Elodie Lafont
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elodie-lafont.bsky.social
Elodie Lafont
@elodie-lafont.bsky.social
1.1K followers 2K following 21 posts
PhD in Oncology. Researcher (CRCN INSERM), Cancer research, Cell Biology, Cell Signalling, PTMs #WomeninSTEM
@csignaling.bsky.social
https://oss-clcc.univ-rennes.fr/
https://scholar.google.com/citations?user=2ZoLzg4AAAAJ&hl=fr
ORCID 0000-0003-1978-749
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elodie-lafont.bsky.social
Elodie Lafont @elodie-lafont.bsky.social · Nov 18
If you're curious about what our group is interested in, our latest publications 😀

doi.org/10.1038/s443...
IRE1 RNase controls CD95-mediated cell death | EMBO reports
imageimageDual regulation of Cell Death Receptor CD95 signalling by ER stress sensor IRE1. IRE1, a mediator of the unfolded protein response (UPR), governs CD95/Fas expression and CD95L-induced cell d...
doi.org
Reposted by Elodie Lafont
ericchevet.bsky.social
Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...
bims-proteo 2025-11-16 papers
biomed.news
November 21, 2025 at 7:46 PM
Reposted by Elodie Lafont
ericchevet.bsky.social
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Secretome translation shaped by lysosomes and lunapark-marked ER junctions www.nature.com/articles/s41...
bims-proteo 2025-11-09 papers
biomed.news
November 9, 2025 at 6:37 AM
Reposted by Elodie Lafont
ericchevet.bsky.social
Cette année @csignaling.bsky.social et #Centre_Eugène_Marquis étaient présents
à #La_Josselinaise_des_femmes -- 👏👏👏👏👏👏 Bravo à toutes les participantes et @celinephilippe.bsky.social #MattLeGallo #MyriamBontonou et MERCI du soutien!!!!
@insermgrandouest.bsky.social @rennesuniv.bsky.social
October 19, 2025 at 1:34 PM
Reposted by Elodie Lafont
ericchevet.bsky.social
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...
bims-proteo 2025-10-19 papers
biomed.news
October 19, 2025 at 5:28 AM
Reposted by Elodie Lafont
ericchevet.bsky.social
@csignaling.bsky.social était présent aux #5h_de_L_Yaigne_2025 aux côtés de #La_fée_Viviane (@fee -- MERCI AU SOUTIEN INCONDITIONNEL À LA RECHERCHE CONTRE LE CANCER DEPUIS 2011 !!!!!!!!
@inserm.fr @insermgrandouest.bsky.social #Centre_Eugene_Marquis @rennesuniv.bsky.social
October 12, 2025 at 4:31 PM
Reposted by Elodie Lafont
ericchevet.bsky.social
Cette année encore @csignaling.bsky.social était présent à #La_Vannetaise_Officielle -- 👏👏👏👏👏👏 Bravo à tous les participants et à @elodie-lafont.bsky.social #Matthieu_LeGallo #Manon_Nivet

@insermgrandouest.bsky.social @inserm.fr @rennesuniv.bsky.social #centre_eugene_marquis
October 12, 2025 at 11:18 AM
elodie-lafont.bsky.social
Such another great marathon of cell death science, this year in Berlin @ecdoorg.bsky.social
Thanks to all organizers !
October 11, 2025 at 7:22 AM
Reposted by Elodie Lafont
ericchevet.bsky.social
This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...
bims-proteo 2025-10-05 papers
biomed.news
October 5, 2025 at 6:28 AM
Reposted by Elodie Lafont
ericchevet.bsky.social
This week's very rich selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Predicting protein-protein interactions in the human proteome www.science.org/doi/10.1126/...
bims-proteo 2025-09-28 papers
biomed.news
September 28, 2025 at 5:56 AM
Reposted by Elodie Lafont
hessofarhan.bsky.social
The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs.
rdcu.be/eHw46
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control
Nature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...
rdcu.be
September 22, 2025 at 8:49 AM
elodie-lafont.bsky.social
Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social.
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR
September 22, 2025 at 2:36 PM
Reposted by Elodie Lafont
labwaggoner.bsky.social
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor
www.nature.com/articles/s41... @natimmunol.nature.com @aarhusuniint.bsky.social
September 19, 2025 at 6:59 PM
Reposted by Elodie Lafont
labwaggoner.bsky.social
@biorxivpreprint.bsky.social Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing @stanforduniversity.bsky.social @lecong.bsky.social @sciencebyravi.bsky.social
www.biorxiv.org/content/10.1...
September 20, 2025 at 5:37 PM
Reposted by Elodie Lafont
ericchevet.bsky.social
This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
bims-proteo 2025-09-21 papers
biomed.news
September 21, 2025 at 6:52 AM
Reposted by Elodie Lafont
ericchevet.bsky.social
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation www.sciencedirect.com/science/arti...
bims-proteo 2025-09-14 papers
biomed.news
September 14, 2025 at 7:09 AM
Reposted by Elodie Lafont
aemonten.bsky.social
"We propose a model in which TF binding is not determined by individual binding sites, but rather by the sum of multiple, overlapping binding sites."

