existwell
@existwell.bsky.social
Science of psychedelics & other altered states of consciousness
Center for Psychedelic and Consciousness Research
@jhpsychedelics.bsky.social
Johns Hopkins University School of Medicine
Oxford Uehiro Institute
Yaden Lab
www.YadenLab.com
Center for Psychedelic and Consciousness Research
@jhpsychedelics.bsky.social
Johns Hopkins University School of Medicine
Oxford Uehiro Institute
Yaden Lab
www.YadenLab.com
Psilocybin phase 3 trial results are out showing larger reductions in depression from a full dose (25mg) than lower doses (10mg and 1mg). It will be interesting to see data on functional unblinding, safety, & timepoints. Largest sample size so far in the field
psychedelicalpha.com/news/breakin...
psychedelicalpha.com/news/breakin...
BREAKING: Second Positive Phase 3 for Compass’ Psilocybin, Though Modest Magnitude Raises Questions - Psychedelic Alpha
Psychedelic Alpha’s Josh Hardman reports from Washington, D.C., where conversations with regulators, lawmakers, and insiders suggest a turbulent but potentially transformative period ahead.
psychedelicalpha.com
February 17, 2026 at 12:34 PM
Psilocybin phase 3 trial results are out showing larger reductions in depression from a full dose (25mg) than lower doses (10mg and 1mg). It will be interesting to see data on functional unblinding, safety, & timepoints. Largest sample size so far in the field
psychedelicalpha.com/news/breakin...
psychedelicalpha.com/news/breakin...
Happening TODAY. Leading psychedelic scholar
Nicolas Langlitz MD PhD will speak about issues in the history of science of psychedelics and beyond-
Nicolas Langlitz MD PhD will speak about issues in the history of science of psychedelics and beyond-
The Psychedelic Archives Project Guest Speaker Series continues this Wednesday with Dr. Nicolas Langlitz.
🗓 February 11th, 2026 | ⏰ 4:30 PM EST
🎟 Attendance is free — registration link below 👇
jhubluejays.zoom.us/j/92622903856
🗓 February 11th, 2026 | ⏰ 4:30 PM EST
🎟 Attendance is free — registration link below 👇
jhubluejays.zoom.us/j/92622903856
February 11, 2026 at 2:55 PM
Happening TODAY. Leading psychedelic scholar
Nicolas Langlitz MD PhD will speak about issues in the history of science of psychedelics and beyond-
Nicolas Langlitz MD PhD will speak about issues in the history of science of psychedelics and beyond-
Reposted by existwell
Please consider taking this if you qualify and spreading widely!
Have you had separate experiences with psychedelics and cannabis? Take our short survey to help expand research on their effects:
tinyurl.com/psyches-cann...
tinyurl.com/psyches-cann...
February 3, 2026 at 8:43 PM
Please consider taking this if you qualify and spreading widely!
Reposted by existwell
New blog post, inspired by the excellent recent qualitative paper by Makel and colleagues: On the reliability and reproducibility of qualitative research.
I reflect on how I will incorporate realist ontologies in my own qualitative research.
daniellakens.blogspot.com/2026/02/on-r...
I reflect on how I will incorporate realist ontologies in my own qualitative research.
daniellakens.blogspot.com/2026/02/on-r...
On the reliability and reproducibility of qualitative research
With my collaborators, I am increasingly performing qualitative research. I find qualitative research projects a useful way to improve my un...
daniellakens.blogspot.com
February 8, 2026 at 7:46 AM
New blog post, inspired by the excellent recent qualitative paper by Makel and colleagues: On the reliability and reproducibility of qualitative research.
I reflect on how I will incorporate realist ontologies in my own qualitative research.
daniellakens.blogspot.com/2026/02/on-r...
I reflect on how I will incorporate realist ontologies in my own qualitative research.
daniellakens.blogspot.com/2026/02/on-r...
