Coleman Research Group (KCL)
@coleman-group-kcl.bsky.social
Announcements/updates from jonicoleman.bsky.social's group at KCL, interested in using statistical genetics to understand the biology of psychiatric disorders
Pleased to have been able to contribute in a small way to this excellent review from Katrina Davis, outlining the value, limitations, and future of @ukbiobank.bsky.social for mental health research
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Unlocking mental health insights with UK Biobank data: Past use and future opportunities | Psychological Medicine | Cambridge Core
Unlocking mental health insights with UK Biobank data: Past use and future opportunities - Volume 55
www.cambridge.org
August 29, 2025 at 9:49 AM
Pleased to have been able to contribute in a small way to this excellent review from Katrina Davis, outlining the value, limitations, and future of @ukbiobank.bsky.social for mental health research
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Reposted by Coleman Research Group (KCL)
Fantastic to see Maria Koromina's great work out in @natneuro.nature.com!
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
Fine-mapping genomic loci refines bipolar disorder risk genes - Nature Neuroscience
This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide fu...
www.nature.com
June 26, 2025 at 1:05 PM
Fantastic to see Maria Koromina's great work out in @natneuro.nature.com!
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
Reposted by Coleman Research Group (KCL)
Can't post this without the acknowledgement:
"We dedicate this paper to Robert Keers, a wonderful friend, colleague, mentor and scientist, whom we lost too soon. This project continued in his absence, with contributions from many colleagues who helped to complete the work that he started."
2/2
"We dedicate this paper to Robert Keers, a wonderful friend, colleague, mentor and scientist, whom we lost too soon. This project continued in his absence, with contributions from many colleagues who helped to complete the work that he started."
2/2
June 10, 2025 at 2:28 PM
Can't post this without the acknowledgement:
"We dedicate this paper to Robert Keers, a wonderful friend, colleague, mentor and scientist, whom we lost too soon. This project continued in his absence, with contributions from many colleagues who helped to complete the work that he started."
2/2
"We dedicate this paper to Robert Keers, a wonderful friend, colleague, mentor and scientist, whom we lost too soon. This project continued in his absence, with contributions from many colleagues who helped to complete the work that he started."
2/2
Reposted by Coleman Research Group (KCL)
Very pleased to see this paper out in @nathumbehav.nature.com – a useful approach to understanding the role of genetics in sensitising people to their environments (and a sobering example of the sample sizes needed...!)
Fantastic work by lead Elham Assary!
1/2
rdcu.be/eqmvJ
Fantastic work by lead Elham Assary!
1/2
rdcu.be/eqmvJ
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
Nature Human Behaviour - This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more...
rdcu.be
June 10, 2025 at 2:28 PM
Very pleased to see this paper out in @nathumbehav.nature.com – a useful approach to understanding the role of genetics in sensitising people to their environments (and a sobering example of the sample sizes needed...!)
Fantastic work by lead Elham Assary!
1/2
rdcu.be/eqmvJ
Fantastic work by lead Elham Assary!
1/2
rdcu.be/eqmvJ
Reposted by Coleman Research Group (KCL)
Thursday 19th June (14:00-16:00) with Emily Petherick, Loughborough University and Anthony Khawaja, UCL and Moorfields Eye Hospital NHS Foundation Trust
Webinar registration link events.teams.microsoft.com/event/0f859b.... 4/4
Webinar registration link events.teams.microsoft.com/event/0f859b.... 4/4
Microsoft Virtual Events Powered by Teams
Microsoft Virtual Events Powered by Teams
events.teams.microsoft.com
June 5, 2025 at 2:29 PM
Thursday 19th June (14:00-16:00) with Emily Petherick, Loughborough University and Anthony Khawaja, UCL and Moorfields Eye Hospital NHS Foundation Trust
Webinar registration link events.teams.microsoft.com/event/0f859b.... 4/4
Webinar registration link events.teams.microsoft.com/event/0f859b.... 4/4
Reposted by Coleman Research Group (KCL)
Monday 16th June (10:00-12:00) with Catherine John, University of Leicester and Daniel Smith, University of Edinburgh
Webinar registration link: events.teams.microsoft.com/event/da8085....
3/4
Webinar registration link: events.teams.microsoft.com/event/da8085....
3/4
Microsoft Virtual Events Powered by Teams
Microsoft Virtual Events Powered by Teams
events.teams.microsoft.com
June 5, 2025 at 2:29 PM
Monday 16th June (10:00-12:00) with Catherine John, University of Leicester and Daniel Smith, University of Edinburgh
Webinar registration link: events.teams.microsoft.com/event/da8085....
