Emil Laust Kristoffersen, PhD
@emillk.bsky.social
Assistant professor at the Interdisciplinary Nanoscience Center, Aarhus University in Denmark and genetically related to the origin of life.
I study functional nucleic acids focusing on their role in starting evolution.
I study functional nucleic acids focusing on their role in starting evolution.
The main structure, a dimer, inhibits RCS but can be reactivated making way for potential double RCS.
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
June 18, 2025 at 9:42 AM
The main structure, a dimer, inhibits RCS but can be reactivated making way for potential double RCS.
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
Overall, the paper emphasizes the importance of template structure for self-replication and offers new insights into how the initial replication machinery might have looked and functioned.
(3/4)
In the paper, we investigate RNA polymerase ribozymes and their ability to perform rolling circle synthesis (RCS).
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
June 18, 2025 at 9:41 AM
In the paper, we investigate RNA polymerase ribozymes and their ability to perform rolling circle synthesis (RCS).
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)