Christos Gournas
@christosgournas.bsky.social
Researcher at Labiris, Brussels.
Yeast Cell Biology, plasma membrane domains, amino acid transport, membrane trafficking, ubiquitin, ferroptosis
Yeast Cell Biology, plasma membrane domains, amino acid transport, membrane trafficking, ubiquitin, ferroptosis
Great new preprint! 🥳. Cools et al use innovate approaches to study Arg and Lys distribution, uncovering complex regulations in import and export, controlling aa toxicity and biosynthesis!
#yeast#transporter#lysosome
www.biorxiv.org/content/10.1...
#yeast#transporter#lysosome
www.biorxiv.org/content/10.1...
Vsb1, Ypq1 and Ypq2 control dynamic cationic amino acid storage in the yeast vacuole
Although the yeast vacuole plays a crucial role in storing and mobilizing cationic amino acids (CAA), CAA transport at the vacuolar membrane remains poorly understood. Here, by combining analysis of C...
www.biorxiv.org
September 18, 2025 at 7:02 AM
Great new preprint! 🥳. Cools et al use innovate approaches to study Arg and Lys distribution, uncovering complex regulations in import and export, controlling aa toxicity and biosynthesis!
#yeast#transporter#lysosome
www.biorxiv.org/content/10.1...
#yeast#transporter#lysosome
www.biorxiv.org/content/10.1...
Reposted by Christos Gournas
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
January 30, 2025 at 9:16 AM
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Christos Gournas
Lipid-CLEM ! Nice, looking forward reading this in depth!
Ooh nice preprint! Studying membrane nanodomains needs nanoscale lipid localization - current methods fall short. 'Lipid-CLEM', correlative light & EM with click chemistry to map lipids. In endosomes, it shows sphingomyelin’s differential partitioning beautifully.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Visualizing sub-organellar lipid distribution using correlative light and electron microscopy
Lipids and proteins compartmentalize biological membranes into nanoscale domains which are crucial for signaling, intracellular trafficking and many other cellular processes. Studying nanodomain funct...
www.biorxiv.org
January 30, 2025 at 6:22 AM
Lipid-CLEM ! Nice, looking forward reading this in depth!
Reposted by Christos Gournas
New paper out💥 in Nano Letters @pubs.acs.org
High throughput single particle profiler with simple confocal imaging. We used this new method to study protein-lipid interactions, drug membrane interactions and biophysics of small particles from human donors: pubs.acs.org/doi/10.1021/...
High throughput single particle profiler with simple confocal imaging. We used this new method to study protein-lipid interactions, drug membrane interactions and biophysics of small particles from human donors: pubs.acs.org/doi/10.1021/...
Imaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy
Single particle profiling (SPP) is a unique methodology to study nanoscale bioparticles such as liposomes, lipid nanoparticles, extracellular vesicles, and lipoproteins in a single particle and high t...
pubs.acs.org
January 30, 2025 at 9:40 AM
New paper out💥 in Nano Letters @pubs.acs.org
High throughput single particle profiler with simple confocal imaging. We used this new method to study protein-lipid interactions, drug membrane interactions and biophysics of small particles from human donors: pubs.acs.org/doi/10.1021/...
High throughput single particle profiler with simple confocal imaging. We used this new method to study protein-lipid interactions, drug membrane interactions and biophysics of small particles from human donors: pubs.acs.org/doi/10.1021/...
Reposted by Christos Gournas
New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.
www.science.org
January 22, 2025 at 7:43 PM
New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...
Reposted by Christos Gournas
🚨🚨 We are proud to launch MemBioMed, a new international Master program offering interdisciplinary training in biomembrane research at 3 sites: Université de Côte d'Azur 🇫🇷 Università di Genova 🇮🇹 & Osnabrück University 🇩🇪. We offer 15 scholarships & encourage talented students to apply by April 6th ♻️🙏
January 25, 2025 at 8:19 PM
🚨🚨 We are proud to launch MemBioMed, a new international Master program offering interdisciplinary training in biomembrane research at 3 sites: Université de Côte d'Azur 🇫🇷 Università di Genova 🇮🇹 & Osnabrück University 🇩🇪. We offer 15 scholarships & encourage talented students to apply by April 6th ♻️🙏
Reposted by Christos Gournas
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research
https://go.nature.com/4gc0Bc5
https://go.nature.com/4gc0Bc5
‘Never seen anything like this’: Trump’s team halts NIH meetings and travel
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.
go.nature.com
January 24, 2025 at 1:08 PM
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research
https://go.nature.com/4gc0Bc5
https://go.nature.com/4gc0Bc5