Reposted by existwell
The Psychedelic Archives Project Guest Speaker Series continues this Wednesday with Dr. Nicolas Langlitz.
🗓 February 11th, 2026 | ⏰ 4:30 PM EST
🎟 Attendance is free — registration link below 👇
jhubluejays.zoom.us/j/92622903856
🗓 February 11th, 2026 | ⏰ 4:30 PM EST
🎟 Attendance is free — registration link below 👇
jhubluejays.zoom.us/j/92622903856
February 4, 2026 at 6:38 PM
The Psychedelic Archives Project Guest Speaker Series continues this Wednesday with Dr. Nicolas Langlitz.
🗓 February 11th, 2026 | ⏰ 4:30 PM EST
🎟 Attendance is free — registration link below 👇
jhubluejays.zoom.us/j/92622903856
🗓 February 11th, 2026 | ⏰ 4:30 PM EST
🎟 Attendance is free — registration link below 👇
jhubluejays.zoom.us/j/92622903856
Please consider taking this if you qualify and spreading widely!
Have you had separate experiences with psychedelics and cannabis? Take our short survey to help expand research on their effects:
tinyurl.com/psyches-cann...
tinyurl.com/psyches-cann...
February 3, 2026 at 8:43 PM
Please consider taking this if you qualify and spreading widely!
Reposted by existwell
Ongoing debate about psychological support versus psychotherapy in psychedelic trials often stems from vague definitions. Clarifying these constructs is essential for rigorous study of safety and efficacy.
January 30, 2026 at 5:32 PM
Ongoing debate about psychological support versus psychotherapy in psychedelic trials often stems from vague definitions. Clarifying these constructs is essential for rigorous study of safety and efficacy.
Reposted by existwell
Join us Wednesday for the Psychedelic Archives Project Guest Speaker Series!
🎤 Dr. Larissa Carneiro
🗓 January 28, 2026 | ⏰ 4:30 PM EST
🎟 Free to attend — sign up at the link below! 👇
jhubluejays.zoom.us/j/92622903856
🎤 Dr. Larissa Carneiro
🗓 January 28, 2026 | ⏰ 4:30 PM EST
🎟 Free to attend — sign up at the link below! 👇
jhubluejays.zoom.us/j/92622903856
January 26, 2026 at 7:02 PM
Join us Wednesday for the Psychedelic Archives Project Guest Speaker Series!
🎤 Dr. Larissa Carneiro
🗓 January 28, 2026 | ⏰ 4:30 PM EST
🎟 Free to attend — sign up at the link below! 👇
jhubluejays.zoom.us/j/92622903856
🎤 Dr. Larissa Carneiro
🗓 January 28, 2026 | ⏰ 4:30 PM EST
🎟 Free to attend — sign up at the link below! 👇
jhubluejays.zoom.us/j/92622903856
Reposted by existwell
Citation:
Schettino, J. R., Cheung, K., Nayak, S. M., Weiss, B. M., & Yaden, D. B. Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work. General hospital psychiatry, 99, 30-40.
OA Link:
www.researchgate.net/publication/...
Schettino, J. R., Cheung, K., Nayak, S. M., Weiss, B. M., & Yaden, D. B. Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work. General hospital psychiatry, 99, 30-40.
OA Link:
www.researchgate.net/publication/...
(PDF) Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work
PDF | On Dec 1, 2025, Jonathan R. Schettino and others published Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work | Find, read and cite all the r...
www.researchgate.net
January 16, 2026 at 8:44 PM
Citation:
Schettino, J. R., Cheung, K., Nayak, S. M., Weiss, B. M., & Yaden, D. B. Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work. General hospital psychiatry, 99, 30-40.
OA Link:
www.researchgate.net/publication/...
Schettino, J. R., Cheung, K., Nayak, S. M., Weiss, B. M., & Yaden, D. B. Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work. General hospital psychiatry, 99, 30-40.
