Denise Sheer
@denisesheer.bsky.social
Reposted by Denise Sheer
Happy to share our latest paper on a new method iNOME-seq that acts as an in vivo bookmarking system to measure open chromatin and other features in plants rdcu.be/eMh36. Project started several years ago with Prof Jose Gutierrez-Marcos and a great collaboration with @plantevolution.bsky.social.
October 23, 2025 at 8:42 AM
Happy to share our latest paper on a new method iNOME-seq that acts as an in vivo bookmarking system to measure open chromatin and other features in plants rdcu.be/eMh36. Project started several years ago with Prof Jose Gutierrez-Marcos and a great collaboration with @plantevolution.bsky.social.
Reposted by Denise Sheer
A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
August 14, 2025 at 5:25 AM
A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
Reposted by Denise Sheer
New research update video from my marine biologist son Rob, who lives on a beautiful island in Fiji doing research into reef conservation.
youtube.com/watch?v=_K78...
youtube.com/watch?v=_K78...
Research Update: How to identify which hard corals are best adapted to high temperatures
YouTube video by Drawaqa Marine Conservation Trust
youtube.com
July 27, 2025 at 4:29 AM
New research update video from my marine biologist son Rob, who lives on a beautiful island in Fiji doing research into reef conservation.
youtube.com/watch?v=_K78...
youtube.com/watch?v=_K78...
Reposted by Denise Sheer
Excited to be part of the editorial team for the FIRST journal specifically focused on pediatric brain tumors. Submissions now open!
💪Neuro-Oncology Pediatrics – a new open access journal by EANO & @neuroonc.bsky.social for the global #pediatric & AYA #NeuroOncology community. Now open for submissions!
🔗 academic.oup.com/neuro-onc-peds
Editor-in-Chief: S. Mueller
Executive Editors: M. A. Roldán (EANO), @bandolab.bsky.social (SNO)
🔗 academic.oup.com/neuro-onc-peds
Editor-in-Chief: S. Mueller
Executive Editors: M. A. Roldán (EANO), @bandolab.bsky.social (SNO)
May 21, 2025 at 5:56 PM
Excited to be part of the editorial team for the FIRST journal specifically focused on pediatric brain tumors. Submissions now open!
Reposted by Denise Sheer
Looking forward to listen to @bayraktarlab.bsky.social talk at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social next Friday. If you cannot join in person, you can use the link.
Our next guest speaker webinar is happening next Friday, May 9th at 14:00 GMT. Omer Bayraktar will give a talk on: "Mapping the rules of glioblastoma using single cell and spatial multiomics". To join please follow the link below: www.qmul.ac.uk/epigenetics/...
May 2, 2025 at 9:42 AM
Looking forward to listen to @bayraktarlab.bsky.social talk at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social next Friday. If you cannot join in person, you can use the link.
Reposted by Denise Sheer
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
March 16, 2025 at 10:31 AM
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Reposted by Denise Sheer
📢 Register! us02web.zoom.us/webinar/regi...
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
May 1, 2025 at 1:36 PM
📢 Register! us02web.zoom.us/webinar/regi...
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
@akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social
#GenomeArchitecture #Senescence
Reposted by Denise Sheer
While most cancers happen by chance, some are passed down through family genes. Understanding cancer genetics can lead to earlier detection and better outcomes. Learn more: bit.ly/4jrUFOp
May 2, 2025 at 4:00 PM
While most cancers happen by chance, some are passed down through family genes. Understanding cancer genetics can lead to earlier detection and better outcomes. Learn more: bit.ly/4jrUFOp
Reposted by Denise Sheer
Hate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally:
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
What if We Can't Rely on PubMed? - Absolutely Maybe
PubMed is incredibly reliable. And a lot depends on it. It’s an ecosystem built around MEDLINE, the steady feed of new publications…
absolutelymaybe.plos.org
February 14, 2025 at 6:06 AM
Hate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally:
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
absolutelymaybe.plos.org/2025/02/14/w...
#medlibs
Reposted by Denise Sheer
QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here
qmul-jobs.tal.net/vx/mobile-0/...
qmul-jobs.tal.net/vx/mobile-0/...
January 24, 2025 at 9:13 AM
QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here
qmul-jobs.tal.net/vx/mobile-0/...
qmul-jobs.tal.net/vx/mobile-0/...
Reposted by Denise Sheer
One week left to get your applications in for this exciting PhD studentship fully-funded for students eligible for UK fees.
Deadline: 31st January 2025
www.findaphd.com/phds/project...
Deadline: 31st January 2025
www.findaphd.com/phds/project...
January 24, 2025 at 7:22 PM
One week left to get your applications in for this exciting PhD studentship fully-funded for students eligible for UK fees.
Deadline: 31st January 2025
www.findaphd.com/phds/project...
Deadline: 31st January 2025
www.findaphd.com/phds/project...
Reposted by Denise Sheer
Happy New Year, blue-sci-peeps!
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
Mechanisms of Inheritance of Chromatin States: From Yeast to Human | Annual Reviews
In this article I review mechanisms that underpin epigenetic inheritance of CpG methylation and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG methylation can be faith...
doi.org
January 7, 2025 at 1:22 AM
Happy New Year, blue-sci-peeps!
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
My piece in Annual Review of Biophysics on chromatin replication is now available online.
doi.org/10.1146/annu...
