Enrico Bagnoli
@ebagnoli.bsky.social
@ASAP Funded Postdoctoral reasercher in Neuroscience full time
@MRCPPU, adventure addict partime.
Project manager for Team Alessi. Scientist, climber, kite-surfer, pasta-eater.
@MRCPPU, adventure addict partime.
Project manager for Team Alessi. Scientist, climber, kite-surfer, pasta-eater.
Reposted by Enrico Bagnoli
Enzyme Inhibition Restores Neuron Pathways in a Parkinson’s Mouse Model www.genengnews.com/topics/drug-... @asapresearch.parkinsonsroadmap.org #MJFF
Enzyme Inhibition Restores Neuron Pathways in a Parkinson's Mouse Model
Inhibition of LKKR2 may rescue neurons that are dying due to a type of Parkinson’s disease that is caused by a single genetic mutation.
www.genengnews.com
July 2, 2025 at 7:41 AM
Enzyme Inhibition Restores Neuron Pathways in a Parkinson’s Mouse Model www.genengnews.com/topics/drug-... @asapresearch.parkinsonsroadmap.org #MJFF
While the political landscape leaves you without words (for the wrong reasons) the natural ones are a joy for the heart #USA #protecttheparks #protectscience
March 23, 2025 at 9:50 AM
While the political landscape leaves you without words (for the wrong reasons) the natural ones are a joy for the heart #USA #protecttheparks #protectscience
Reposted by Enrico Bagnoli
An advancement in lysosomal research with diagnostic applications!
Esther M. Sammler @ebagnoli.bsky.social & team present a tagless method for profiling lysosomal content from clinical samples: https://buff.ly/4kiVuu3
Esther M. Sammler @ebagnoli.bsky.social & team present a tagless method for profiling lysosomal content from clinical samples: https://buff.ly/4kiVuu3
February 25, 2025 at 4:33 PM
An advancement in lysosomal research with diagnostic applications!
Esther M. Sammler @ebagnoli.bsky.social & team present a tagless method for profiling lysosomal content from clinical samples: https://buff.ly/4kiVuu3
Esther M. Sammler @ebagnoli.bsky.social & team present a tagless method for profiling lysosomal content from clinical samples: https://buff.ly/4kiVuu3
Reposted by Enrico Bagnoli
📣 Mark your calendars for Thursday, February 27! Andrew West from Duke University will present as part of our LRRK2 Central #webinar series. Reserve your spot below! #Neurosky
📅 February 27
⏰ 1:00 PM ET
RSVP: us06web.zoom.us/meeting/regi...
📅 February 27
⏰ 1:00 PM ET
RSVP: us06web.zoom.us/meeting/regi...
February 21, 2025 at 4:33 PM
📣 Mark your calendars for Thursday, February 27! Andrew West from Duke University will present as part of our LRRK2 Central #webinar series. Reserve your spot below! #Neurosky
📅 February 27
⏰ 1:00 PM ET
RSVP: us06web.zoom.us/meeting/regi...
📅 February 27
⏰ 1:00 PM ET
RSVP: us06web.zoom.us/meeting/regi...
Happy to share our new work on LRRK2 and PINK1 signalling in the brain. The two kinases appear to work on parallel pathway, but both converging on cilia. PINK1 KO animals have shorter and fewer cilia in striatal cholinergic interneurons and less GDNF.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain | PNAS
Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1)
are associated with familial Parkinson’s disease (PD). LRRK2 ph...
www.pnas.org
January 29, 2025 at 12:15 PM
Happy to share our new work on LRRK2 and PINK1 signalling in the brain. The two kinases appear to work on parallel pathway, but both converging on cilia. PINK1 KO animals have shorter and fewer cilia in striatal cholinergic interneurons and less GDNF.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Enrico Bagnoli
Is anyone else starting to think that its all about cillia?
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
January 29, 2025 at 7:01 AM
Is anyone else starting to think that its all about cillia?
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice
A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...
Reposted by Enrico Bagnoli
📣 We are kicking off 2025 with a #LRRK2 webinar hosted by Luis Bonet Ponce, PhD from the Ohio State Department of Neurology at 1 pm ET. Mark your calendars!
📅 1/23
⏰ 1 pm ET
RSVP: us06web.zoom.us/meeting/regi...
📅 1/23
⏰ 1 pm ET
RSVP: us06web.zoom.us/meeting/regi...
January 17, 2025 at 5:29 PM
📣 We are kicking off 2025 with a #LRRK2 webinar hosted by Luis Bonet Ponce, PhD from the Ohio State Department of Neurology at 1 pm ET. Mark your calendars!
📅 1/23
⏰ 1 pm ET
RSVP: us06web.zoom.us/meeting/regi...
📅 1/23
⏰ 1 pm ET
RSVP: us06web.zoom.us/meeting/regi...
Reposted by Enrico Bagnoli
🚨New job post alert 🚨
We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more!
www.denalitherapeutics.com/job?id=0844a...
We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more!
www.denalitherapeutics.com/job?id=0844a...
Job
Denali Therapeutics is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.
www.denalitherapeutics.com
January 16, 2025 at 5:48 PM
🚨New job post alert 🚨
We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more!
www.denalitherapeutics.com/job?id=0844a...
We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more!
www.denalitherapeutics.com/job?id=0844a...
