Ting Gang Chew
@chewtg.bsky.social
Cell biologist. We use mostly microscopy and genetics to understand cells.
Reposted by Ting Gang Chew
One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.
buff.ly/pMGXJVM
buff.ly/pMGXJVM
June 27, 2025 at 8:02 PM
One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.
buff.ly/pMGXJVM
buff.ly/pMGXJVM
Reposted by Ting Gang Chew
@joanavferreira.bsky.social, Carvalho @ox.ac.uk et al show that the integrity of multiple ER membrane contact sites requires Pex30 binding to phosphatidic acid via its dysferlin domain, & that Pex30 activity is regulated by phosphorylation in response to metabolic cues rupress.org/jcb/article/...
May 23, 2025 at 4:13 PM
@joanavferreira.bsky.social, Carvalho @ox.ac.uk et al show that the integrity of multiple ER membrane contact sites requires Pex30 binding to phosphatidic acid via its dysferlin domain, & that Pex30 activity is regulated by phosphorylation in response to metabolic cues rupress.org/jcb/article/...
Reposted by Ting Gang Chew
House et al. @joshilaboratory.bsky.social show that Pex30 dysferlin domain binds PA through its two hydrophobic regions adjacent to beta sheets, & propose that PA, a precursor for neutral lipids, recruits Pex30 at ER subdomains that plays a critical role in LD biogenesis rupress.org/jcb/article/...
May 23, 2025 at 4:58 PM
House et al. @joshilaboratory.bsky.social show that Pex30 dysferlin domain binds PA through its two hydrophobic regions adjacent to beta sheets, & propose that PA, a precursor for neutral lipids, recruits Pex30 at ER subdomains that plays a critical role in LD biogenesis rupress.org/jcb/article/...
Reposted by Ting Gang Chew
Insight Article: A new mode of action for unconventional NMDA receptors
Presynaptic #NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role. #Neuroscience
buff.ly/cwk0rwc
Presynaptic #NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role. #Neuroscience
buff.ly/cwk0rwc
May 23, 2025 at 8:02 PM
Insight Article: A new mode of action for unconventional NMDA receptors
Presynaptic #NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role. #Neuroscience
buff.ly/cwk0rwc
Presynaptic #NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role. #Neuroscience
buff.ly/cwk0rwc
Reposted by Ting Gang Chew
“By identifying & promoting good science, treating authors with decency and respect, and ensuring quality of peer review, editors nurture the reputation and quality of journals” editorial by our sister journal @lsajournal.org's @timisstuck.bsky.social: www.life-science-alliance.org/content/8/5/...
May 21, 2025 at 3:03 PM
“By identifying & promoting good science, treating authors with decency and respect, and ensuring quality of peer review, editors nurture the reputation and quality of journals” editorial by our sister journal @lsajournal.org's @timisstuck.bsky.social: www.life-science-alliance.org/content/8/5/...
Reposted by Ting Gang Chew
Organoids derived from placental tissue can be used to study processes involving syncytiotrophoblasts – cells that contain billions of nuclei – in the placenta. #DevBio
buff.ly/PfFsd30
buff.ly/PfFsd30
May 21, 2025 at 3:15 PM
Organoids derived from placental tissue can be used to study processes involving syncytiotrophoblasts – cells that contain billions of nuclei – in the placenta. #DevBio
buff.ly/PfFsd30
buff.ly/PfFsd30
Reposted by Ting Gang Chew
Check out the Special Issue below 👇
https://elifesciences.org/collections/f8cc6f3f/special-issue-reproductive-health?utm_source=bluesky&utm_medium=social&utm_campaign=organic
https://elifesciences.org/collections/f8cc6f3f/special-issue-reproductive-health?utm_source=bluesky&utm_medium=social&utm_campaign=organic
February 9, 2025 at 4:15 PM
Check out the Special Issue below 👇
https://elifesciences.org/collections/f8cc6f3f/special-issue-reproductive-health?utm_source=bluesky&utm_medium=social&utm_campaign=organic
https://elifesciences.org/collections/f8cc6f3f/special-issue-reproductive-health?utm_source=bluesky&utm_medium=social&utm_campaign=organic
Reposted by Ting Gang Chew
🌟 Special Issue highlight 🌟
The essential role of Slingshot phosphatase 2 in acrosome biogenesis in sperm. Read this and more in our #ReproductiveHealth Special Issue!
