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carajgottardi.bsky.social
Gottardi Lab
@carajgottardi.bsky.social
1.1K followers 980 following 33 posts
We study the multiple functions of catenins in cell-cell adhesion, cytoskeleton/nuclear signaling and lung repair after injury.
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Reposted by Gottardi Lab
sciencex.bsky.social
A new enzyme-free technique uses alternating electrochemical currents to gently detach cells from culture surfaces, maintaining high cell viability and reducing waste in biomanufacturing processes. doi.org/hbbs27
Enzyme-free approach gently detaches cells from culture surfaces
Anchorage-dependent cells are cells that require physical attachment to a solid surface, such as a culture dish, to survive, grow, and reproduce.
phys.org
November 18, 2025 at 10:19 PM
Reposted by Gottardi Lab
peiferlabunc.bsky.social
Thank you UVa for being the first places asking for grad school recomendations that did not include ANY of the silly ratings questions
November 4, 2025 at 10:53 PM
carajgottardi.bsky.social
Bluesky folks, @jfhorner.bsky.social is also ON THE JOB MARKET! Check out his work 🧐... he's SUPER TALENTED and a pleasure to work with!
October 31, 2025 at 9:49 PM
Reposted by Gottardi Lab
peiferlabunc.bsky.social
Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
Full text in links Full text in links
October 6, 2025 at 6:09 PM
Reposted by Gottardi Lab
nucleosomepolice.bsky.social
that time of the year... writing letters for 8 UG's applying to grad school, each of them to ~15 programs. And while I passionately support every one of them, thats A LOT of letters, a lot of web sites to keep track of, a lot of my time. Why dont Grad programs use interfolio? One and done???
October 4, 2025 at 11:41 AM
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peiferlabunc.bsky.social
After a "suspension" of just a few days, UNC Professor Dwayne Dixon is re-instated, revealing the weakness of the fabricated issues used for the suspension. Here is his response. Stand up to the fascists--when we work together we can triumph.
Text of a statement from Dr. Dixon
October 4, 2025 at 1:18 PM
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maikbischoff.bsky.social
My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls

Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨

🔗 www.nikonsmallworld.com/galleries/20...

#NikonSmallWorld #Microscopy #ScienceArt
October 3, 2025 at 9:06 AM
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peiferlabunc.bsky.social
Kate's work is remarkable--saw it at the Cell Contact and Adhesion GRC. Hiring faculty--she's a scientist to watch
katecavanaugh.bsky.social Kate Cavanaugh @katecavanaugh.bsky.social · Oct 1
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 11:28 PM
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jeremymberg.bsky.social
A new email to Director Bhattacharya this morning.

1/n
Dear Director Bhattacharya: I listened to more of your conversation with Glenn Beck. You made a number of statements that are false and misleading. You have considerable responsibilities in your current position and need to live up to them. You dismiss critics of President Trump's comments at the press conference by saying: "I think the key point here is something called "Trump Derangement Syndrome".
September 28, 2025 at 12:05 PM
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labonnelab.bsky.social
"Head down focus on the science" folks: here is one super easy thing you can do today.
peiferlabunc.bsky.social Mark Peifer (He, him) @peiferlabunc.bsky.social · Sep 27
Here's my comment--join me. This would effectively remove foreign PhD students and postdocs from our labs. please share
September 27, 2025 at 2:53 PM
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jeremymberg.bsky.social
An email to Director Bhattacharya to start the day

