Trends in Genetics
LightNews LightNews
banner
cp-trendsgenetics.bsky.social
Trends in Genetics
@cp-trendsgenetics.bsky.social
2.9K followers 1.4K following 110 posts
A reviews journal from Cell Press that fosters an appreciation for advances being made on all fronts of genetic research.
Editor: Maria Smit
https://www.cell.com/trends/genetics/home
Posts Replies Media Videos
Reposted by Trends in Genetics
mollyprz.bsky.social
SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the
@simonsfoundation.org. Details to follow. Please RT.
November 14, 2025 at 5:05 PM
cp-trendsgenetics.bsky.social
"Homologous recombination counteracts mismatch repair to promote fertility and genetic diversity"
by Ting-Fang Wang (@tingfangwang.bsky.social) & Ji-Long Liao (廖吉隆)

"We postulate that counter-actions of MMR and HR contribute to the post-zygotic isolation..."

authors.elsevier.com/sd/article/S...
Figure 1. During homeologous recombination, homologous recombination (HR) proteins antagonize mismatch repair (MMR) in several homology-directed double-strand break (DSB) repair steps, including D-loop formation, capture of the second processed DSB ends, and formation of ZZM-dependent class I crossover (CO) products.
November 14, 2025 at 2:25 PM
cp-trendsgenetics.bsky.social
"HistENCODE: a proposed project to decipher functional interactions among and between histone PTMs"
by A. Gregory Matera

FREE till Dec. 24th with this link:
authors.elsevier.com/a/1m2gJcQbJF...
Figure 1. Genetic platform to study roles of histone residues during animal development.
November 10, 2025 at 4:10 PM
Reposted by Trends in Genetics
gemmaeling.bsky.social
Happy to see my illustration featured on the cover!
cp-trendsgenetics.bsky.social Trends in Genetics @cp-trendsgenetics.bsky.social · 11d
TiG’s November issue is live!

Huge thanks to Rosa Fernández (@rosafernandez.bsky.social) and colleagues for the cool cover image! Check out their Review on massive genome rearrangements in clitellates.

The entire contents list with links to articles is at
www.cell.com/trends/genet...
November 7, 2025 at 9:42 AM
Reposted by Trends in Genetics
fusionconf.bsky.social
Meet the minds behind the manuscripts! We are so pleased to welcome Margot Brandt (@natgenet.nature.com), Anne Mirabella (@natcomms.nature.com), Maria Smit (@cp-trendsgenetics.bsky.social) & Jun Yu (Genetics, Proteomics & Bioinformatics) who have joined us for our Editor panel discussion at #EREHD25
November 5, 2025 at 12:46 AM
cp-trendsgenetics.bsky.social
TiG’s November issue is live!

Huge thanks to Rosa Fernández (@rosafernandez.bsky.social) and colleagues for the cool cover image! Check out their Review on massive genome rearrangements in clitellates.

The entire contents list with links to articles is at
www.cell.com/trends/genet...
November 3, 2025 at 7:06 PM
cp-trendsgenetics.bsky.social
"The Reciprocal Influence of Genetics and Culture"
by Jay Clayton & colleagues

"Scientists dedicate their careers to expanding knowledge of the natural world, but they are not the only people shaping the meaning of science..."

FREE to read till Dec. 19th here:
authors.elsevier.com/a/1m0x1cQbJF...
November 1, 2025 at 1:59 PM
Reposted by Trends in Genetics
jsantoyo.bsky.social
Sequence-independent 6mA methyltransferases for epigenetic profiling and editing. #DNAmodification #6mA #Epigenetics #Genomics @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
October 24, 2025 at 1:49 PM
cp-trendsgenetics.bsky.social
"If We Could Turn Back Time"
by R. Alta Charo

"De-extinction sits at the intersection of scientific possibility and ethical complexity...

FREE till Dec. 12th at
authors.elsevier.com/a/1l%7ERLcQb...
Figure 1. The Tasmanian tiger was driven to extinction by human activities in the 19th and 20th centuries.
October 23, 2025 at 1:56 PM
cp-trendsgenetics.bsky.social
Happy World CRISPR Day!

The CRISPR revolution began with genome editing, but the platform has evolved into a versatile molecular toolkit with wide-ranging applications.

