Dillon Corvino
@eomesodermin.bsky.social
Immunology researcher interested in T-cell and NK cell anti-tumor responses.
Australian currently working in Germany.
Australian currently working in Germany.
Pinned
Dillon Corvino
@eomesodermin.bsky.social
· Nov 17
Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer
Multimodal single-cell RNA sequencing identified a population of CD8+ T cells elevated in tumor tissue enriched for interferon-stimulated genes (ISG). These ISG cells are clonally related to a popula...
onlinelibrary.wiley.com
I am excited to share our latest paper. We profiled CD8+ TILs from HPV- HNSCC patients using scRNA/TCRseq. In addition, we performed an ex vivo stimulation of cells to capture their transcriptional response. 1/n
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Dillon Corvino
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Dillon Corvino
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
October 26, 2025 at 2:01 AM
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Reposted by Dillon Corvino
A protein kinase D-Ikaros pathway linking invariant TCR to PLZF during iNKT cell development @jem.org @uosaka.bsky.social rupress.org/jem/article-...
September 18, 2025 at 6:07 PM
A protein kinase D-Ikaros pathway linking invariant TCR to PLZF during iNKT cell development @jem.org @uosaka.bsky.social rupress.org/jem/article-...
The lab is looking for two PhD students.
Apply to join the team and do some exciting Immunology research.
Apply to join the team and do some exciting Immunology research.
🚨 Open #position! The group of Zeinab Abdullah is looking for two PhD students for
a) Characterisation of hepatic NK-like T cells
b) Dissecting the role of STING signalling in anti-viral T cell responses
Application deadline: October 30
More information: www.immunosensation.de/opportunitie...
a) Characterisation of hepatic NK-like T cells
b) Dissecting the role of STING signalling in anti-viral T cell responses
Application deadline: October 30
More information: www.immunosensation.de/opportunitie...
September 17, 2025 at 8:24 AM
The lab is looking for two PhD students.
Apply to join the team and do some exciting Immunology research.
Apply to join the team and do some exciting Immunology research.
Open Post-doc position in the lab.
Apply to join the team and do some exciting Immunology research.
Apply to join the team and do some exciting Immunology research.
🚨 Open #position! The group of Zeinab Abdullah at the Institute of Molecular Medicine and Experimental Immunology is looking for a
Postdoc in Immunology (TVL13/100%)
Application deadline: October 30
Apply now!
More information on our website: www.immunosensation.de/opportunitie...
Postdoc in Immunology (TVL13/100%)
Application deadline: October 30
Apply now!
More information on our website: www.immunosensation.de/opportunitie...
September 17, 2025 at 8:23 AM
Open Post-doc position in the lab.
Apply to join the team and do some exciting Immunology research.
Apply to join the team and do some exciting Immunology research.
A number of open positions in the lab.
Apply to join the team and do some exciting Immunology research.
Apply to join the team and do some exciting Immunology research.
🚨 #Job alert! The group of Zeinab Abdullah at the Institute of Molecular Medicine and Experimental Immunology is looking for a
BTA or Biological laboratory technician (m/w/d)
Application deadline: October 30
Apply now!
More information on our website: www.immunosensation.de/opportunitie...
BTA or Biological laboratory technician (m/w/d)
Application deadline: October 30
Apply now!
More information on our website: www.immunosensation.de/opportunitie...
September 17, 2025 at 8:23 AM
A number of open positions in the lab.
Apply to join the team and do some exciting Immunology research.
Apply to join the team and do some exciting Immunology research.
Reposted by Dillon Corvino
The Junior PI call @ccii-kyoto.bsky.social is open until the end of the month.
Join us in Kyoto! 👇
#Immunology #Immunotherapy #Immunosky
Join us in Kyoto! 👇
#Immunology #Immunotherapy #Immunosky
Our streamlined Junior PI application process asks you to submit:
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/careers-e...
July 21, 2025 at 9:12 AM
The Junior PI call @ccii-kyoto.bsky.social is open until the end of the month.
Join us in Kyoto! 👇
#Immunology #Immunotherapy #Immunosky
Join us in Kyoto! 👇
#Immunology #Immunotherapy #Immunosky
Reposted by Dillon Corvino
Migrating immune cells globally coordinate protrusive forces @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 15, 2025 at 2:12 PM
Migrating immune cells globally coordinate protrusive forces @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dillon Corvino
🚨 New Paper in European Journal of Immunology!
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...
NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment
Cytotoxicity-associated genes exhibit heterogeneity at the cellular and tissue levels (left). NKG7 gene expression is strongly associated with a cytotoxic gene signature (middle). NKG7 expression is ...
onlinelibrary.wiley.com
June 24, 2025 at 1:59 PM
🚨 New Paper in European Journal of Immunology!
