Katie Downes
@dr-downes.bsky.social
Post Doc @ Francis Crick Institute and UCL - COPII, CryoCLEM, cats, mammalian secretory pathway, image analysis
Reposted by Katie Downes
🔬At #MFS25, Giulia Zanetti from @TheCrick unveiled the molecular architecture of the early secretory pathway using cryo-ET & super-resolution microscopy resolving the debate on COPII vesicles and mapping ER-to-Golgi transport in human cells.
🔗https://mfs2025.com/
🔗https://mfs2025.com/
September 26, 2025 at 10:38 AM
🔬At #MFS25, Giulia Zanetti from @TheCrick unveiled the molecular architecture of the early secretory pathway using cryo-ET & super-resolution microscopy resolving the debate on COPII vesicles and mapping ER-to-Golgi transport in human cells.
🔗https://mfs2025.com/
🔗https://mfs2025.com/
I attended this course last year and cannot recommend it enough!
This was a brilliant course last year; I highly recommend it to anyone looking to improve their CryoFIB and CryoET skills!
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
August 20, 2025 at 10:26 AM
I attended this course last year and cannot recommend it enough!
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
July 30, 2025 at 3:28 PM
Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Make my day and check it out!
www.biorxiv.org/content/10.1...
#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬
Reposted by Katie Downes
🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
April 25, 2025 at 7:28 AM
🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
Ready for BBCs #AQuestionofScience here @crick.ac.uk 🔬🧬🥼🧪🦠
March 28, 2025 at 3:01 PM
Ready for BBCs #AQuestionofScience here @crick.ac.uk 🔬🧬🥼🧪🦠
Reposted by Katie Downes
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin.
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
PhD /Postdoc in In Situ Structural Biology by Cryo-ET
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
March 28, 2025 at 8:42 AM
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin.
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...
I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway
Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...
rdcu.be
March 25, 2025 at 12:37 PM
I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Check it out here!
rdcu.be/eeY1J
#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES
Reposted by Katie Downes
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
January 15, 2025 at 7:59 PM
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Lets play...
What
Am
I
Looking
At??
Low mag tomogram of milled RPE-1s.
Any guesses of whats going on here? #TeamTomo
Prize? idk... bragging rights? The feeling of superiority?
I'll collect a high mag tomo tomorrow, so the answer may actually be revealed! (mysteries mysteries mysteries).
What
Am
I
Looking
At??
Low mag tomogram of milled RPE-1s.
Any guesses of whats going on here? #TeamTomo
Prize? idk... bragging rights? The feeling of superiority?
I'll collect a high mag tomo tomorrow, so the answer may actually be revealed! (mysteries mysteries mysteries).
November 28, 2024 at 5:08 PM
Lets play...
What
Am
I
Looking
At??
Low mag tomogram of milled RPE-1s.
Any guesses of whats going on here? #TeamTomo
Prize? idk... bragging rights? The feeling of superiority?
I'll collect a high mag tomo tomorrow, so the answer may actually be revealed! (mysteries mysteries mysteries).
What
Am
I
Looking
At??
Low mag tomogram of milled RPE-1s.
Any guesses of whats going on here? #TeamTomo
Prize? idk... bragging rights? The feeling of superiority?
I'll collect a high mag tomo tomorrow, so the answer may actually be revealed! (mysteries mysteries mysteries).
Reposted by Katie Downes
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
November 27, 2024 at 12:15 PM
If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪
Reposted by Katie Downes
This year’s UK Membrane Trafficking Meeting is on Dec 16th at King’s College London (Guy’s Campus, London Bridge).
Registration closes 9th December. Sign up is here.
estore.kcl.ac.uk/conferences-...
Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!
Registration closes 9th December. Sign up is here.
estore.kcl.ac.uk/conferences-...
Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!
UK Membrane Trafficking Meeting 2024 | King's College London eStore
Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even
estore.kcl.ac.uk
November 12, 2024 at 7:38 AM
This year’s UK Membrane Trafficking Meeting is on Dec 16th at King’s College London (Guy’s Campus, London Bridge).
Registration closes 9th December. Sign up is here.
estore.kcl.ac.uk/conferences-...
Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!
Registration closes 9th December. Sign up is here.
estore.kcl.ac.uk/conferences-...
Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!
Reposted by Katie Downes
📢 Announcing the Membrane Trafficker Starter Pack! This list highlights researchers advancing our understanding of membrane trafficking pathways. This is just a beginning—help expand the list!
go.bsky.app/J9GvL3S
go.bsky.app/J9GvL3S
November 11, 2024 at 1:31 PM
📢 Announcing the Membrane Trafficker Starter Pack! This list highlights researchers advancing our understanding of membrane trafficking pathways. This is just a beginning—help expand the list!
go.bsky.app/J9GvL3S
go.bsky.app/J9GvL3S
November 22, 2024 at 4:15 PM