Francesca Ceroni
@ceronifranci.bsky.social
Senior Lecturer @ Chemical Engineering Department, Imperial College London
(views are my own)
(views are my own)
Pinned
STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion
While secretion plays a key role in the diverse applications of cell engineering, to date only a handful of mammalian signal peptides have been characterised in depth and systematic efforts to build n...
www.biorxiv.org
Do you want to engineer mammalian protein secretion? We present STAMPS: signal-peptide transformer for tuning mammalian protein secretion! Led by Jacopo in the lab, in collaboration with Cleo Kontoravdi and colleagues at Astra Zeneca, STAMPS is now on Bioarxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Do you want to engineer mammalian protein secretion? We present STAMPS: signal-peptide transformer for tuning mammalian protein secretion! Led by Jacopo in the lab, in collaboration with Cleo Kontoravdi and colleagues at Astra Zeneca, STAMPS is now on Bioarxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion
While secretion plays a key role in the diverse applications of cell engineering, to date only a handful of mammalian signal peptides have been characterised in depth and systematic efforts to build n...
www.biorxiv.org
November 21, 2025 at 9:10 AM
Do you want to engineer mammalian protein secretion? We present STAMPS: signal-peptide transformer for tuning mammalian protein secretion! Led by Jacopo in the lab, in collaboration with Cleo Kontoravdi and colleagues at Astra Zeneca, STAMPS is now on Bioarxiv!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
'Transgene integration in mammalian cells' led by John Fong from the group, is out now! Check it at www.sciencedirect.com/science/arti...
Thanks @cp-cellsystems.bsky.social for the opportunity!
Thanks @cp-cellsystems.bsky.social for the opportunity!
Transgene integration in mammalian cells: The tools, the challenges, and the future
Robust and stable expression of genes of interest is crucial for studying and engineering biology. While expressing desired gene products in some micr…
www.sciencedirect.com
October 27, 2025 at 4:55 PM
'Transgene integration in mammalian cells' led by John Fong from the group, is out now! Check it at www.sciencedirect.com/science/arti...
Thanks @cp-cellsystems.bsky.social for the opportunity!
Thanks @cp-cellsystems.bsky.social for the opportunity!
PhD positions available in our group! Please share! www.findaphd.com/phds/project...
PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London on FindAPhD.com
PhD Project - PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London, listed on FindAPhD.com
www.findaphd.com
October 6, 2025 at 7:31 AM
PhD positions available in our group! Please share! www.findaphd.com/phds/project...
Just out: 'Aptamer-based burden biosensors' led by Alice in the lab. Funded by NSF-BBSRC in collaboration with @francolab.bsky.social, we show aptamers cause burden in E.coli. We then develop a burden biosensor for identification of low-burden genetic variants: www.sciencedirect.com/science/arti...
July 2, 2025 at 6:20 PM
Just out: 'Aptamer-based burden biosensors' led by Alice in the lab. Funded by NSF-BBSRC in collaboration with @francolab.bsky.social, we show aptamers cause burden in E.coli. We then develop a burden biosensor for identification of low-burden genetic variants: www.sciencedirect.com/science/arti...
Reposted by Francesca Ceroni
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-...
June 30, 2025 at 2:34 PM
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-...
Thanks @manishmicrobe.bsky.social and @oborkowski.bsky.social for two wonderful days!
Two days of excellent discussions with @ceronifranci.bsky.social and Luca Ciandrini. So great to have them visit.
June 19, 2025 at 2:45 PM
Thanks @manishmicrobe.bsky.social and @oborkowski.bsky.social for two wonderful days!
Reposted by Francesca Ceroni
Annalise Zouein's main PhD research paper is published today in Trends in Biotech. Building and using repetitive transcription factor-binding arrays to modulate gene regulation in mammalian cells. No RNA, no protein - just DNA doing the work! www.sciencedirect.com/science/arti...
June 10, 2025 at 12:33 PM
Annalise Zouein's main PhD research paper is published today in Trends in Biotech. Building and using repetitive transcription factor-binding arrays to modulate gene regulation in mammalian cells. No RNA, no protein - just DNA doing the work! www.sciencedirect.com/science/arti...