OA Link:
www.researchgate.net/publication/...
Reposted by existwell
With clearer definitions, we can operationalize with empirical tests (which we are now working on).
We can operationalize psychological support vs psychotherapy, measure when each actually occurs, and, eventually, use factorial designs to test their distinct benefits and risks.
We can operationalize psychological support vs psychotherapy, measure when each actually occurs, and, eventually, use factorial designs to test their distinct benefits and risks.
January 16, 2026 at 8:44 PM
With clearer definitions, we can operationalize with empirical tests (which we are now working on).
We can operationalize psychological support vs psychotherapy, measure when each actually occurs, and, eventually, use factorial designs to test their distinct benefits and risks.
We can operationalize psychological support vs psychotherapy, measure when each actually occurs, and, eventually, use factorial designs to test their distinct benefits and risks.
Reposted by existwell
Curious about psychedelics beyond the hype? Our new Coursera course, Psychedelic Science and Medicine, offers clear, evidence-based insight into how they work and who may benefit. Ideal for clinicians, students, researchers, and curious learners. Enroll below 👇
January 12, 2026 at 8:50 PM
Curious about psychedelics beyond the hype? Our new Coursera course, Psychedelic Science and Medicine, offers clear, evidence-based insight into how they work and who may benefit. Ideal for clinicians, students, researchers, and curious learners. Enroll below 👇
Reposted by existwell
Have you had separate experiences with psychedelics and cannabis? Take our short survey to help expand research on their effects:
tinyurl.com/psyches-cann...
tinyurl.com/psyches-cann...
January 14, 2026 at 3:40 PM
Have you had separate experiences with psychedelics and cannabis? Take our short survey to help expand research on their effects:
tinyurl.com/psyches-cann...
tinyurl.com/psyches-cann...
Reposted by existwell
The debate over psychological support vs psychotherapy in psychedelic treatment is confused—and that confusion matters for science, safety, and regulation.
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
(PDF) Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work
PDF | On Dec 1, 2025, Jonathan R. Schettino and others published Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work | Find, read and cite all the r...
www.researchgate.net
January 16, 2026 at 8:40 PM
The debate over psychological support vs psychotherapy in psychedelic treatment is confused—and that confusion matters for science, safety, and regulation.
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
Reposted by existwell
The specific substance and indication under discussion matter here! For example, psychotherapy is extensive in MDMA for PTSD but typically absent in ketamine for depression...
Classic psychedelics will fall somewhere in-between:
Classic psychedelics will fall somewhere in-between:
January 16, 2026 at 8:40 PM
The specific substance and indication under discussion matter here! For example, psychotherapy is extensive in MDMA for PTSD but typically absent in ketamine for depression...
Classic psychedelics will fall somewhere in-between:
Classic psychedelics will fall somewhere in-between:
The debate over psychological support vs psychotherapy in psychedelic treatment is confused—and that confusion matters for science, safety, and regulation.
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
(PDF) Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work
PDF | On Dec 1, 2025, Jonathan R. Schettino and others published Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work | Find, read and cite all the r...
www.researchgate.net
January 16, 2026 at 8:40 PM
The debate over psychological support vs psychotherapy in psychedelic treatment is confused—and that confusion matters for science, safety, and regulation.
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
We were confused too. So we worked it through together and published what clarified it for us... 🧵
www.researchgate.net/publication/...
Reposted by existwell
Psychedelics don’t require ethical exemptions. We argue against “ethical exceptionalism” while supporting context-sensitive policies that uphold shared research and clinical standards. Distinctive effects ≠ new ethics.
OA Link: www.researchgate.net/publication/...
OA Link: www.researchgate.net/publication/...
(PDF) Are Psychedelics Ethically Exceptional After All? Some Further Reflections
PDF | In this response to commentators on our target article, we clarify and refine our position on claims of psychedelic ethical exceptionalism.... | Find, read and cite all the research you need on…
www.researchgate.net
December 30, 2025 at 8:43 AM
Psychedelics don’t require ethical exemptions. We argue against “ethical exceptionalism” while supporting context-sensitive policies that uphold shared research and clinical standards. Distinctive effects ≠ new ethics.