LysoIP goes tagless. Happy to have contributed to this work funded by @asapresearch.bsky.social and @lrrk2central.bsky.social
New paper presents ‘tagless LysoIP’ method, which enables enrichment of lysosomes (using TMEM192) directly from clinical samples & human cell lines; Metabolic profiling shows accumulation of glycerophosphodiesters in CLN3 patients; New tool for #Parkinsons research
www.jci.org/articles/vie...
www.jci.org/articles/vie...
January 15, 2025 at 5:39 PM
LysoIP goes tagless. Happy to have contributed to this work funded by @asapresearch.bsky.social and @lrrk2central.bsky.social
Reposted by Enrico Bagnoli
📢 Exciting news: Our call for LOIs is OPEN for the CRN 2025 Scientific Track!
This #FundingOpportunity focuses on dissecting the mechanisms that can contribute to PD heterogeneity.
Be part of a global network pushing the boundaries of #ParkinsonsResearch.
Submit your LOI: bit.ly/3DXOBxt
This #FundingOpportunity focuses on dissecting the mechanisms that can contribute to PD heterogeneity.
Be part of a global network pushing the boundaries of #ParkinsonsResearch.
Submit your LOI: bit.ly/3DXOBxt
January 15, 2025 at 3:27 PM
📢 Exciting news: Our call for LOIs is OPEN for the CRN 2025 Scientific Track!
This #FundingOpportunity focuses on dissecting the mechanisms that can contribute to PD heterogeneity.
Be part of a global network pushing the boundaries of #ParkinsonsResearch.
Submit your LOI: bit.ly/3DXOBxt
This #FundingOpportunity focuses on dissecting the mechanisms that can contribute to PD heterogeneity.
Be part of a global network pushing the boundaries of #ParkinsonsResearch.
Submit your LOI: bit.ly/3DXOBxt
Beautiful review on mitophagy in neurodegeneration from @odettaantico.bsky.social, @mmuqit.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting mitophagy in neurodegenerative diseases - Nature Reviews Drug Discovery
Impaired mitophagy leading to the accumulation of damaged mitochondria is associated with the onset and progression of neurodegenerative diseases. This Review provides an overview of the molecular pat...
www.nature.com
January 15, 2025 at 10:22 AM
Beautiful review on mitophagy in neurodegeneration from @odettaantico.bsky.social, @mmuqit.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Enrico Bagnoli
Tomorrow is the day 📣
The first installment of the #mito911 webinar series, featuring Viktor Korochulk from the University of Newcastle, UK, will take place tomorrow at 11 am ET. It is not too late to reserve your spot - RSVP using the link below 🧪
us06web.zoom.us/webinar/regi...
The first installment of the #mito911 webinar series, featuring Viktor Korochulk from the University of Newcastle, UK, will take place tomorrow at 11 am ET. It is not too late to reserve your spot - RSVP using the link below 🧪
us06web.zoom.us/webinar/regi...
January 14, 2025 at 6:33 PM
Tomorrow is the day 📣
The first installment of the #mito911 webinar series, featuring Viktor Korochulk from the University of Newcastle, UK, will take place tomorrow at 11 am ET. It is not too late to reserve your spot - RSVP using the link below 🧪
us06web.zoom.us/webinar/regi...
The first installment of the #mito911 webinar series, featuring Viktor Korochulk from the University of Newcastle, UK, will take place tomorrow at 11 am ET. It is not too late to reserve your spot - RSVP using the link below 🧪
us06web.zoom.us/webinar/regi...
Squid Game!
Squid primary cell culture as a model system and experimental tool www.biorxiv.org/content/10.1...
Squid primary cell culture as a model system and experimental tool
Squid primary cells from various tissues and ages are isolated, maintained in culture, and express exogenous genes. This protocol opens up numerous opportunities in molecular biology, neuroscience, an...
www.biorxiv.org
January 13, 2025 at 5:43 PM
Squid Game!
Reposted by Enrico Bagnoli
📣NEW FUNDING CALL: Early Career Development Fund 2025 🧑🎓
Aims to support researchers in their endeavours to develop their own independent academic research track 🚀
💰Apply for up to £4k!
📌 Call closes 24/02
💻 Join our information session to learn more: buff.ly/4j69lmR
Aims to support researchers in their endeavours to develop their own independent academic research track 🚀
💰Apply for up to £4k!
📌 Call closes 24/02
💻 Join our information session to learn more: buff.ly/4j69lmR
January 13, 2025 at 10:55 AM
📣NEW FUNDING CALL: Early Career Development Fund 2025 🧑🎓
Aims to support researchers in their endeavours to develop their own independent academic research track 🚀
💰Apply for up to £4k!
📌 Call closes 24/02
💻 Join our information session to learn more: buff.ly/4j69lmR
Aims to support researchers in their endeavours to develop their own independent academic research track 🚀
💰Apply for up to £4k!
📌 Call closes 24/02
💻 Join our information session to learn more: buff.ly/4j69lmR
Reposted by Enrico Bagnoli
Great to connect with fellow ASAP CRN members, PINK1 pathway to Parkinson's disease: 20 years on! @biochemsoc @asapresearch.bsky.social
November 26, 2024 at 7:16 PM
Great to connect with fellow ASAP CRN members, PINK1 pathway to Parkinson's disease: 20 years on! @biochemsoc @asapresearch.bsky.social