3/4
Webinar registration link: events.teams.microsoft.com/event/da8085....
3/4
Reposted by Coleman Research Group (KCL)
Tuesday 10th June (12.00-14.00) with Robert Maidstone, University of Manchester
Webinar registration link - events.teams.microsoft.com/event/4364bc... 2/4
Webinar registration link - events.teams.microsoft.com/event/4364bc... 2/4
Microsoft Virtual Events Powered by Teams
Microsoft Virtual Events Powered by Teams
events.teams.microsoft.com
June 5, 2025 at 2:29 PM
Tuesday 10th June (12.00-14.00) with Robert Maidstone, University of Manchester
Webinar registration link - events.teams.microsoft.com/event/4364bc... 2/4
Webinar registration link - events.teams.microsoft.com/event/4364bc... 2/4
Reposted by Coleman Research Group (KCL)
I'm fortunate enough to be a Research Scholar with OurFutureHealth, the UK’s largest health research programme. They are hosting webinars for researchers to share the exciting opportunities this unique resource can offer your research. 1/4
June 5, 2025 at 2:29 PM
I'm fortunate enough to be a Research Scholar with OurFutureHealth, the UK’s largest health research programme. They are hosting webinars for researchers to share the exciting opportunities this unique resource can offer your research. 1/4
Reposted by Coleman Research Group (KCL)
Very pleased to see our paper describing the @ukbiobank.bsky.social second online mental health questionnaire has now been published in @plosone.org! This describes the origin of the resource as well as the data.
Fantastic work by Katrina Davis in leading this 👏👏👏
dx.plos.org/10.1371/jour...
Fantastic work by Katrina Davis in leading this 👏👏👏
dx.plos.org/10.1371/jour...
The UK Biobank mental health enhancement 2022: Methods and results
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over ...
dx.plos.org
May 29, 2025 at 2:28 PM
Very pleased to see our paper describing the @ukbiobank.bsky.social second online mental health questionnaire has now been published in @plosone.org! This describes the origin of the resource as well as the data.
Fantastic work by Katrina Davis in leading this 👏👏👏
dx.plos.org/10.1371/jour...
Fantastic work by Katrina Davis in leading this 👏👏👏
dx.plos.org/10.1371/jour...
🚨 NEW PREPRINT ALERT! 🚨
Very pleased to have the latest @pgcgenetics.bsky.social eating disorders GWAS now out on medrxiv!
Featuring one first author from our group (Sang Hyuck) and one senior author (Joni), alongside 168 others!
www.medrxiv.org/content/10.1...
Very pleased to have the latest @pgcgenetics.bsky.social eating disorders GWAS now out on medrxiv!
Featuring one first author from our group (Sang Hyuck) and one senior author (Joni), alongside 168 others!
www.medrxiv.org/content/10.1...
Genome-wide association studies of binge eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes
Eating disorders - including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder - are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mos...
www.medrxiv.org
May 9, 2025 at 10:32 AM
🚨 NEW PREPRINT ALERT! 🚨
Very pleased to have the latest @pgcgenetics.bsky.social eating disorders GWAS now out on medrxiv!
Featuring one first author from our group (Sang Hyuck) and one senior author (Joni), alongside 168 others!
www.medrxiv.org/content/10.1...
Very pleased to have the latest @pgcgenetics.bsky.social eating disorders GWAS now out on medrxiv!
Featuring one first author from our group (Sang Hyuck) and one senior author (Joni), alongside 168 others!
www.medrxiv.org/content/10.1...
Reposted by Coleman Research Group (KCL)
Join Jean Campbell & Foundation-funded Dr @jonicoleman.bsky.social (@kingsioppn.bsky.social) for a thought-provoking conversation about #depression:
www.youtube.com/watch?v=sFeA...
This is part of our new collaboration with 'I'm Fine' podcast, exploring overlooked areas of medical research. #MedSky
www.youtube.com/watch?v=sFeA...
This is part of our new collaboration with 'I'm Fine' podcast, exploring overlooked areas of medical research. #MedSky
Depression: Understanding risk factors, symptoms and therapies
YouTube video by Medical Research Foundation
www.youtube.com
April 15, 2025 at 8:48 AM
Join Jean Campbell & Foundation-funded Dr @jonicoleman.bsky.social (@kingsioppn.bsky.social) for a thought-provoking conversation about #depression:
www.youtube.com/watch?v=sFeA...
This is part of our new collaboration with 'I'm Fine' podcast, exploring overlooked areas of medical research. #MedSky
www.youtube.com/watch?v=sFeA...
