Cathryn Lewis
@cathrynlewis.bsky.social
Genetics - Statistics - Psychiatry.
Depression pharmacogenetics.
SGDP Centre, King’s College London. Psychiatric Genomics Consortium.
Depression pharmacogenetics.
SGDP Centre, King’s College London. Psychiatric Genomics Consortium.
Pinned
Cathryn Lewis
@cathrynlewis.bsky.social
· Aug 11
🚨 My new paper is out! | Oliver Pain, PhD posted on the topic | LinkedIn
🚨 My new paper is out! 🧬
Improving polygenic score (PGS) accuracy and equity across ancestrally diverse populations — with and without individual-level tuning data.
I benchmarked leading single-sou...
www.linkedin.com
Do you analyse #polygenic scores across ancestry groups? See Oliver Pain's extension to the GenoPred pipeline, with recommendations for good practice and efficient analysis. @oliverpain.bsky.social
🔗 Paper: lnkd.in/evJ9daBF
🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ
www.linkedin.com/posts/oliver...
🔗 Paper: lnkd.in/evJ9daBF
🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ
www.linkedin.com/posts/oliver...
Reposted by Cathryn Lewis
In today’s article, @kingsioppn.bsky.social Professor Cathryn Lewis @cathrynlewis.bsky.social discusses current evidence on the efficacy of #antidepressants and how research should move forward to support #precisionmedicine approaches in #mentalhealth.
www.inspirethemind.org/post/underst...
www.inspirethemind.org/post/underst...
Understanding who benefits from antidepressants
Why is the use of antidepressants so controversial, and how could we prescribe them more effectively? This question is a priority in my research at King’s College London, where I work as professor of ...
www.inspirethemind.org
October 29, 2025 at 2:09 PM
In today’s article, @kingsioppn.bsky.social Professor Cathryn Lewis @cathrynlewis.bsky.social discusses current evidence on the efficacy of #antidepressants and how research should move forward to support #precisionmedicine approaches in #mentalhealth.
www.inspirethemind.org/post/underst...
www.inspirethemind.org/post/underst...
Autumns has arrived - the @kingsioppn.bsky.social campuses are buzzing with new students but still sunny and mild enough for an early morning coffee outside at Ortus.
September 23, 2025 at 7:33 AM
Autumns has arrived - the @kingsioppn.bsky.social campuses are buzzing with new students but still sunny and mild enough for an early morning coffee outside at Ortus.
If your Monday morning is challenging, this post is a reminder of positive changes over the last 10 years.
From cancer treatment to music access to dresses-with-pockets
Hang in there amid the turmoil.
From cancer treatment to music access to dresses-with-pockets
Hang in there amid the turmoil.
Please give me an unironic list of things that have gotten better over the last ten years because I’m spiraling.
I’ll start: you can buy an enormous TV from Costco for like $100 bucks now.
I’ll start: you can buy an enormous TV from Costco for like $100 bucks now.
September 15, 2025 at 11:22 AM
If your Monday morning is challenging, this post is a reminder of positive changes over the last 10 years.
From cancer treatment to music access to dresses-with-pockets
Hang in there amid the turmoil.
From cancer treatment to music access to dresses-with-pockets
Hang in there amid the turmoil.
🚨Come work with us!🚨 Open post for Clinical Psychology Lecturer, combining NHS clinical work with research and education at the SGDP Centre.
Delighted to be hiring a new Clinical Psychology Lecturer to come and join our vibrant environment at the SGDP Centre @kingsioppn.bsky.social @kingscollegelondon.bsky.social please share!
my.corehr.com/pls/coreport...
my.corehr.com/pls/coreport...
my.corehr.com
August 11, 2025 at 8:56 AM
🚨Come work with us!🚨 Open post for Clinical Psychology Lecturer, combining NHS clinical work with research and education at the SGDP Centre.
Do you analyse #polygenic scores across ancestry groups? See Oliver Pain's extension to the GenoPred pipeline, with recommendations for good practice and efficient analysis. @oliverpain.bsky.social
🔗 Paper: lnkd.in/evJ9daBF
🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ
www.linkedin.com/posts/oliver...
