Cell Host & Microbe
@cp-cellhostmicrobe.bsky.social
The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Pinned
Our October issue is live—rooted in strong microbiology and growing insights.
With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...
With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...
Global atlas of mouse microbiomes:
Searchable resource of microbiome composition across 51 vivaria & 12 wild colonies worldwide. Conserved metabolic outputs occur independently of taxonomic diversity, linking species variants to host metabolic phenotypes
www.cell.com/cell-host-mi...
Searchable resource of microbiome composition across 51 vivaria & 12 wild colonies worldwide. Conserved metabolic outputs occur independently of taxonomic diversity, linking species variants to host metabolic phenotypes
www.cell.com/cell-host-mi...
A global survey of taxa-metabolic associations across mouse microbiome communities
Yilmaz et al. provide a global atlas of murine microbiota and their species variants
across many vivaria and wild colonies. By integrating strain-resolved metagenomics,
metabolomics, and structural an...
www.cell.com
November 11, 2025 at 3:21 PM
Global atlas of mouse microbiomes:
Searchable resource of microbiome composition across 51 vivaria & 12 wild colonies worldwide. Conserved metabolic outputs occur independently of taxonomic diversity, linking species variants to host metabolic phenotypes
www.cell.com/cell-host-mi...
Searchable resource of microbiome composition across 51 vivaria & 12 wild colonies worldwide. Conserved metabolic outputs occur independently of taxonomic diversity, linking species variants to host metabolic phenotypes
www.cell.com/cell-host-mi...
Microbial synthesis of L-DOPA as Parkinson’s disease treatment
Gut microbe bioengineered to produce L-DOPA in non-pulsatile manner. Biotherapeutic reduces drug fluctuations causing debilitating symptoms & improves motor performance in multiple animal models
www.cell.com/cell-host-mi...
Gut microbe bioengineered to produce L-DOPA in non-pulsatile manner. Biotherapeutic reduces drug fluctuations causing debilitating symptoms & improves motor performance in multiple animal models
www.cell.com/cell-host-mi...
Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson’s disease
Padhi et al. bioengineered a gut-beneficial microbe to continuously produce and deliver
L-DOPA, the gold-standard treatment for Parkinson’s disease, in a non-pulsatile manner.
This biotherapeutic appr...
www.cell.com
October 30, 2025 at 4:01 PM
Microbial synthesis of L-DOPA as Parkinson’s disease treatment
Gut microbe bioengineered to produce L-DOPA in non-pulsatile manner. Biotherapeutic reduces drug fluctuations causing debilitating symptoms & improves motor performance in multiple animal models
www.cell.com/cell-host-mi...
Gut microbe bioengineered to produce L-DOPA in non-pulsatile manner. Biotherapeutic reduces drug fluctuations causing debilitating symptoms & improves motor performance in multiple animal models
www.cell.com/cell-host-mi...
Soil organic carbon-microbiome axis:
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Soil organic carbon mediates plant immunity-rhizosphere microbiome interactions and controls colonization resistance to microbial inoculants
Huang et al. report that soil organic carbon (SOC) influences microbial inoculant
performance, with wheat yield responses peaking at intermediate SOC. At these levels,
shifts in plant immunity and mic...
www.cell.com
October 30, 2025 at 3:28 PM
Soil organic carbon-microbiome axis:
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Catalog of human oral microbiome:
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights
Oral microbiome shows rising importance in human health. Cha et al. present the human
reference oral microbiome (HROM), comprising 72,641 high-quality genomes from 3,426
species, including 2,019 previ...
www.cell.com
October 29, 2025 at 7:06 PM
Catalog of human oral microbiome:
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
Bacterial effector hijacks apoptosis via remodeling BCL-2 family proteins:
Shigella OspB enzymatically recombines BH3-only activators & BAX/BAK via peptide-bond exchange. Chimeric proteins fail to mediate mitochondrial membrane permeabilization & apoptosis
www.cell.com/cell-host-mi...