www.nature.com/articles/s41...
Multiple overlapping binding sites determine transcription factor occupancy - Nature
A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create ov...
www.nature.com
September 3, 2025 at 8:57 PM
Reposted by Elodie Lafont
labwaggoner.bsky.social
Toxic amyloid-β induces oxidation & fragmentation of mitoDNA in microglia, facilitating B-to-Z conformational transition that activates ZBP1-RIPK1 driven neuroinflammation in #Alzheimer's @cp-immunity.bsky.social
www.cell.com/immunity/ful...
September 2, 2025 at 4:34 PM
Reposted by Elodie Lafont
ocoleman.bsky.social
Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism
The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...
www.nature.com
September 2, 2025 at 7:01 PM
Reposted by Elodie Lafont
labwaggoner.bsky.social
Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier @cp-immunity.bsky.social @gpasp.bsky.social
www.cell.com/immunity/ful...
August 27, 2025 at 3:07 AM
Reposted by Elodie Lafont
rohankhadilkar.bsky.social
Delighted to share our latest collaborative work with Santosh Chauhan's group at CCMB, Hyderabad, out now in @embojournal.org
We use the Drosophila hematopoietic progenitors in this study to investigate pro-self-renewal mechanisms!
Congrats to all the authors!
www.embopress.org/doi/full/10....
Programmed cell revival from imminent cell death enhances tissue repair and regeneration | The EMBO Journal
imageimageThe ability of cells to recover after the initiation of cell death pathways is only little understood. This study challenges the dogma of irreversible cell death by characterizing a programm...
www.embopress.org
August 22, 2025 at 4:59 PM
Reposted by Elodie Lafont
natchembio.nature.com
A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation.

www.nature.com/articles/s41...
Highly specific intracellular ubiquitination of a small molecule - Nature Chemical Biology
Li et al. discovered that the cytotoxic synthetic small molecule BRD1732 is directly ubiquitinated in cells. Ubiquitination of BRD1732 is E3 ligase dependent and leads to inhibition of proteasomal deg...
www.nature.com
August 21, 2025 at 4:25 PM
Reposted by Elodie Lafont
ericchevet.bsky.social
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy www.nature.com/articles/s41...
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature
Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with a...
www.nature.com
August 23, 2025 at 12:45 PM
Reposted by Elodie Lafont
ericchevet.bsky.social
#ER_literature ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis: Developmental Cell www.cell.com/developmenta...
ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis
Salomo-Coll et al. show that pre-cancerous acinar-ductal metaplasia emerging upon Kras mutation in pancreas is driven by downregulation of CCPG1-mediated acinar ER-phagy, resulting in defective cleara...
www.cell.com
August 23, 2025 at 12:39 PM
Reposted by Elodie Lafont
natcellbio.nature.com
💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk
A multichaperone condensate enhances protein folding in the endoplasmic reticulum - Nature Cell Biology
Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.
bit.ly
August 22, 2025 at 5:36 PM
Reposted by Elodie Lafont
gianmaria-liccardi.bsky.social
I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature
Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
www.nature.com
August 21, 2025 at 6:12 AM