Thrilled I am going to be speaking at the Royal Society Theo Murphy Workshop on Generative Biology next October! royalsociety.org/science-even...
Generative biology: new approaches to study developmental design principles | Royal Society
Theo Murphy meeting organised by Mr Jake Cornwall-Scoones, Dr Dirk Benzinger, and Professor Sally Lowell.
royalsociety.org
May 12, 2025 at 2:03 PM
Thrilled I am going to be speaking at the Royal Society Theo Murphy Workshop on Generative Biology next October! royalsociety.org/science-even...
Reposted by Francesca Ceroni
A huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...
PlasmidScope: a comprehensive plasmid database with rich annotations and online analytical tools
Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co
academic.oup.com
April 22, 2025 at 5:00 AM
A huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...
Reposted by Francesca Ceroni
Reposted by Francesca Ceroni
Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability #NBTHighlight
www.science.org/doi/10.1126/... and www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... and www.science.org/doi/10.1126/...
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
www.science.org
January 31, 2025 at 4:19 PM
Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability #NBTHighlight
www.science.org/doi/10.1126/... and www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... and www.science.org/doi/10.1126/...
Our work on 'Degradation bottlenecks in mammalian cells' is now out @NatureComms:
www.nature.com/articles/s41...
Well done to the whole team! You can read this at rdcu.be/d5o2h
Happy 2025 everyone!
www.nature.com/articles/s41...
Well done to the whole team! You can read this at rdcu.be/d5o2h
Happy 2025 everyone!
https://nature.com/articles/s4146…
January 3, 2025 at 1:51 PM
Our work on 'Degradation bottlenecks in mammalian cells' is now out @NatureComms:
www.nature.com/articles/s41...
Well done to the whole team! You can read this at rdcu.be/d5o2h
Happy 2025 everyone!
www.nature.com/articles/s41...
Well done to the whole team! You can read this at rdcu.be/d5o2h
Happy 2025 everyone!
Reposted by Francesca Ceroni
Check out our latest pre-print where we used our ASP-#SPARK #sensor to unveil #SnRK1's multifaceted role during #plant growth and #development! bit.ly/49JVZrY
Including real-time #spatiotemporal visualization of SnRK1 activity in a growing #Arabidopsis root! 😀
Including real-time #spatiotemporal visualization of SnRK1 activity in a growing #Arabidopsis root! 😀
December 19, 2024 at 3:41 PM
Check out our latest pre-print where we used our ASP-#SPARK #sensor to unveil #SnRK1's multifaceted role during #plant growth and #development! bit.ly/49JVZrY
Including real-time #spatiotemporal visualization of SnRK1 activity in a growing #Arabidopsis root! 😀
Including real-time #spatiotemporal visualization of SnRK1 activity in a growing #Arabidopsis root! 😀
Reposted by Francesca Ceroni
Latest preprint from Jane (Xinyu Lu) in our group explores what happens when we build a synthetic genome cluster in yeast for Histidine biosynthesis and SCRaMbLE it to see whether selected-for gene rearrangements can guide better design.
Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes https://www.biorxiv.org/content/10.1101/2024.12.06.627136v1
December 8, 2024 at 1:55 PM
Latest preprint from Jane (Xinyu Lu) in our group explores what happens when we build a synthetic genome cluster in yeast for Histidine biosynthesis and SCRaMbLE it to see whether selected-for gene rearrangements can guide better design.
Still time to apply, please share and spread the opportunity!
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg.
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
December 5, 2024 at 9:26 AM
Still time to apply, please share and spread the opportunity!
Great to have @ciaranlkelly.bsky.social presenting the exciting work his group is doing here at Imperial!
November 20, 2024 at 2:24 PM
Great to have @ciaranlkelly.bsky.social presenting the exciting work his group is doing here at Imperial!
NAPIC website is now live!: www.napic.ac.uk
November 20, 2024 at 11:53 AM
NAPIC website is now live!: www.napic.ac.uk
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg.
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
November 13, 2024 at 9:21 PM
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg.
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...