@encoreunefoie.bsky.social
MD, PhD in Gastroenterology & Hepatology. Based in the Netherlands.
Reposted
Great review of reproductive health in the liver transplant recipient by Dr Sarkar et al
journals.lww.com/lt/abstract/...
#liversky
journals.lww.com/lt/abstract/...
#liversky
September 29, 2025 at 12:12 AM
Great review of reproductive health in the liver transplant recipient by Dr Sarkar et al
journals.lww.com/lt/abstract/...
#liversky
journals.lww.com/lt/abstract/...
#liversky
Reposted
MAP >65 mmHg VS higher targets to improve AKI post LT
💫 LIVER-PAM trial
📌 open-label, single-center, RCT
📌 174 adult pts randomized to MAP 85-90 mmHg or 65-70 mmHg first 24 hrs
📌 primary outcome: AKI incidence within 7 days
🔑 Did not reduce AKI incidence
#liversky
pubmed.ncbi.nlm.nih.gov/40774358/
💫 LIVER-PAM trial
📌 open-label, single-center, RCT
📌 174 adult pts randomized to MAP 85-90 mmHg or 65-70 mmHg first 24 hrs
📌 primary outcome: AKI incidence within 7 days
🔑 Did not reduce AKI incidence
#liversky
pubmed.ncbi.nlm.nih.gov/40774358/
Higher versus Standard Mean Arterial Pressure Target in the Immediate Postoperative Period of Liver Transplantation to Prevent Acute Kidney Injury: A Randomized Clinical Trial - (LIVER-PAM) - PubMed
Acute kidney injury (AKI) is a frequent complication after liver transplantation, with incidence up to 81%, and is associated with impaired long-term renal function, graft survival, and increased mort...
pubmed.ncbi.nlm.nih.gov
August 25, 2025 at 11:22 PM
MAP >65 mmHg VS higher targets to improve AKI post LT
💫 LIVER-PAM trial
📌 open-label, single-center, RCT
📌 174 adult pts randomized to MAP 85-90 mmHg or 65-70 mmHg first 24 hrs
📌 primary outcome: AKI incidence within 7 days
🔑 Did not reduce AKI incidence
#liversky
pubmed.ncbi.nlm.nih.gov/40774358/
💫 LIVER-PAM trial
📌 open-label, single-center, RCT
📌 174 adult pts randomized to MAP 85-90 mmHg or 65-70 mmHg first 24 hrs
📌 primary outcome: AKI incidence within 7 days
🔑 Did not reduce AKI incidence
#liversky
pubmed.ncbi.nlm.nih.gov/40774358/
Reposted
New Review - Recompensation in decompensated cirrhosis
www.thelancet.com/journals/lan...
#LiverSky #MedSky
www.thelancet.com/journals/lan...
#LiverSky #MedSky
Recompensation in decompensated cirrhosis
Recompensation of decompensated cirrhosis has been defined by the Baveno consensus
as control or cure of the main underlying cause; resolution of clinical manifestations,
including ascites and hepatic...
www.thelancet.com
August 6, 2025 at 7:37 AM
New Review - Recompensation in decompensated cirrhosis
www.thelancet.com/journals/lan...
#LiverSky #MedSky
www.thelancet.com/journals/lan...
#LiverSky #MedSky
Reposted
New research - Pre-emptive TIPS for gastric variceal bleeding in patients with cirrhosis (GAVAPROSEC): an open-label randomised clinical trial
www.thelancet.com/journals/lan...
#LiverSky #MedSky
www.thelancet.com/journals/lan...
#LiverSky #MedSky
June 13, 2025 at 5:31 AM
New research - Pre-emptive TIPS for gastric variceal bleeding in patients with cirrhosis (GAVAPROSEC): an open-label randomised clinical trial
www.thelancet.com/journals/lan...
#LiverSky #MedSky
www.thelancet.com/journals/lan...
#LiverSky #MedSky
Reposted
Impact of #HBV #treatment in reducing liver #cancer, #transplant and HBsAg loss over >10 year follow up.
