Emil Laust Kristoffersen, PhD
@emillk.bsky.social
Assistant professor at the Interdisciplinary Nanoscience Center, Aarhus University in Denmark and genetically related to the origin of life.
I study functional nucleic acids focusing on their role in starting evolution.
I study functional nucleic acids focusing on their role in starting evolution.
🌍
Today is is early deadline for registering for the first Danish Origins of Life Symposium in Copenhagen, which we are organizing.
projects.au.dk/doli/danish-...
Sign up now if you want to be in the run for presenting at the meeting. Registration will remain open for poster presentations.
🪐
Today is is early deadline for registering for the first Danish Origins of Life Symposium in Copenhagen, which we are organizing.
projects.au.dk/doli/danish-...
Sign up now if you want to be in the run for presenting at the meeting. Registration will remain open for poster presentations.
🪐
June 20, 2025 at 6:37 AM
🌍
Today is is early deadline for registering for the first Danish Origins of Life Symposium in Copenhagen, which we are organizing.
projects.au.dk/doli/danish-...
Sign up now if you want to be in the run for presenting at the meeting. Registration will remain open for poster presentations.
🪐
Today is is early deadline for registering for the first Danish Origins of Life Symposium in Copenhagen, which we are organizing.
projects.au.dk/doli/danish-...
Sign up now if you want to be in the run for presenting at the meeting. Registration will remain open for poster presentations.
🪐
Literature 📝:
New paper:
(doi.org/10.1093/nar/...)
Previous paper:
(doi.org/10.7554/eLif...)
Additional reading:
(doi.org/10.1073/pnas...)
(4/4)
New paper:
(doi.org/10.1093/nar/...)
Previous paper:
(doi.org/10.7554/eLif...)
Additional reading:
(doi.org/10.1073/pnas...)
(4/4)
June 18, 2025 at 9:42 AM
Literature 📝:
New paper:
(doi.org/10.1093/nar/...)
Previous paper:
(doi.org/10.7554/eLif...)
Additional reading:
(doi.org/10.1073/pnas...)
(4/4)
New paper:
(doi.org/10.1093/nar/...)
Previous paper:
(doi.org/10.7554/eLif...)
Additional reading:
(doi.org/10.1073/pnas...)
(4/4)
The main structure, a dimer, inhibits RCS but can be reactivated making way for potential double RCS.
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
June 18, 2025 at 9:42 AM
The main structure, a dimer, inhibits RCS but can be reactivated making way for potential double RCS.
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
In the paper, we investigate RNA polymerase ribozymes and their ability to perform rolling circle synthesis (RCS).
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
June 18, 2025 at 9:41 AM
In the paper, we investigate RNA polymerase ribozymes and their ability to perform rolling circle synthesis (RCS).
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
📜:🧬🔬
I am excited to announce that our paper is now out in the journal NAR!
doi.org/10.1093/nar/...
A big thank you to all the co-authors — Ewan, Phil, and Ebbe! And, most notably, congratulations to Niels on your first publication! Thanks also to the EMBION facility at AU 🔬!
(1/4)
I am excited to announce that our paper is now out in the journal NAR!
doi.org/10.1093/nar/...
A big thank you to all the co-authors — Ewan, Phil, and Ebbe! And, most notably, congratulations to Niels on your first publication! Thanks also to the EMBION facility at AU 🔬!
(1/4)
Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis
Abstract. The RNA world hypothesis is supported by the discovery of RNA polymerase ribozymes that can perform RNA-catalyzed RNA replication processes on di
doi.org
June 18, 2025 at 9:40 AM
📜:🧬🔬
I am excited to announce that our paper is now out in the journal NAR!
doi.org/10.1093/nar/...
A big thank you to all the co-authors — Ewan, Phil, and Ebbe! And, most notably, congratulations to Niels on your first publication! Thanks also to the EMBION facility at AU 🔬!
(1/4)
I am excited to announce that our paper is now out in the journal NAR!
doi.org/10.1093/nar/...
