Zampieri Lab
@zampierilab.bsky.social
Systems Pharmacology and Biology Lab at @DepBiomedicine, University of Basel, Switzerland.
We exploit metabolic weaknesses for therapeutic applications.
www.zampierilab.org
We exploit metabolic weaknesses for therapeutic applications.
www.zampierilab.org
In this week’s journal club, we discussed how sugar-sweetened beverages - America’s sweetest legacy - may drive colorectal cancer metastasis. Glucose + fructose relieve CRC cells from NAD+ limitation through SORD to boost metastasis.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD - Nature Metabolism
Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrog...
www.nature.com
October 21, 2025 at 6:34 AM
In this week’s journal club, we discussed how sugar-sweetened beverages - America’s sweetest legacy - may drive colorectal cancer metastasis. Glucose + fructose relieve CRC cells from NAD+ limitation through SORD to boost metastasis.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
In our recent journal club, we discussed an impressive paper published in Nature Microbiology titled “A shared alarmone–GTP switch controls persister formation in bacteria”. A comprehensive work on a (p)ppGpp–GTP antagonism pathway!
Check it out:
doi.org/10.1038/s415...
Check it out:
doi.org/10.1038/s415...
A shared alarmone–GTP switch controls persister formation in bacteria - Nature Microbiology
Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.
doi.org
September 29, 2025 at 5:28 PM
In our recent journal club, we discussed an impressive paper published in Nature Microbiology titled “A shared alarmone–GTP switch controls persister formation in bacteria”. A comprehensive work on a (p)ppGpp–GTP antagonism pathway!
Check it out:
doi.org/10.1038/s415...
Check it out:
doi.org/10.1038/s415...
We are happy to welcome Charleen Braun, doing her Master’s degree in Bioanalytics at Coburg University of Applied Sciences with a specialization in Human Biology.
September 2, 2025 at 8:57 AM
We are happy to welcome Charleen Braun, doing her Master’s degree in Bioanalytics at Coburg University of Applied Sciences with a specialization in Human Biology.
At our annual Summer Symposium, Laurentz Schuhknecht from our Lab received this year’s DBM Research Prize, for his groundbreaking work in drug discovery and systems pharmacology, published in Nature Biotechnology (Nature Portfolio) earlier this year.
biomedizin.unibas.ch/en/communica...
biomedizin.unibas.ch/en/communica...
DBM Research Prize Winner 2024 / 2025
Congratulations to this year’s DBM research prize winner! As we enjoy our annual summer symposium, we would like to recognize Dr. Laurentz Schuhknecht from Mattia Zampieri’s Systems Pharmacology and B...
biomedizin.unibas.ch
August 21, 2025 at 8:36 AM
At our annual Summer Symposium, Laurentz Schuhknecht from our Lab received this year’s DBM Research Prize, for his groundbreaking work in drug discovery and systems pharmacology, published in Nature Biotechnology (Nature Portfolio) earlier this year.
biomedizin.unibas.ch/en/communica...
biomedizin.unibas.ch/en/communica...
In our today's journal club, we discussed this impressive work by the Ralser Lab appearing this month in Nature:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The role of metabolism in shaping enzyme structures over 400 million years - Nature
By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...
www.nature.com
July 21, 2025 at 1:54 PM
In our today's journal club, we discussed this impressive work by the Ralser Lab appearing this month in Nature:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In our recent journal club, we discussed insights obtained by in vivo NMR in the context of antibiotic resistance.
Check it out!
pubs.rsc.org/en/content/a...
Check it out!
pubs.rsc.org/en/content/a...
In-cell NMR reveals metabolic adaptations in central carbon pathways driving antibiotic tolerance in Salmonella Typhimurium
Antibiotic tolerance presents a significant challenge in eradicating bacterial infections, as tolerant strains can survive antibiotic treatment, contributing to the recurrence of infections and the de...
pubs.rsc.org
July 1, 2025 at 7:59 AM
In our recent journal club, we discussed insights obtained by in vivo NMR in the context of antibiotic resistance.
Check it out!
pubs.rsc.org/en/content/a...
Check it out!
pubs.rsc.org/en/content/a...
We are happy to welcome Sandra Pflästerer, doing her Master’s degree in Molecular and Cellular Biology at Ludwig-Maximilian University.
June 12, 2025 at 7:48 AM
We are happy to welcome Sandra Pflästerer, doing her Master’s degree in Molecular and Cellular Biology at Ludwig-Maximilian University.
In our recent journal club, we discussed a nice publication from Nature: “Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses”. These exciting findings open the door to approaches that regulate immunometabolism during bacterial infections.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
May 27, 2025 at 1:22 PM
In our recent journal club, we discussed a nice publication from Nature: “Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses”. These exciting findings open the door to approaches that regulate immunometabolism during bacterial infections.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We are looking for highly motivated Master and Bachelor Students to work on computational projects to better understand how bacteria and cancer cells metabolically adapt to chemical perturbations. Write us and find out how to conduct your semester or master project in our lab!
www.zampierilab.org
www.zampierilab.org
Home - Zampieri Lab
By studying fundamental mechanisms regulating short- and long-term metabolic adaptation to genetic and chemical perturbations, our lab aims at finding new and unconventional therapeutic strategies, fr...
www.zampierilab.org
May 19, 2025 at 11:44 AM
We are looking for highly motivated Master and Bachelor Students to work on computational projects to better understand how bacteria and cancer cells metabolically adapt to chemical perturbations. Write us and find out how to conduct your semester or master project in our lab!
www.zampierilab.org
www.zampierilab.org
We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.
Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...
www.biorxiv.org
May 13, 2025 at 9:49 AM
We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A warm welcome to Dana Reddmann, Biochemistry Master's student at Freie Universität Berlin, starting her Master Thesis in our lab!
April 7, 2025 at 7:58 AM
A warm welcome to Dana Reddmann, Biochemistry Master's student at Freie Universität Berlin, starting her Master Thesis in our lab!
We are happy to welcome Elena Pintea, MSc-Student in the Drug Sciences program at the University of Basel.
March 25, 2025 at 7:34 AM
We are happy to welcome Elena Pintea, MSc-Student in the Drug Sciences program at the University of Basel.
Our recent publication has been featured in The Scientist! Thanks to Sneha Khedkar for such a clear and exciting presentation of our research.
www.the-scientist.com/same-drug-ne...
www.the-scientist.com/same-drug-ne...
Same Drug, New Actions: Metabolomics Reveals Hidden Drug Effects
Studying drug-induced metabolic changes with high-throughput systems shed light on drug modes of action, providing an efficient drug discovery platform.
www.the-scientist.com
March 10, 2025 at 5:28 PM
Our recent publication has been featured in The Scientist! Thanks to Sneha Khedkar for such a clear and exciting presentation of our research.
www.the-scientist.com/same-drug-ne...
www.the-scientist.com/same-drug-ne...
In today's journal club, we discussed the work by Sunil Guharajan, Vinuselvi Parisutham and Robert C. Brewster from @brewsterlab.bsky.social, which was recently published in Nucleic Acids Research.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
A systematic survey of TF function in E. coli suggests RNAP stabilization is a prevalent strategy for both repressors and activators
Abstract. Transcription factors (TFs) are often classified as activators or repressors, yet these context-dependent labels are inadequate to predict quanti
doi.org
March 3, 2025 at 4:24 PM
In today's journal club, we discussed the work by Sunil Guharajan, Vinuselvi Parisutham and Robert C. Brewster from @brewsterlab.bsky.social, which was recently published in Nucleic Acids Research.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
A warm welcome to Thomas Gosselin-Monplaisir, visiting PhD-Student from Toulouse Biotechnology Institute.
March 3, 2025 at 4:21 PM
A warm welcome to Thomas Gosselin-Monplaisir, visiting PhD-Student from Toulouse Biotechnology Institute.
We are seeking for a talented semester or master student for a computational project on antimicrobial effects of drugs. Check it out!
www.zampierilab.org/join-us/
www.zampierilab.org/join-us/
Join us - Zampieri Lab
Interested to join our lab? Feel free to inquire about open positions or semester/master projects in our lab. We are always looking for highly motivated Master and Bachelor Students. We continuously o...
www.zampierilab.org
February 12, 2025 at 11:26 AM
We are seeking for a talented semester or master student for a computational project on antimicrobial effects of drugs. Check it out!
www.zampierilab.org/join-us/
www.zampierilab.org/join-us/
Our work was featured in chemistryworld. Fantastic pitch of our research by Anthony King.
www.chemistryworld.com/news/mapping...
www.chemistryworld.com/news/mapping...
Mapping metabolite disturbances by drugs
High-throughput metabolomic profiling gives insight into unpredictable drug effects
www.chemistryworld.com
February 5, 2025 at 4:05 PM
Our work was featured in chemistryworld. Fantastic pitch of our research by Anthony King.
www.chemistryworld.com/news/mapping...
www.chemistryworld.com/news/mapping...
Today in our journal club: impressive work by the group of S.M. Fendt KU Leuven, published in Nature:
www.nature.com/articles/s41...
Here they present how elevated pulmonary aspartate levels trigger a translational program that boosts the aggressiveness of lung metastases.
www.nature.com/articles/s41...
Here they present how elevated pulmonary aspartate levels trigger a translational program that boosts the aggressiveness of lung metastases.
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
www.nature.com
February 3, 2025 at 4:47 PM
Today in our journal club: impressive work by the group of S.M. Fendt KU Leuven, published in Nature:
www.nature.com/articles/s41...
Here they present how elevated pulmonary aspartate levels trigger a translational program that boosts the aggressiveness of lung metastases.
www.nature.com/articles/s41...
Here they present how elevated pulmonary aspartate levels trigger a translational program that boosts the aggressiveness of lung metastases.
We are very excited to share that the recent research from our lab has been published in Nature Biotechnology!
Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...
Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...
A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology
Mapping the metabolic effects of drugs helps define their mode of action.
www.nature.com
January 28, 2025 at 11:24 AM
We are very excited to share that the recent research from our lab has been published in Nature Biotechnology!
Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...
Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...
Today in our journal club: impressive work by Tofani et al. in Cell Metabolism. www.cell.com/cell-metabol...
Gut microbiota regulates stress responsivity via the circadian system
Gut microbes are known to modulate stress responsivity and behavior. Tofani et al.
demonstrate that such modulations occur via the circadian system. The oscillations
in gut microbiota composition regu...
www.cell.com
November 28, 2024 at 3:14 PM
Today in our journal club: impressive work by Tofani et al. in Cell Metabolism. www.cell.com/cell-metabol...