George Papatheodoridis presenting with risk stratification.
#EASLCongress @easlnews.bsky.social
George Papatheodoridis presenting with risk stratification.
#EASLCongress @easlnews.bsky.social
May 10, 2025 at 7:51 AM
Impact of #HBV #treatment in reducing liver #cancer, #transplant and HBsAg loss over >10 year follow up.
George Papatheodoridis presenting with risk stratification.
#EASLCongress @easlnews.bsky.social
George Papatheodoridis presenting with risk stratification.
#EASLCongress @easlnews.bsky.social
Reposted
BSG 2025 Guidelines: Colorectal Surveillance in IBD
gut.bmj.com/content/earl...
@bmj.com #GISky #IBDSky
gut.bmj.com/content/earl...
@bmj.com #GISky #IBDSky
May 1, 2025 at 8:02 AM
BSG 2025 Guidelines: Colorectal Surveillance in IBD
gut.bmj.com/content/earl...
@bmj.com #GISky #IBDSky
gut.bmj.com/content/earl...
@bmj.com #GISky #IBDSky
Reposted
Fantastic to see the updated BSG/BASL decompensated cirrhosis admission bundle in print at FG
- practical guidance to improve care in the first 24 hours as well as implementation strategy - congrats Stuart McPherson for driving this! #livertwitter
fg.bmj.com/content/earl...
- practical guidance to improve care in the first 24 hours as well as implementation strategy - congrats Stuart McPherson for driving this! #livertwitter
fg.bmj.com/content/earl...
Decompensated cirrhosis: an update of the BSG/BASL admission care bundle
Acute decompensated cirrhosis (DC) and acute-on-chronic liver failure are common reasons for hospital admission that have a high in-hospital mortality rate (10%–20%). Patients require a detailed asses...
fg.bmj.com
April 16, 2025 at 6:54 PM
Fantastic to see the updated BSG/BASL decompensated cirrhosis admission bundle in print at FG
- practical guidance to improve care in the first 24 hours as well as implementation strategy - congrats Stuart McPherson for driving this! #livertwitter
fg.bmj.com/content/earl...
- practical guidance to improve care in the first 24 hours as well as implementation strategy - congrats Stuart McPherson for driving this! #livertwitter
fg.bmj.com/content/earl...
Reposted
Four people with liver failure will be connected to an external organ from genetically modified pigs
https://go.nature.com/3Yv2nig
https://go.nature.com/3Yv2nig
Pig livers for people: US regulator greenlights first safety trial
Four people with liver failure will be connected to an external organ from genetically modified pigs.
go.nature.com
April 15, 2025 at 1:16 PM
Four people with liver failure will be connected to an external organ from genetically modified pigs
https://go.nature.com/3Yv2nig
https://go.nature.com/3Yv2nig
Reposted
🚨New paper from us in Journal of Hepatology - Using PEth values on >50,000 persons to predict outcomes. www.sciencedirect.com/science/arti...
Phosphatidylethanol levels distinguish steatotic liver disease subgroups and are associated with risk of major liver outcomes
Phosphatidylethanol (PEth) is an ethanol metabolite used as a specific biomarker for recent alcohol consumption. We aimed to determine the proportion …
www.sciencedirect.com
April 13, 2025 at 8:58 AM
🚨New paper from us in Journal of Hepatology - Using PEth values on >50,000 persons to predict outcomes. www.sciencedirect.com/science/arti...
Reposted
ADMIT-ASC index for ASUC.
Score of ≥3 was 84% predictive of steroid failure
- CRP ≥100mg/L (1 point)
- albumin ≤25g/L (1 point)
- UCEIS ≥4 (1 point) or ≥7 (2 points)
Will these pts benefit from early 'salvage' therapy instead of waiting till Day 3?
#IBDSky #GISky
gut.bmj.com/content/72/3...