Shigella OspB enzymatically recombines BH3-only activators & BAX/BAK via peptide-bond exchange. Chimeric proteins fail to mediate mitochondrial membrane permeabilization & apoptosis
www.cell.com/cell-host-mi...
Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins
Shao et al. show that the Shigella effector OspB blocks apoptosis by enzymatically
remodeling host BCL-2 proteins through peptide-bond recombination. This reveals a
unique pathogen strategy to rewire ...
www.cell.com
October 29, 2025 at 6:58 PM
Bacterial effector hijacks apoptosis via remodeling BCL-2 family proteins:
Shigella OspB enzymatically recombines BH3-only activators & BAX/BAK via peptide-bond exchange. Chimeric proteins fail to mediate mitochondrial membrane permeabilization & apoptosis
www.cell.com/cell-host-mi...
Shigella OspB enzymatically recombines BH3-only activators & BAX/BAK via peptide-bond exchange. Chimeric proteins fail to mediate mitochondrial membrane permeabilization & apoptosis
www.cell.com/cell-host-mi...
Genetically engineered plant endophytes broaden ETI:
Engineered plant endophytes express effectors that trigger NLR-mediated ETI upon pathogen infection. Sentinel bacterium maintains plant growth & microbiota diversity & broadens plant defense
www.cell.com/cell-host-mi...
Engineered plant endophytes express effectors that trigger NLR-mediated ETI upon pathogen infection. Sentinel bacterium maintains plant growth & microbiota diversity & broadens plant defense
www.cell.com/cell-host-mi...
Genetically engineered plant endophytes broaden effector-triggered immunity
Hou et al. engineer plant endophytes to express effectors that trigger NLR-mediated
ETI upon pathogen infection, regardless of whether pathogens carry recognizable effectors.
The sentinel bacterium ma...
www.cell.com
October 27, 2025 at 12:03 PM
Genetically engineered plant endophytes broaden ETI:
Engineered plant endophytes express effectors that trigger NLR-mediated ETI upon pathogen infection. Sentinel bacterium maintains plant growth & microbiota diversity & broadens plant defense
www.cell.com/cell-host-mi...
Engineered plant endophytes express effectors that trigger NLR-mediated ETI upon pathogen infection. Sentinel bacterium maintains plant growth & microbiota diversity & broadens plant defense
www.cell.com/cell-host-mi...
Gut bacterial metabolism of steroid hormones
Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability
www.cell.com/cell-host-mi...
Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability
www.cell.com/cell-host-mi...
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway
Jacoby et al. identify a gut bacterial pathway that reduces natural and synthetic
steroid hormones, including the anti-inflammatory drug prednisolone. This microbial
activity is enriched in Crohn’s di...
www.cell.com
October 22, 2025 at 5:46 PM
Gut bacterial metabolism of steroid hormones
Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability
www.cell.com/cell-host-mi...
Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability
www.cell.com/cell-host-mi...
Evolution of Ab cross-reactivity to influenza H5N1 NA
New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social
www.cell.com/cell-host-mi...
New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social
www.cell.com/cell-host-mi...
Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline
Lv et al. isolated a protective antibody against influenza neuraminidase that acquires
cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human
H3N2. Along with structural an...
www.cell.com
October 22, 2025 at 11:38 AM
Evolution of Ab cross-reactivity to influenza H5N1 NA
New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social
www.cell.com/cell-host-mi...
New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social
www.cell.com/cell-host-mi...
Co-secretion of T6SS effectors:
Bacteroidota T6SS effectors BtpeA & BtaeB have distinct cell-wall destructive activities yet are co-delivered via coordinated binding to adaptor BtapC. This conserved synergistic system enhances fitness of encoding strains
www.cell.com/cell-host-mi...
Bacteroidota T6SS effectors BtpeA & BtaeB have distinct cell-wall destructive activities yet are co-delivered via coordinated binding to adaptor BtapC. This conserved synergistic system enhances fitness of encoding strains
www.cell.com/cell-host-mi...