This is part of our new collaboration with 'I'm Fine' podcast, exploring overlooked areas of medical research. #MedSky
Reposted by Coleman Research Group (KCL)
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
March 27, 2025 at 6:05 PM
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
Reposted by Coleman Research Group (KCL)
A much needed article by @peiferlabunc.bsky.social on the need for eugenics pseudoscience as a topic in genetics teaching- sadly not just for historic reasons. Also courageous in the current climate, even though it shouldn't have to be. Lots for my own teaching in @geneticscam.bsky.social
Eugenics deserves a place in our genetics curriculum
Eugenics, that promoted planned breeding to ensure 'racial improvement', was central
to the development of genetics and led to horrifying policies. However, eugenics is
not dead and continues to influ...
www.cell.com
March 31, 2025 at 8:29 AM
A much needed article by @peiferlabunc.bsky.social on the need for eugenics pseudoscience as a topic in genetics teaching- sadly not just for historic reasons. Also courageous in the current climate, even though it shouldn't have to be. Lots for my own teaching in @geneticscam.bsky.social
Another week, another major contribution from the @pgcgenetics.bsky.social !
This time, new GWAS of bipolar disorder. Threads to follow.
www.nature.com/articles/s41...
This time, new GWAS of bipolar disorder. Threads to follow.
www.nature.com/articles/s41...
Genomics yields biological and phenotypic insights into bipolar disorder - Nature
Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.
www.nature.com
January 23, 2025 at 8:34 AM
Another week, another major contribution from the @pgcgenetics.bsky.social !
This time, new GWAS of bipolar disorder. Threads to follow.
www.nature.com/articles/s41...
This time, new GWAS of bipolar disorder. Threads to follow.
www.nature.com/articles/s41...
Just out — great work from Lachlan Gilchrist investigating the genetic relationship between depression and Alzheimer's. Pleased to have been able to contribute a little to this one. Open access, so read all about it below!
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease - Nature Mental Health
Using genome-wide meta-analyses of clinical measures of depression and biobank data, the authors investigate symptom-specific genetic associations between depression and subsequent risk for Alzheimer’...
www.nature.com
January 16, 2025 at 8:33 AM
Just out — great work from Lachlan Gilchrist investigating the genetic relationship between depression and Alzheimer's. Pleased to have been able to contribute a little to this one. Open access, so read all about it below!
www.nature.com/articles/s44...
www.nature.com/articles/s44...
V. pleased to see this work out — huge effort from 10s of analysts, 100s of scientists, 1000000s of participants. 🤞 a key resource in future MDD research.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
January 14, 2025 at 5:59 PM
V. pleased to see this work out — huge effort from 10s of analysts, 100s of scientists, 1000000s of participants. 🤞 a key resource in future MDD research.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
🤲 to @markjamesadams.bsky.social, @mcintosh2001.bsky.social and @cathrynlewis.bsky.social for leading.
Read all about it below.
Reposted by Coleman Research Group (KCL)
New study from the @pgcgenetics.bsky.social:
Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.
www.cell.com/cell/fulltex...
Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.
www.cell.com/cell/fulltex...
Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies
Trans-ancestry GWAS of major depression identifies 697 genetic variants and 308 genes,
implicating neural and molecular mechanisms and drug repurposing opportunities.
www.cell.com
January 14, 2025 at 4:10 PM
New study from the @pgcgenetics.bsky.social:
Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.
www.cell.com/cell/fulltex...
Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.
www.cell.com/cell/fulltex...
Reposted by Coleman Research Group (KCL)
You wanted starter packs to be searchable. Our engineers are busy keeping us online, so in the meantime, an independent developer built a new searchable library of starter packs. This is the beauty of building in the open 🦋
November 26, 2024 at 5:11 AM
You wanted starter packs to be searchable. Our engineers are busy keeping us online, so in the meantime, an independent developer built a new searchable library of starter packs. This is the beauty of building in the open 🦋
Our paper describing the creation and data from the UK Biobank 2022 online Mental Health Phenotyping is now up on Medrxiv (doi.org/10.1101/2024...)
All feedbak welcome!
1/3
All feedbak welcome!
1/3
The UK Biobank Mental Health Enhancement 2022: Methods and Results
Background: This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over...
doi.org
November 26, 2024 at 10:31 AM
Our paper describing the creation and data from the UK Biobank 2022 online Mental Health Phenotyping is now up on Medrxiv (doi.org/10.1101/2024...)
All feedbak welcome!
1/3
All feedbak welcome!
1/3