Score of ≥3 was 84% predictive of steroid failure
- CRP ≥100mg/L (1 point)
- albumin ≤25g/L (1 point)
- UCEIS ≥4 (1 point) or ≥7 (2 points)
Will these pts benefit from early 'salvage' therapy instead of waiting till Day 3?
#IBDSky #GISky
gut.bmj.com/content/72/3...
April 14, 2025 at 6:02 AM
ADMIT-ASC index for ASUC.
Score of ≥3 was 84% predictive of steroid failure
- CRP ≥100mg/L (1 point)
- albumin ≤25g/L (1 point)
- UCEIS ≥4 (1 point) or ≥7 (2 points)
Will these pts benefit from early 'salvage' therapy instead of waiting till Day 3?
#IBDSky #GISky
gut.bmj.com/content/72/3...
Score of ≥3 was 84% predictive of steroid failure
- CRP ≥100mg/L (1 point)
- albumin ≤25g/L (1 point)
- UCEIS ≥4 (1 point) or ≥7 (2 points)
Will these pts benefit from early 'salvage' therapy instead of waiting till Day 3?
#IBDSky #GISky
gut.bmj.com/content/72/3...
Reposted
I’m looking for all your liver related questions! Doing a mailbag episode dedicated to our finest organ.
Reply below, DM or send email to hopquestions@gmail.com.
No question too big or small.
Reply below, DM or send email to hopquestions@gmail.com.
No question too big or small.
April 10, 2025 at 2:15 PM
I’m looking for all your liver related questions! Doing a mailbag episode dedicated to our finest organ.
Reply below, DM or send email to hopquestions@gmail.com.
No question too big or small.
Reply below, DM or send email to hopquestions@gmail.com.
No question too big or small.
Reposted
A 16-year-old girl presented with a 2-month history of leg swelling. Laboratory results were notable for a low albumin level. Abdominal CT revealed diffuse thickening of the gastric wall with enlarged gastric folds. Full case details: nej.md/441oqAJ
#MedSky #PedSky #GastroSky
#MedSky #PedSky #GastroSky
April 7, 2025 at 1:02 PM
A 16-year-old girl presented with a 2-month history of leg swelling. Laboratory results were notable for a low albumin level. Abdominal CT revealed diffuse thickening of the gastric wall with enlarged gastric folds. Full case details: nej.md/441oqAJ
#MedSky #PedSky #GastroSky
#MedSky #PedSky #GastroSky
Reposted
A practical review of new AGA guidance on PVT management by @drjessicadavis.bsky.social
#liversky
📍don’t delay AC
📍can hold AC for EGD for 48 hours
📍AC does NOT increase risk of bleeding from varices while you wait for EGD
#liversky
📍don’t delay AC
📍can hold AC for EGD for 48 hours
📍AC does NOT increase risk of bleeding from varices while you wait for EGD
April 5, 2025 at 2:00 PM
A practical review of new AGA guidance on PVT management by @drjessicadavis.bsky.social
#liversky
📍don’t delay AC
📍can hold AC for EGD for 48 hours
📍AC does NOT increase risk of bleeding from varices while you wait for EGD
#liversky
📍don’t delay AC
📍can hold AC for EGD for 48 hours
📍AC does NOT increase risk of bleeding from varices while you wait for EGD
Reposted
Reposted
Naltrexone in 🍷🍸🍺-associated liver disease
✅ Overall, safe for treatment of alcohol use disorder in this population
Black box warning for chronic liver disease was REMOVED in 2013: 🚫 evidence of harm
🔑 Alcohol causes harm to the liver, naltrexone does NOT
Slides: #ALD-ALLY Lamia Haque #liversky
✅ Overall, safe for treatment of alcohol use disorder in this population
Black box warning for chronic liver disease was REMOVED in 2013: 🚫 evidence of harm
🔑 Alcohol causes harm to the liver, naltrexone does NOT
Slides: #ALD-ALLY Lamia Haque #liversky
April 4, 2025 at 11:54 AM
Reposted
Here is an update on the cirrhosis epidemiology in Denmark: doi.org/10.1016/j.jh...
