Dominique Vanhecke
@d-vanhecke.bsky.social
Scientist/Immunologist. Immune Oncology/Tolerance. 3R.
Broad interest in science. My views are my own. Retweets, likes ≠ endorsement. 🇨🇭🌏
Broad interest in science. My views are my own. Retweets, likes ≠ endorsement. 🇨🇭🌏
Reposted by Dominique Vanhecke
In our today's journal club, we discussed this impressive work by the Ralser Lab appearing this month in Nature:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The role of metabolism in shaping enzyme structures over 400 million years - Nature
By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...
www.nature.com
July 21, 2025 at 1:54 PM
In our today's journal club, we discussed this impressive work by the Ralser Lab appearing this month in Nature:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dominique Vanhecke
A rundown on the big advances we’re seeing on the brain-immune axis
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
Our Brain—Immune Axis Gets A Jolt
Facts, data and analytics about biomedical matters
erictopol.substack.com
August 3, 2025 at 6:33 PM
A rundown on the big advances we’re seeing on the brain-immune axis
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
Reposted by Dominique Vanhecke
Controlling the immune system and inflammation through stimulating the vagus nerve. FDA approval of an implant for refractory rheumatoid arthritis that is also being studied for various autoimmune diseases.
Front page NY Times www.nytimes.com/2025/07/31/h...
Front page NY Times www.nytimes.com/2025/07/31/h...
New Implant Offers Hope for Easing Rheumatoid Arthritis
www.nytimes.com
August 1, 2025 at 3:04 PM
Controlling the immune system and inflammation through stimulating the vagus nerve. FDA approval of an implant for refractory rheumatoid arthritis that is also being studied for various autoimmune diseases.
Front page NY Times www.nytimes.com/2025/07/31/h...
Front page NY Times www.nytimes.com/2025/07/31/h...
Reposted by Dominique Vanhecke
Moss Medicines: The Next Revolution in #Biotech?
Plant biotechnologists are favoring #moss factories over other models to produce certain valuable #proteins.
Great article based on an interview with yours truly.
www.the-scientist.com/moss-medicin...
Plant biotechnologists are favoring #moss factories over other models to produce certain valuable #proteins.
Great article based on an interview with yours truly.
www.the-scientist.com/moss-medicin...
Moss Medicines: The Next Revolution in Biotech?
Plant biotechnologists are favoring moss factories over other models to produce certain valuable proteins.
www.the-scientist.com
August 4, 2025 at 9:05 AM
Moss Medicines: The Next Revolution in #Biotech?
Plant biotechnologists are favoring #moss factories over other models to produce certain valuable #proteins.
Great article based on an interview with yours truly.
www.the-scientist.com/moss-medicin...
Plant biotechnologists are favoring #moss factories over other models to produce certain valuable #proteins.
Great article based on an interview with yours truly.
www.the-scientist.com/moss-medicin...
Reposted by Dominique Vanhecke
Multitasking.. 😅
July 11, 2025 at 8:24 PM
Multitasking.. 😅
Reposted by Dominique Vanhecke
Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative
diseases. This study reveals that the interferon-induced immunoproteasome drastically
decreases proteasomal ac...
www.cell.com
June 17, 2025 at 7:18 PM
Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
Reposted by Dominique Vanhecke
Why are there intronic reads in your bulk RNA-seq data?
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
June 6, 2025 at 1:45 PM
Why are there intronic reads in your bulk RNA-seq data?
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
Reposted by Dominique Vanhecke
hey everyone! i made a list of some useful starter packs (primarily biology/earth sciences with a few bonus things thrown in) to share with friends who have joined bsky in the last week and thought it may be useful for some people here too! 🌍🧪 #SciSky #BioSky docs.google.com/document/d/1...
Starter packs
BIOLOGY Ecology Macroecology https://go.bsky.app/GBn9pNZ Global ecology https://go.bsky.app/V6tN4cv Trait based ecology and evolution https://go.bsky.app/PThMXeX Invasion biology https://go.b...
docs.google.com
November 11, 2024 at 5:41 PM
hey everyone! i made a list of some useful starter packs (primarily biology/earth sciences with a few bonus things thrown in) to share with friends who have joined bsky in the last week and thought it may be useful for some people here too! 🌍🧪 #SciSky #BioSky docs.google.com/document/d/1...
What are we looking at?
April 3, 2025 at 7:40 AM
What are we looking at?
So beautiful, congratulations!
April 3, 2025 at 7:39 AM
So beautiful, congratulations!
Two?
April 3, 2025 at 7:39 AM
Two?
Reposted by Dominique Vanhecke
Hot take: the only true metric of human progress is the global reduction of suffering. Any technological advancement that does not work in service to this is a lateral step, not forward progress. I don't care if we get to Mars, when rampant famine and disease and poverty remain unsolved for.
March 11, 2025 at 3:18 PM
Hot take: the only true metric of human progress is the global reduction of suffering. Any technological advancement that does not work in service to this is a lateral step, not forward progress. I don't care if we get to Mars, when rampant famine and disease and poverty remain unsolved for.
Reposted by Dominique Vanhecke
We've known about the gut-brain axis.
Now we're learning about the gut-brain-lung axis whereby food intake can trigger an immune response in the airway. www.cell.com/neuron/fullt...
Now we're learning about the gut-brain-lung axis whereby food intake can trigger an immune response in the airway. www.cell.com/neuron/fullt...
March 9, 2025 at 4:21 PM
We've known about the gut-brain axis.