https://buff.ly/4hLnKTV
The essential role of Slingshot phosphatase 2 in acrosome biogenesis in sperm. Read this and more in our #ReproductiveHealth Special Issue!
https://buff.ly/4hLnKTV
February 9, 2025 at 4:15 PM
🌟 Special Issue highlight 🌟
The essential role of Slingshot phosphatase 2 in acrosome biogenesis in sperm. Read this and more in our #ReproductiveHealth Special Issue!
https://buff.ly/4hLnKTV
The essential role of Slingshot phosphatase 2 in acrosome biogenesis in sperm. Read this and more in our #ReproductiveHealth Special Issue!
https://buff.ly/4hLnKTV
Reposted by Ting Gang Chew
February 4, 2025 at 6:07 AM
Reposted by Ting Gang Chew
How do real scientists find our publishing model? Well, we’ve been asking authors like Hironori Funabiki at Rockefeller University. Read about his experience in our latest blog.
https://buff.ly/4hmln9O
https://buff.ly/4hmln9O
Publishing with eLife: “make positive impacts by contributing to such nourishing culture”
Why do authors choose the eLife Model? We spoke to Hironori Funabiki at the Rockefeller University to learn his reasons.
buff.ly
February 1, 2025 at 7:09 PM
How do real scientists find our publishing model? Well, we’ve been asking authors like Hironori Funabiki at Rockefeller University. Read about his experience in our latest blog.
https://buff.ly/4hmln9O
https://buff.ly/4hmln9O
Reposted by Ting Gang Chew
Fluorescent-Localized Cell Cycle Reporter (FLCCR) for fission yeast @plosbiology.org
journals.plos.org/plosbiology/...
In Movie, mCherry-Pcn1 (nuclear, magenta), mCherry-RitC (membrane, magenta), Sid2-GFP (cyan), and SynCut3-mTagBFP2 (green).
journals.plos.org/plosbiology/...
In Movie, mCherry-Pcn1 (nuclear, magenta), mCherry-RitC (membrane, magenta), Sid2-GFP (cyan), and SynCut3-mTagBFP2 (green).
January 23, 2025 at 3:17 PM
Fluorescent-Localized Cell Cycle Reporter (FLCCR) for fission yeast @plosbiology.org
journals.plos.org/plosbiology/...
In Movie, mCherry-Pcn1 (nuclear, magenta), mCherry-RitC (membrane, magenta), Sid2-GFP (cyan), and SynCut3-mTagBFP2 (green).
journals.plos.org/plosbiology/...
In Movie, mCherry-Pcn1 (nuclear, magenta), mCherry-RitC (membrane, magenta), Sid2-GFP (cyan), and SynCut3-mTagBFP2 (green).
Reposted by Ting Gang Chew
AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵 1/12 rupress.org/jcb/article-...
α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure
This paper shows how epithelial cell–cell junctions play a critical role in the fidelity of cell division, where persistent unfolding of the mechanosensiti
rupress.org
January 10, 2025 at 9:19 PM
AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵 1/12 rupress.org/jcb/article-...
Reposted by Ting Gang Chew
A piece of science history about RNA, oxygen, and mice cages
There is nothing is more important in an experiment than the proper controls. But what should you do if your experimental control fails? - read my short essay on failed experimental controls.
www.embopress.org/doi/full/10....?
There is nothing is more important in an experiment than the proper controls. But what should you do if your experimental control fails? - read my short essay on failed experimental controls.
www.embopress.org/doi/full/10....?
January 21, 2025 at 5:19 PM
A piece of science history about RNA, oxygen, and mice cages
There is nothing is more important in an experiment than the proper controls. But what should you do if your experimental control fails? - read my short essay on failed experimental controls.
www.embopress.org/doi/full/10....?
There is nothing is more important in an experiment than the proper controls. But what should you do if your experimental control fails? - read my short essay on failed experimental controls.
www.embopress.org/doi/full/10....?