🔗 Paper: lnkd.in/evJ9daBF
🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ
www.linkedin.com/posts/oliver...
🚨 My new paper is out! | Oliver Pain, PhD posted on the topic | LinkedIn
🚨 My new paper is out! 🧬
Improving polygenic score (PGS) accuracy and equity across ancestrally diverse populations — with and without individual-level tuning data.
I benchmarked leading single-sou...
www.linkedin.com
August 11, 2025 at 8:43 AM
Do you analyse #polygenic scores across ancestry groups? See Oliver Pain's extension to the GenoPred pipeline, with recommendations for good practice and efficient analysis. @oliverpain.bsky.social
🔗 Paper: lnkd.in/evJ9daBF
🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ
www.linkedin.com/posts/oliver...
🔗 Paper: lnkd.in/evJ9daBF
🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ
www.linkedin.com/posts/oliver...
Reposted by Cathryn Lewis
We're back, with a fresh new lineup of talks and workshops!
Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud!
This event is free and open to all: tinyurl.com/3ewaduvm
Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud!
This event is free and open to all: tinyurl.com/3ewaduvm
June 11, 2025 at 9:44 AM
We're back, with a fresh new lineup of talks and workshops!
Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud!
This event is free and open to all: tinyurl.com/3ewaduvm
Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud!
This event is free and open to all: tinyurl.com/3ewaduvm
Reposted by Cathryn Lewis
🎉(1/4) Excited to share that our latest paper is now published!
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank - European Journal of Human Genetics
European Journal of Human Genetics - Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank
www.nature.com
July 2, 2025 at 8:47 AM
🎉(1/4) Excited to share that our latest paper is now published!
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
This morning's email had *four* paper review requests - again.
Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers.
Suggestions for short-term fixes to help this broken system?
#academia #publishing
Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers.
Suggestions for short-term fixes to help this broken system?
#academia #publishing
June 27, 2025 at 7:56 AM
This morning's email had *four* paper review requests - again.
Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers.
Suggestions for short-term fixes to help this broken system?
#academia #publishing
Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers.
Suggestions for short-term fixes to help this broken system?
#academia #publishing
At @edinburghup.bsky.social University for two day AMBER team meeting.
@wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.
@wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.
June 9, 2025 at 9:51 AM
At @edinburghup.bsky.social University for two day AMBER team meeting.
@wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.
@wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.
Reposted by Cathryn Lewis
(1/2) Only one-third of people taking antidepressants for depression respond to the first drug they are prescribed and we know little about WHICH drug will work for each patient.
June 5, 2025 at 1:55 PM
(1/2) Only one-third of people taking antidepressants for depression respond to the first drug they are prescribed and we know little about WHICH drug will work for each patient.
Reposted by Cathryn Lewis
Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
Gender equality in research publishing is a responsibility for everyone
A concerted effort is needed to support women in their choice of journal when submitting their manuscript.
www.nature.com
May 31, 2025 at 4:31 AM
Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
Reposted by Cathryn Lewis
"This work is a first step in using health records to define and predict SSRI drug responses." - Professor Cathryn Lewis @cathrynlewis.bsky.social is Deputy Lead of our Trials, Genomics and Prediction theme, and the research was supported by @nihr.bsky.social and @wellcometrust.bsky.social 👇
Who benefits from antidepressants? New research from IoPPN ( @cathrynlewis.bsky.social) and University of Edinburgh shows how measuring antidepressant ‘switching can help scientists and clinicians understand why antidepressants work for some people and not for others www.kcl.ac.uk/news/who-ben...
Who benefits from antidepressants? Using medication switching as a measure of non-response
Switching from one selective serotonin reuptake inhibitor (SSRI) to another antidepressant could be used to measure antidepressant non-response, according to new research from the Institute of Psychia...
www.kcl.ac.uk
May 29, 2025 at 8:39 AM
"This work is a first step in using health records to define and predict SSRI drug responses." - Professor Cathryn Lewis @cathrynlewis.bsky.social is Deputy Lead of our Trials, Genomics and Prediction theme, and the research was supported by @nihr.bsky.social and @wellcometrust.bsky.social 👇
Our new paper assessing switching between antidepressants as a measure of non-response is now out in BPGOS.
