Daniel Brock
@danielbrock.bsky.social
MD/PhD Student Baylor College of Medicine
Genetics and retinal degeneration 🧬👀
I like bikes 🚲
Genetics and retinal degeneration 🧬👀
I like bikes 🚲
Reposted by Daniel Brock
Nature research paper: In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma
go.nature.com/3IeODUh
go.nature.com/3IeODUh
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
go.nature.com
September 28, 2025 at 12:09 PM
Nature research paper: In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma
go.nature.com/3IeODUh
go.nature.com/3IeODUh
Reposted by Daniel Brock
In a large-scale proteomic study of biological aging of 11 organs, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity, according to a paper in Nature Medicine. go.nature.com/44nLb1M #medsky 🧪
July 13, 2025 at 7:28 PM
In a large-scale proteomic study of biological aging of 11 organs, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity, according to a paper in Nature Medicine. go.nature.com/44nLb1M #medsky 🧪
Reposted by Daniel Brock
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Decoding gene networks controlling hypothalamic and prethalamic neuron development
Kim et al. map gene regulatory networks of the developing mouse hypothalamus and prethalamus
using single-cell multiomics, identifying regulators of regionalization and neurogenesis.
They further show...
www.cell.com
June 14, 2025 at 12:48 AM
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Drop by poster B0008 today to learn about genetic risk factors for retinal detachment! We found that variants in VSX2 were associated with an increased risk of retinal detachment in the UK Biobank.
Shout out to my PIs Ben Frankfort and @ryandhindsa.bsky.social!
@arvoinfo.bsky.social #visionscience
Shout out to my PIs Ben Frankfort and @ryandhindsa.bsky.social!
@arvoinfo.bsky.social #visionscience
May 7, 2025 at 3:13 PM
Drop by poster B0008 today to learn about genetic risk factors for retinal detachment! We found that variants in VSX2 were associated with an increased risk of retinal detachment in the UK Biobank.
Shout out to my PIs Ben Frankfort and @ryandhindsa.bsky.social!
@arvoinfo.bsky.social #visionscience
Shout out to my PIs Ben Frankfort and @ryandhindsa.bsky.social!
@arvoinfo.bsky.social #visionscience
Reposted by Daniel Brock
Today at the #JointMeeting2025, Svetlana Mojsov, 2024 #LaskerLaureate, gave an impressive overview of how her research on GLP-1 revolutionized the field of glucose metabolism. Her findings led to development of novel therapeutics for #diabetes and #obesity. 🧪 @a-p-s-a.bsky.social
April 26, 2025 at 9:16 PM
Today at the #JointMeeting2025, Svetlana Mojsov, 2024 #LaskerLaureate, gave an impressive overview of how her research on GLP-1 revolutionized the field of glucose metabolism. Her findings led to development of novel therapeutics for #diabetes and #obesity. 🧪 @a-p-s-a.bsky.social
Reposted by Daniel Brock
🚨 We’re hiring postdocs! Join our lab in Houston to study human disease using stem cell models, functional genomics, and big genomic data. Wet & dry lab backgrounds welcome.
Please email me if you're interested (ryan.dhindsa@bcm.edu) or apply directly: jobs.bcm.edu/job/Postdoct...
📩
Please email me if you're interested (ryan.dhindsa@bcm.edu) or apply directly: jobs.bcm.edu/job/Postdoct...
📩
Postdoctoral Associate- Human Genetics
Postdoctoral Associate- Human Genetics
jobs.bcm.edu
April 9, 2025 at 2:48 PM
🚨 We’re hiring postdocs! Join our lab in Houston to study human disease using stem cell models, functional genomics, and big genomic data. Wet & dry lab backgrounds welcome.
Please email me if you're interested (ryan.dhindsa@bcm.edu) or apply directly: jobs.bcm.edu/job/Postdoct...
📩
Please email me if you're interested (ryan.dhindsa@bcm.edu) or apply directly: jobs.bcm.edu/job/Postdoct...
📩
Reposted by Daniel Brock
Check out this tour de force work from @christ3na.bsky.social in my lab!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids https://www.biorxiv.org/content/10.1101/2025.03.20.644422v1
March 24, 2025 at 10:29 PM
Check out this tour de force work from @christ3na.bsky.social in my lab!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!!