A conserved adaptor orchestrates co-secretion of synergistic type VI effectors in gut Bacteroidota
Type VI secretion systems (T6SSs) mediate bacterial competition. Li et al. reveal
that Bacteroidota T6SS effectors BtpeA and BtaeB induce distinct cell-wall destructive
activities yet are co-delivered...
www.cell.com
October 17, 2025 at 4:54 PM
Co-secretion of T6SS effectors:
Bacteroidota T6SS effectors BtpeA & BtaeB have distinct cell-wall destructive activities yet are co-delivered via coordinated binding to adaptor BtapC. This conserved synergistic system enhances fitness of encoding strains
www.cell.com/cell-host-mi...
Bacteroidota T6SS effectors BtpeA & BtaeB have distinct cell-wall destructive activities yet are co-delivered via coordinated binding to adaptor BtapC. This conserved synergistic system enhances fitness of encoding strains
www.cell.com/cell-host-mi...
Carving out the microbiota of Earth’s largest biomass reservoir
@naturalist1986.bsky.social @finkel-lab.bsky.social highlight work of Peccia lab on microbiome of trees- an overdue dive into unique & diverse prokaryotic & fungal communities of heartwood & sapwood
www.cell.com/cell-host-mi...
@naturalist1986.bsky.social @finkel-lab.bsky.social highlight work of Peccia lab on microbiome of trees- an overdue dive into unique & diverse prokaryotic & fungal communities of heartwood & sapwood
www.cell.com/cell-host-mi...
Carving out the microbiota of Earth’s largest biomass reservoir
Despite being an essential part of terrestrial ecosystems for ∼400 million years,
the microbiome of wood is surprisingly underexplored. In a recent issue of Nature,
Arnold et al. make a long overdue d...
www.cell.com
October 17, 2025 at 4:33 PM
Carving out the microbiota of Earth’s largest biomass reservoir
@naturalist1986.bsky.social @finkel-lab.bsky.social highlight work of Peccia lab on microbiome of trees- an overdue dive into unique & diverse prokaryotic & fungal communities of heartwood & sapwood
www.cell.com/cell-host-mi...
@naturalist1986.bsky.social @finkel-lab.bsky.social highlight work of Peccia lab on microbiome of trees- an overdue dive into unique & diverse prokaryotic & fungal communities of heartwood & sapwood
www.cell.com/cell-host-mi...
Prophage intercepts pathogenic activity of infecting phage:
Antitermination during phage replication activates RemS/PokE, encoded in prophage. PokE, membrane-depolarizing protein embedded in prophage lysis cassette, disrupts phage lytic cycle
www.cell.com/cell-host-mi...
Antitermination during phage replication activates RemS/PokE, encoded in prophage. PokE, membrane-depolarizing protein embedded in prophage lysis cassette, disrupts phage lytic cycle
www.cell.com/cell-host-mi...
A prophage intercepts pathogenic activity of infecting phage for defense
Sargen and Helaine characterize how antitermination during phage replication activates
the expression of a small membrane-depolarizing protein embedded in the lysis cassette
of the prophage. This reve...
www.cell.com
October 17, 2025 at 4:17 PM
Prophage intercepts pathogenic activity of infecting phage:
Antitermination during phage replication activates RemS/PokE, encoded in prophage. PokE, membrane-depolarizing protein embedded in prophage lysis cassette, disrupts phage lytic cycle
www.cell.com/cell-host-mi...
Antitermination during phage replication activates RemS/PokE, encoded in prophage. PokE, membrane-depolarizing protein embedded in prophage lysis cassette, disrupts phage lytic cycle
www.cell.com/cell-host-mi...