Genetic studies show prediction from polygenic scores of remission from clinical studies.
Paper: www.sciencedirect.com/science/arti...
@kingsioppn.bsky.social Webstory ⬇️
Genetic studies show prediction from polygenic scores of remission from clinical studies.
Paper: www.sciencedirect.com/science/arti...
@kingsioppn.bsky.social Webstory ⬇️
May 28, 2025 at 4:49 PM
Our new paper assessing switching between antidepressants as a measure of non-response is now out in BPGOS.
Genetic studies show prediction from polygenic scores of remission from clinical studies.
Paper: www.sciencedirect.com/science/arti...
@kingsioppn.bsky.social Webstory ⬇️
Genetic studies show prediction from polygenic scores of remission from clinical studies.
Paper: www.sciencedirect.com/science/arti...
@kingsioppn.bsky.social Webstory ⬇️
Congratulations to Lachlan Gilchrist for his successful #PhD viva on Friday. He even admitted to enjoying the discussion!
Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social.
@kingsioppn.bsky.social
Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social.
@kingsioppn.bsky.social
May 27, 2025 at 8:11 AM
Congratulations to Lachlan Gilchrist for his successful #PhD viva on Friday. He even admitted to enjoying the discussion!
Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social.
@kingsioppn.bsky.social
Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social.
@kingsioppn.bsky.social
The SGDP Centre Atrium bookshare captures so much of our work culture.
From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas.
Books in English, Chinese, French.
Suggested donations supporting local charity.
All welcome to donate & borrow, @kingsioppn.bsky.social
From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas.
Books in English, Chinese, French.
Suggested donations supporting local charity.
All welcome to donate & borrow, @kingsioppn.bsky.social
May 22, 2025 at 8:25 AM
The SGDP Centre Atrium bookshare captures so much of our work culture.
From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas.
Books in English, Chinese, French.
Suggested donations supporting local charity.
All welcome to donate & borrow, @kingsioppn.bsky.social
From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas.
Books in English, Chinese, French.
Suggested donations supporting local charity.
All welcome to donate & borrow, @kingsioppn.bsky.social
#IoPPNFestival Fran Denk @denklab.bsky.social, winner of @kingsioppn.bsky.social Dean’s award for Research Integrity highlighting the importance of statistical understanding and application to support good research practices - honest, rigorous, open, respectful.
#statistics rocks!
#statistics rocks!
May 14, 2025 at 3:42 PM
#IoPPNFestival Fran Denk @denklab.bsky.social, winner of @kingsioppn.bsky.social Dean’s award for Research Integrity highlighting the importance of statistical understanding and application to support good research practices - honest, rigorous, open, respectful.
#statistics rocks!
#statistics rocks!
Reposted by Cathryn Lewis
The #IoPPNResearchFest is here! Join us for rapid-fire talks by IoPPN staff on the latest research in psychiatry, psychology + neuroscience, from the power of belief, neurotrauma and more.
Follow us and @thementalelf.bsky.social for highlights and key messages.
#AcademiaSky
Follow us and @thementalelf.bsky.social for highlights and key messages.
#AcademiaSky
May 14, 2025 at 12:45 PM
The #IoPPNResearchFest is here! Join us for rapid-fire talks by IoPPN staff on the latest research in psychiatry, psychology + neuroscience, from the power of belief, neurotrauma and more.
Follow us and @thementalelf.bsky.social for highlights and key messages.
#AcademiaSky
Follow us and @thementalelf.bsky.social for highlights and key messages.
