Matthew Reid, @existwell.bsky.social, and Sarah Walser, Stu Charney, UT Austin’s D. Greg Fonzo, and Utah’s Dr. Ben Lewis
September 25, 2025 at 9:43 PM
10/ Led by former @hopkinsmedicine.bsky.social Megan Hosein and Zach Cordner, cochairs @fredbarrettphd.bsky.social and Trisha Suppes, CPCR’s Dr. Matthew Reid, @existwell.bsky.social, and Sarah Walser, Stu Charney, UT Austin’s D. Greg Fonzo, and Utah’s Dr. Ben Lewis
Reposted by existwell
Jingle-jangle detection!
September 23, 2025 at 1:00 PM
Jingle-jangle detection!
Reposted by existwell
Next up, @dirkwulff.bsky.social talks about conceptual clutter and jingle & jangle in psych #DPPD25
September 23, 2025 at 12:56 PM
Next up, @dirkwulff.bsky.social talks about conceptual clutter and jingle & jangle in psych #DPPD25
Reposted by existwell
In the 1970s, it took 8,000 pounds of pancreas glands from 23,500 animals just to make a single pound of insulin.
100 years of insulin in 15 minutes
open.spotify.com
September 18, 2025 at 8:05 PM
In the 1970s, it took 8,000 pounds of pancreas glands from 23,500 animals just to make a single pound of insulin.