Reposted by Cell Host & Microbe
Eislmayr et al. find neutrophils are *not* key to clearing Shigella. Instead, macrophages trigger IL-12 → IFN-γ, restricting bacterial replication in intestinal epithelial cells. New innate immunity from the lab of Russell Vance in @cp-cellhostmicrobe.bsky.social
doi.org/10.1016/j.ch... 🧪
doi.org/10.1016/j.ch... 🧪
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
Bacteria of the genus Shigella replicate in intestinal epithelial cells and cause shigellosis, a severe diarrheal disease that resolves spontaneously …
doi.org
October 11, 2025 at 8:33 AM
Eislmayr et al. find neutrophils are *not* key to clearing Shigella. Instead, macrophages trigger IL-12 → IFN-γ, restricting bacterial replication in intestinal epithelial cells. New innate immunity from the lab of Russell Vance in @cp-cellhostmicrobe.bsky.social
doi.org/10.1016/j.ch... 🧪
doi.org/10.1016/j.ch... 🧪
Misfortunes never come singly
Fu & Knoers @rug.nl highlight work reporting toxin-generating E.coli tryptophan metabolism induces myocardial apoptosis, contributing to heart failure risk w/kidney dysfunction. Probiotic reduces risk.
www.cell.com/cell-host-mi...
Fu & Knoers @rug.nl highlight work reporting toxin-generating E.coli tryptophan metabolism induces myocardial apoptosis, contributing to heart failure risk w/kidney dysfunction. Probiotic reduces risk.
www.cell.com/cell-host-mi...
Misfortunes never come singly: Microbial metabolites link heart failure and chronic kidney disease
Heart failure is life threatening and common in chronic kidney disease patients. In
this issue, Zheng et al. report that toxin-generating E. coli tryptophan metabolism
induces myocardial apoptosis, co...
www.cell.com
October 10, 2025 at 2:12 PM
Misfortunes never come singly
Fu & Knoers @rug.nl highlight work reporting toxin-generating E.coli tryptophan metabolism induces myocardial apoptosis, contributing to heart failure risk w/kidney dysfunction. Probiotic reduces risk.
www.cell.com/cell-host-mi...
Fu & Knoers @rug.nl highlight work reporting toxin-generating E.coli tryptophan metabolism induces myocardial apoptosis, contributing to heart failure risk w/kidney dysfunction. Probiotic reduces risk.
www.cell.com/cell-host-mi...
Microbiota-derived indole sulfate promotes heart failure in CKD:
E. coli-derived indoxyl sulfate promotes heart failure progression in chronic kidney disease via AHR-CYP1B1. Targeting microbiota-indoxyl sulfate pathway offers therapeutic potential
www.cell.com/cell-host-mi...
E. coli-derived indoxyl sulfate promotes heart failure progression in chronic kidney disease via AHR-CYP1B1. Targeting microbiota-indoxyl sulfate pathway offers therapeutic potential
www.cell.com/cell-host-mi...
Gut-microbiota-derived indole sulfate promotes heart failure in chronic kidney disease
Heart failure (HF) is highly prevalent among patients with chronic kidney disease
(CKD), yet the exact mechanisms remain unclear. Zhang et al. demonstrate that E. coli-derived
indoxyl sulfate promotes...
www.cell.com
October 10, 2025 at 1:54 PM
Microbiota-derived indole sulfate promotes heart failure in CKD:
E. coli-derived indoxyl sulfate promotes heart failure progression in chronic kidney disease via AHR-CYP1B1. Targeting microbiota-indoxyl sulfate pathway offers therapeutic potential
www.cell.com/cell-host-mi...
E. coli-derived indoxyl sulfate promotes heart failure progression in chronic kidney disease via AHR-CYP1B1. Targeting microbiota-indoxyl sulfate pathway offers therapeutic potential
www.cell.com/cell-host-mi...
Lost & found: Reconstituting PRR immune function through co-receptor transfer
@isabelmonte.bsky.social highlights work revealing cross-species co-receptor transfer can overcome restricted taxonomic functionality in rice, pointing to strategies for crop protection
www.cell.com/cell-host-mi...
@isabelmonte.bsky.social highlights work revealing cross-species co-receptor transfer can overcome restricted taxonomic functionality in rice, pointing to strategies for crop protection
www.cell.com/cell-host-mi...