Now we're learning about the gut-brain-lung axis whereby food intake can trigger an immune response in the airway. www.cell.com/neuron/fullt...
Now we're learning about the gut-brain-lung axis whereby food intake can trigger an immune response in the airway. www.cell.com/neuron/fullt...
Reposted by Dominique Vanhecke
The molecular mechanisms of hair greying and how to prevent it
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
March 10, 2025 at 1:28 AM
The molecular mechanisms of hair greying and how to prevent it
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
Reposted by Dominique Vanhecke
Feeder-cell-free system for ex vivo production of NK cells from cord blood hematopoietic stem and progenitor cells
doi.org/10.3389/fimm...
doi.org/10.3389/fimm...
March 9, 2025 at 4:44 PM
Feeder-cell-free system for ex vivo production of NK cells from cord blood hematopoietic stem and progenitor cells
doi.org/10.3389/fimm...
doi.org/10.3389/fimm...
Reposted by Dominique Vanhecke
Important article on the urgent question how to upkeep key information platforms for science
Science must step away from nationally managed infrastructure
Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political…
www.thetransmitter.org
February 21, 2025 at 12:42 PM
Important article on the urgent question how to upkeep key information platforms for science
Reposted by Dominique Vanhecke
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
Reposted by Dominique Vanhecke
A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
November 20, 2024 at 5:04 PM
A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
Reposted by Dominique Vanhecke
Ever wondered how fasting is benefiting the adaptive immune response? In @Nature we show that #ketogenesis promotes the function of #tcell in severe respiratory viral infections by providing #ketonebodies BHB as carbon source. Final edited version: www.nature.com/articles/s41...
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature
The ketone body β-hydroxybutyrate can be used as an alternative carbon source by T cells to maintain their function during severe respiratory viral infections, including infection with&...
www.nature.com
November 19, 2024 at 11:33 AM
Ever wondered how fasting is benefiting the adaptive immune response? In @Nature we show that #ketogenesis promotes the function of #tcell in severe respiratory viral infections by providing #ketonebodies BHB as carbon source. Final edited version: www.nature.com/articles/s41...
Reposted by Dominique Vanhecke
Mind blown🤯
Just playing around with Google's NotebookLM.
notebooklm.google
You upload a PDF of your favourite paper and it spits out a great podcast 🎧
Enjoy a 60s snippet about our recent work in Nature on γδ T cells.
The level of understanding is amazing!
Paper: www.nature.com/articles/s41...
Just playing around with Google's NotebookLM.
notebooklm.google
You upload a PDF of your favourite paper and it spits out a great podcast 🎧
Enjoy a 60s snippet about our recent work in Nature on γδ T cells.
The level of understanding is amazing!
Paper: www.nature.com/articles/s41...
November 19, 2024 at 1:31 PM
Mind blown🤯
Just playing around with Google's NotebookLM.
notebooklm.google
You upload a PDF of your favourite paper and it spits out a great podcast 🎧
Enjoy a 60s snippet about our recent work in Nature on γδ T cells.
The level of understanding is amazing!
Paper: www.nature.com/articles/s41...
Just playing around with Google's NotebookLM.
notebooklm.google
You upload a PDF of your favourite paper and it spits out a great podcast 🎧
Enjoy a 60s snippet about our recent work in Nature on γδ T cells.
The level of understanding is amazing!
Paper: www.nature.com/articles/s41...
Reposted by Dominique Vanhecke
Last month in #ScienceImmunology, Alex Chudnovskiy,
@victora.bsky.social, & al. used proximity-based labeling in combination with single-cell transcriptomics to characterize antigen-presenting dendritic cells in tumors and their draining lymph nodes.
@victora.bsky.social, & al. used proximity-based labeling in combination with single-cell transcriptomics to characterize antigen-presenting dendritic cells in tumors and their draining lymph nodes.
Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response
This study characterizes the dendritic cells that present antigen to tumor-specific CD4+ T cells in the tumor and tumor-draining lymph node.
www.science.org
November 19, 2024 at 4:59 PM
Last month in #ScienceImmunology, Alex Chudnovskiy,
@victora.bsky.social, & al. used proximity-based labeling in combination with single-cell transcriptomics to characterize antigen-presenting dendritic cells in tumors and their draining lymph nodes.
@victora.bsky.social, & al. used proximity-based labeling in combination with single-cell transcriptomics to characterize antigen-presenting dendritic cells in tumors and their draining lymph nodes.
Reposted by Dominique Vanhecke
Beautiful paper from Burkhard Ludewig’s group showing the importance of immunoregulatory stroma to support anti-tumour immunity.
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
November 19, 2024 at 8:50 PM
Beautiful paper from Burkhard Ludewig’s group showing the importance of immunoregulatory stroma to support anti-tumour immunity.
www.cell.com/action/showP...
www.cell.com/action/showP...
Reposted by Dominique Vanhecke
Bluesky now has over 20M people!! 🎉
We've been adding over a million users per day for the last few days. To celebrate, here are 20 fun facts about Bluesky:
We've been adding over a million users per day for the last few days. To celebrate, here are 20 fun facts about Bluesky:
November 19, 2024 at 6:51 PM
Bluesky now has over 20M people!! 🎉
We've been adding over a million users per day for the last few days. To celebrate, here are 20 fun facts about Bluesky:
We've been adding over a million users per day for the last few days. To celebrate, here are 20 fun facts about Bluesky:
Reposted by Dominique Vanhecke
November 19, 2024 at 4:38 PM