The current issue of TiG includes a Review of these applications.

Check it out!

www.cell.com/trends/genet...
Expanding horizons of CRISPR applications beyond genome editing
Clustered regularly interspaced short palindromic repeats (CRISPR) technologies have rapidly evolved beyond genome editing, transforming fields such as molecular diagnostics, biosensing, transcription...
www.cell.com
October 20, 2025 at 4:17 PM
Reposted by Trends in Genetics
dnatodaypodcast.bsky.social
October 20th is World CRISPR Day! 🧬🔧

Learn about the latest advancements in CRISPR technology and where CRISPR can take the future of biotech in this #sciencepodcast ! ⬇️
#352 Why Biotech Will Define the 21st Century — DNA Today
Gene Pool Media’s RealPharma episode features British investor and author Andrew Craig who shares how biotechnology is our future and is being driven by innovations in CRISPR, AI, and genomic…
dnapodcast.com
October 20, 2025 at 1:31 PM
Reposted by Trends in Genetics
cellpress.bsky.social
Genetics of human handedness: microtubules and beyond. Check out this review by @ocklenburg.bsky.social published in @cp-trendsgenetics.bsky.social http://dlvr.it/TNjZCR #ASHG25
Genetics of human handedness: microtubules and beyond
October 16, 2025 at 1:28 PM
cp-trendsgenetics.bsky.social
A new preprint Spotlight from @genomicspc.bsky.social is now live!

"Advancing methods for multi-ancestry genomics"
by Lathan Liou & Christa Caggiano

authors.elsevier.com/a/1lxdMcQbJF...
Figure 1. Novel methods addressing the challenge of multi-ancestry individuals.
October 15, 2025 at 1:36 PM
Reposted by Trends in Genetics
leibnizlib.bsky.social
#LIBresearch: Great to see this call to rethink the value of short-read sequencing for biodiversity research — still so much potential to explore!

Proud to see LIB researchers among the co-authors. 🌿🧬
@lpodsiadlowski.bsky.social
cp-trendsgenetics.bsky.social Trends in Genetics @cp-trendsgenetics.bsky.social · Oct 2
"The untapped potential of short-read sequencing in biodiversity research"
by Christoph Bleidorn (@cblei.bsky.social) et al

"Genomic resources have the potential to transform our understanding of the vast, still largely unknown diversity of species..."

More at:
authors.elsevier.com/sd/article/S...
Figure 1. Graphic summary of short-read applications discussed in this review.
October 13, 2025 at 2:54 PM
cp-trendsgenetics.bsky.social
"The histone code at a crossroads: history, context, and new approaches"
by Michael Werner & colleagues

"Recent ‘top-down’ approaches within an eco-evo-devo framework have been successful at finding epigenetic mechanisms in an unbiased way."

FREE till Dec 2nd:
authors.elsevier.com/a/1lwwPcQbJF...
Figure 2. ‘Top-down’ versus ‘bottom-up’ approaches for studying histone modifications. In ‘top-down’ experiments, environmentally influenced phenotypes serve as the starting point, from which molecular methods are used to reveal underlying mechanisms. This approach is in contrast to traditional ‘bottom-up’ approaches, which start with a molecule of interest and then attempt to assign function. Cartoon images adapted from [77,81,82].
October 13, 2025 at 1:42 PM
cp-trendsgenetics.bsky.social
"Sequence-independent 6mA methyltransferases for epigenetic profiling and editing"
by Shan Gao & colleagues

"The newly re-recognized DNA N6-methyladenine (6mA)...has facilitated the development of innovative chromatin profiling approaches..."

FREE till Nov 28:
authors.elsevier.com/a/1lvWNcQbJF...
Figure 3. Sequence-independent methyltransferase as a tool to profile protein–DNA interactions.
October 9, 2025 at 2:07 PM
Reposted by Trends in Genetics
currentbiology.bsky.social
“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”

He proved them wrong! RIP John Gurdon

www.cell.com/current-biol...
John Gurdon
John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from classics to zoology. Dur...
www.cell.com
October 7, 2025 at 4:21 PM
Reposted by Trends in Genetics
skypeascientist.bsky.social
On October 7th, learn how to communicate genetics topics to classrooms and informal settings with with @robomalley.bsky.social from @pged.bsky.social!