Lost and found: Reconstituting PRR immune function through co-receptor transfer
Plant immune receptors hold great promise for engineering broad-spectrum disease resistance,
but their effectiveness is very limited by restricted taxonomic functionality (RTF).
In this issue of Cell ...
www.cell.com
October 9, 2025 at 2:33 PM
Lost & found: Reconstituting PRR immune function through co-receptor transfer
@isabelmonte.bsky.social highlights work revealing cross-species co-receptor transfer can overcome restricted taxonomic functionality in rice, pointing to strategies for crop protection
www.cell.com/cell-host-mi...
@isabelmonte.bsky.social highlights work revealing cross-species co-receptor transfer can overcome restricted taxonomic functionality in rice, pointing to strategies for crop protection
www.cell.com/cell-host-mi...
Restoring fungal resistance in rice:
Identification of STOM, a fungal MAMP, and its receptor-co-receptor pair, STOMR/STOMRh. Evolutionary loss of functional STOMRh in monocots restricts immune recognition, while restoring it in rice reconstitutes defense
www.cell.com/cell-host-mi...
Identification of STOM, a fungal MAMP, and its receptor-co-receptor pair, STOMR/STOMRh. Evolutionary loss of functional STOMRh in monocots restricts immune recognition, while restoring it in rice reconstitutes defense
www.cell.com/cell-host-mi...
Fungal resistance in rice is restored by interfamily transfer of an evolutionarily lost co-receptor
Zhang et al. identify STOM, a previously unknown fungal MAMP, and its receptor-co-receptor
pair, STOMR/STOMRh. The evolutionary loss of functional STOMRh in monocots restricts
immune recognition, whil...
www.cell.com
October 9, 2025 at 2:32 PM
Restoring fungal resistance in rice:
Identification of STOM, a fungal MAMP, and its receptor-co-receptor pair, STOMR/STOMRh. Evolutionary loss of functional STOMRh in monocots restricts immune recognition, while restoring it in rice reconstitutes defense
www.cell.com/cell-host-mi...
Identification of STOM, a fungal MAMP, and its receptor-co-receptor pair, STOMR/STOMRh. Evolutionary loss of functional STOMRh in monocots restricts immune recognition, while restoring it in rice reconstitutes defense
www.cell.com/cell-host-mi...
Metabolic tug-of-war: Mitochondria starve Toxoplasma of folate
@drdstojanovski.bsky.social highlights work of Pernas lab @science.org showing infected cells use mitochondria as metabolic guardians, outcompeting Toxoplasma for folate-essential for DNA synthesis
www.cell.com/cell-host-mi...
@drdstojanovski.bsky.social highlights work of Pernas lab @science.org showing infected cells use mitochondria as metabolic guardians, outcompeting Toxoplasma for folate-essential for DNA synthesis
www.cell.com/cell-host-mi...
Metabolic tug-of-war: Mitochondria starve Toxoplasma of folate
In a recent Science paper, Medeiros et al. describe how infected cells use mitochondria
as metabolic guardians, outcompeting Toxoplasma parasites for folate, an essential
vitamin for DNA synthesis. Th...
www.cell.com
October 9, 2025 at 11:40 AM
Metabolic tug-of-war: Mitochondria starve Toxoplasma of folate
@drdstojanovski.bsky.social highlights work of Pernas lab @science.org showing infected cells use mitochondria as metabolic guardians, outcompeting Toxoplasma for folate-essential for DNA synthesis
www.cell.com/cell-host-mi...
@drdstojanovski.bsky.social highlights work of Pernas lab @science.org showing infected cells use mitochondria as metabolic guardians, outcompeting Toxoplasma for folate-essential for DNA synthesis
www.cell.com/cell-host-mi...
Featured Article: Mycorrhizal networks facilitate resistance:
Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants induces shifts in root exudates that recruit disease-suppressive bacteria to rhizosphere, yielding resistance
www.cell.com/cell-host-mi...
Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants induces shifts in root exudates that recruit disease-suppressive bacteria to rhizosphere, yielding resistance
www.cell.com/cell-host-mi...