OA Link: www.researchgate.net/publication/...
OA Link: www.researchgate.net/publication/...
Reposted by existwell
Learn more about our course here: www.hopkinsmedicine.org/news/article...
Johns Hopkins Researchers Create Course on Psychedelics
www.hopkinsmedicine.org
November 20, 2025 at 9:41 PM
Learn more about our course here: www.hopkinsmedicine.org/news/article...
Reposted by existwell
Next up in the Psychedelic Archives Project guest speaker series is Dr. Catherine Freddo, presenting on Jan 7, 2025 at 4:30pm EST. Join for free at the link below! 👇
jhubluejays.zoom.us/j/92622903856
jhubluejays.zoom.us/j/92622903856
December 18, 2025 at 9:18 PM
Next up in the Psychedelic Archives Project guest speaker series is Dr. Catherine Freddo, presenting on Jan 7, 2025 at 4:30pm EST. Join for free at the link below! 👇
jhubluejays.zoom.us/j/92622903856
jhubluejays.zoom.us/j/92622903856
Reposted by existwell
New co-authored paper! 🚨 together with Katherine Cheung, Kyle Patch, and David Yaden: Distinctive But Not Exceptional: The Risks of Psychedelic Ethical Exceptionalism https://buff.ly/425UxOV
January 13, 2025 at 4:01 PM
New co-authored paper! 🚨 together with Katherine Cheung, Kyle Patch, and David Yaden: Distinctive But Not Exceptional: The Risks of Psychedelic Ethical Exceptionalism https://buff.ly/425UxOV
Reposted by existwell
Gaps in US Psychedelic Policy and How to Close Them | Health Policy - By @caleighpropes.bsky.social, @katherinecheung.bsky.social, Matthew Eisenberg, David Yaden | @jama.com Health Forum jamanetwork.com/journals/jam...
Gaps in US Psychedelic Policy and How to Close Them
This Viewpoint discusses how to fill policy gaps surrounding the use of psychedelics to treat mental health and substance use conditions, should they be approved by the US Food and Drug Administration...
jamanetwork.com
November 7, 2025 at 8:33 PM
Gaps in US Psychedelic Policy and How to Close Them | Health Policy - By @caleighpropes.bsky.social, @katherinecheung.bsky.social, Matthew Eisenberg, David Yaden | @jama.com Health Forum jamanetwork.com/journals/jam...
Reposted by existwell
It has a name now 😜
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
December 29, 2025 at 11:19 AM
It has a name now 😜
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
Reposted by existwell
Semiotic paradox alert!
December 29, 2025 at 3:47 PM
Semiotic paradox alert!
Reposted by existwell
New Paper 🚨
"Are Psychedelics Ethically Exceptional After All? Some Further Reflections" by @Katherine_Chg, @ExistWell (David B. Yaden), and Kyle Patch in @bioethics_net
"Are Psychedelics Ethically Exceptional After All? Some Further Reflections" by @Katherine_Chg, @ExistWell (David B. Yaden), and Kyle Patch in @bioethics_net
December 30, 2025 at 8:43 AM
New Paper 🚨
"Are Psychedelics Ethically Exceptional After All? Some Further Reflections" by @Katherine_Chg, @ExistWell (David B. Yaden), and Kyle Patch in @bioethics_net
"Are Psychedelics Ethically Exceptional After All? Some Further Reflections" by @Katherine_Chg, @ExistWell (David B. Yaden), and Kyle Patch in @bioethics_net
Reposted by existwell
Nice thread describing our new study on why kids play
oh what fun it is to have this paper out :)
December 15, 2025 at 2:11 PM
Nice thread describing our new study on why kids play