* Median age at cirrhosis diagnosis up from 56y in 1998 to 66y in 2022
* Proportion with ALD cirrhosis down from 80% to 58%
* Prevalence of cirrhosis peaked in 2024
* Survival has improved
#Liversky
* Median age at cirrhosis diagnosis up from 56y in 1998 to 66y in 2022
* Proportion with ALD cirrhosis down from 80% to 58%
* Prevalence of cirrhosis peaked in 2024
* Survival has improved
#Liversky
Redirecting
doi.org
April 3, 2025 at 11:21 AM
Here is an update on the cirrhosis epidemiology in Denmark: doi.org/10.1016/j.jh...
* Median age at cirrhosis diagnosis up from 56y in 1998 to 66y in 2022
* Proportion with ALD cirrhosis down from 80% to 58%
* Prevalence of cirrhosis peaked in 2024
* Survival has improved
#Liversky
* Median age at cirrhosis diagnosis up from 56y in 1998 to 66y in 2022
* Proportion with ALD cirrhosis down from 80% to 58%
* Prevalence of cirrhosis peaked in 2024
* Survival has improved
#Liversky
Reposted
🆕CPG❕
EASL Clinical Practice Guidelines on TIPS
✅Addresses all aspects of #TIPS in patients with #cirrhosis
Full text here: bit.ly/4hZuMUK
#LiverSky
@easlnews.bsky.social
EASL Clinical Practice Guidelines on TIPS
✅Addresses all aspects of #TIPS in patients with #cirrhosis
Full text here: bit.ly/4hZuMUK
#LiverSky
@easlnews.bsky.social
April 3, 2025 at 7:56 AM
🆕CPG❕
EASL Clinical Practice Guidelines on TIPS
✅Addresses all aspects of #TIPS in patients with #cirrhosis
Full text here: bit.ly/4hZuMUK
#LiverSky
@easlnews.bsky.social
EASL Clinical Practice Guidelines on TIPS
✅Addresses all aspects of #TIPS in patients with #cirrhosis
Full text here: bit.ly/4hZuMUK
#LiverSky
@easlnews.bsky.social
Can we still trust American science, now that politics reach far into Academia? How do we deal with this?
April 2, 2025 at 5:33 AM
Can we still trust American science, now that politics reach far into Academia? How do we deal with this?
Reposted
Real-world 12 month outcomes of anti-TNF vs UST vs VDZ in ulcerative colitis.
UST group has 90% who are bio-experienced compared to VDZ and anti-TNF group (30+%), leading to:
1. High 'persistence' cos lack of options
2. 'Lower' efficacy of UST
#IBDSky #GISky
academic.oup.com/ecco-jcc/adv...
UST group has 90% who are bio-experienced compared to VDZ and anti-TNF group (30+%), leading to:
1. High 'persistence' cos lack of options
2. 'Lower' efficacy of UST
#IBDSky #GISky
academic.oup.com/ecco-jcc/adv...
March 30, 2025 at 12:57 AM
Real-world 12 month outcomes of anti-TNF vs UST vs VDZ in ulcerative colitis.
UST group has 90% who are bio-experienced compared to VDZ and anti-TNF group (30+%), leading to:
1. High 'persistence' cos lack of options
2. 'Lower' efficacy of UST
#IBDSky #GISky
academic.oup.com/ecco-jcc/adv...
UST group has 90% who are bio-experienced compared to VDZ and anti-TNF group (30+%), leading to:
1. High 'persistence' cos lack of options
2. 'Lower' efficacy of UST
#IBDSky #GISky
academic.oup.com/ecco-jcc/adv...
Reposted
Colorectal cancer screening:
- FIT is non-inferior to colonoscopy for CRC-related deaths at 10 years
n= 57404
Participation rates higher for FIT (39.9%) vs scope (31.8%)
CRC-deaths similar: FIT (0.24%) vs scope (0.22%)
#GISky #SurgSky
@thelancet.bsky.social
www.thelancet.com/journals/lan...