Common mycorrhizal networks facilitate plant disease resistance by altering rhizosphere microbiome assembly
Common mycorrhizal networks (CMNs) facilitate chemical communication between plants.
Zhang et al. demonstrate the transfer of jasmonic acid via CMN from Botrytis cinerea-infected
donor plants to healt...
www.cell.com
October 8, 2025 at 5:45 PM
Featured Article: Mycorrhizal networks facilitate resistance:
Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants induces shifts in root exudates that recruit disease-suppressive bacteria to rhizosphere, yielding resistance
www.cell.com/cell-host-mi...
Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants induces shifts in root exudates that recruit disease-suppressive bacteria to rhizosphere, yielding resistance
www.cell.com/cell-host-mi...
Inter-kingdom lipid messengers sustain gut harmony
Preview of work revealing uLCFAs accumulate in gut upon immune activation. Blautia ohyA converts uLCFAs into non-toxic hydroxy FAs that suppress pro-inflammatory T cells, thereby regulating immunostasis
www.cell.com/cell-host-mi...
Preview of work revealing uLCFAs accumulate in gut upon immune activation. Blautia ohyA converts uLCFAs into non-toxic hydroxy FAs that suppress pro-inflammatory T cells, thereby regulating immunostasis
www.cell.com/cell-host-mi...
Inter-kingdom lipid messengers sustain gut harmony
In this issue of Cell Host & Microbe, Czauderna et al. reveal that unsaturated long-chain
fatty acids (uLCFAs) accumulate in the gut during immune activation, yet are toxic
to commensals, notably Blau...
www.cell.com
October 8, 2025 at 4:05 PM
Inter-kingdom lipid messengers sustain gut harmony
Preview of work revealing uLCFAs accumulate in gut upon immune activation. Blautia ohyA converts uLCFAs into non-toxic hydroxy FAs that suppress pro-inflammatory T cells, thereby regulating immunostasis
www.cell.com/cell-host-mi...
Preview of work revealing uLCFAs accumulate in gut upon immune activation. Blautia ohyA converts uLCFAs into non-toxic hydroxy FAs that suppress pro-inflammatory T cells, thereby regulating immunostasis
www.cell.com/cell-host-mi...
Featured Article: uLCFAs in host-microbe crosstalk
Immune responses trigger release of unsaturated long-chain fatty acids (uLCFAs) in gut, reprogramming bacteria, ie Blautia. Blaudia ohyA converts toxic uLCFAs to hydroxy-FAs w/immunomodulatory effects
www.cell.com/cell-host-mi...
Immune responses trigger release of unsaturated long-chain fatty acids (uLCFAs) in gut, reprogramming bacteria, ie Blautia. Blaudia ohyA converts toxic uLCFAs to hydroxy-FAs w/immunomodulatory effects
www.cell.com/cell-host-mi...
Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication
Czauderna et al. report that immune responses stimulate the release of dietary-like
fatty acids in the gut, reprogramming beneficial bacteria such as Blautia to produce
anti-inflammatory molecules. Th...
www.cell.com
October 8, 2025 at 4:02 PM
Featured Article: uLCFAs in host-microbe crosstalk
Immune responses trigger release of unsaturated long-chain fatty acids (uLCFAs) in gut, reprogramming bacteria, ie Blautia. Blaudia ohyA converts toxic uLCFAs to hydroxy-FAs w/immunomodulatory effects
www.cell.com/cell-host-mi...
Immune responses trigger release of unsaturated long-chain fatty acids (uLCFAs) in gut, reprogramming bacteria, ie Blautia. Blaudia ohyA converts toxic uLCFAs to hydroxy-FAs w/immunomodulatory effects
www.cell.com/cell-host-mi...
Our October issue is live—rooted in strong microbiology and growing insights.
With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...
With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...
October 8, 2025 at 3:49 PM
Our October issue is live—rooted in strong microbiology and growing insights.
With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...
With cover art highlighting the gut-brain axis and work from @katesadlerphd.bsky.social
www.cell.com/cell-host-mi...