1/6
Dear Director Bhattacharya: I attended the NIAID Council meeting online. I wanted to raise two points. First, I was disappointed that you sent a video of your presentation rather than showing up in person or, at least, attending live but virtually. You are missing out on important opportunities to interact with NIH staff and Advisory Council members. These individuals use their expertise and considerable time and energy to try to further the NIH mission. In addition, you are sending a signal about your priorities. This is especially true when you spend your time by appearing on The Glenn Show within a day. I realize that it was important to try to clean up the mess made primarily by President Trump at your press conference when he said repeatedly "Don't Take Tylenol!".
September 27, 2025 at 1:07 PM
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theajacobs.bsky.social
Super cool work from our institute!
uni-muenster.de Universität Münster @uni-muenster.de · Sep 8
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology
How epithelial junctions mature: Study shows conformational transition in key protein
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...
www.uni-muenster.de
September 10, 2025 at 8:10 AM
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frelab.bsky.social
Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...
Geometry first: how positional cues dictate fate in bilayered epithelia - the Node
Behind the paper story focussed on research on early fate decisions in bilayered epithelia.
thenode.biologists.com
September 9, 2025 at 7:12 AM
Reposted by Gottardi Lab
biorxivpreprint.bsky.social
Top-Down Individual Ion Mass Spectrometry Reveals 85-110 kDa Catenin Phospho-Proteoforms Regulated by Actomyosin Contractility https://www.biorxiv.org/content/10.1101/2025.09.06.674621v1
September 8, 2025 at 2:46 AM
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peiferlabunc.bsky.social
I'm more than a little excited about this interstellar visitor 🧪
The images keep getting better and the insights deeper
PS this is just some of the science funded by the NSF that is threatened by devastating budget cuts--speak up and call Congress.
www.sci.news/astronomy/in...
Interstellar Comet 3I/ATLAS Displays Broad Coma and Growing Tail | Sci.News
Using the Gemini Multi-Object Spectrograph (GMOS) on the Gemini South telescope at NSF’s International Gemini Observatory in the Chilean Andes, astronomers have captured new multi-color images of the ...
www.sci.news
September 6, 2025 at 6:41 PM
Reposted by Gottardi Lab
paveltomancak.bsky.social
We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12)

www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterned invagination prevents mechanical instability during gastrulation - Nature
In Drosophila, the cephalic furrow counteracts mechanical stress as the developing head and the trunk tissues meet, providing evidence for how mechanical forces influence the evolution of morphog...
www.nature.com
September 4, 2025 at 8:22 AM
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biorxiv-cellbio.bsky.social
α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin https://www.biorxiv.org/content/10.1101/2025.08.21.671625v1
August 22, 2025 at 11:30 PM
Reposted by Gottardi Lab
drugmonkey.bsky.social
NIH progress on new R01s in FY 2025 drugmonkey.wordpress.com/2025/08/18/n...
NIH progress on new R01s in FY 2025
I know Doctor Editor Director Professor Berg has more sophisticated analyses going but this simple data set made sense to me once I realized how few new R01 NIAAA has issued so far (5). Since we ar…
drugmonkey.wordpress.com
August 19, 2025 at 1:56 AM
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jeremymberg.bsky.social
Indirect cost fun facts (from FY2024)

3 of the top 5 institutions in terms of negotiated indirect rates are pediatric hospitals.

The University of Kansas Medical Center had a higher negotiated indirect rate that Stanford.
August 7, 2025 at 11:38 PM
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maikbischoff.bsky.social
This thread below is criminally under-liked and under-shared!

Young #Drosophila researchers (PhDs, postdocs, and early-career Drosophilists): fill out the survey by Sept 1st to get matched with a mentor who can support you with your career.

Established Drosophilists, like/share Shefali's Thread ;)
July 30, 2025 at 3:41 PM
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richardsever.bsky.social
bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏
July 31, 2025 at 12:32 PM
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jeremymberg.bsky.social
Post Sunday morning shows Bhattacharya email...
July 27, 2025 at 7:34 PM
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peiferlabunc.bsky.social
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
Diagram illustrating the two-hit model of retinoblastoma
July 26, 2025 at 2:11 PM
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dgaboriau.bsky.social
Getting closer to the “if proteins could talk…” moment of biochemistry
July 23, 2025 at 10:48 AM
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mirresimons.bsky.social
New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits.
www.biorxiv.org/content/10.1...
July 18, 2025 at 6:57 PM