#AcademiaSky
#BNA2025 Great addition to a conference- a Reading Room - with a view. Thanks to The Queen’s Reading Room for funding and interesting sessions on reading + neuroscience
April 29, 2025 at 7:27 AM
#BNA2025 Great addition to a conference- a Reading Room - with a view. Thanks to The Queen’s Reading Room for funding and interesting sessions on reading + neuroscience
#BNA2025 Ekta Patel from the Psychiatry Consortium, part of @md-catapult.bsky.social launches our Academia - Industry symposium. Strengthening collaborations through grand challenges, target validation and engagement
April 28, 2025 at 8:41 AM
#BNA2025 Ekta Patel from the Psychiatry Consortium, part of @md-catapult.bsky.social launches our Academia - Industry symposium. Strengthening collaborations through grand challenges, target validation and engagement
Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
April 8, 2025 at 5:40 AM
Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social
Reposted by Cathryn Lewis
(1/1) 🧠🌎 Just published in Nature Genetics:
“Psychiatric genetics in the diverse landscape of Latin American populations”
A comprehensive review of progress, challenges, and future directions.
🔗 www.nature.com/articles/s41...
#PsychiatricGenetics #GlobalGenomics
“Psychiatric genetics in the diverse landscape of Latin American populations”
A comprehensive review of progress, challenges, and future directions.
🔗 www.nature.com/articles/s41...
#PsychiatricGenetics #GlobalGenomics
April 4, 2025 at 4:59 PM
(1/1) 🧠🌎 Just published in Nature Genetics:
“Psychiatric genetics in the diverse landscape of Latin American populations”
A comprehensive review of progress, challenges, and future directions.
🔗 www.nature.com/articles/s41...
#PsychiatricGenetics #GlobalGenomics
“Psychiatric genetics in the diverse landscape of Latin American populations”
A comprehensive review of progress, challenges, and future directions.
🔗 www.nature.com/articles/s41...
#PsychiatricGenetics #GlobalGenomics
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
March 27, 2025 at 6:05 PM
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
Reposted by Cathryn Lewis
Join us for the ISPG Members' Meetup on March 26th!
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
March 23, 2025 at 1:25 AM
Join us for the ISPG Members' Meetup on March 26th!
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
Paper published: first output from our Wellcome Trust Mental Health Award, AMBER, on how UK Biobank participants report on whether antidepressants helped their depression.
tl;dr 75% said SSRI antidepressants helped them feel better
➡️ Paper in Psychological Medicine
bit.ly/4ifjcWC
🧵
tl;dr 75% said SSRI antidepressants helped them feel better
➡️ Paper in Psychological Medicine
bit.ly/4ifjcWC
🧵
March 17, 2025 at 2:52 PM
Paper published: first output from our Wellcome Trust Mental Health Award, AMBER, on how UK Biobank participants report on whether antidepressants helped their depression.
tl;dr 75% said SSRI antidepressants helped them feel better
➡️ Paper in Psychological Medicine
bit.ly/4ifjcWC
🧵
tl;dr 75% said SSRI antidepressants helped them feel better
➡️ Paper in Psychological Medicine
bit.ly/4ifjcWC
🧵
Reposted by Cathryn Lewis
Three quarters of people who have taken #antidepressants say they helped them "feel better" in new IoPPN research.
Read more➡️ www.kcl.ac.uk/news/three-q...
#SSRI @wellcometrust.bsky.social @edinburghuni.bsky.social @nihrmaudsleybrc.bsky.social @ukbiobank.bsky.social @kingscollegelondon.bsky.social
Read more➡️ www.kcl.ac.uk/news/three-q...
#SSRI @wellcometrust.bsky.social @edinburghuni.bsky.social @nihrmaudsleybrc.bsky.social @ukbiobank.bsky.social @kingscollegelondon.bsky.social
March 13, 2025 at 4:17 PM
Three quarters of people who have taken #antidepressants say they helped them "feel better" in new IoPPN research.
Read more➡️ www.kcl.ac.uk/news/three-q...
#SSRI @wellcometrust.bsky.social @edinburghuni.bsky.social @nihrmaudsleybrc.bsky.social @ukbiobank.bsky.social @kingscollegelondon.bsky.social
Read more➡️ www.kcl.ac.uk/news/three-q...
#SSRI @wellcometrust.bsky.social @edinburghuni.bsky.social @nihrmaudsleybrc.bsky.social @ukbiobank.bsky.social @kingscollegelondon.bsky.social