Molecular mechanisms of host-microbiome interactions:
We teamed up w/ @cp-cellchembiol.bsky.social for a Collection of articles uncovering mechanisms by which microbes communicate w/their hosts, shedding light on various conditions & offering therapeutic avenues.Enjoy!
www.cell.com/cp/collectio...
We teamed up w/ @cp-cellchembiol.bsky.social for a Collection of articles uncovering mechanisms by which microbes communicate w/their hosts, shedding light on various conditions & offering therapeutic avenues.Enjoy!
www.cell.com/cp/collectio...
October 7, 2025 at 7:15 PM
Molecular mechanisms of host-microbiome interactions:
We teamed up w/ @cp-cellchembiol.bsky.social for a Collection of articles uncovering mechanisms by which microbes communicate w/their hosts, shedding light on various conditions & offering therapeutic avenues.Enjoy!
www.cell.com/cp/collectio...
We teamed up w/ @cp-cellchembiol.bsky.social for a Collection of articles uncovering mechanisms by which microbes communicate w/their hosts, shedding light on various conditions & offering therapeutic avenues.Enjoy!
www.cell.com/cp/collectio...
Cadaverine rewires macrophages:
Gut-microbiota-derived cadaverine reprograms macrophage energy metabolism, altering inflammatory immunophenotypes. In IBD, cadaverine is associated w/increased flare risk & regulated by Enterobacteriaceae
www.cell.com/cell-host-mi...
Gut-microbiota-derived cadaverine reprograms macrophage energy metabolism, altering inflammatory immunophenotypes. In IBD, cadaverine is associated w/increased flare risk & regulated by Enterobacteriaceae
www.cell.com/cell-host-mi...
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms
macrophage energy metabolism in a concentration-dependent fashion, promoting either
anti- or pro-inflammatory immun...
www.cell.com
October 7, 2025 at 6:39 PM
Cadaverine rewires macrophages:
Gut-microbiota-derived cadaverine reprograms macrophage energy metabolism, altering inflammatory immunophenotypes. In IBD, cadaverine is associated w/increased flare risk & regulated by Enterobacteriaceae
www.cell.com/cell-host-mi...
Gut-microbiota-derived cadaverine reprograms macrophage energy metabolism, altering inflammatory immunophenotypes. In IBD, cadaverine is associated w/increased flare risk & regulated by Enterobacteriaceae
www.cell.com/cell-host-mi...
Reposted by Cell Host & Microbe
#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟♂️ controls macrophage metabolism & gut inflammation. Low 🧟♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟♂️ drives glycolysis & intestinal inflammation 🔥 !!
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms
macrophage energy metabolism in a concentration-dependent fashion, promoting either
anti- or pro-inflammatory immun...
www.cell.com
October 4, 2025 at 3:07 PM
#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟♂️ controls macrophage metabolism & gut inflammation. Low 🧟♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟♂️ drives glycolysis & intestinal inflammation 🔥 !!
Reposted by Cell Host & Microbe
Thrilled to see our paper published!
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.
A huge thank you to everyone involved!
@cp-cellhostmicrobe.bsky.social @ucberkeleyofficial.bsky.social
www.cell.com/cell-host-mi...
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.
A huge thank you to everyone involved!
@cp-cellhostmicrobe.bsky.social @ucberkeleyofficial.bsky.social
www.cell.com/cell-host-mi...
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
Eislmayr et al. reveal a previously unrecognized role of macrophages in controlling
the intracellular pathogen Shigella. By sensing bacteria and triggering IFN-γ production,
macrophages, not neutrophi...
www.cell.com
October 1, 2025 at 3:54 AM
Thrilled to see our paper published!
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.
A huge thank you to everyone involved!
@cp-cellhostmicrobe.bsky.social @ucberkeleyofficial.bsky.social
www.cell.com/cell-host-mi...
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.
A huge thank you to everyone involved!
@cp-cellhostmicrobe.bsky.social @ucberkeleyofficial.bsky.social
www.cell.com/cell-host-mi...