- FIT is non-inferior to colonoscopy for CRC-related deaths at 10 years
n= 57404
Participation rates higher for FIT (39.9%) vs scope (31.8%)
CRC-deaths similar: FIT (0.24%) vs scope (0.22%)
#GISky #SurgSky
@thelancet.bsky.social
www.thelancet.com/journals/lan...
March 29, 2025 at 7:28 AM
Colorectal cancer screening:
- FIT is non-inferior to colonoscopy for CRC-related deaths at 10 years
n= 57404
Participation rates higher for FIT (39.9%) vs scope (31.8%)
CRC-deaths similar: FIT (0.24%) vs scope (0.22%)
#GISky #SurgSky
@thelancet.bsky.social
www.thelancet.com/journals/lan...
- FIT is non-inferior to colonoscopy for CRC-related deaths at 10 years
n= 57404
Participation rates higher for FIT (39.9%) vs scope (31.8%)
CRC-deaths similar: FIT (0.24%) vs scope (0.22%)
#GISky #SurgSky
@thelancet.bsky.social
www.thelancet.com/journals/lan...
Reposted
🧠 AI-assisted colonoscopy detects more polyps — but does that further prevent #colorectalcancer? Our guideline published in @aga-gastro.bsky.social explores the potential and challenges of CADe systems — and why more data is needed.
Read more: gastro.org/news/new-gui...
🌟 #AI
Read more: gastro.org/news/new-gui...
🌟 #AI
March 25, 2025 at 6:00 PM
🧠 AI-assisted colonoscopy detects more polyps — but does that further prevent #colorectalcancer? Our guideline published in @aga-gastro.bsky.social explores the potential and challenges of CADe systems — and why more data is needed.
Read more: gastro.org/news/new-gui...
🌟 #AI
Read more: gastro.org/news/new-gui...
🌟 #AI
Reposted
With a heavy heart, I've decided to suspend all academic travel to the USA for me and my lab. Given the escalation of tensions and uncertainties, it seems to be the wisest move. To our US colleagues, please be certain that we will continue to do what we can to support you. Science is global.
March 16, 2025 at 11:07 PM
With a heavy heart, I've decided to suspend all academic travel to the USA for me and my lab. Given the escalation of tensions and uncertainties, it seems to be the wisest move. To our US colleagues, please be certain that we will continue to do what we can to support you. Science is global.
Reposted
After five decades, steroid dosing in AAH is revisited: Tapered prednisolone proves superior in reducing infections.
#STASH trial @jasmohanbajaj.bsky.social @juanpabloarab.bsky.social @ebtapper.bsky.social @tonybreu.bsky.social
@blaneymd.medsky.social
journals.lww.com/ajg/abstract... #liversky
#STASH trial @jasmohanbajaj.bsky.social @juanpabloarab.bsky.social @ebtapper.bsky.social @tonybreu.bsky.social
@blaneymd.medsky.social
journals.lww.com/ajg/abstract... #liversky
Infections in Standard or Tapered Dose of Prednisolone for... : Official journal of the American College of Gastroenterology | ACG
mary objective was to assess the incidence of infection by day 90. The key secondary objectives were the incidence of mortality, acute kidney injury (AKI), readmissions rate and adverse events.
Metho...
journals.lww.com
March 13, 2025 at 5:12 PM
After five decades, steroid dosing in AAH is revisited: Tapered prednisolone proves superior in reducing infections.
#STASH trial @jasmohanbajaj.bsky.social @juanpabloarab.bsky.social @ebtapper.bsky.social @tonybreu.bsky.social
@blaneymd.medsky.social
journals.lww.com/ajg/abstract... #liversky
#STASH trial @jasmohanbajaj.bsky.social @juanpabloarab.bsky.social @ebtapper.bsky.social @tonybreu.bsky.social
@blaneymd.medsky.social
journals.lww.com/ajg/abstract... #liversky