If you have paywall issues, try this link:
madhanilab.ucsf.edu/s/annurev-bi...
Reposted by Denise Sheer
jimmy carter’s message that was included on the voyager spacecraft.
rest in peace, jimmy carter 🌌
rest in peace, jimmy carter 🌌
December 29, 2024 at 9:44 PM
jimmy carter’s message that was included on the voyager spacecraft.
rest in peace, jimmy carter 🌌
rest in peace, jimmy carter 🌌
Reposted by Denise Sheer
New postdoc position available! We are recruiting for a new postdoc position to develop immune-response human skin models. Please feel free to get in touch or pass along to others. tinyurl.com/avujvc7y
Postdoctoral Research Associate - QMUL Jobs
ID: 4581. Title: Postdoctoral Research Associate . Application Deadline:
tinyurl.com
December 5, 2024 at 3:54 PM
New postdoc position available! We are recruiting for a new postdoc position to develop immune-response human skin models. Please feel free to get in touch or pass along to others. tinyurl.com/avujvc7y
Reposted by Denise Sheer
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr
November 25, 2024 at 6:37 PM
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr
Reposted by Denise Sheer
So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states
Abstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o
academic.oup.com
December 11, 2024 at 5:02 PM
So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by Denise Sheer
Fascinating work!
sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
Solar UVB light causes damage to the outermost layer of skin. This insult induces rapid local responses, such as dermal inflammation, keratinocyte cel…
www.sciencedirect.com
November 27, 2024 at 6:31 AM
Fascinating work!
Reposted by Denise Sheer
First post on Bluesky, let’s share some websites offering many free illustrations for scientific figures 🖼️ 🧪 🌍 :
scidraw.io
bioart.niaid.nih.gov
www.phylopic.org
More well known but very nice though: www.freepik.com
scidraw.io
bioart.niaid.nih.gov
www.phylopic.org
More well known but very nice though: www.freepik.com
SciDraw |
Scientific Drawings
SciDraw - an open repository of science drawings
scidraw.io
November 23, 2024 at 6:57 AM
First post on Bluesky, let’s share some websites offering many free illustrations for scientific figures 🖼️ 🧪 🌍 :
scidraw.io
bioart.niaid.nih.gov
www.phylopic.org
More well known but very nice though: www.freepik.com
scidraw.io
bioart.niaid.nih.gov
www.phylopic.org
More well known but very nice though: www.freepik.com
Reposted by Denise Sheer
“Researchers have created the most detailed 3D cellular map yet of a mouse embryo, visualizing close to eight million cells. The map shows how cells interact and migrate in an embryo less than two weeks after conception, and could help researchers to identify causes of congenital diseases.” #MedSky
8 million cells: virtual embryo shows organs forming in exquisite detail
Model used to create a cellular 'hologram' of a mouse embryo could be used to visualize development in any species.
www.nature.com
November 11, 2024 at 11:17 PM
“Researchers have created the most detailed 3D cellular map yet of a mouse embryo, visualizing close to eight million cells. The map shows how cells interact and migrate in an embryo less than two weeks after conception, and could help researchers to identify causes of congenital diseases.” #MedSky
Reposted by Denise Sheer
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
November 14, 2024 at 4:02 PM
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...
Reposted by Denise Sheer
Since Twitter died, I wanted to post my most popular one. Something like 120k likes.
November 8, 2024 at 5:33 PM
Since Twitter died, I wanted to post my most popular one. Something like 120k likes.
Reposted by Denise Sheer
Amazing trio of papers on ecDNA in @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Can't wait to dig into these!!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Can't wait to dig into these!!!
Origins and impact of extrachromosomal DNA - Nature
A study examines the diversity of extrachromosomal DNA elements in cancer, and provides details on the frequency and origin of extrachromosomal DNA and its role in the development of different types o...
www.nature.com
November 7, 2024 at 2:36 AM
Amazing trio of papers on ecDNA in @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Can't wait to dig into these!!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Can't wait to dig into these!!!
Reposted by Denise Sheer
I'm delighted to release the first half of my new textbook in human genetics:
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
An Owner's Guide to the Human Genome
An Owner's Guide to the Human Genome
web.stanford.edu
October 1, 2023 at 10:53 PM
I'm delighted to release the first half of my new textbook in human genetics:
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
web.stanford.edu/group/pritch...
"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
Reposted by Denise Sheer
Excited to share our latest work, where we investigated how plants use DNA methylation to adapt to naturally fluctuating light regimes. Work led by the amazing Robyn Emmerson
and co-lead with Prof Tracy Lawson. Great collab with
Ulrike Bechtold. biorxiv.org/content/10.1...
1/n
and co-lead with Prof Tracy Lawson. Great collab with
Ulrike Bechtold. biorxiv.org/content/10.1...
1/n
DNA methylation contributes to plant acclimation to naturally fluctuating light
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
June 10, 2024 at 9:51 AM
Excited to share our latest work, where we investigated how plants use DNA methylation to adapt to naturally fluctuating light regimes. Work led by the amazing Robyn Emmerson
and co-lead with Prof Tracy Lawson. Great collab with
Ulrike Bechtold. biorxiv.org/content/10.1...
1/n
and co-lead with Prof Tracy Lawson. Great collab with
Ulrike Bechtold. biorxiv.org/content/10.1...
1/n