Reposted by Daniel Brock
Congratulations to all the medical students who matched today! We are particularly proud of the 15 MDPhD Students that Matched! We can't wait to see what you do next!! @bcmhouston.bsky.social #Match2025 #MatchBCM #doubledoctor
March 21, 2025 at 6:27 PM
Congratulations to all the medical students who matched today! We are particularly proud of the 15 MDPhD Students that Matched! We can't wait to see what you do next!! @bcmhouston.bsky.social #Match2025 #MatchBCM #doubledoctor
Reposted by Daniel Brock
Had a lot of fun teaming up with my younger brother and collaborators @bcmfromthelabs.bsky.social and @astrazeneca.bsky.social on this paper! We trained ML models that predict genes linked to dominant and recessive neurodevelopmental disorders @ajhgnews.bsky.social
www.cell.com/ajhg/abstrac...
www.cell.com/ajhg/abstrac...
Genome-wide prediction of dominant and recessive neurodevelopmental disorder-associated genes
Thousands of neurodevelopmental disorder (NDD)-associated genes remain undiscovered,
limiting genetic diagnoses. Here, we employ inheritance-specific machine learning
models, incorporating gene expres...
www.cell.com
February 26, 2025 at 11:00 PM
Had a lot of fun teaming up with my younger brother and collaborators @bcmfromthelabs.bsky.social and @astrazeneca.bsky.social on this paper! We trained ML models that predict genes linked to dominant and recessive neurodevelopmental disorders @ajhgnews.bsky.social
www.cell.com/ajhg/abstrac...
www.cell.com/ajhg/abstrac...
Reposted by Daniel Brock
Baylor College of Medicine MSTP hosted the south regional APSA @a-p-s-a.bsky.social conference on Friday, February 21. Kudos to the student organizers for a great turnout!
February 25, 2025 at 5:50 PM
Baylor College of Medicine MSTP hosted the south regional APSA @a-p-s-a.bsky.social conference on Friday, February 21. Kudos to the student organizers for a great turnout!
Excited that the APSA South Regional Meeting was a success! 🎉
Huge thanks to attendees, organizers, Baylor & Texas Children's for hosting, and @a-p-s-a.bsky.social for making it happen!
Interested in hosting next year’s meeting? DM me—we’ve got resources to share! #APSA #PhysicianScientists
Huge thanks to attendees, organizers, Baylor & Texas Children's for hosting, and @a-p-s-a.bsky.social for making it happen!
Interested in hosting next year’s meeting? DM me—we’ve got resources to share! #APSA #PhysicianScientists
February 25, 2025 at 9:04 PM
Excited that the APSA South Regional Meeting was a success! 🎉
Huge thanks to attendees, organizers, Baylor & Texas Children's for hosting, and @a-p-s-a.bsky.social for making it happen!
Interested in hosting next year’s meeting? DM me—we’ve got resources to share! #APSA #PhysicianScientists
Huge thanks to attendees, organizers, Baylor & Texas Children's for hosting, and @a-p-s-a.bsky.social for making it happen!
Interested in hosting next year’s meeting? DM me—we’ve got resources to share! #APSA #PhysicianScientists
Reposted by Daniel Brock
Epigenetics Update - KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition bit.ly/3Q9xlYV
#Epigenetics #HIstoneMethylation
---
Discover the Paired-tag breakthrough at epigenome.us
#Epigenetics #HIstoneMethylation
---
Discover the Paired-tag breakthrough at epigenome.us
February 7, 2025 at 7:51 AM
Epigenetics Update - KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition bit.ly/3Q9xlYV
#Epigenetics #HIstoneMethylation
---
Discover the Paired-tag breakthrough at epigenome.us
#Epigenetics #HIstoneMethylation
---
Discover the Paired-tag breakthrough at epigenome.us
Reposted by Daniel Brock
Hello Vision Science Peeps!
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org
February 6, 2025 at 11:24 PM
Hello Vision Science Peeps!
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org
Be sure to put the @iser.bsky.social / @brightfocus.bsky.social Concepts and Breakthroughs In Glaucoma Meeting on your schedule. It will be in Atlanta, Georgia, USA from October 8-11, 2025
iserbrightfocusglaucoma.org