This is for teachers and all other kinds of educators.

RSVP for free here: givebutter.com/8TVNiA
DNA floats in the background of a texty event flyer that says "Personal genetics engagement in classrooms and communities, Learn about genetic advances and about how to bring conversations about ethical, legal, and social dimensions of genetics into classrooms and informal science learning. Tuesday October 7, 2025, 12pm EDT. brought to you by Skype a scientist and the personal genetics education and dialogue program. RSVP at linktr.ee/skypeascientist
September 29, 2025 at 10:54 PM
cp-trendsgenetics.bsky.social
Today's Nobel Prize announcement was a win for the field of genetics as well. Congrats to all involved!
labliston.bsky.social Adrian Liston @labliston.bsky.social · Oct 6
In 2003, the key breakthrough happened - groups lead by Sakaguchi, Ramsdell and Sasha Rudensky all demonstrated that FOXP3, the IPEX gene, was also the master transcription factor that made Tregs immunosuppressive. Suddenly everyone could study Tregs and manipulate their genetics.
October 6, 2025 at 7:19 PM
cp-trendsgenetics.bsky.social
October is here!

The issue begins with a fascinating TrendsTalk with Gene Robinson and Dalton Conley on the field(s?!) of sociogenomics.

Other topics include arcRNAs (see cover), pathway-level convergence, male infertility, protist genomics, and more.

Check it out!
www.cell.com/trends/genet...
The October 2025 cover of Trends in Genetics Description: Architectural RNAs (arcRNAs) represent a novel functional category of lncRNAs. In this issue, Tetsuro Hirose et al. describe how arcRNAs serve as blueprints for assembling membraneless organelles (MLOs) via phase separation. They show how arcRNAs, by sequestering multiple RNA-binding proteins through modular domains into MLOs, act as crucibles, sponges, or hubs to regulate gene expression. These findings highlight the essential roles of arcRNAs in organizing dynamic intracellular compartments and orchestrating diverse cellular functions. Illustration by Hiroko Uchida.
October 6, 2025 at 4:35 PM
cp-trendsgenetics.bsky.social
"The untapped potential of short-read sequencing in biodiversity research"
by Christoph Bleidorn (@cblei.bsky.social) et al

"Genomic resources have the potential to transform our understanding of the vast, still largely unknown diversity of species..."

More at:
authors.elsevier.com/sd/article/S...
Figure 1. Graphic summary of short-read applications discussed in this review.
October 2, 2025 at 8:35 PM
Reposted by Trends in Genetics
biogeneurope.bsky.social
🔔🎙️ New episode of the #GenomicConnections Podcast! This month we discuss #ScienceCommunication and its importance for #biodiversity genomics 💬
🎧 Listen here: open.spotify.com/episode/7oGP...

@iboleurope.bsky.social @biogeneurope.bsky.social @ebpgenome.bsky.social @horizoneu.bsky.social
#5. Communicating the Science behind Biodiversity Genomics
open.spotify.com
September 17, 2025 at 10:58 AM
Reposted by Trends in Genetics
carmeloferrai.bsky.social
EpiSci - 🧬 - 🧪 -
Hello, let me introduce U “happy Histone”!
September 17, 2025 at 12:54 PM
Reposted by Trends in Genetics
jsantoyo.bsky.social
Unmasked: transposable elements as drivers and targets in cancer. #TransposableElements #TEs #CancerDrivers @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
September 15, 2025 at 4:32 PM
Reposted by Trends in Genetics
wesaint.bsky.social
Excited to share our new review in Trends in Genetics! Grateful for a great collaboration with co-first author Mitchell Grinwald!
cp-trendsgenetics.bsky.social Trends in Genetics @cp-trendsgenetics.bsky.social · Sep 11
"Unmasked: transposable elements as drivers and targets in cancer"
by Ting Wang & colleagues

"This review synthesizes a growing body of work that positions TEs as both catalysts and antagonists of the tumor state."

Check it out!
authors.elsevier.com/sd/article/S...
Figure I. Origins of transposable element (TE)-encoded and TE-derived proteins in cancer.
September 15, 2025 at 2:55 PM