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Dillon Corvino
NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social
February 9, 2025 at 9:25 PM
NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social
Reposted by Dillon Corvino
🚨 Job alert 🚨
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇
January 14, 2025 at 7:28 PM
🚨 Job alert 🚨
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇
Reposted by Dillon Corvino
🚨Open positions! The group of Laura Surace from the University Hospital Bonn is looking for a
🧑🔬 PhD student in metabolic regulation of tissue-resident immune cells during metastasis
🧑🔬 and a Technical Assistant
Application Deadline is March 31!
#job #science #PhD #immunology #openposition
🧑🔬 PhD student in metabolic regulation of tissue-resident immune cells during metastasis
🧑🔬 and a Technical Assistant
Application Deadline is March 31!
#job #science #PhD #immunology #openposition
January 16, 2025 at 6:45 AM
🚨Open positions! The group of Laura Surace from the University Hospital Bonn is looking for a
🧑🔬 PhD student in metabolic regulation of tissue-resident immune cells during metastasis
🧑🔬 and a Technical Assistant
Application Deadline is March 31!
#job #science #PhD #immunology #openposition
🧑🔬 PhD student in metabolic regulation of tissue-resident immune cells during metastasis
🧑🔬 and a Technical Assistant
Application Deadline is March 31!
#job #science #PhD #immunology #openposition
Reposted by Dillon Corvino
icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...
doi.org/10.1101/2025...
January 15, 2025 at 3:11 AM
icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Dillon Corvino
Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11
wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org
January 14, 2025 at 9:55 AM
Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11
wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org/articles/9-3...
Reposted by Dillon Corvino
scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 31, 2024 at 8:11 PM
scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dillon Corvino
@cellcellpress.bsky.social resource:
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
www.cell.com/cell/fulltex...
@marcoyannic.bsky.social
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
www.cell.com/cell/fulltex...
@marcoyannic.bsky.social
December 31, 2024 at 8:26 PM
@cellcellpress.bsky.social resource:
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
www.cell.com/cell/fulltex...
@marcoyannic.bsky.social
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
www.cell.com/cell/fulltex...
@marcoyannic.bsky.social
Reposted by Dillon Corvino
Timescales in Cell Biology
December 1, 2024 at 1:35 PM
Timescales in Cell Biology
Reposted by Dillon Corvino
Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...
Tissue determinants of the human T cell receptor repertoire
98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors’ autologous blood and tonsils a...
www.biorxiv.org
November 15, 2024 at 2:13 PM
Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...
Reposted by Dillon Corvino
Cancer escapes immunotherapies by mutating its surface, meaning even groundbreaking #CARTCell therapies fail too often. But what if #GenerativeAI could design CAR-T with de novo binders faster, targeting resistant tumors? 🧵 www.biorxiv.org/content/10.1... (1)
November 26, 2024 at 1:36 PM
Cancer escapes immunotherapies by mutating its surface, meaning even groundbreaking #CARTCell therapies fail too often. But what if #GenerativeAI could design CAR-T with de novo binders faster, targeting resistant tumors? 🧵 www.biorxiv.org/content/10.1... (1)
Reposted by Dillon Corvino
How do T cells reach melanoma brain tumors?
Using in vivo microscopy 🔬🐭, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels.
We recently published this work in Immunity: authors.elsevier.com/sd/article/S...
Using in vivo microscopy 🔬🐭, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels.
We recently published this work in Immunity: authors.elsevier.com/sd/article/S...
November 20, 2024 at 3:00 PM
How do T cells reach melanoma brain tumors?
Using in vivo microscopy 🔬🐭, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels.
We recently published this work in Immunity: authors.elsevier.com/sd/article/S...
Using in vivo microscopy 🔬🐭, we discovered a new route for T cells to enter the brain via distinct peri-tumoral venous vessels.
We recently published this work in Immunity: authors.elsevier.com/sd/article/S...
Reposted by Dillon Corvino
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
November 21, 2024 at 2:56 PM
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
Reposted by Dillon Corvino
Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology
www.cell.com/trends/immun...
www.cell.com/trends/immun...
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases
Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous
human diseases. Interpreting these associations requires a molecular understanding
of the multiple killer-cell i...
www.cell.com
November 22, 2024 at 2:39 PM
Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Reposted by Dillon Corvino
Happy to transition to this platform to discuss science and share our fascination.
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)
November 12, 2024 at 7:27 AM
Happy to transition to this platform to discuss science and share our fascination.
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)
The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).
(Kroll et al, EMBO J 2023)
Reposted by Dillon Corvino
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1
biorxiv.org/content/10.1101/2024.11.06.622266v1
November 20, 2024 at 2:29 PM
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1
biorxiv.org/content/10.1101/2024.11.06.622266v1
Reposted by Dillon Corvino
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 21, 2024 at 7:47 PM
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...