A big thank you to all the co-authors — Ewan, Phil, and Ebbe! And, most notably, congratulations to Niels on your first publication! Thanks also to the EMBION facility at AU 🔬!
(1/4)
Just received this super cool comic book on the origins of life in the RNA world! Great work! ❤️
June 3, 2025 at 7:55 AM
Just received this super cool comic book on the origins of life in the RNA world! Great work! ❤️
🪐 🧬 🦠
Very excited to announce our Origins of Life Seminar in the summer of 2025 at the Royal Danish Academy of Sciences and Letters!!!
The meeting will focus on bridging the distances in which life works - from light years to nanometers. 📐
Checkout our great speaker-list and stay tuned for more!
Very excited to announce our Origins of Life Seminar in the summer of 2025 at the Royal Danish Academy of Sciences and Letters!!!
The meeting will focus on bridging the distances in which life works - from light years to nanometers. 📐
Checkout our great speaker-list and stay tuned for more!
April 29, 2025 at 11:04 AM
🪐 🧬 🦠
Very excited to announce our Origins of Life Seminar in the summer of 2025 at the Royal Danish Academy of Sciences and Letters!!!
The meeting will focus on bridging the distances in which life works - from light years to nanometers. 📐
Checkout our great speaker-list and stay tuned for more!
Very excited to announce our Origins of Life Seminar in the summer of 2025 at the Royal Danish Academy of Sciences and Letters!!!
The meeting will focus on bridging the distances in which life works - from light years to nanometers. 📐
Checkout our great speaker-list and stay tuned for more!
The new promotion video for studying natural sciences at Aarhus University.
DNA and RNA are credited 🤘🧬
DNA and RNA are credited 🤘🧬
Læs naturvidenskab på AU – sammen skaber vi ny viden
YouTube video by Aarhus Universitet
www.youtube.com
February 5, 2025 at 7:55 AM
The new promotion video for studying natural sciences at Aarhus University.
DNA and RNA are credited 🤘🧬
DNA and RNA are credited 🤘🧬
Reposted by Emil Laust Kristoffersen, PhD
The Cryo-EM: the next 50 years Symposium held yesterday at @ucberkeleyofficial.bsky.social was a smashing success!!
January 12, 2025 at 4:51 PM
The Cryo-EM: the next 50 years Symposium held yesterday at @ucberkeleyofficial.bsky.social was a smashing success!!
Very interesting program at the Cryo-EM: next 50 years symposium at Berkely. Solving more RNA structures is on the todo!
January 12, 2025 at 2:55 PM
Very interesting program at the Cryo-EM: next 50 years symposium at Berkely. Solving more RNA structures is on the todo!
Reposted by Emil Laust Kristoffersen, PhD
The one time @theguardian.com could rightly use a left-handed DNA image... and they choose right-handed 🤦🏻♂️🤦🏻♂️🤦🏻♂️
@iansample.bsky.social
@iansample.bsky.social
December 13, 2024 at 8:18 AM
The one time @theguardian.com could rightly use a left-handed DNA image... and they choose right-handed 🤦🏻♂️🤦🏻♂️🤦🏻♂️
@iansample.bsky.social
@iansample.bsky.social
Reading this paper on non-catalysed polymerization of nucleic acids.
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 9, 2024 at 5:18 PM
Reading this paper on non-catalysed polymerization of nucleic acids.
Looking at the 2D structure of the heterodimeric triplet polymerase ribozyme (TPR), always reminds me of the bronze-age petroglyphs of the plow driven by oxes 😅
Cool example that evolution likes cooperativity.
See the full paper: www.pnas.org/doi/10.1073/...
Cool example that evolution likes cooperativity.
See the full paper: www.pnas.org/doi/10.1073/...
December 7, 2024 at 1:38 PM
Looking at the 2D structure of the heterodimeric triplet polymerase ribozyme (TPR), always reminds me of the bronze-age petroglyphs of the plow driven by oxes 😅
Cool example that evolution likes cooperativity.
See the full paper: www.pnas.org/doi/10.1073/...
Cool example that evolution likes cooperativity.
See the full paper: www.pnas.org/doi/10.1073/...